669 results about "Animals experiments" patented technology

The invention provides an application of a fermentation lactobacillus mucus strain A21196 in preparation of a product for resisting anxiety and improving memory and concentration, and belongs to the technical field of biological medicines. Animal experiments show that the fermented lactobacillus mucus strain A21196 has the effects of resisting anxiety, resisting depression, improving cognitive impairment function and improving memory concentration, and provides a new means for preventing and / or treating nerve diseases related to anxiety disorder, depression and cognitive impairment.

The invention relates to an antidepressant pharmaceutical composition and application thereof, and particularly discloses a pharmaceutical composition for treating depression as well as a preparation method and application thereof. The active pharmaceutical ingredients of the pharmaceutical composition are prepared from the following traditional Chinese medicines in parts by weight: 500 to 600 parts of radix bupleuri, 500 to 600 parts of fructus aurantii immaturus, 500 to 600 parts of radix aucklandiae, 500 to 600 parts of pericarpium citri reticulatae, 500 to 600 parts of rhizoma pinelliae preparata, 750 to 900 parts of herba taraxaci, 500 to 600 parts of scorched fructus crataegi, 300 to 360 parts of scorched semen arecae, 500 to 600 parts of paederia scandens, 300 to 400 parts of radix codonopsis, 300 to 400 parts of rhizoma corydalis and 500 to 600 parts of fried medicated leaven. The pharmaceutical composition has a remarkable curative effect on depression, animal experiments show that the pharmaceutical composition can remarkably enhance the social coefficient (showing that the pharmaceutical composition can improve social fear of depression patients) and improve sweet water preference (showing that the pharmaceutical composition is beneficial to transformation of negative emotions such as interest deficiency of the depression patients), and the pharmaceutical composition is safe to take, free of adverse reaction and toxic and side effects and free of toxic and side effects. And the composition can take effect quickly, and can take effect generally within 1-2 weeks after medication.

The invention relates to the technical field of animal experiment teaching demonstration, in particular to an animal experiment teaching demonstration center management device and a use method thereof, and the method comprises the following steps: I, device initialization: arranging remote monitoring equipment and close sensing equipment, and ensuring that an animal activity area is covered and no blind area exists; defining monitoring modes in the main control system, wherein the monitoring modes comprise a remote monitoring mode, a close monitoring mode and a cooperative monitoring mode; according to the invention, through the dynamic cooperation of remote and close-range monitoring equipment and in combination with an interference evaluation algorithm, the balance between monitoring accuracy and interference minimization is realized, the natural behavior mode of animals is effectively reserved, and meanwhile, an adaptive mechanism is adopted, so that equipment parameters and a monitoring mode can be adjusted in real time, and the monitoring effect is dynamically optimized according to an experimental scene; manual intervention requirements are greatly reduced, the contradiction between accuracy and interference of an existing animal behavior monitoring system is effectively solved, and the animal behavior monitoring system is suitable for various animal experiment teaching and scientific research scenes.

The invention belongs to the technical field of microorganisms and fermentation engineering, and particularly relates to application of bifidobacterium longum subsp. Infantis Y46 in the aspects of enhancing cell defense and repair and regulating metabolic homeostasis of a host. The strain is isolated from infant feces. Animal experiments prove that living cell thalli of the bifidobacterium longum subsp. Infantis Y46, which are obtained by culturing an MRS liquid culture medium added with L-cysteine hydrochloride (0.05%, v / v), can significantly enhance the oxidative stress resistance of an organism and reduce the level of active oxygen in the organism compared with a control bacterium bifidobacterium longum subsp. Infantis 15697. Transcriptomics analysis shows that the bifidobacterium longum subsp. Infantis Y46 can enhance self-protection of cells and improve physiological imbalance caused by external pressure by regulating related signal channels of an organism. The action mechanism is closely related to signaling pathways related to cell defense, metabolic homeostasis and barrier functions. The invention provides a new strain resource and an application scheme for developing functional food or medicinal preparations for enhancing the health defense function of a human body.

