117 results about "Granuloma" patented technology

A combination device for gastrostomy or jejunostomy usage having a retaining member, an elongated member having a gastrostomy lumen and a jejustomy lumen, and an inflatable balloon mounted on the elongated member. The retaining member is of a low profile and is arranged to be located on the skin adjacent a stoma in the abdominal wall through which the elongated member extends. The balloon seals the stoma about the elongated member. The retaining member includes at least one access port to communicate with respective ones of the lumens. The device, related compositions, and processes can prevent and/or treat granulomas.

Provided herein is an in vitro granuloma model and methods of its use. Methods of detecting and/or diagnosing latent tuberculosis in a subject are also provided, as are latency-specific antigens (and antibodies thereto), such as alpha-crystallin, and methods of identifying and using such molecules. Also provided are immunostimulatory compositions, for instance for use in eliciting an immune response in a subject, such as an immune response to a latent tuberculosis infection. Kits for carrying out the provided methods are also described.

The invention relates to an oral medicinal combination and the preparing method, using Epimedium Herb, Coix Seed, Tangerine Peel, Perilla Leaf, Common Floweringqince Fruit and other Chinese drugs as raw materials, first decocting these raw materials to extract fragrant liquid, then decocting twice and filtering, combining the filtrate, fragrant liquid and auxiliaries and making the mixture into different preparations. It can remove damp and dredge meridian, and eliminating rheumatism and stop pain, and is used to relieve joint gall of toes and metatarsi caused by gout caused by damp and corruption. In addition, the curative effect test verifies that it can prohibit joint gall of sole of the foot of a rat caused by sodium urate (MSU), remarkably reduce white cells in joint liquid of a rabit with acute arthritis induced by MSU, remarkably prohibit the foot swelling of a rat caused by carageen glue and the ear swelling of a mouse caused by dimethylbenzene, and obviously prohibit the forming of granulation swelling of a rat.

The invention provides a lung cell pathology rapid on-site evaluation system and method and a computer readable storage medium, which are used for rapidly evaluating a cell sample on an operation site. The lung cell pathology rapid on-site evaluation system comprises a microscopic image acquisition device which comprises an objective table used for bearing a lung cell sample and a camera used forshooting the cell sample to obtain a microscopic image of the sample; an image evaluation device with a neural network classification model used for classifying the microscopic images, wherein the obtained classification result is one of lung squamous cell carcinoma, lung adenocarcinoma, small cell lung cancer, unclear non-small cell lung cancer, other malignant lesions, no obvious abnormality, granuloma and inflammation; and an output device connected to the image evaluation device and used for outputting the classification result to a user. According to the invention, the neural network classification model is used for evaluating the microscopic image acquired by the microscopic image acquisition device, and an evaluation result is obtained on an operation site, so that the problems thatthe current cell pathological diagnosis is complex and time-consuming, and the pathological diagnosis result cannot be obtained immediately are solved, and the diagnosis efficiency is effectively improved.

The present invention provides humanized antibodies that immunospecifically recognize human 9 integrin. Some of these antibodies inhibit the biological functions of the 9 integrin, thereby exhibiting therapeutic effects on various disorders or diseases that are associated with 9 integrin, including cancer, e.g., the growth and metastasis of a cancer cell, and inflammatory diseases, e.g., rheumatoid arthritis, osteoarthritis, hepatitis, bronchial asthma, fibrosis, diabetes, arteriosclerosis, multiple sclerosis, granuloma, an inflammatory bowel disease (ulcerative colitis and Crohn's disease), an autoimmune disease, and so forth.

The present invention provides humanized antibodies that immunospecifically recognize human α9 integrin. Some of these antibodies inhibit the biological functions of the α9 integrin, thereby exhibiting therapeutic effects on various disorders or diseases that are associated with α9 integrin, including cancer, e.g., the growth and metastasis of a cancer cell, and inflammatory diseases, e.g., rheumatoid arthritis, osteoarthritis, hepatitis, bronchial asthma, fibrosis, diabetes, arteriosclerosis, multiple sclerosis, granuloma, an inflammatory bowel disease (ulcerative colitis and Crohn's disease), an autoimmune disease, and so forth.

The invention discloses a new medical use of myricetin, belonging to the technology field of medicines. Through acetic acid writhing test, formaldehyde-induced pain test, glacial acetic acid-induced capillary permeability test, dimethybenzene-induced mouse ear swelling test, egg white and carrageenin-induced paw edema test, test of leukocytoplania of pleurisy caused by carboxymethyl cellulose, granuloma (chronic) inflammation test, and screening of adjuvant arthritis animal models with primary and secondary inflammations, the myricetin is found to have high antiphlogistic and analgesic activity and can prevent and treat adjuvant arthritis, the antiphlogistic activity of myricetin is equivalent to that of aspirin but no gastrointestinal toxicity, and the anti-rheumatoid arthritis activity of myricetin is equivalent to that of Tripterygium wilfordii, and the myricetin has liver protecting effect and is an ideal drug for preventing and treating acute and chronic inflammations and rheumatoid arthritis. The myricetin can be prepared into various preparations with pharmaceutically-acceptable carrier for relieving inflammations, reliving pain and treating rheumatoid arthritis.

