153 results about "Spondarthritis" patented technology

The present invention relates to compounds of Formula (I),

methods for preparing these compounds, compositions, intermediates and derivatives thereof and for treating a condition including but not limited to ankylosing spondylitis, artherosclerosis, arthritis (such as rheumatoid arthritis, infectious arthritis, childhood arthritis, psoriatic arthritis, reactive arthritis), bone-related diseases (including those related to bone formation), breast cancer (including those unresponsive to anti-estrogen therapy), cardiovascular disorders, cartilage-related disease (such as cartilage injury/loss, cartilage degeneration, and those related to cartilage formation), chondrodysplasia, chondrosarcoma, chronic back injury, chronic bronchitis, chronic inflammatory airway disease, chronic obstructive pulmonary disease, diabetes, disorders of energy homeostasis, gout, pseudogout, lipid disorders, metabolic syndrome, multiple myeloma, obesity, osteoarthritis, osteogenesis imperfecta, osteolytic bone metastasis, osteomalacia, osteoporosis, Paget's disease, periodontal disease, polymyalgia rheumatica, Reiter's syndrome, repetitive stress injury, hyperglycemia, elevated blood glucose level, and insulin resistance.

The present invention is related to a bilayer pharmaceutical composition comprising naproxen or a pharmaceutically acceptable salt thereof. The present invention is particularly related to a bilayer pharmaceutical composition comprising an immediate release component and a controlled release component of naproxen or a pharmaceutically acceptable salt thereof and the process for preparation thereof. Moreover, the present invention is related to the treatment of rheumatoid arthritis, oesteoarthritis, ankylosing spondylitis, pain, primary dysmenorrhoea, acute tendinitis, bursitis and acute gout.

The invention relates to a Chinese medicinal capsule for treating chronic infectious arthritis and rigid rachitis and process for preparation, wherein the raw materials include agkistrodon acutus, black-tail snake, black ants, ginseng, asaryl, scorpion, earthworm, large-leaf gentian root, seed of nuxvomica, dried rehmannia root, eucommia bark and epimeddium.

The present invention relates to compounds of Formula (I),

methods for preparing these compounds, compositions, intermediates and derivatives thereof and for treating a condition including but not limited to ankylosing spondylitis, artherosclerosis, arthritis (such as rheumatoid arthritis, infectious arthritis, childhood arthritis, psoriatic arthritis, reactive arthritis), bone-related diseases (including those related to bone formation), breast cancer (including those unresponsive to anti-estrogen therapy), cardiovascular disorders, cartilage-related disease (such as cartilage injury/loss, cartilage degeneration, and those related to cartilage formation), chondrodysplasia, chondrosarcoma, chronic back injury, chronic bronchitis, chronic inflammatory airway disease, chronic obstructive pulmonary disease, diabetes, disorders of energy homeostasis, gout, pseudogout, lipid disorders, metabolic syndrome, multiple myeloma, obesity, osteoarthritis, osteogenesis imperfecta, osteolytic bone metastasis, osteomalacia, osteoporosis, Paget's disease, periodontal disease, polymyalgia rheumatica, Reiter's syndrome, repetitive stress injury, hyperglycemia, elevated blood glucose level, and insulin resistance.

The invention relates to a traditional Chinese medicine composition, particularly a traditional Chinese medicine composition for treating ankylosing spondylitis and a preparation method thereof. The traditional Chinese medicine composition for treating ankylosing spondylitis is prepared from kudzu root, angelica, white peony root, radix rehmanniae preparata, epimedium, Colla Cornus Cervi, Chinese wolfberry, radix psuedostellariae, notopterygium root, heracleum hemsleyanum michaux, red paeonia, cornel, mistletoe, himalayan teasel root, cassia twig, radix salviae miltiorrhizae, spatholobus stem, wolfberry fruit, glossy privet fruit, broomrape, radix achyranthis bidentatae, rhizoma drynariae, cibot rhizome, eucommia, Curculigo orchioides, fleece-flower root, Morinda officinalis, glossy privet fruit, figwort, costus root, hemlock parsley, tuckahoe, Gentiana macrophylla, radix sileris, radix cyathulae, asarum, cassia twig, radix clematidis, prepared szechuan aconite, prepared myrrh, prepared frankincense, licorice and pangolin. The traditional Chinese medicine composition is safe for clinical application, does not stimulate the viscera when being taken orally, is convenient to make and take, ensures the cleanliness of the medicines, is easy for storage, has the advantages of obvious curative effect, many absorbable effective components and favorable drug effect taking, and can treat both the symptoms and root causes; and the total effective rate is up to 97%.

The invention relates to clinical application of a substituted aryl hydrazone compound and a derivative thereof serving as an anti-tumor necrosis factor inhibitor. A test result shows that the compound has a lower cytotoxicity in animal bodies, so the medical compound is expected to be used as an anti-TNF-alpha and TNF-beta inhibitor in the clinical application and is mainly used for treating some TNF related immunological diseases such as rheumatic arthritis, inflammatory bowel diseases, diabetes, hematosepsis, psoriasis, ankylosing spondylitis and some communicable diseases including HIV. A current TNF related research also shows that the medical compound can be used for treating clinical blood and solid tumor such as myelodysplastic syndrome, myelofibrosis, acute bone marrow cell leucocythemia, acute/chronic graft-versus-host reaction, ovarian cancer, nephrocyte cancer and the like.