The invention belongs to the technical field of microorganisms and fermentation engineering, and particularly relates to application of bifidobacterium longum subsp. Infantis Y46 in the anti-aging aspect. The bifidobacterium longum subsp. Infantis Y46 is obtained from excrement of infants. Animal experiments prove that living cell thalli (Y46) and thermally inactivated cell thalli (HKY46) obtained by culturing the bifidobacterium longum subsp. Infantis Y46 by using an MRS liquid culture medium containing L-cysteine hydrochloride (0.05%, v / v) can significantly reduce accumulation of lipofuscin in a host, and prolong the healthy life and life of the host. Therefore, the bifidobacterium longum subsp. Infantis Y46 is a promising probiotic and a promising metagen with an anti-aging function.

The invention provides an application of clofazimine in preparation of a medicine for treating cancers. Animal experiments show that clofazimine can regulate the tumor immune environment and enhance the anti-tumor immune effect; the number of tumors is reduced, and tumor bodies are reduced; the survival time of tumor animals is prolonged.

The utility model provides a protection device for an underwater animal experiment, and belongs to the field of underwater animal experiments. The brain cover part, the viscera cover part and the hip cover part are driven to be opened or closed through the opening and closing module, and the problem that in the prior art, an experimental device capable of protecting the brain and viscera of an experimental animal body from being damaged by vibration signals is lacked is solved. The device comprises a cover body module, a mounting base and an opening and closing module, the cover body module is fixedly mounted on the mounting base, and the opening and closing module controls the cover body module to be opened and closed; the cover body module comprises a brain cover part, an internal organ cover part, a hip cover part, a front side cover, a rear side cover, a bottom cover, a first partition plate and a second partition plate; the brain cover part, the viscera cover part, the hip cover part, the front side cover, the rear side cover, the bottom cover, the first partition plate and the second partition plate are each provided with an interlayer.

The invention relates to the technical field of microorganisms, and particularly discloses bifidobacterium adolescentis AGE17 capable of promoting growth and development of muscles and bones and application of the bifidobacterium adolescentis AGE17. The bifidobacterium adolescentis AGE17 is separated from excrement of healthy children and is preserved in the China General Microbiological Culture Collection Center (CGMCC), the preservation number is CGMCC No.33452, and the preservation date is January 17, 2025. The bifidobacterium adolescentis AGE17 has the advantages that the bifidobacterium adolescentis AGE17 can be used for preparing the biological organic fertilizer; animal experiments prove that the bifidobacterium adolescentis strain AGE17 provided by the invention has the function of promoting muscle and skeletal development, has more obvious and prominent effects compared with a model strain bifidobacterium adolescentis ATCC15703, and has important application value in increasing the muscle strength and height of children and adolescents.

The invention belongs to the technical field of biological agriculture, and particularly relates to a method for promoting growth of natural calculus bovis by using a novel small molecule peptide combination, which comprises the following steps: selecting a plurality of small molecule peptides with specific functions, and mixing the small molecule peptides according to a specific proportion to form a small molecule peptide combination with a synergistic effect. The growth of the natural calculus bovis can be effectively promoted, and the yield and the quality of the natural calculus bovis are improved. Meanwhile, the method disclosed by the invention has relatively high safety and has a wide prospect in practical application. Animal experiment data further verifies the effectiveness and safety of the method.

The invention provides an application of a pediococcus pentosaceus strain A20001 in preparation of a product for improving memory concentration and anxiety and depression behaviors, and belongs to the technical field of biological medicines. Animal experiments show that the pediococcus pentosaceus strain A20001 has the functions of resisting anxiety behavior, resisting depression, improving cognitive function and improving memory concentration. Therefore, the invention provides the application of the pediococcus pentosaceus strain A20001 in the preparation of the medicine for preventing and / or treating the anxiety disorder, the depression or the cognitive impairment and improving the memory, and further provides the application of the pediococcus pentosaceus strain A20001 in the preparation of the medicine for preventing and / or treating the anxiety disorder, the depression or the cognitive impairment.

