The invention discloses multi-effect vitamin E skin-moistening anti-bacterial paste for an infant and a preparation method thereof. The multi-effect vitamin E skin-moistening anti-bacterial paste forthe infant is prepared from the following components in parts by weight: 1-15 parts of a flos lonicerae japonicae extract, 1-15 parts of a fructus cnidii extract, 1-10 parts of eucalyptus oil, 1-15 parts of a herba portulacae extract, 1-15 parts of a cortex phellodendri extract, 1-10 parts of a vitamin E, 1-10 parts of Manuka honey, 20-50 parts of wool fat, 3-10 parts of 1,2-propylene glycol, 3-10parts of glycerinum, 5-30 parts of distilled water, and 5-10 parts of cetostearyl alcohol. The raw materials of the flos lonicerae japonicae extract, the fructus cnidii extract, the eucalyptus oil, the herba portulacae extract, the cortex phellodendri extract, the vitamin E and the like used by a product are substances all extracted from natural-occurring substances, natural and low-toxic withoutsensitization, no stimulation to a skin, high in safety, and can be used by both infants and adults. In addition, the product does not contain a preservative and essence, has the synergistic effect in each component, and is stable in system, long in guarantee period, effectively anti-bacterial and antiphlogistic, and capable of preserving moisture and moistening the skin powerfully.