Disclosed is an externally applied pure Chinese medicine for treating spondylitis ankylopoietica and arthritis, which comprises the following Chinese medicinal materials (by weight portion), musk 2-35, wild aconkite root 2-30, Clematis chinensis 2.5-40 and seed of nuxvomica 2-40.

In the present invention, the sequences of the camel-derived anti-TNF-alpha and anti-human serum albumin (HSA) nanobodies are fused together through a flexible linker peptide to form an anti-TNF-alpha nanobody (TNF60) with stronger biological activity , the coding gene was connected to the expression plasmid of Escherichia coli, and the prokaryotic expression plasmid of TNF60 was constructed, after transformation of Escherichia coli, two kinds of genetically engineered expression bacteria of TNF60 were obtained by screening, and the optimal expression of TNF60 was determined by response surface method optimization conditions, using solid-phase affinity chromatography to establish a purity process, the purity of the obtained target protein can reach 95%, and analysis of the recombinant TNF60 protein sequence by mass spectrometry, Western blot (Western blot), mouse paw swelling and inflammation model experiments shows that the sequence is correct and It has good antigen binding and anti-inflammatory activity in vivo. The antibody of the present invention can be used for the treatment of rheumatoid arthritis, ankylosing spondylitis and other diseases.

Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated pathologies and conditions, including ankylosing spondylitis, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.

The invention provides traditional Chinese medicine unguent warming yang, dredging collaterals, activating blood and stopping pain and a preparation method thereof. The traditional Chinese medicine unguent is prepared from coarse materials and fine materials, wherein the coarse materials comprise crude sichuan aconite roots, raw kusnezoff monkshood roots, epimedium, dry ginger, rhizoma chuanxiong, cistanche salsa, teasel roots, zedoary, zaocys dhumnade, angelica sinensis, long-noded pit viper, costus roots, artemisia anomala, corydalis tubers, morinda officinalis, rhizoma curcumae longae, drynaria rhizomes, Chaenomeles speciosa Nakai, curculigo orchioides, bark of eucommia, cherokee rose fruits, astragalus, seeds of Chinese dodder, rhizoma cibotii, rhizoma sparganii, gecko, parasitic loranthus, eucalyptus globulus labill, caulis spatholobi, smilax bockii warb, dysosma versipellis and paris polyphylla, and the fine materials comprise mastix, curnu cervi pantotrichum, musk, cinnamon, raw pinellia ternate, asarum, Chinese clematis, angelica roots, unprocessed rhizoma arisaematis, scorpio, peach kernels, Chinese Alangi, pseudo-ginseng, bornel, Chinese azalea flowers, datura metel, dragon's blood and myrrh. The traditional Chinese medicine unguent mainly has a very good treatment effect on lumbar dish outstanding, cervical spondylosis, periarthritis of shoulders, rheumatism, rheumatoid arthritis, hyperplasia, spur, limb numbness, ankylosing spondylitis, traumatic injuries, stroke hemiplegia and lumbar hernia.

The invention discloses a medicinal composition for treating ankylosing spondylitis and a preparation method of the medicinal composition. The medicinal composition comprises the following various raw herbal materials: cyrtomium fortunei, holly leaf, picria fel-terrae, parasitic loranthus, radix clematidis, chinaroot greenbrier, box-wood, cat's-ear, Yunnan wintergreen stem and leaf, girald daphne bark, trifoliate acanthopanax root or root-bark, wintercreeper, morinda officinalis, sinomenium acutum, rauvolfia latifrons, semen brassicae, lysionotus pauciflorus, glabrousleaf pittosporum root, lanceolate jasmine root or stem, Chinese ixora root, evans begonia root, madder and rosette thistle herb. The medicinal composition has the benefits of effects of nourishing liver and kidney, dispelling wind and dampness and strengthening muscles and bones, combination of effects of activating meridians to stop pain and activating blood to remove stasis and advantages of high response speed, high efficiency, exact curative effect, short treatment course, no toxic or side effects, low price and the like.

The invention discloses a medicament for treating spondylitis, which is prepared mainly from deer horn gum, Cinnamomum cassia, Chinese ephedra, white mustard seed, buthus martensi karsch, centipede, root of red rooted saliva, bitter orange, morinda root, dipsacus root, east Asian tree fern rhizome, astragalus root and Chinese angelica root by a predetermined weight proportions. The medicament can be prepared into decoction, pills and capsules.