The invention relates to the technical field of animal experiments, and particularly discloses an experimental animal PET-CT examination auxiliary fixing device which comprises a fixing base, the upper surface of the fixing base is fixedly connected with a first supporting column, the upper surface of the first supporting column is fixedly connected with a first limiting plate, and the side surface of the first limiting plate is fixedly connected with two supporting limiting blocks. The experimental animal PET-CT examination auxiliary fixing device is provided with a supporting limiting block and a positioning sliding rail, when the experimental animal PET-CT examination auxiliary fixing device works, by sliding a second supporting column, a transmission rolling wheel at the lower end of the second supporting column is used for supporting, friction force is dropped through rotation of the transmission rolling wheel, and therefore practicability is improved; and a second supporting column is conveniently guided, so that the movement stability of the second supporting column is improved, the distance between a first limiting plate and a second limiting plate is conveniently changed, and the convenience of fixing different rabbits is improved.

The invention relates to the technical field of animal experiment equipment, and discloses an isolated culture device for mouse sweet water preference test in an IVC cage, which comprises a shell cover, the partition plate is fixedly installed on the inner side wall of the shell cover, and an inner cavity of the shell cover is divided into a living area and a functional area through the partition plate; the sliding cover is arranged in the living area of the shell cover and used for containing solid feed, and multiple sets of feeding trough openings which are arranged at equal intervals are formed in the bottom of the sliding cover; according to the device, an innovative cage-in-cage design is adopted, a single cage is converted into a plurality of independent experiment units on the premise that an existing IVC system is not changed, and cage position resources are greatly saved. The functions of isolation, double-bottle water drinking and independent feeding are integrated, and convenient operation is achieved through the pull-out type fixing plate and the sliding cover plate. The centrifugal tube is adopted to replace a special water bottle, so that the cost is reduced, the SPF environment is kept in the whole process, data accuracy and reliability are ensured, and the traditional SPT test problem is effectively solved.

The present invention relates to the technical field of the development and utilization of probiotics, specifically to a Weissella confusa DY12 with probiotic activity and its application. The Weissella confusa DY12 was isolated from sheep feces. The present invention identified the probiotic effect of Weissella confusa DY12 through animal experiments. The results showed that Weissella confusa DY12 could tolerate acid and bile salts and resist the gastrointestinal internal environment; its hydrophobicity was 39.47% and its auto-aggregation was 48.12%, demonstrating that the Weissella confusa DY12 of the present invention has good intestinal adhesion ability and has the potential of probiotics. The present invention verified that Weissella confusa DY12 can effectively regulate the immune function of the animal body, improve the antioxidant capacity of the body, as well as the content of lysozyme and the activity of alkaline phosphatase, and increase the daily weight gain, ultimately improving the growth performance of animals.

The invention discloses a medicine for treating autism, application of the medicine for treating autism in preparation of a medicine for improving social competence damage of autism animals or people, and application of the medicine for treating autism in preparation of a medicine for improving anxiety behaviors of autism animals or people. When the high-dose vitamin D is used for intervening autism mice, the method has the advantages of being economical, convenient to take and good in effect, animal experiment evidence is provided for supplementing large-dose VD to intervene autism spectrum disorders in the early stage of clinical experiments, and a new thought is provided for early prevention and treatment of neurodevelopment disorders of clinical children.

The invention discloses application of an active compound in an anti-cataract drug, and particularly relates to the field of drugs. The active compound is lenalidomide, mycophenolic acid, glycyrrhetinic acid or bromfenac sodium hydrate. Through a solution based on a CRYAB structure and animal experiment screening, it is found that the active compound can serve as an effective component of an anti-cataract drug, the progress of cataract can be remarkably relieved or inhibited, and a new strategy and potential drug selection are provided for treatment of cataract.

The invention relates to the technical field of animal experiment devices, and discloses a spatial cognition enhancement device and method for three-dimensional rotational stimulation of a vestibular-hippocampus pathway, and the device comprises a rotational stimulation unit which is used for generating multi-axial angular acceleration stimulation; the animal adaptation unit is connected with the rotary stimulation unit and is used for fixing an experimental animal and blocking visual input; the control unit is in signal connection with the rotary stimulation unit and is used for adjusting stimulation parameters and collecting dynamic data; and the signal acquisition unit comprises a piezoresistive sensor and an analog-to-digital converter and is used for acquiring kinetic parameters of angular velocity and angular acceleration in real time. According to the space cognition enhancement device and method for three-dimensional rotation stimulation of the vestibular-hippocampus pathway, real three-dimensional space motion is simulated through multi-axial rotation, and targeted stimulation of the vestibular-hippocampus pathway is achieved in combination with adjustable rotating speed and visual shielding maintenance. The device is integrated with an acoustic intervention module and supports multi-mode intervention.

