35 results about "Hypericum perforatum" patented technology

The invention discloses a traditional Chinese medicine composition, a preparation method of the traditional Chinese medicine composition, a traditional Chinese medicine preparation and application of the traditional Chinese medicine preparation, and relates to the technical field of medicine production. 9 to 12 parts of ginkgo leaf; 9-30 parts of radix astragali; 9 to 15 parts of hypericum perforatum; 6 to 15 parts of jujube; 3-9 parts of red ginseng; 9-15 parts of semen ziziphi spinosae; and 3-6 parts of valerian. All the medicines in the traditional Chinese medicine composition have a synergistic effect, the curative effect is enhanced, and the depressive symptom is improved together.

The invention relates to the technical field of traditional Chinese medicine analysis, in particular to a method for determining the content of five flavonoid components in a hypericum perforatum medicinal material. The content determination method comprises the following steps: preparing rutin, hyperoside, isoquercitrin, quercitrin and quercetin into a mixed reference solution; extracting a hypericum perforatum medicinal material by using an extraction solvent to prepare a test solution; the mixed reference substance solutions and the test solution with different volumes are subjected to high performance liquid chromatography respectively, a mobile phase A is acetonitrile, a mobile phase B is a phosphoric acid aqueous solution with the volume concentration of 0.08-0.12%, and elution gradient is adopted. The content determination method has the advantages of high sensitivity, simplicity and convenience in operation, low cost and high detection speed.

The invention provides a traditional Chinese medicine preparation for treating chronic prostatitis, and relates to the technical field of traditional Chinese medicine pharmacy. The traditional Chinese medicine preparation is prepared from black nightshade, hypericum perforatum, yam rhizome, rhizoma sparganii, common sage herb, chingma abutilon seed, polyporus umbellatus, uniflower swisscentaury root, corydalis amabilis, aspongopus, glossy privet fruit, fructus broussonetiae, radix ophiopogonis, tuber fleeceflower stem, day lily and liquorice. The traditional Chinese medicine preparation has the effects of clearing heat and promoting diuresis, promoting blood circulation to remove blood stasis, nourishing yin and soothing nerves and tonifying liver and kidney. The traditional Chinese medicine preparation disclosed by the invention has a remarkable treatment effect on CNP rats, and the prostate pathological injury condition and inflammatory response of the CNP rats are effectively relieved. In addition, the traditional Chinese medicine composition has a good treatment effect on relieving pain, frequent micturition, urgent urination, dysuria and other clinical symptoms and inflammation conditions of patients, and has a high total treatment effective rate on chronic prostatitis. The traditional Chinese medicine preparation provides a new scheme for treating chronic prostate.

The invention provides a traditional Chinese medicine preparation for treating postpartum depression and a preparation method thereof, and relates to the technical field of traditional Chinese medicine preparation. The traditional Chinese medicine preparation is prepared from Chinese rose flowers, hypericum perforatum, caulis polygoni multiflori, tortoise shells, radix hedysari, aleppo avens, perilla stems, officinal magnolia flowers, fructus podophylli, loofah sponge, fructus choerospondiatis, entada phaseoloides, rhizoma polygonati and other traditional Chinese medicine raw materials. The traditional Chinese medicine preparation integrates the methods of soothing liver-qi stagnation, nourishing blood for tranquilization, tonifying qi and nourishing yin, promoting blood circulation to remove meridian obstruction and promoting qi circulation to relieve middle energizer, gives consideration to both symptoms and root causes, not only relieves the symptom of postpartum liver depression, but also tonifies the root cause of deficiency of qi and blood, so that liver qi is smooth, qi and blood are full and mind is nourished, and the traditional Chinese medicine preparation has the effect of preventing and treating postpartum depression. The traditional Chinese medicine preparation provided by the invention can improve nervous system functions by influencing expression of hippocampus 5-HT and DA so as to realize the effect of regulating depression-like behaviors; the traditional Chinese medicine composition has a remarkable curative effect on postpartum depression and has a remarkable effect of improving and relieving depressive clinical symptoms of patients.