The invention discloses a blood stasis removing pill for treating ankylosing spondylitis. The blood stasis removing pill for treating ankylosing spondylitis is prepared by bulk pharmaceutical chemicals of 35-55 parts of notoginseng, 65-80 parts of angelica sinensis, 60-80 parts of salvia miltiorrhiza, 40-55 parts of flowers carthami, 40-60 parts of radix clematidis, 45-55 parts of ligusticum wallichii, 40-60 parts of rhizoma corydalis, 35-55 parts of myrrh, 35-55 parts of rhizoma wenyujin concisum, 40-55 parts of medicinal cyathula root, 45-65 parts of astragalus mongholicus, 35-55 parts of rhizoma cyperi, 45-65 parts of polygonum multiflorum, 40-50 parts of peach kernel, 40-55 parts of radix paeoniae rubra, 40-50 parts of lumbricus, 14-28 parts of scorpion, 10-16 parts of centipede, 35-55 parts of ramulus mori and 30-50 parts of zaocys dhumnade. The blood stasis removing pill for treating ankylosing spondylitis patients is remarkable in curing effect and has the effective rate as 93.8%.

The invention relates to a medicine for treating ankylosing spondylitis. The medicine mainly comprises medicines for oral administration and medicines for external use, wherein the medicines for oral administration include 15g of Chinese dodder seed, 15g of fried himalayan teasel root, 10g of fried eucommia bark, 10g of prepared rhizome of adhesive rehmannia, 10g of common macrocarpium fruit, 15g of east Asian tree fern rhizome, 15g of Chinese taxillus twig, 15g of medicinal cyathula root, 10g of malaytea scurfpea fruit, 15g of cassia twig, 8g of glossy privet fruit, 8g of yerbadetajo herb, 15g of Chinese angelica, 15g of peach seed, 30g of white paeony root and 6g of liquorice root; one dose is taken each day and is decocted in water; the medicines for external use include 15g of incised notopterygium, 15g of cassia twig, 15g of stem of sargentgloryvine, 15g of common clubmoss herb, 15g of garden balsam stem, 8g of sappan wood, 10g of Chinese starjasmine stem and 30g of coix seed; patients lie supine on a fumigating bed, and the medicines for external use are added to water to be decocted for fumigating the patients. The medicine combines the interior and the exterior and treats both symptoms and root causes when being used for treating ankylosing spondylitis, and has obvious efficiency especially when being used for treating ankylosing spondylitis caused by deficiency of the liver and kidneys.

The invention relates to the field of biological medicines, and particularly provides an injection preparation of an anti-IL-17RA monoclonal antibody. The preparation comprises pharmacodynamic molecules and a buffer solution, the pharmacodynamic molecules are the anti-IL-17RA monoclonal antibody, and the buffer solution comprises a buffer salt, a protein protective agent, an osmotic pressure regulator and a surfactant, wherein the pH value of the buffer solution is 5.5-6.5. According to the invention, all components in the buffer solution interact with each other for synergistic cooperation, astorage environment suitable for long-term storage is provided for the anti-IL-17RA monoclonal antibody, the degradation, aggregation or precipitation of the antibody caused in the long-term storageor transportation process of the preparation can be avoided, the antibody can be stored in the environment for 36 months or more, the activity and the purity of the antibody can be kept stable in thestorage period, and the drug effect of the biological drug is guaranteed; the injection preparation can be used for various autoimmune diseases including but not limited to psoriasis, rheumatoid arthritis, ankylosing spondylitis or scleroderma and the like.

The invention relates to a traditional Chinese medicine formula for treating rheumatism, gout and spondylitis ankylopoietica and a preparation method thereof. The traditional Chinese medicine formulacomprises the following components, by weight percent: 5-15% of moxa grass, 10-30% of showy chloris, 40-60% of cone of lacebak pine, 2-8% of chrysanthemum, 5-10% of radish tassel and 5-10% of ginger.The traditional Chinese medicine formula for treating rheumatism, gout and spondylitis ankylopoietica has short treating time, good curative effect and small side effect.

The invention discloses a rheumatism pain-relieving plaster patch which is prepared from the following raw materials: rough materials are zaocys dhumnade, ephedra, saponin, radix aconiti, kusnezoff monkshood root, red paeony root; the seed of Job's tears, clematis root, angelica sinensis, ligusticum wallichii, rhizoma atractylodis, herba siegesbeckiae, radix angelicae pubescentis, pittosporum tobira, yam rhizome, akebiaquinata, peach kernel, centipede and Scorpio; and the fine material is prepared frankincense. The rheumatism pain-relieving plaster patch provided by the invention has the effects of warming yang and dispersing cold, benefiting qi and activating blood as well as relieving swelling and pain, and is used for treating arthrocele, non-agile motion, pain relieving with heat and pain increasing with cold, insensitiveness and pain immigration which are caused by the blocking of cold and dampness, has certain treatment efficacy for diseases of each kind of rheumatoid arthritis, rheumatic arthritis, cervical spondylosis, slipped discs, hyperostosis, scapulohumeral periarthritis, ankylosing spondylitis and the like, is convenient and rapid to use, has good treatment efficacy, is not administrated orally, has no side effects, and is low in treatment expense.

Provided is an antibody that specifically recognizes IL-17A and can bind to IL-17A. It can be used to treat inflammatory and autoimmune diseases caused by high expression of interleukin-17A, including psoriasis, psoriatic arthritis, ankylosing spondylitis, multiple sclerosis, inflammatory arthritis, etc.