4 results about "Verapamil" patented technology

This invention belongs to the field of biomedical technology, specifically relating to a composition for treating ischemic heart disease and its application. This invention combines two or more of ginsenoside Rg1, ginsenoside Rb1, ginsenoside Re, and notoginsenoside R1, which can significantly downregulate the levels of myocardial enzymes, aspartate aminotransferase (AST), creatine kinase (CK), and lactate dehydrogenase (LDH) in myocardial coronary effusion, with an inhibitory effect significantly higher than that of a single saponin component and the positive control drug verapamil. Simultaneously, the composition exhibits better recovery capabilities for coronary flow (CF), left ventricular developmental pressure (LVDP), maximum rate of decrease in left ventricular pressure (-dp / dtmax), and heart rate (HR) in myocardial coronary effusion. Therefore, the composition can alleviate and treat myocardial ischemia-reperfusion injury through multiple targets and mechanisms, fundamentally inhibiting the development of ischemic heart disease.

The invention discloses a method for detecting colopivir in plasma by an HPLC-MS / MS (high performance liquid chromatography-mass spectrometry / mass spectrometry) method. According to the method, a protein precipitation method is adopted for pretreatment, a Waters CORTECS C8 chromatographic column is adopted as a chromatographic condition, a water solution containing 0.01% formic acid of 2 mM ammonium acetate and acetonitrile are taken as mobile phases, and gradient elution is carried out; an electrospray ionization source (ESI) tandem mass spectrum is adopted as a mass spectrum condition, and verapamil is used as an internal standard for quantitative detection. The method disclosed by the invention is simple and convenient to operate, high in analysis speed, high in sensitivity and suitable in linear range, and meets pre-clinical and clinical research large-batch sample analysis requirements.

The application discloses a method for detecting calopivir in blood plasma by HPLC-MS / MS. The method is pretreated by a protein precipitation method, and chromatographic conditions are as follows: a Waters CORTECS C8 chromatographic column is used, 2 mM ammonium acetate containing 0.01% formic acid in water and acetonitrile are used as mobile phases, and gradient elution is carried out; mass spectrometry conditions are as follows: an electrospray ionization source (ESI) tandem mass spectrometer is used, and verapamil is used as an internal standard for quantitative detection. The method is simple in operation, fast in analysis speed, high in sensitivity, suitable in linear range, and meets the requirements of large quantities of sample analysis in preclinical and clinical research.

The invention discloses an inclusion compound, a composition and a medicinal preparation containing the inclusion compound, and a method for preparing the inclusion compound, the composition or the medicinal preparation. Specifically, the clathrate compound contains vilazodone or a pharmaceutically acceptable salt and a clathrate material of vilazodone.