The invention provides an application of cichorium glandulosum polysaccharide in preparation, basic characterization and type 2 diabetes mellitus relieving medicines, and belongs to the technical field of medicines. Animal experiment results show that after the cichorium glandulosum polysaccharide is applied to type 2 diabetic mice, serum biochemical indexes can be adjusted, the blood sugar level can be reduced, organ injuries can be protected or repaired, and PI3K / AKT / mTOR signal channel related protein expression in the main glycometabolism target organ liver can be adjusted. Therefore, the prepared cichorium glandulosum polysaccharide can be used as a medicine for relieving type 2 diabetes mellitus.

The invention discloses application of Trolox in preparation of a medicine for treating toxicity caused by valproic acid, and belongs to the technical field of biological medicine. The invention discovers for the first time that Trolox has a new medicine application of preventing and / or treating developmental toxicity caused by valproic acid or redox level imbalance caused by valproic acid; furthermore, animal experiments prove that Trolox can relieve zebra fish development malformation caused by valproic acid and also can relieve zebra fish redox level imbalance caused by valproic acid; this provides a new solution for the prevention and / or treatment of developmental toxicity caused by valproic acid or redox level imbalance caused by valproic acid.

The utility model discloses an experimental mouse cage, and relates to the technical field of animal experiments. The experimental mouse cage can automatically monitor food intake of mice. The experimental mouse cage comprises a mouse cage body, a first mouse cage cover, a second mouse cage cover, a feeder, a water feeder and a weighing sensor; the number of the weighing sensors is two, and the two weighing sensors are installed at the same end of the mouse cage body and arranged in a spaced mode. The first mouse cage cover and the second mouse cage cover are arranged at an interval, one end of the first mouse cage cover and one end of the second mouse cage cover are hinged to the same end of the mouse cage body, and the other end of the first mouse cage cover and the other end of the second mouse cage cover are lapped on the two weighing sensors respectively; the feeder is installed on the first mouse cage cover and extends into the mouse cage body, and the water feeder is installed on the second mouse cage cover and extends into the mouse cage body. The mouse diet frequency and diet amount monitoring system can automatically monitor the diet frequency and diet amount of the mouse, and frequent manual participation is not needed.

The invention relates to the technical field of animal experiment instruments, in particular to a detonation injury simulation experiment device, which controls the displacement of a telescopic cylinder through a pressurizing mechanism, and controls the length of the telescopic cylinder through a telescopic mechanism, so that in the process that the pressurizing mechanism continuously pressurizes the inside of a sealed cavity, the detonation injury can be simulated. After the telescopic cylinder body sleeves the sealing mechanism to move for a specified distance, the telescopic cylinder body is separated from the sealing mechanism, and the sealing baffle plate is popped out, so that the gas with specified pressure is released, and the effect of controlling the gas flow with specified pressure to perform knocking impact simulation on animals is achieved. According to the experimental device, knocking impact simulation conditions in fixed spaces with different sizes are realized by arranging different pressurizing structures; meanwhile, structures such as a water tank and a pressure relief hole are arranged, so that the knocking impact condition when air or water is used as a medium can be simulated; in addition, by setting different rotation directions of the stainless steel mesh, the knocking impact conditions under different body positions and states can be simulated.

The invention discloses an animal experiment acupuncture point massage parameter self-correction method combined with deep learning, and relates to the technical field of animal intervention experiments. The specific operation of the animal experiment acupoint massage parameter self-correction method combined with deep learning comprises the steps of simulating human hand tactile characteristic device design, deep learning model construction and training and massage parameter self-correction operation flow, and the human hand tactile characteristic device design comprises a tactile sensing module and a force feedback execution module. The step of deep learning model construction and training comprises data acquisition and labeling, model structure design and model training and optimization, and the step of massage parameter self-correction operation comprises an experiment preparation stage, an experiment proceeding stage and an experiment ending stage. Spatial feature data, including pressure distribution and strain images, collected by a multi-mode sensor can be effectively processed.