This invention relates to the field of natural product separation technology, specifically to coumarin compounds isolated from *Hypericum perforatum*, their preparation methods, and applications. The preparation method of these coumarin compounds includes alcohol extraction from *Hypericum perforatum*, followed by macroporous resin adsorption separation and column separation. The coumarin compounds of this invention can be used for anti-inflammatory purposes, exhibiting inhibitory activity against RAW264.7 cells and the expression of TNF-α, IL-1β, and IL-6 proteins.

The invention relates to the technical field of traditional Chinese medicine compositions, in particular to a traditional Chinese medicine composition and application of the traditional Chinese medicine composition in preparation of drugs for improving sleep disorder and treating mood disorder or cognitive disorder. The invention provides a traditional Chinese medicine composition. The traditional Chinese medicine composition comprises the following components in parts by mass: 20-30 parts of lycium ruthenicum, 30-40 parts of nitraria fruit, 15-25 parts of gastrodia elata, 13-25 parts of hyperforin perforatum and 2-6 parts of lycopene. The traditional Chinese medicine composition provided by the invention is prepared from lycium ruthenicum, nitraria fruit, gastrodia elata, hyperforin perforatum and lycopene according to a specific ratio, and the composition can effectively relieve anxiety behaviors of chronic stress bound anxiety model mice through ways of resisting oxidation and inflammation, regulating expression of neurotransmitters and the like, prolong sleep time and improve sleep quality. The learning ability and the memory ability of cognitive impairment mice induced by scopolamine are improved, and the neuron density of brain tissues is increased, so that the neuroprotective effect is achieved.

This invention discloses an optimized extraction and purification process for total flavonoids from Hypericum perforatum and its application in photodamage protection. Belonging to the field of natural product extraction technology, the process includes the following steps: using Hypericum perforatum powder as raw material, ultrasonic-assisted extraction is performed, followed by centrifugation, collection of the supernatant, and repeated extraction of the residue twice. The supernatants are combined to obtain a total flavonoid extract from Hypericum perforatum. The extract is then purified by adsorption using a macroporous adsorption resin, and the eluent is collected, concentrated, and dried to obtain high-purity total flavonoids from Hypericum perforatum. This invention features a stable process, high extraction efficiency, and is environmentally friendly, making it suitable for industrial production. The prepared total flavonoids from Hypericum perforatum exhibit high purity and significant antioxidant and photoprotective effects, and can be widely used in antioxidant, skin protection, and sunscreen products.

The invention belongs to the technical field of field targeted spraying, and discloses a hypericum perforatum field targeted spraying device based on multispectral recognition. The device comprises a crop hazard identification and extraction module, a fixed-point pesticide spraying decision optimization module, a pesticide spraying instruction generation and transmission module, a pesticide residue prediction and traceability module and a planting standard conformity evaluation module, hazard factors are analyzed based on a standardized data set, a crop hazard report is obtained, analysis is performed based on the crop hazard report, and a pesticide residue prediction and traceability result is obtained. The method comprises the steps of obtaining a crop pesticide spraying strategy report, a pesticide spraying operation record report and a pesticide residue prediction report, evaluating the standard degree of a planting process, providing corresponding improvement suggestions, and obtaining a planting standard conformity evaluation report. The system has the remarkable advantages of high basic data reliability, high dynamic and accurate regulation and control intelligence capability and good crop full life cycle management effect.

The invention provides a traditional Chinese medicine composition for treating hypothyroidism and a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicine compositions. In the traditional Chinese medicine composition, fomes officinalis ames, stigma croci, aloe, resina scammoniae, kalimeris indica, radix aucklandiae, pogonatherum crinitum and rhizoma nardostachyos are taken as main medicines of a formula, asamur, cortex cinnamomi, rhizoma calami, myrrh branches, euphorbia pekinensis resina, common jasminum seeds and champignon are taken as auxiliary medicines of the formula, and vernonia anthelmintica, hypericum perforatum, black pepper and white pepper are taken as correction medicines of the formula. The traditional Chinese medicine composition is clear in compatibility, has the effects of promoting blood circulation to remove blood stasis, eliminating cold to stop pain, relaxing tendons and activating collaterals and tonifying the liver and kidney, can effectively treat hypothyroidism, and is definite in curative effect on improvement of clinical manifestations and laboratory indexes of patients, safe and reasonable.

