4 results about "Cetrorelix" patented technology

The invention discloses a cetrorelix acetate freeze-dried preparation and a preparation method thereof, and belongs to the technical field of pharmaceutical preparations, the preparation method comprises the following steps: dissolving cetrorelix acetate and then freeze-drying; the freeze-drying process comprises the following stages: S1, a pre-cooling stage; s2, a pre-freezing stage; s3, a sublimation drying stage; s4, a desorption drying stage; ice crystal nucleation is induced in the pre-cooling stage, so that the product is completely frozen at the pre-freezing temperature, in addition, the desorption drying temperature is increased, the water and impurity levels of the freeze-dried product are reduced, the freeze-drying time is shortened, and the product quality is improved. The product obtained by the technology disclosed by the invention is controllable in key quality attributes such as character, acidity, solution clarity, related substances and the like in a storage process, and is relatively good in stability; the product freeze-drying process time is short, the energy consumption in the production process is reduced, and the production cost is reduced.

The present disclosure relates to methods for reproductive management of mammalian animals using a GnRH antagonist such as Cetrorelix. Specifically, the GnRH antagonist can be used for synchronizing follicular wave emergence in a population of female mammals, and / or for fixed-time reproductive management protocols such as oocyte collection protocols, embryo collection protocols, artificial insemination protocols or embryo transfer protocols. Also described are devices and kits for reproductive management, comprising a GnRH antagonist and optionally one or more additional drugs useful for reproductive management.

The application discloses a method for determining chiral amino acids in cetrotide acetate. Specifically relates to a method for determining the content of chiral amino acids in cetrotide acetate based on pre-column derivatization high performance liquid chromatography. Simple operation, without extraction separation of the sample after derivatization, the content of 10 kinds of chiral amino acids after hydrolysis of cetrotide acetate can be determined simultaneously, the sensitivity is high, more basis can be provided for structure confirmation, and reference can be provided for separation of chiral amino acids of polypeptide drugs.

The present invention relates to a liquid pharmaceutical cetrolix composition comprising a stabilizer selected from the group consisting of poloxamer having an average molecular weight of 7,000-12,000 g / mol and / or benzyl alcohol, and a pharmaceutical dosage form comprising the liquid pharmaceutical composition, and their use in inhibiting premature luteinizing hormone surge in a woman undergoing controlled ovarian stimulation. Furthermore, a method for preparing a liquid pharmaceutical cetrolix composition and a pharmaceutical dosage form is disclosed.