The utility model belongs to the technical field of experiment tables, and particularly provides a lifting type animal experiment table which comprises a lifting operation table and a side cabinet, the side cabinet is arranged on the side edge of the lifting operation table, the lifting operation table comprises a base, a fixing column, a lifting column, a first rotating plate, a second rotating plate and an operation plate, and the fixing column is fixedly arranged in the middle of the upper wall of the base; the interior of the fixed column is hollow, the lifting column is vertically and slidably arranged on the inner wall of the fixed column, the first rotating plate is rotatably arranged at the upper end of the lifting column, the second rotating plate is rotatably arranged at the upper end of the first rotating plate, rotating planes of the first rotating plate and the second rotating plate are perpendicular to each other, and the operation plate is fixedly arranged on the upper wall of the second rotating plate. According to the lifting type animal experiment table, the vertical lifting mechanism, the left-right deflection mechanism and the front-back deflection mechanism are arranged, and the lifting type animal experiment table in the scheme is simpler to operate through the change of various postures in cooperation with the convenient operation control mode of the control box, more postures can be adjusted, and the table top can be freely adjusted in the inclined state; various animal experiments can be conveniently carried out.

The transportable xenogenic organ transplantation donor animal experiment shelter comprises an outer cabin and an inner cabin, the outer cabin is a transport box, the inner cabin is arranged in the middle area in the outer cabin, and the areas on the two sides in the outer cabin are arranged as equipment rooms; the inner cabin is provided with a barrier area and a common area, a changing room, a feeding room and a dissecting room are arranged in the barrier area, and a preparation room, a first transfer cabinet, a feed room, a clean water room, a waste water collecting room, a second transfer cabinet and a decompression bin are arranged in the common area; a personnel circulation channel and an article and animal circulation channel are arranged in the inner cabin; the controller is arranged in the preparation room, and the controller is connected with the air conditioner, the waste gas treatment device and the generator set; living animals are transported to an organ transplantation site in the square cabin, experimental animals with organs to be removed can live in the square cabin, are in a standby state all the time, are removed after the operation of a patient is prepared, and are quickly implanted into the body of the patient, so that the problems existing in long-distance transportation of xenogenic organ transplantation at present are solved.

The invention relates to the technical field of animal experiment analysis, in particular to an animal behavior monitoring method, device and equipment and a medium. The method comprises the following steps: acquiring video stream data for a target area; determining target information of each animal in the video frame, wherein the target information comprises number information, center point information and attitude information; and performing behavior monitoring on the animals according to the number information, the center point information and the attitude information of the animals in each video frame to obtain animal behavior monitoring information. According to the method, continuous behavior monitoring, such as trajectory tracking, posture change, position change and other state or behavior monitoring, is carried out on the animals with different serial number information in combination with continuous video frames through the serial number information, the center point information and the posture information of the animals; the problems that in the prior art, influence of non-experimental factors is likely to happen, and the monitoring efficiency is low are solved.

The invention provides an animal multi-mode experiment control system for controlling the concentration of hydrogen and oxygen, an integrated sensor module, a gas concentration control system and a user interface. The sensor module monitors the temperature, the humidity, the hydrogen concentration and the oxygen concentration in the experiment module in real time and feeds back the data to the gas concentration control system, the actual flow value and the set flow value are compared through the central control PCB according to flow information provided by the float flowmeter, the opening degree of the valve is automatically adjusted, and the gas concentration is controlled. And the concentration of hydrogen and oxygen in the experiment module is maintained in a preset range. The high-precision sensor module can accurately capture key parameter changes. A PID algorithm is adopted for gas concentration control, a float flowmeter and an automatic regulating valve are combined, the concentration control precision within + / -1% is achieved, and the high-precision experiment requirement is met. According to the invention, a stable and accurate hydrogen and oxygen concentration management scheme is provided for animal experiments, and the controllability and data reliability of the experiments are improved.