The invention discloses a traditional Chinese medicine composition for treating obesity phlegm-dampness obstructing spleen syndrome. Comprising the following raw material medicines in parts by weight: 18-25 parts of astragalus membranaceus, 11-15 parts of bighead atractylodes rhizome (fried), 11-15 parts of poria cocos, 8-12 parts of rhizoma alismatis, 3-5 parts of coptis chinensis (fried with wine), 4-6 parts of rheum officinale (fried with wine), 8-12 parts of semen cassiae (fried), 7-12 parts of radix bupleuri (fried with vinegar), 11-15 parts of hyperforin perforatum, 13-18 parts of oriental wormwood, 10-15 parts of salvia miltiorrhiza (fried with wine), 7-9 parts of curcuma zedoary (fried with vinegar), 7-10 parts of polygonum cuspidatum, 14-20 parts of herba epimedii (fried), 6-8 parts of rhizoma zingiberis and 10-15 parts of glossy privet fruit (steamed with wine). The traditional Chinese medicine composition is prepared from 14-20 parts of prepared rehmannia roots, 18-25 parts of hawthorn fruits, 10-15 parts of lotus leaves, 8-12 parts of mulberry twigs, 7-9 parts of baikal skullcap roots (roasted with wine), 8-12 parts of polygala roots, 10-15 parts of kudzuvine roots and 7-9 parts of licorice roots (roasted). The traditional Chinese medicine composition is researched and developed on the basis of complex pathogenesis and pathogenesis of the obesity phlegm-dampness obstructing spleen syndrome, and has an expected effect of treating the obesity phlegm-dampness obstructing spleen syndrome.

Embodiments of the present disclosure relate to methods for extracting and purifying melatonin from natural melatonin sources. Such methods may include extracting melatonin from Hypericum perforatum or from tomatoes. Such methods may include mixing the melatonin source with a first solvent; filtering the extraction solution; and concentrating the filtrate to obtain coarse extract. Compositions of the melatonin extract obtained from the methods are also provided.

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for protecting gastric mucosa and a preparation method thereof. Comprising 10-12 parts of poria cocos, 8-10 parts of pericarpium citri reticulatae, 2-4 parts of scorched hawthorn fruit, 2-4 parts of hypericum perforatum, 2-4 parts of fried medicated leaven, 5-8 parts of sweet-scented osmanthus, 2-4 parts of amomum cardamomum, 0-20 parts of rhizoma bletillae, 0-15 parts of cuttlebone, 0-15 parts of astragalus membranaceus, 0-15 parts of hairyvein agrimony, 0-6 parts of pseudo-ginseng, 0-12 parts of dandelion, 0-5 parts of dried ginger, 0-9 parts of smoked plum and 0-8 parts of liquorice. The comprehensiveness and the safety of the formula are ensured. The traditional Chinese medicine composition for protecting the gastric mucosa, provided by the invention, ensures the comprehensiveness and safety of the formula from the aspects of enhancing the curative effect, adapting to the syndrome type, avoiding side effects and the like through the synergistic effect of various medicinal materials, and is suitable for preventing and repairing gastric mucosa lesion.

The application discloses a traditional Chinese medicine composition for treating coronary heart disease combined with anxiety and depression and a preparation method of the traditional Chinese medicine composition. The composition comprises the following components in parts by weight: American ginseng powder 3-10 parts, panax notoginseng powder 3-6 parts, amber powder 1-2 parts, curcuma zedoaria powder 3-10 parts and hypericum perforatum powder 1-5 parts. The composition can effectively treat coronary heart disease combined with anxiety and depression.

