213results about "Hydrocarbon active ingredients" patented technology

Provided herein are pharmaceutical compositions comprising carotenoids, including liposomes that encapsulate carotenoids including ionizable carotenoids such as trans-crocetin. The provided compositions have uses in treating diseases, disorders and conditions associated with, but not limited to, infection, endotoxemia, inflammation, sepsis, ischemia, hypoxia, shock, stroke, lung injury, wound healing, traumatic injury, reperfusion injury, cardiovascular disease, kidney disease, liver disease, inflammatory disease, metabolic disease, pulmonary disorders, blood related disorders and hyperproliferative diseases such as cancer. Methods of making, delivering, and using the pharmaceutical compositions are also provided.

The present invention relates to a pharmaceutical liquid composition, wherein said liquid composition comprises at least one cooling agent comprising of a phenyl ring containing a polar side group at least one viscosity enhancing agent and at least one surfactant. The invention also relates to a method to produce such a pharmaceutical composition as well as a method of alleviating a symptom selected from the group consisting of cough, nasal congestion and sore throat in a subject comprising administering the composition according to any of preceding claims.

The invention discloses a traditional Chinese medicine combination effective part capable of improving diabetic peripheral neuropathy. The traditional Chinese medicine combination effective part is prepared from a volatile oil effective part, a water-soluble effective part and an alcohol-soluble effective part, the effective part of the volatile oil comprises alpha-ocimene, alpha-santalene, bisabolol, beta-bisabolol and nerolidol; the water-soluble effective part comprises salvianolic acid A, salvianolic acid B and tanshinol; the alcohol-soluble effective part is prepared from Z-ligustilide, alpha-masticinic acid, beta-masticinic acid, tanshinone IIA, and 2-methoxy-5-acetyl-furangermacane-1 (10)-ene-6-ketone, and the alcohol-soluble effective part is prepared from the following raw materials in parts by weight: 2-methoxy-5-acetyl-furangermacane-1 (10)-ene-6-ketone. The traditional Chinese medicine composition effective part provided by the invention can regulate blood sugar, improve the conduction speed of sciatic nerves, repair damaged tissues, inhibit oxidative stress reaction, resist inflammation and relieve pain, so that the diabetic peripheral neuropathy is improved, the curative effect is reliable, the safety is good, the adverse reaction is low, and the traditional Chinese medicine composition effective part can be used for preparing a medicinal preparation for improving the diabetic peripheral neuropathy.

The formula comprises the following raw materials in parts by weight: 70-85 parts of base liquor, 5-15 parts of fresh pandan leaves, 0.5-3 parts of baked pandan leaf powder, 1-3 parts of a flavor modifier, 3-8 parts of a sugar source and 0.1-0.6 part of a functional additive. The unique flavor of the pandan leaves originates from the rich 2-acetyl-1-pyrroline, and the pandan leaves give out charming rice dumpling fragrance and have the effects of promoting appetite and metabolism at the same time. The pandan leaves are blended into the food, so that the delicious taste is improved, and additional nutritional value is also brought. The pandan leaves are rich in dietary fibers, vitamin B family, vitamin C and various minerals. The composition also contains squalene, linoleic acid, estragole, phytol and other active ingredients. Squalene is a natural organic terpenoid, widely exists in a living body, and has remarkable effects in the aspects of promoting blood circulation, resisting oxidation, resisting inflammation, resisting tumors and the like. The prepared pandan wine has multiple effects and is beneficial to body health after being drunk for a long time.

The invention relates to the technical field of traditional Chinese medicine compositions, in particular to a traditional Chinese medicine composition and application of the traditional Chinese medicine composition in preparation of drugs for improving sleep disorder and treating mood disorder or cognitive disorder. The invention provides a traditional Chinese medicine composition. The traditional Chinese medicine composition comprises the following components in parts by mass: 20-30 parts of lycium ruthenicum, 30-40 parts of nitraria fruit, 15-25 parts of gastrodia elata, 13-25 parts of hyperforin perforatum and 2-6 parts of lycopene. The traditional Chinese medicine composition provided by the invention is prepared from lycium ruthenicum, nitraria fruit, gastrodia elata, hyperforin perforatum and lycopene according to a specific ratio, and the composition can effectively relieve anxiety behaviors of chronic stress bound anxiety model mice through ways of resisting oxidation and inflammation, regulating expression of neurotransmitters and the like, prolong sleep time and improve sleep quality. The learning ability and the memory ability of cognitive impairment mice induced by scopolamine are improved, and the neuron density of brain tissues is increased, so that the neuroprotective effect is achieved.