The invention relates to the technical field of animal experiments, and provides a small animal experiment operation platform which comprises a platform body, the platform body comprises an operation area used for placing small animals for experiment operation, vertical rods are evenly arranged on the bottom side of the operation area in a penetrating mode, and each vertical rod can independently ascend and descend. The operation platform further comprises a plurality of pressing pieces used for being arranged on the vertical rods in a sleeving mode to press and fix the small animals. After a small animal to be experimented is placed in the operation area, a fixing part is determined according to the actual size of the small animal body and the experimental design, then the vertical rods near the fixing part are sequentially selected and moved upwards by a certain distance, and then the vertical rods moving upwards are sequentially sleeved with pressing pieces matched with the fixing part. The vertical rods which are uniformly distributed in a dot-matrix manner are used as fixing anchor points, and then the pressing sheet is sleeved on the fixing anchor points for pressing and fixing, so that the fixing requirements of different body sizes and custom fixing parts are met, and the flexibility and the accuracy of small animal experiment operation are greatly improved.

The invention relates to the technical field of animal experiment auxiliary equipment, in particular to a periodontitis modeling mouth angle retraction device and equipment with fixed illumination and view amplification, and the device comprises a supporting and fixing mechanism, a mechanical transmission mechanism and a fixed expansion mechanism; the supporting and fixing mechanism is used for supporting and fixing the whole device and the rat to be experimented; through a fixed supporting plate, a movable threaded rod, a first movable half clamp and a second movable half clamp in the fixed expansion mechanism, the mouth corners of to-be-experimented rats with different sizes are retracted; the mechanical transmission mechanism is provided with a first rotating mechanical plate, a second rotating mechanical plate, a magnifying observation mirror and illumination light, so that a clear view field and sufficient and uniform light are provided for an operator. By means of the unique structural design of the oral corner retracting device, the stability, comfort, safety, observation conditions, operation efficiency and accuracy in the periodontitis molding process are remarkably improved, and the problems that an existing oral corner retracting device is poor in fixing effect, safety and operability are solved.

The invention provides application of bifidobacterium breve in preparation of a product for resisting gastric ulcer and gastric inflammation caused by helicobacter pylori, and belongs to the technical field of microorganisms. The preservation number of the bifidobacterium breve NKU BB1-2 is GDMCC NO: 65956, and the bifidobacterium breve NKU BB1-2 can antagonize helicobacter pylori colonization and relieve gastric ulcer aggravation caused by helicobacter pylori. The bifidobacterium breve NKU BB 1-2 has good helicobacter pylori antagonism ability in an in-vitro environment, and can significantly inhibit colonization growth of helicobacter pylori; animal experiments show that the bifidobacterium breve NKU BB 1-2 can relieve gastric ulcer aggravation caused by helicobacter pylori infection in vivo, and the gastric mucosa lesion is relieved, the stomach inflammation is relieved, and the stomach pH value is increased; in addition, the bifidobacterium breve NKU BB1-2 can also significantly improve the diversity of stomach microorganisms, regulate and improve the structure of the stomach microorganisms, and assist antagonism and removal of helicobacter pylori infection.

The invention provides an animal experiment time-limited feeding method and system. The animal experiment time-limited feeding method and system are applied to an intelligent door control system comprising a feeding box body, an electric control door control channel, a multi-mode sensor array and an intelligent control unit. According to the method, monitoring data streams of animal states and behaviors are obtained through a multi-modal sensor array; implementing execution control of the time-limited feeding mode based on the monitoring data stream and preset parameters; outputting a personalized time-limited feeding intervention strategy based on the execution data and the monitoring data stream; and management and analysis of experimental data are realized through the data management module. The invention further provides a corresponding time-limited feeding system, the system has dynamic adaptability, comprehensive monitoring dimension, high flexibility and deep data integration capacity, the problems that in the prior art, manual control accuracy is poor, intelligent adaptability and data deep mining are lacked are solved, and the system is suitable for large-scale popularization and application. And the accuracy, scientificity and animal welfare level of animal experiments are improved.