The invention discloses a hypericum perforatum plug seedling raising method, and relates to the technical field of plant seedling raising engineering, and the method comprises the following steps: S1, land selection and preparation: selecting an area with a flat land and a deep soil layer as a seedling raising site, building an arched greenhouse, arranging a sunshade net outside the greenhouse, and erecting a sprinkling irrigation facility in the greenhouse, and then leveling the land in the greenhouse. A peat and moss matrix and vermiculite are uniformly mixed according to the proportion of 1: 1, then thoroughly watered and manually filled into a hole tray with the size of 530mm * 270mm, the height of 40mm and 200 holes by using a scraper blade. As the peat moss substrate is a substrate formed by inactivating and sterilizing moss at high temperature, the peat moss substrate does not contain germs which have any image on seed germination and seedling growth, and also does not contain weeds and other plant seeds, and the inactivated moss can continuously provide corresponding nutrients in the seed germination and growth process; vermiculite has good air permeability, the air permeability of roots in the seedling growth process can be improved by mixing vermiculite with the substrate, and therefore growth of seedlings is promoted.

The invention discloses artificial saliva and a preparation method of artificial saliva hydrogel. The artificial saliva is prepared from the following raw materials in parts by mass: 0.5 to 1 g of KCl, 0.2 to 0.4 g of K2HPO4, 0.2 to 0.8 g of NaCl, 0.2 to 0.4 g of KH2P O4, 10.04 to 20.8 g of CaCl2, 1.5 to 3 g of Nacaboxymethlecellulose, 60 to 120 mg of brown moss alcohol, 495 to 1000 ml of natural coconut juice and 5 to 10 ml of herba sarcandrae extract. By selecting the glabrous sarcandra herb extract, anti-inflammatory and anti-tumor treatment is realized, so that the traditional Chinese medicine composition has a remarkable effect on dry mouth caused by radiotherapy; through the form of a gel bead preparation, the beverage is more portable and unique in taste. The gel beads serve as one of oral local administration preparations, and after the gel beads are exploded, drugs can target small glands which are located below oral mucosa and secrete saliva, and the rapid drug effect is achieved. Direct local administration to the oral mucosa may provide rapid drug action, activate small salivary glands within the buccal mucosa, while avoiding systemic drug exposure and off-target effect.

The invention relates to application of an activating agent in promotion of uranium element discharge. Specifically, the activating agent is prepared from rifampicin, erythromycin, progesterone, aldosterone, bilirubin, cholate vinblastine, doxomicin, adriamycin, paclitaxel, bosentan, ambrisentan, digoxin, verapamil, tonavir, amprenavir, indinavir, hypericum perforatum juice, curcumin, atorvastatin beclomethasone, budesonide, divaricasone carbamazepine and caffeine. And phenytoin. The use dosage of the activating agent is 10 to 60 mg / kg. According to the method, the accumulation amount of uranium in important organs such as bones and kidneys can be remarkably reduced, so that the potential toxic influence on the key organs is reduced.

The present invention discloses a polycyclic polyisopentenyl phloroglucinol compound and its preparation method and application, belonging to the field of biomedicine technology. The dried aerial part of Hypericum perforatum is used as raw material, and an extract is obtained after diafiltration extraction and concentration, and the extract is suspended in water to obtain a suspension, and a petroleum ether extract is obtained after extraction and concentration; the extract is taken and subjected to positive and reverse phase silica gel column, MCI medium pressure column chromatography, Sephadex LH-20 gel column chromatography separation and high performance liquid chromatography purification to obtain a polycyclic polyisopentenyl phloroglucinol compound, and the structure and configuration of the compound are determined by means of spectral analysis technology, quantum chemical calculation and X-ray single crystal diffraction. This type of compound can inhibit TNF-α protein from exerting an immunosuppressive effect and has the use as an immunosuppressive drug.