The present invention provides a composition that possesses antioxidant activity while having high bioavailability. [Solution] The present invention provides a composition containing 1 to 15% by weight of prolycopene, and a method of using the composition, such as to prevent or treat a condition related to oxidative stress.

A composition containing a plurality of particles containing a core having a lipid matrix including an active ingredient dispersed therein is disclosed. The active ingredient can include a fat-soluble active ingredient. The particles can be contained in a capsule. Also provided are methods for producing a pharmaceutical composition containing a plurality of particles containing a core having a lipid matrix including an active ingredient dispersed therein.

The present invention provides a topical composition for pain relief containing a topical analgesic, as well as a volatile emollient and / or an absorbant. The topical composition is substantially free of volatile alcohol. The topical composition may be used to relieve pain in a user with sensitive skin. Additionally, the present invention includes methods of relieving pain in a user with sensitive skin. The methods include topically applying to an exterior skin portion of the user's body in need of pain treatment a composition including a topical analgesic, as well as a volatile emollient and / or an absorbant.

The present invention relates to a kit of nutrient blend compositions for young individuals, in particular children aged between 0 and 66 months, each one of the compositions having age-specific ingredients. The kit of nutrient blend compositions is specifically aimed at promoting myelination of targeted brain regions, in particular the social brain, of children at specific ages and stages of brain development.

The present disclosure relates to compositions and methods for the treatment of topical skin conditions. Also provided are topically applied compositions and delivery systems. Also provided are methods of using the compositions and delivery systems in cosmetic, personal care and dermatology applications. Also provided is a sprayable composition that comprises petrolatum.

The invention relates to the use of herbal preparation, characterized by presence of 4 dominant compounds (carvacrol a from about 35% to about 50%, γ-terpinene from about 10% to about 30%, thymol from about 10% to about 25%, p-cymene from about 8% to about 20%, as expressed in % of total peak area in GC / MS chromatogram), obtained by mixing at least two essential oils from species selected from the group of genera Satureja L., Origanum L. and Thymus L., to prepare food supplement or medicament for treatment and prevention of gastric Helicobacter pylori infection in humans. The mixture may be placed on liquid or solid carrier and capsulated in non gastro-resistant capsules. The invention also relates to dosage regiment of herbal preparation for treatment and prevention of patients with Helicobacter pylori infection which leads to successful eradication of bacteria without any side-effects.

A heart boosting formulation comprises: L-carnitine, alpha-linolenic acid, citrulline, vitamin D3, lycopene, holy basil, cinnamon and beetroot.

The invention provides antimicrobial composition comprising (a) a first active ingredient, wherein in the first active ingredient is selected from the group consisting of petroleum jelly, EpiCeram® emulsion, and / or glycerin, and (b) a second active ingredient selected from the group consisting of 1-octanoyl-rac-glycerol, 1-decanoyl-rac-glycerol, glycerol monolaurate (GML), rac-glycerol 1-myrstate, glycerol monocaprate, glycerol monocaprylate, glycerol monomyristate, or reutericyclin, wherein the second active ingredient is present at a concentration of 10 μg / ml to 100 mg / ml in the composition. The compositions are useful as antimicrobial agents.

The present disclosure provides a method for producing an electrolyte solution which can contain a high concentration of micro bubbles, and a method for producing a micro bubble-containing solvent which can be used for preparing the electrolyte solution, by suppressing decrease in micro bubbles during filtration.

Provided is the use of isocitrate dehydrogenase (IDH1 and IDH2) mutations for selecting and treating cancer patients for zotiraciclib (TG02) therapy, for example, in treating cancers such as glioma, medulloblastoma, chondrosarcoma, cholangiocarcinoma, AML, astrocytoma, and others, as a single agent of in conjunction with other chemotherapeutics

The invention discloses a preparation for improving male erectile function and sperm quality. The health-care food is characterized by being prepared from the following raw materials in parts by weight: 30-50 parts of herba epimedii extract, 20-40 parts of herba cistanche extract, 15-30 parts of fructus lycii extract, 18-35 parts of semen cuscutae extract, 10-25 parts of herba cynomorii extract, 8-20 parts of maca powder, 6-18 parts of raspberry extract, 0.5-2 parts of lycopene, 1-3 parts of L-carnitine and 0.3-1 part of vitamin B family (vitamin B1, vitamin B2, vitamin B6 and vitamin B12 are mixed according to the mass ratio of 1: 1: 2: 0.5). The herba epimedii extract is selected as a main component, the content of icariin is regulated to be not lower than 60%, the high-content icariin can more effectively promote sex hormone secretion, enhance sexual desire and improve erectile function, the total content of echinacoside and verbascoside in the herba cistanche extract is not lower than 45%, and the herba epimedii extract and the herba cistanche extract have the effect of promoting sex hormone secretion, enhancing sexual desire and improving erectile function. The two components have the effects of tonifying kidney yang and benefiting essence and blood, and can enhance kidney functions.

