203 results about "Sacroiliitis" patented technology

The invention discloses a deep learning algorithm-based spinal MRI precise synthesis CT image processing system and method for central axis type spinal arthritis, and the system comprises a data obtaining unit which is used for obtaining a three-dimensional T1 weighted multi-gradient echo sequence, a T2 weighted sequence and a water-fat separation sequence which are obtained through the magnetic resonance imaging of the spinal column of a target user; the spatial registration unit is used for inputting the multi-sequence data into a deformable registration network so as to carry out spatial registration on the multi-modal features; the feature processing unit is used for carrying out feature fusion on the registered multi-modal features and carrying out double-domain splitting based on an anatomical attention gating mechanism to obtain skeleton features and soft tissue features; and the image fusion unit is used for synthesizing a synthesized CT image with an HU value corresponding to the spine of the target user based on the skeleton features and the soft tissue features, so that radiation-free high-precision CT image acquisition is realized, the diagnosis grading requirement on the axis type spine joint in the spine can be met, and the influence of radiation on the target user can be reduced.

The invention discloses a novel benzofuran component in eupatorium chinense and application of the benzofuran component in anti-inflammatory activity. The obtained compound is separated from an eupatorium chinense extract. The eupatorium chinense root extract is separated by using an extraction method, macroporous adsorption resin impurity removal, Sephadex LH-20 gel column chromatography, high performance liquid chromatography and other methods. According to the present invention, all the separated compounds and the analogues thereof have good inhibition activity on target cyclooxygenase-2 of inflammation-related diseases, and have good inhibition activity on COX-2 enzyme, and the molecular docking experiment results show that the compounds and the target proteins have good binding energy. Therefore, the compound can be used for preparing drugs for treating inflammatory related diseases, or anti-inflammatory and analgesic drugs, or tumor drugs by inhibiting COX-2 enzyme, such as drugs for rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, Alzheimer's disease and the like, and related natural lead compounds are provided.

The invention belongs to the technical field of biological medicine, and particularly relates to a recombinant RNA aptamer as well as a preparation method and application thereof. The recombinant RNA aptamer is obtained by taking active tRNA as a bracket, embedding an RNA aptamer and expressing in escherichia coli. The sequence of the active tRNA is a sequence which is similar to a human cysteine tRNA sequence by 90% or more, and the human cysteine tRNA sequence is shown as SEQ ID NO. 1; the RNA aptamer is directly embedded at an active tRNA anticodon, and the embedded sequence is a sequence with the similarity of more than 50% with the SEQ ID NO.2 sequence. According to the production method of the recombinant RNA aptamer, various RNA aptamers can be conveniently and quickly prepared, and the produced and prepared recombinant RNA aptamer can be used for preparing a medicine for treating arthritis and meets the requirements of scientific research and medicine research and development.

A sacroiliac (SI) joint implant assembly addresses SI joint dysfunction and degenerative sacroiliitis. The assembly includes a first implant body, a second implant body, and a piezoelectric layer positioned between them. The piezoelectric layer generates electrical charges when subjected to mechanical stress, stimulating bone growth and enhancing stability of the SI joint after surgery. The implant bodies may feature non-planar surfaces to distribute compressive and shear forces unevenly across the piezoelectric layer. The assembly can be secured using fasteners such as screws, pins, or brackets, and may include porous or fenestrated bodies made from materials like titanium or polymers. Some implant assemblies are designed for minimally invasive surgical procedures, with configurations that allow for precise placement using guide wires and imaging techniques. The assembly aims to stabilize the SI joint and promote bone fusion, leveraging the piezoelectric effect to improve the overall efficacy of the fusion procedure.

The invention discloses a carbamylated polypeptide and application thereof in preparation of a rheumatoid arthritis diagnostic kit. The invention provides a cyclization carbamylation polypeptide as shown in SEQ ID NO. 1 and SEQ ID NO. 2 or a combination of the cyclization carbamylation polypeptide and the combination of the cyclization carbamylation polypeptide and the combination. Tests prove that the cyclized carbamylation polypeptide antigens as shown in SEQ ID NO.1 and SEQ ID NO.2 independently have high diagnostic value for diagnosing the negative RA of the anti-cyclic citrullinated peptide antibody, and respectively have application prospects of being developed into diagnostic kits for the negative RA of the anti-cyclic citrullinated peptide antibody; the combination of SEQ ID NO.1 and SEQ ID NO.2 further improves the diagnosis value of the anti-cyclic citrullinated peptide protein antibody negative RA, and has the application prospect of being developed into the anti-cyclic citrullinated peptide protein antibody negative RA diagnosis kit in a combined manner.