The invention provides traditional Chinese medicine compound Tianyuantong granules which are prepared from the following raw materials by weight: 3-18g of gastrodia elata, 3-18g of ligusticum wallichii, 3-18g of radix angelicae, 2-12g of vinegar-processed rhizoma corydalis, 2-12g of moutan bark, 2-12g of fructus viticis, 2-12g of angelica sinensis, 6-24g of spina date seed, 3-18g of prepared radix morindae officinalis, 3-18g of rhizoma pinelliae preparata, 3-18g of herba patriniae, 3-18g of valerian, 3-18g of hypericum perforatum, 1-6g of blood amber and 10-40g of raw oyster. In the traditional Chinese medicine compound Tianyuantong granules, gastrodia elata is used as a monarch drug for calming liver and activating collaterals; ligusticum wallichii and dahurian angelica root lead medicines to move upwards, dispel wind and relieve pain, and serve as ministerial The corydalis tuber, the moutan bark and the fructus viticis promote qi circulation to relieve pain, and the angelica sinensis and the spina date seeds enrich and activate blood; prepared radix morindae officinalis and rhizoma pinelliae preparata have the effects of warming yang and reducing phlegm; the granule is a granular preparation with a certain granularity prepared from traditional Chinese medicine extracts and auxiliary materials, keeps the characteristics of high decoction absorption efficiency and quick effect, and is small in dosage.

This invention belongs to the field of genetic engineering, and specifically relates to a 4-coumaric acid-coenzyme A ligase gene Gl4CL from *Gynostemma pentaphyllum*, its encoded product, and its applications. This invention is the first to clone and prepare the 4-coumaric acid-coenzyme A ligase gene Gl4CL from the medicinal plant *Gynostemma pentaphyllum*. The nucleotide sequence of this gene is shown in SEQ ID NO.1, and the amino acid sequence of the product encoded by this nucleotide sequence is shown in SEQ ID NO.2. The 4-coumaric acid-coenzyme A ligase gene Gl4CL is a key regulatory gene in the flavonoid biosynthesis pathway of *Gynostemma pentaphyllum*. This enzyme can be used in the preparation of p-coumaryl-CoA using p-coumaric acid as a substrate, further promoting the biosynthesis of flavonoid compounds. This invention can provide an effective method to meet the huge market demand for flavonoid compounds.

The invention relates to the technical field of preparation and application of traditional Chinese medicine compositions, and particularly discloses a traditional Chinese medicine composition for treating Alzheimer's disease and a preparation method and application thereof. The traditional Chinese medicine composition is prepared from the following traditional Chinese medicine raw materials in parts by weight: 3-9 parts of ginseng, 3-10 parts of morinda officinalis, 6-12 parts of dogwood, 3-10 parts of rhizoma acori graminei, 3-10 parts of polygala tenuifolia, 3-6 parts of rhodiola rosea, 3-6 parts of China rose, 2-3 parts of hypericum perforatum, 3-6 parts of saussurea involucrate, 9-15 parts of cortex lycii radicis, 3-12 parts of golden cypress and 1-5 parts of agilawood. The traditional Chinese medicine composition provided by the invention accords with the traditional Chinese medicine treatment concept of tonifying deficiency and filling marrow, inducing resuscitation and soothing nerves, dredging collaterals and eliminating evil, and tonifying spleen and assisting transportation, not only can relieve damage of neurons, but also can reverse alzheimer disease related disorder signal channels in neuronal cells, microglial cells and astrocytes.