The invention belongs to the technical field of biological medicine, and particularly relates to a small-molecule exosome-loaded composition based on bone marrow mesenchymal stem cells and application of the small-molecule exosome-loaded composition. The invention discloses the treatment effect of squalene on osteoarthritis for the first time, and further prepares the squalene-loaded bone marrow mesenchymal stem cell exosome. An in-vitro cell experiment and a model animal experiment prove that the composition has a synergistic treatment effect on osteoarthritis. In-vitro tests prove that the squalene-loaded mesenchymal stem cell exosome can improve the survival rate of inflammatory cartilage cells, inhibit release of proinflammatory factors and restore expression of repair factors. Model animal experiments prove that the squalene-loaded mesenchymal stem cell exosome has the effects of resisting inflammation, easing pain and protecting cartilage in the treatment of osteoarthritis.

The invention discloses a composition for improving sexual life and / or prostate symptoms and a preparation method thereof. The composition is prepared from the following components in parts by weight: 30 to 50 parts of algal polysaccharides, 15 to 25 parts of phospholipid, 8 to 12 parts of euphausia superba oil, 8 to 12 parts of magnesium oxide, 8 to 12 parts of lycopene, 2 to 4 parts of zinc gluconate, 1 to 3 parts of radix ginseng extract, 0.8 to 1.2 parts of flos sophorae immaturus extract, 0.8 to 1.2 parts of fructus rubi extract, 0.8 to 1.2 parts of mulberry fruit extract, 0.8 to 1.2 parts of fructus lycii extract and 0.8 to 1.2 parts of sodium selenite. By limiting the raw materials and the dosage, under the combined action of the raw materials, the prepared composition can improve erectile, ejaculation and anterior lacrimal gland symptoms, can improve the quality of sexual life, and has no side effect on the body.

Provided herein are terpenoid- and cannabinoid-encapsulating PLGA nanoparticles and pharmaceutical compositions comprising the nanoparticles. Further provided are methods of making and using the terpenoid- and cannabinoid-encapsulating PLGA nanoparticles for therapeutic purposes.

Microemulsion beverages are described where hydrophobic liquid droplets are distributed in a continuous hydrophilic liquid phase. The described microemulsion beverages may be thought of as modified oil-in-water (MOIHW) microemulsions, where both the “oil” and “water” phases of the microemulsion are modified. The oil phase droplets of the MOIHW microemulsion are modified with alcohol and can solubilize oil-soluble species, including cannabis extracts. The polar continuous “water” phase of the MOIHW microemulsion is modified with a sugar or sugar alcohol.

A method for preparing stable liquid emulsion forms of plant extract is provided. A plant extract having a bitter flavor is mixed with diluent oil as an oil mixture and heat is applied to the oil mixture. An emulsifying agent is dispersed in water as an emulsifying solution. The oil mixture is mixed with the emulsifying solution. The mixed oil mixture and emulsifying solution is homogenized as a liquid form of the plant extract. Gluconic acid is added to the liquid form of the plant extract. The bitter flavor of the plant extract is disguised by adding a bitter blocker to the liquid form of the plant extract.

Novel fragrant and flavorful Cannabis plant products with defined chemistry customized to provide a desired, consistent and stable Entourage of Interest (EOI) and processes for making and using the same are provided.

The invention belongs to the technical field of health-care food and traditional Chinese medicine preparation, and discloses a medicinal and edible drink for treating prostatitis and a preparation method thereof.The drink is prepared by taking houttuynia cordata, dandelion, purslane and endive as monarch drugs, matching lalang grass rhizome, reed stem root, talc and yam rhizome as ministerial drugs, assisting saffron, and supplementing astragalus membranaceus, Chinese yam, fructus lycii and oyster; and meanwhile, lycopene and fucoidan are added. The preparation method comprises the following steps: pretreatment of raw material cleaning, drying and grouped crushing; carrying out low-temperature cold extraction by adopting water or an ethanol-water mixed solvent at 0-10 DEG C; the cold extraction liquid is heated to 80-95 DEG C and kept for 10-30 min, and high-temperature glowing is completed; the obtained liquid is sequentially subjected to rough filtration, fine filtration and vacuum concentration, instant high-temperature sterilization is conducted under the condition of 121 DEG C, and finally a liquid beverage, a concentrated solution or instant powder is prepared. Through combination of a reasonable formula and a specific technology, stable extraction and retention of various effective components are achieved, and the product quality consistency is good.