The invention relates to the technical field of health-care products, in particular to a traditional Chinese medicine composition with the clear-heat-from-throat function and a deep-processing preparing method and product thereof. The traditional Chinese medicine composition is prepared from lonicera japonica extract, fructus momordicae extract, figwort root extract, platycodon extract, medicine terminalia fruit extract and licorice root extract. According to the traditional Chinese medicine composition with the clear-heat-from-throat function and the deep-processing preparing method and product thereof, a functional test is carried out, the result shows that by means of the traditional Chinese medicine composition, the mouse ear swelling rate can be effectively reduced, the weight of cotton ball granuloma can be obviously reduced, the effect of the traditional Chinese medicine composition is better than the effect that all single dosages are separately used, the traditional Chinese medicine composition has the remarkable anti-inflammatory effect and the clear-heat-from-throat function, and synergistic interaction is achieved.

The invention discloses the application of a 15-methylene replaced andrographolide derivant as shown in general formula 1 in preparing anti-inflammatory, antipyretics and analgetics drugs, pertaining to the pharmaceutical chemistry field. Mice auricular swelling induced by dimethylbenzene, cotton ball granuloma of mice, hyperpyrexia of rats induced by yeast, mouse hot-plate test, writhing test of mice and other models are used for testifying that the 15-methylene replaced andrographolide derivant has anti-inflammatory, antipyretic and analgetic functions. Compared with andrographolide, the 15-methylene replaced andrographolide derivant has better anti-inflammatory, antipyretic and analgetic functions, and the research result of mouse acute toxicity test shows that the toxicity of the 15-methylene replaced andrographolide derivant is very slight. The 15-methylene replaced andrographolide derivant has relatively good application prospect by being applied to the development of anti-inflammatory, antipyretics and analgetics drugs.

The invention relates to a traditional Chinese medicine composition preventing and curing cardiovascular and cerebrovascular diseases. With milkvetch roots being principal herbs, the composition of salvia roots, ginkgo leaves and pseudo-ginseng in a specific proportion has the obvious effect of preventing and curing the cardiovascular and cerebrovascular diseases, can obviously reduce blood lipid of rats with hyperlipemia, has the obvious effect of restraining artery, vein and vein bypass thrombus and can improve hemorheology, restrain ear swelling caused by xylene and inflammatory reaction caused by cotton ball granuloma and obviously prolong survival time of the rats which are suffered from normal-pressure hypoxia tolerance, sodium nitrite poisoning and acute cerebral ischemic anoxia. In this way, the hypoxia tolerance capacity of organisms is improved, and the traditional Chinese medicine composition has a certain effect of protecting myocardial ischaemia injuries and cerebral injuries, and is free of acute toxicity, genetic toxicity and chronic toxicity and suitable for preventing and curing the cardiovascular and cerebrovascular diseases.

The invention discloses a compound preparation for treating cecal granuloma and a preparation method thereof. The compound preparation comprises chloroquine phosphate, diiodohydroxyquinoline, chlorogenic acid, liquiritin, cistanoside, ursolic acid, polysavone, levamisole, albendazole, okra powder, lactein, vitamin B1, lactalbumin and arginine. The compound preparation can effectively expand intestinal tubes, prevent intestinal obstruction, prevent mesentery and intestinal wall inflammatory infiltration and edema, prevent intestinal wall fibrosis, adjust body metabolism, improve immunity, reduce drug side effects and treat cecal granuloma and has a wide application prospect.

The invention discloses an external medicament for treating bacterial vaginosis and colpitis mycotica. The external medicament is a medicament prepared from Chinese medicinal raw materials including 35-70 parts by weight of amur corktree bark, 30-60 parts by weight of lightyellow sophora root, 30-60 parts by weight of cortex ailanthi, 20-40 parts by weight of polygonum aviculare, 10-35 parts by weight of selinum japenious seed and 1-2.5 parts by weight of borneol according to the conventional preparation method. As proved by a pharmacodynamic test, the medicament has a remarkable in-vitro antibacterial action, and can be used for effectively killing and suppressing common pathogenic bacteria of reproductive tract infection; the medicament has a remarkable treatment effect on rabbit colpitis mycotica; compared with a model control group, a medicament group has the advantages: the vagina cleanliness and curative ratio are increased remarkably, and the pathological feature of rabbit colpitis mycotica can be improved remarkably; the medicament has a remarkable anti-inflammatory effect, and can be used for remarkably relieving dimethyl benzene-caused mouse auricle inflammation, suppressing the formation of mouse granuloma and reducing the mouse abdominal cavity capillary permeability; and the medicament has a certain itching relieving effect.