Topical polyherbal oleogel composition, comprising, in weight percent of the finished product: (i) Boswellia serrata CO2 select extract 1.0–5.0%; (ii) Curcuma longa phytosome 0.5–2.5% with curcuminoids complexed to phospholipids together with turmerone-rich turmeric essential oil 0.2–0.8%; (iii) Zingiber officinale CO2 select extract 0.5–2.5%; (iv) Hypericum perforatum macerate oil 3.0–10.0%; (v) Capsaicinoids in an equivalent amount of 0.01–0.05%, obtained from Capsicum oleoresin, and Mentha piperita oil 0.3–1.0% together with Rosmarinus officinalis oil 0.2–0.6%; (vi) a carrier phase of sesame oil and medium-chain triglycerides in a ratio of 2:1 to 1:1, and castor oil 8–12% and squalane 1.0–3.0%; (vii) a structuring phase of sunflower lecithin 0.8–2.0% and beeswax 3.0–6.0%, providing a lamellar, shear-thinning oleogel; and (viii) mixed tocopherols 0.1–0.3% and a rosemary diterpene antioxidant extract 0.05–0.2%;wherein the composition is anhydrous with a water activity ≤ 0.55, and wherein the mass ratio of total boswellic acids to total curcuminoids is 0.8:1 to 1.6:1 and the mass ratio of menthol to total capsaicinoids is 10:1 to 30:1.;

This invention relates to a plant-derived compound, its preparation method, and its applications. The invention involves research on Hypericum perforatum (St. John's wort), yielding a novel active component. Experiments show that this compound can specifically activate the TGR5 receptor and can be developed as a lead compound into a drug for treating obesity and other metabolic diseases.

This invention relates to the field of plant-derived extracellular vesicles, and discloses a method for preparing and applying Hypericum perforatum-derived exosome-like nanovesicles (HPDENs). This invention prepares HPDENs with natural vesicle structures through a specific process, utilizing the natural characteristics of plant-derived vesicles to encapsulate Hypericum perforatum (…). HP The active ingredient, combined with nasal drops, achieves targeted delivery to the brain. It exerts its antidepressant effect by regulating microglia polarization imbalance and reshaping the "neuroimmune-synaptic" axis. This solves the core problems of traditional antidepressants, such as slow onset of action, poor treatment response, and large side effects. It can also improve the core pathological features of depression (neuritis, synaptic plasticity damage) and improve depressive-like behaviors, providing a brand-new option for the clinical treatment of depression.

The invention relates to the field of composite extracts, in particular to an anti-HPV (human papillomavirus) composite extract and a preparation method thereof. The invention relates to an anti-HPV (human papillomavirus) compound extract, which is prepared from the following components in percentage by mass: 0.2 to 0.8 percent of radix arnebiae seu lithospermi extract, 3 to 8 percent of hyperforin perforatum extract, 1 to 5 percent of radix bupleuri root extract, 5 to 12 percent of supplementary plant extract, 18 to 80 percent of alcohol solvent and the balance of water, the preparation method comprises the following steps: adding the radix arnebiae seu lithospermi extract, the hyperforin perforatum extract, the radix bupleuri root extract and the supplementary plant extract into an alcoholic solution, and stirring until the materials are uniformly dissolved; and then adding water, mixing, and uniformly stirring to obtain the composite extract. The application has the advantage of relieving the injury of HPV virus to infected women.

The herbal ointment treats hemorrhoids and fistula. The flowering branches of plants (Malva Sylvestris + purslane + Hypericum perforatum), olive oil, white grape juice, egg oil, hemp oil, animal bone marrow oil, wheat flour, red grape seed oil and nigella oil are the ingredients to prepare this herbal ointment. By using this ointment, there is no need to use ointments that are composed of chemicals, and also because of the use of different plants and plant oils in the preparation of this ointment, it will not have any therapeutic side effects or adverse effects on the human body and to use it for hemorrhoids it prevents surgery for hemorrhoids.

The invention provides a traditional Chinese medicine composition for treating diarrhea-type irritable bowel syndrome. The traditional Chinese medicine composition is prepared from the following traditional Chinese medicine raw materials: radix paeoniae alba, hypericum perforatum, codonopsis pilosula, rhizoma atractylodis macrocephalae, semen cuscutae, fructus evodiae, rhizoma zingiberis, fructus amomi rotundus, schisandra chinensis and radix curcumae. The traditional Chinese medicine composition has the effects of warming kidney and strengthening spleen, soothing liver-qi stagnation and relieving diarrhea with astringents. The traditional Chinese medicine composition disclosed by the invention has an outstanding clinical effect on treating the diarrhea-type irritable bowel syndrome, and particularly has an obvious curative effect on patients with abdominal distension, abdominal pain, diarrhea, belching, dysphoria, dull pain, bitter mouth, light tongue, white and smooth tongue coating and deep and thin pulse caused by spleen-kidney yang deficiency, liver-qi stagnation and intestinal dysfunction.

