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Preparation method of freeze-dried powder

A freeze-dried powder and pre-freezing technology, which is applied in freeze-dried transportation, medical preparations containing active ingredients, and drying, etc., can solve the problems of prone to collapse, uneven texture, and difficulty in collecting powder during the preparation process of freeze-dried powder. problems, to avoid the damage of material structure and the influence of active ingredients, to solve the effect of insufficient drying and low water content

Active Publication Date: 2021-12-07
BEIJING KANGRENTANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005]Therefore, the technical problem to be solved by the present invention is to overcome the problems of collapse, bubbling, uneven texture and powder collection in the preparation process of freeze-dried powder in the prior art. Difficult to wait for defects

Method used

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  • Preparation method of freeze-dried powder

Examples

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Comparison scheme
Effect test

Embodiment 1

[0087] The present embodiment provides a kind of preparation method of Hypericum perforatum freeze-dried powder, comprising the following steps,

[0088] Preparation of Hypericum perforatum extract: take 100g decoction pieces of Hypericum perforatum, add 12 times the amount of water to the first decoction, soak for 30 minutes, and then decoct for 20 minutes; Filter through mesh filter cloth, combine the filtrates, place the filtrate at a rotating speed of 55r / min, and concentrate under reduced pressure at 55°C until the density of the concentrated solution is 1.05g / ml to obtain the Hypericum perforatum traditional Chinese medicine extract.

[0089] Determination of the eutectic point of Hypericum perforatum: Take an appropriate amount of Hypericum perforatum extract and place it in the material tray, insert the platinum resistance temperature measuring probe and electrode into the extract solution (keep a certain distance between the two electrodes and the temperature probe and...

Embodiment 2

[0100] This embodiment provides a preparation method of fried Vitex lyophilized powder, comprising the following steps,

[0101] Preparation of fried Vitex extract: take 200g of fried Vitex herbal decoction pieces, add 12 times the amount of water to the first decoction, soak for 30 minutes and then decoct for 20 minutes; add 10 times the amount of water to the second decoction, decoct for 15 minutes, and decoct Filtrate with a 150-mesh filter cloth, combine the filtrates, place the filtrate at a speed of 55 r / min, and concentrate under reduced pressure at 55°C until the density of the concentrated solution is 1.05g / ml to obtain the extract of fried Vitex chinensis traditional Chinese medicine.

[0102] The method for measuring the eutectic point of Hypericum perforatum according to embodiment 1 measures the eutectic point of fried Vitex, see image 3 . pass image 3 It can be known that the temperature of the eutectic point of fried Vitex is -26~-24°C.

[0103] Preparation...

Embodiment 3

[0113] This embodiment provides a method for preparing freeze-dried powder of Fructus Chickpea, comprising the following steps,

[0114] To prepare the extract of Azurite chinensis: take 100g decoction pieces of Azurite chinense, add 10 times the amount of water to the first decoction, soak for 30 minutes, and then decoct for 30 minutes; add 8 times the amount of water to the second decoction, decoct for 20 minutes, and use 150 Filter through mesh filter cloth, combine the filtrates, place the filtrate at a rotating speed of 55r / min, and concentrate under reduced pressure at 55°C until the density of the concentrated solution is 1.05g / ml to obtain the traditional Chinese medicine extract of Fructus Chickpeas.

[0115] The method for measuring the eutectic point of Hypericum perforatum according to embodiment 1 measures the eutectic point of Fructus Chinensis, see Figure 5 . pass Figure 5 It can be known that the temperature of the eutectic point of Chickweed is -40~-42°C. ...

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Abstract

The invention belongs to the technical field of preparation of freeze-dried powder and particularly relates to a preparation method of the freeze-dried powder. The method comprises the following steps: placing a traditional Chinese medicine extract at a pre-freezing temperature, and then, heating the temperature to 25-35 DEG C to obtain traditional Chinese medicine freeze-dried powder, wherein the pre-freezing temperature is 5-14 DEG C lower than an eutectic point of the traditional Chinese medicine extract; and the process of raising the pre-freezing temperature to 25-35 DEG C at least comprises 8 heat preservation processes. The freeze-dried powder obtained by the method can keep the original volume, does not collapse, has a smooth surface, can integrally fall off without being broken, has uniform color and luster, is free of spots and has fine texture. In addition, the freeze-dried powder prepared by the method provided by the invention is low in water content and short in redissolution time, the specific surface area and porosity are increased, and the redissolution time of the freeze-dried powder is effectively shortened.

Description

technical field [0001] The invention belongs to the technical field of freeze-dried powder preparation, and in particular relates to a preparation method of freeze-dried powder. Background technique [0002] At present, most traditional Chinese medicine products are divided into decoction pieces, Chinese patent medicines and traditional Chinese medicine formula granules. For modern urban life, granules are easy to carry and store, do not need to be boiled, and can be prepared with warm water. Patient approval. Traditional Chinese medicine ingredients include active ingredients, auxiliary ingredients and ineffective ingredients. The extraction process involves extraction, separation, concentration, purification, drying and other processes. The type of extracted Chinese medicine components is closely related to the quality of the product. Among them, selecting a suitable temperature and method to dry the extract of traditional Chinese medicine is one of the important steps i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/19F26B5/06A61K36/38A61K36/85A61K36/533A61K36/185A61K36/282A61K36/9066A61K36/9068
CPCA61K9/19F26B5/06A61K36/38A61K36/85A61K36/533A61K36/185A61K36/282A61K36/9066A61K36/9068A61K2236/51
Inventor 张志强刘香云姚杭琦张美玲周永康程立伟
Owner BEIJING KANGRENTANG PHARMA
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