The present invention provides humanized antibodies that immunospecifically recognize the RGD sequence. Some of these antibodies inhibit the biological functions of the RGD proteins, thereby exhibiting therapeutic effects on various disorders or diseases that are associated with RGD proteins, including cancer, e.g., the growth and metastasis of a cancer cell, and inflammatory diseases, e.g., rheumatoid arthritis, osteoarthritis, hepatitis, endometriosis, bronchial asthma, fibrosis, diabetes, arteriosclerosis, multiple sclerosis, granuloma, an inflammatory bowel disease (ulcerative colitis and Crohn's disease), an autoimmune disease, and so forth.

The present invention relates to novel Phosphodiesterase type 4 (PDE4) inhibitors of the formula (1) and analogs, tautomers, enantiomers, diasteromers, regioisomers, stereoisomers, polymorphs, pharmaceutically acceptable salts, appropriate N-oxides, pharmaceutically acceptable solvates thereof and the pharmaceutical compositions containing them which are useful in the treatment of allergic and inflammatory diseases including asthma, chronic bronchitis, atopic dermatitis, urticaria, allergic rhinitis, allergic conjunctivitis, vernal conjuctivitis, eosinophilic granuloma, psoriasis, rheumatoid arthritis, septic shock, ulcerative colitis, Crohn's disease, reperfusion injury of the myocardium and reperfusion injury of the brain, chronic glomerulonephritis, endotoxic shock and adult respiratory distress syndrome.

The invention discloses a Chinese medicinal fumigant for treating rheumatoid arthritis. The rheumatoid arthritis mainly comprises symptoms of articular cavity arthromeningitis, seepage, cell proliferation, formation of granuloma, cartilage and bone tissue breakage, final ankylosis and dysfunction. At present, Western medicine is short of an ideal treatment method. After many years' clinic testes by the applicant, the Chinese medicinal fumigant is prepared from Chinese medicaments including long-stalked kadsura, root of veined inula, root of Chinese coriaria, pedicularis resupinata, artemisia capillaries, root of saururus sinensis, pika droppings, craspedolobium root, tripterygium hypograucum, lysidice rhodostegia, pungent litsea root and horehound which have effects of dispelling wind to relieve pain, clearing heat and dampness, promoting blood circulation to remove blood stasis and relaxing muscles and tendons to activate the channels. Clinical tests show that the effective rate of the Chinese medicinal fumigant reaches 97.9%, and compared with an orally-taken western medicine, the Chinese medicinal fumigant has few side effects.

The invention relates to application of oxymatrine (oxymatrine and matrine) and glycyrrhizic acid or pharmaceutically-acceptable forms of oxymatrine and glycyrrhizic acid or derivatives of oxymatrine and glycyrrhizic, a medicine containing the compositions, also comprises matrine glycyrrhizinate and oxymatrine glycyrrhizinate, and application of the compositions to prepare medicines treating cutaneous vasculitis (allergic cutaneous vasculitis, allergic purpura, erythema elevatum diutinum, acute febrile neutrophilic dermatosis, urticarial vasculitis, pustular vasculitis, polyarteritis nodosa, pyoderma gangrenosum, eosinophilic vasculitis, eosinophilic cellulitis, pigmented purpuric dermatoses, Wegener's granulomatosis, Behcet's disease, erythema nodosum, and erythema induratum).

The invention provides a gradient injection containing mixed polymer microspheres. The injection is freeze-dried powder composed of a filling agent, cross-linked sodium hyaluronate microspheres, poly-L-lactic acid (PLLA) microspheres and an excipient. The powder is used for injection beauty after being mixed with sterile water, a triple gradient action effect is formed by mixing the filler, the cross-linked sodium hyaluronate microspheres and the PLLA microspheres, the subcutaneous volume of human skin can be improved, wrinkles, wrinkles, scars and aging of the skin can be repaired, the powder is also suitable for correcting large-volume facial fat loss, and the effect of beautifying the face is achieved. Adverse reactions such as nodules and granuloma are avoided.

The invention discloses a traditional Chinese medicine composition for treating granuloma cheilitis. The traditional Chinese medicine composition comprises the following raw material medicines in parts by weight: 20-30g of radix polygonati officinalis, 10-20g of glossy privet fruit, 10-20g of fried atractylodes macrocephala, 10-20g of honeysuckle 10-20g of dandelion, 10-20g of loofah sponge, 10-20g of plantago asiatica, 10-20g of fritillaria cirrhosa, 10-20g of amomum cardamomnm, 8-15g of tetrapanax papyriferus, 8-12g of Chinese yam, 8-12g of cassia twig, 8-12g of lotus plumule, 8-12g of Lotus Plumule and 8-12g of aloe. The medicines are precisely matched, the formula is moderate and gentle, can effectively focus on pathogenesis, has the effects of tonifying spleen and removing dampness, removing heat and stasis, clearing the heart and expelling internal heat, clearing away heat and toxic materials and nourishing yin and stomach, is remarkable in treatment effect of treating granuloma cheilitis, is free of side effects, high in treatment rate, and worthy of clinical popularization and application.