This invention provides a traditional Chinese medicine composition for treating viral upper respiratory tract infections, its preparation method, and its application. The composition is made from the following medicinal materials in parts by weight: 500-800g of Artemisia annua and 250-550g of Hypericum perforatum. This composition addresses the long-term clinical application needs and can effectively treat patients with viral upper respiratory tract infections, demonstrating significant application value. This invention provides a traditional Chinese medicine composition for treating viral upper respiratory tract infections and establishes its preparation method. The safety and efficacy of this composition have been confirmed through various animal model experiments.

The invention relates to the field of traditional Chinese medicines, and particularly discloses a traditional Chinese medicine composition, a pharmaceutical preparation and a preparation method and application thereof. The traditional Chinese medicine composition comprises the following components in parts by weight: 6-12 parts of eclipta, 3-9 parts of pseudo-ginseng, 6-12 parts of dogwood, 9-15 parts of teasel root, 6-12 parts of grifola, 3-6 parts of felwort, 3-10 parts of polygala tenuifolia, 2-3 parts of hypericum perforatum, 10-30 parts of sedum sarmentosum, 3-9 parts of inula flower, 6-9 parts of curcuma zedoary, 5-10 parts of cowherb seed, 6-12 parts of changium smyrnioides and 9-15 parts of erigeron breviscapus. The traditional Chinese medicine composition can regulate and control non-alcoholic steatohepatitis related signal channels on HepG2, LX2, THP1 and HUVECT1 cell lines, reduce the fat content in a HepG2 cell high-fat model, reduce the serum alanine aminotransferase, serum aspartate aminotransferase, serum low-density lipoprotein cholesterol and liver triglyceride level of a mouse non-alcoholic steatohepatitis model, and improve the non-alcoholic steatohepatitis content in the mouse non-alcoholic steatohepatitis model. The traditional Chinese medicine composition is capable of reducing liver fat accumulation, relieving liver injury and improving liver fibrosis pathology, and is used for related treatment or adjuvant treatment of non-alcoholic steatohepatitis.

The present application relates to a kind of Hypericum perforatum polysaccharide with the efficacy of preventing and treating depression, the weight average molecular weight (Mw) of the Hypericum perforatum polysaccharide is 200Da-70000Da.The Hypericum perforatum polysaccharide of the present application can be used to prevent and treat depression and anti-fatigue, etc., and has the advantages of high bioavailability, safe and effective, etc.

This invention relates to the field of traditional Chinese medicine extracts and drug preparation technology, and discloses a *Hypericum perforatum* extract composition, its preparation method, and its application, including the application of an ethanol extract of *Hypericum perforatum* or components isolated from its ethanol extract in the preparation of drugs for the prevention and / or treatment of psoriasis. In vitro and in vivo experiments have demonstrated that *Hypericum perforatum* extract can significantly improve imiquimod (IMQ)-induced psoriasis-like skin lesions (erythema, scaling, and skin thickening) in mice and reduce PASI scores. Its mechanism of action differs from single-target biological agents; instead, it simultaneously regulates the IL-23 / IL-17 inflammatory axis, corrects Th17 / Treg immune imbalance, and inhibits abnormal activation of the NF-κB signaling pathway, demonstrating the advantages of multi-component, multi-target synergistic effects of natural drugs. Furthermore, *Hypericum perforatum* is a unique plant resource in my country with a wide distribution. Compared to expensive biological agents, this invention has a significant cost advantage and is expected to be developed into a more affordable and accessible anti-psoriasis drug.