47results about How to "Short reconstitution time" patented technology

The invention relates to panax notoginseng saponins freeze-dried powder injection and a preparation method thereof. The freeze-dried powder injection is prepared by panax notoginseng saponins and water for injection. The panax notoginseng saponins freeze-dried powder injection is free of auxiliary materials or stent agents, good in re-dissolubility, low in water content and good in appearance forming.

The invention provides poly-L-lactic acid (PLLA) particles and a PLLA filler for injection prepared from the particles. The PLLA particles with different molecular weights and granularities are mixed to prepare the PLLA for injection, and the prepared PLLA for injection can achieve the beautifying effects of quick response and long maintenance time. Compared with an existing product, the PLLA filler has better redissolving and suspending effects, can reduce subcutaneous nodules, remarkably improves the comfort of a user, and provides a new choice for the field of medical cosmetology.

The invention provides a preparation method of an anti-hepatitis B immune ribonucleic acid freeze-dried powder injection. The preparation method of the anti-hepatitis B immune ribonucleic acid freeze-dried powder injection comprises the following steps: a) mixing anti-hepatitis B immune ribonucleic acid, an excipient and water for injection, so that a mixed solution A is obtained; b) filtering, and freeze-drying the mixed solution A, so that the anti-hepatitis B immune ribonucleic acid freeze-dried powder injection is obtained, wherein mass ratio of the anti-hepatitis B immune ribonucleic acid to the excipient to the water for injection is 1:(2-15):(200-600). Compared with the prior art, the preparation method provided by the invention has the advantages that uniformity of anti-hepatitis B immune ribonucleic acid in the anti-hepatitis B immune ribonucleic acid freeze-dried powder injection can be effectively controlled, and redissolution time of a product is reduced; and experiment results show that the redissolution time of the anti-hepatitis B immune ribonucleic acid freeze-dried powder injection obtained by adopting the preparation method provided by the invention is within 12 seconds.

The invention belongs to the technical field of medicine, and relates to a corimycin freeze-dried powder preparation and a preparation method thereof. The freeze-dried powder preparation is prepared by corimycin, an organic acid or an inorganic acid, a proppant and water for injection. to make. Wherein, every 1000ml of water for injection contains 40-115g of corimycin, 20-100g of organic acid or inorganic acid, and 15-30g of proppant. The weight ratio of carrimycin, organic acid or inorganic acid is: 1:1-5:1, preferably 2:1-4:1. Inorganic acid includes hydrochloric acid, sulfuric acid or phosphoric acid; described organic acid includes citric acid, anhydrous citric acid, maleic acid, adipic acid, acetic acid, methanesulfonic acid, ethanesulfonic acid, fumaric acid, tartaric acid, apple Acid, pyroglutamic acid, lactic acid, succinic acid or C1-C4 straight chain or branched chain alkane sulfonate unsubstituted or substituted by any position of 1-3 hydroxyl groups. The freeze-dried powder injection of the invention has the characteristics of short reconstitution time, few insoluble particles, easy preparation and relatively stable characteristics.

The invention provides a method for preparing a biapenem bulk drug, the method comprising the following steps: 1) at a certain dissolution temperature T 1 2) The crude biapenem aqueous solution obtained in step 1) is controlled at T 1 or cool down to T 2 , add activated carbon, stir to decolorize, filter, and cool the filtrate to T 3 Standby; 3) the filtrate of step 2) gained is added dropwise to pre-cooling to T 4 4) growing crystals; 5) separating, washing and drying the crystals precipitated in step 4) to obtain the biapenem bulk drug.

The invention provides a preparation method of a blood coagulation factor XIII. The preparation method has the advantages of high yield, high purity and short production period, and comprises the steps of blood plasma and blood cell separation, virus inactivation, ammonium sulfate graded sedimentation, DEAE-FF chromatographic column treatment, split charging and freeze drying, wherein an auxiliary agent is added during the virus inactivation; the graded sedimentation and dissolution process of the blood coagulation factor XIII is performed in an environment being 0 to 4 DEG C; different dissolving agents are added for performing graded dissolution on precipitates; the dissolution efficiency is improved; the production period is shortened; the bacteria breeding is reduced; and the yield and the purity of the blood coagulation factor XIII are improved. The preparation method of the blood coagulation factor XIII provided by the invention has the beneficial effects that the extraction efficiency is high; more than 10mg of the blood coagulation factor XIII can be extracted from per liter of blood plasma; in a prepared blood coagulation factor XIII freeze-drying product, the purity of the blood coagulation factor XIII is higher than 90 percent; the operation is simple; the production period is short; and the preparation of the blood coagulation factor XIII can be completed in two days.

The invention relates to a freeze-drying method of pseudo-ginseng total saponin freeze-dried injection powder with a filling amount more than 500 mg. In the method, freeze-dried is carried out mainly through specific refrigerating parameters. The freeze-drying method provided by the invention has good drying effect and significantly shortened freeze-drying time, which is 20-50% of common freeze-drying time.

The invention provides a preparation method of a cytidine disdoium triphosphate freeze-dried powder injection. The preparation method comprises the following steps of: (a) mixing cytidine disdoium triphosphate, an excipient with first water for injection, and adjusting the pH value to obtain mixed solution A; and (b) mixing the mixed solution A with second water for injection, and filtering, freezing and drying in sequence so as to obtain the cytidine disdoium triphosphate freeze-dried powder injection, wherein the mass ratio of the first water for injection to the second water for injection is 6:(3-5). Compared with the prior art, the preparation method provided by the invention can be used for effectively controlling the content of impurities in the cytidine disdoium triphosphate freeze-dried powder injection and increasing the mass stability and the yield of products; and experimental results show that the impurity content of the cytidine disdoium triphosphate freeze-dried powder injection prepared through the preparation method provided by the invention is below 0.41%.

The invention relates to a preparation method of a cortical hormone preparation, and concretely relates to a preparation method of a betamethasone sodium phosphate freeze-dried powder injection. The method comprises the following steps: dissolving betamethasone sodium phosphate and auxiliary materials in injection, filling the obtained solution, and freeze-drying the filled solution, wherein nitrogen is introduced in the whole sublimation drying stage and desorption drying stage of freeze-drying. The method solves the problem of increase of the content of impurities in the storage process in the prior art, substantially improves the stability of the betamethasone sodium phosphate freeze-dried powder, and also solves the problem of low production efficiency in the prior art.