Provided are compositions comprising terpene mixtures consisting of 1000-4500 ppm myrcene, 1000-4000 ppm terpineol, 1000-5500 ppm caryophyllene and 1000-45000 ppm nerolidol; 1000-4500 ppm alpha-pinene, 1000-4000 ppm sabinene, 1000-4000 ppm limonene, 500-4000 ppm borneol and 1000-4500 ppm caryophyllene; 1000-4500 ppm alpha-pinene, 1000-4000 ppm linalool, 1000-4000 ppm terpineol, 1000-4000 ppm borneol, 1000-4500 ppm caryophyllene and 1000-4000 ppm nerolidol; 1000-4000 ppm myrcene, 500-5000 ppm linalool, 1000-4500 ppm caryophyllene and 500-4500 ppm nerolidol; or 1000-5500 ppm alpha-pinene, 1000-4000 ppm limonene, 500-4000 ppm linalool and 1000-4500 ppm caryophyllene, and uses in therapy.

Provided are methods of providing a cooling sensation to skin afflicted with eczema, the methods comprising topically applying to skin afflicted with eczema a composition comprising isododecane.

To provide a new composition for suppressing the accumulation of glycated proteins.SOLUTION: Provided is a composition for suppressing the accumulation of glycated proteins, the composition containing squalene as an active ingredient.SELECTED DRAWING: None

The invention relates to the technical field of biological medicine, and particularly discloses a targeted nano NK cell exosome gel loaded with lycopene and application thereof, the targeted nano NK cell exosome gel loaded with lycopene is prepared from the following components in percentage by mass: 0.1 to 1 weight percent of lycopene oleoresin, 0.5 to 5 weight percent of NK cell exosome, 60 to 80 weight percent of gel system and the balance of ultrapure water; the lycopene oleoresin is prepared by the following steps: firstly, adding a eutectic solvent into a tomato fermentation extracting solution, carrying out ultrasonic extraction on lycopene, and then uniformly mixing the lycopene, sophorolipid and vegetable oil. According to the application, the NK cell exosome and the lycopene are organically matched, the NK cell exosome directly acts on the local part of the cervix uteri through the NK cell, and meanwhile, the lycopene can repair the damaged cervix uteri cell and restore the damaged cervix uteri cell to a normal structure, so that the purposes of removing viruses and preventing and treating cervical cancer are achieved.

The invention belongs to the technical field of biological materials, and provides a preparation method of a polysaccharide modified metal organic framework carrier of pH response type trophic factor-loaded liposome. Comprising the following steps: preparing a lipidosome carrier loaded with nutritional factors through a film hydration method, and combining the lipidosome carrier with a metal organic framework to obtain a metal organic framework loaded with nutritional factor lipidosome; the preparation method comprises the following steps: dispersing the metal organic framework loaded with the nutritional factor liposome into a polysaccharide composite solution, slowly stirring, centrifuging, washing and drying to obtain the polysaccharide modified metal organic framework carrier of the pH response type nutritional factor liposome, so that adverse effects on a human body due to excessive intake of cholesterol can be avoided; meanwhile, under the synergistic interaction of the lipidosome, the metal organic framework and the polysaccharide, the stability of the nutritional factors in the gastrointestinal tract environment is improved, and the biological accessibility of the nutritional factors is improved.

The invention relates to the technical field of soft capsule preparation, in particular to a soft capsule capable of enhancing immunity and resisting oxidation and a preparation method thereof, and the preparation method comprises the following steps: putting auxiliary materials into stirring equipment for mixing, heating and stirring; respectively detecting the stress of the stirring paddle and the linear distance between the micelles and the stirring paddle; determining a micelle bulge adhesion risk according to the stress and the linear distance; determining a rotational flow strength coefficient of an inner rotational flow area of the test mixture; determining the rotating speed of the stirring paddle; the auxiliary materials are actually mixed, heated and stirred according to the rotating speed of the stirring paddle; carrying out defoaming treatment; sequentially filtering, preserving heat and standing to output a glue solution, and cooling and shaping the glue solution to form an upper glue cap and a lower glue cap; the pressing strength of the upper rubber cap and the lower rubber cap is determined according to the strength coefficient difference value; and pressing the upper rubber cap and the lower rubber cap according to the pressing strength to form the soft capsule capable of enhancing immunity and resisting oxidation. According to the invention, the uniformity, the stability and the reliability of the product quality are improved.

The present invention relates to a composition comprising (i) an extract of Crocus sativus comprising at least safranal, and (ii) an extract of Cannabis sativa comprising cannabidiol (CBD) and uses thereof as a pharmaceutical product, a food supplement, a nutritional product, a cosmetic product, or a liquid suitable for electronic cigarettes.