The invention relates to the technical field of medical image auxiliary diagnosis, and provides an intervertebral joint osteoarthritis image feature evaluation method based on deep learning, which can synchronously identify five types of FJOA image features such as joint space stenosis, osteophyte, hypertrophy, subchondral bone erosion and subchondral cyst, and improves the comprehensiveness and efficiency of evaluation. The nnU-Net model is adopted to perform high-precision segmentation on an intervertebral joint region, so that the positioning precision is effectively improved; by introducing a shared feature extraction network based on ResNet-18 and five parallel classification sub-networks, joint modeling of multi-scale semantic information is realized, and the recognition accuracy and generalization ability of the model are improved; according to the method, a Grad-CAM technology is combined to generate an activation thermodynamic diagram, a model interpretation basis is superposed to an original image, visual display of an evaluation result is realized, interpretability and clinical applicability of the model are enhanced, and FJOA image features in axial lumbar vertebra CT images from two central data sets can be quantitatively evaluated so as to comprehensively quantify individual FJOA image features.

This invention generally relates to methods for the treatment of IL-23 related diseases, in particular inflammatory diseases, such as psoriasis or psoriatic arthritis, utilizing anti-IL-23A antibodies.

The invention relates to the field of middle-axis type spinal arthritis diagnosis, in particular to a middle-axis type spinal arthritis auxiliary diagnosis and analysis system based on PSO-TabNet, and the system comprises a data collection unit which is used for collecting clinical feature data and iconography feature data; the data preprocessing unit is used for preprocessing the feature data; the axSpA prediction model construction unit is used for optimizing a TabNet model hyper-parameter by using a particle swarm algorithm to obtain a PSO-TabNet model; and the prediction analysis unit is used for performing axSpA classification prediction on the clinical data based on the PSO-TabNet model to obtain auxiliary diagnosis suggestions. According to the invention, the PSO algorithm is adopted to optimize the hyper-parameters in the TabNet model, the PSO algorithm can automatically adjust the hyper-parameters, manual intervention is not needed, the complexity of hyper-parameter adjustment is reduced, the stability and effect of the model are improved, and doctors can be more reliably assisted in diagnosing diseases.

Described herein are methods and compositions for using microbial agents (probiotics) and agents that promote growth of certain microbes (prebiotics) for management (including prevention and treatment) of musculoskeletal disorders, including osteoporosis, osteopenia, Paget's disease, stunting, osteoarthritis, osteomyelitis, and delayed or non-union fractures. Also described herein are methods and compositions for using probiotics and prebiotics for management of inflammation, and symptoms of menopause.

The invention provides application of apoptotic cell pretreated macrophages in preparation of an osteoarthritis treatment preparation, a cell preparation and a preparation method, and relates to the technical field of biomedicine.In the embodiment of the invention, based on a mouse development model and an osteoarthritis (OA) model, it is found that in the area away from the cartilage surface, the apoptotic cell pretreated macrophages are subjected to apoptotic cell pretreatment, and the apoptotic cell pretreated macrophages are subjected to apoptotic cell pretreatment in the area away from the cartilage surface; in the macrophages, the content of the interment-related LAMP1 protein is obviously higher than that of the macrophages close to the cartilage surface area, and the expression results of TGF-beta 1 and LRG1 are respectively opposite and consistent with those of the LAMP1. The invention also finds that after the chemotactic effect of apoptotic cells on macrophages is weakened, the cellular burial effect is limited, and the cartilage matrix development disorder is caused. Based on development process inspiration, the invention provides a treatment strategy: bone marrow-derived macrophages pretreated by apoptotic cells are injected into articular cavities, and a good cartilage regeneration treatment effect can be achieved in a mouse arthritis model. In addition, the bone marrow-derived macrophages pretreated by apoptotic cells can still express TGF-beta1 after being injected into the body for 3 days, so that the effect of continuously promoting cartilage regeneration is achieved.

The present invention covers furoindazole compounds of general formula (I): in which R1, R2, R3, R4, R5, R6a and R6b are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of autoimmune diseases such as multiple sclerosis, psoriasis, psoriatic arthritis, rheumatoid arthritis, ankylosing spondylitis, systemic lupus erythematosus, primary and secondary autoimmune uveitis, inflammatory disorders like endometriosis, inflammatory eye diseases, inflammatory kidney diseases, inflammatory liver diseases like non-alcoholic, alcoholic- and toxic fatty liver diseases, lung diseases like asthma, idiopathic pulmonary fibrosis, chronic obstructive pulmonary disease and metabolic and metabolic-endocrine disorders like metabolic syndrome, insulin resistance, diabetes mellitus type I and type II, and polycystic ovary syndrome (PCOS) disorders, neuropathic and inflammatory pain disorders in humans and animals.

The invention discloses a long-acting GGG three-target agonist, and the compound provided by the invention simultaneously achieves nM-level excellent agonist ability on three targets of GLP-l / GIP / GCGR, and can fully excite corresponding target organ tissue cells. The compound provided by the invention can promote insulin secretion and reduce blood sugar; in addition, ingestion can be inhibited, gastric emptying can be delayed, energy consumption can be increased, and finally the weight reduction effect can be observed. The compound provided by the invention can reduce pancreatic beta-cell apoptosis, increase the quantity of pancreatic beta-cells and improve functions of pancreatic cells. The compound disclosed by the invention can also improve blood fat, reduce liver fat accumulation and inhibit liver inflammation development. The compound or the composition can be used for preventing and / or treating metabolic disorder diseases and related complications thereof. The compound or the composition can be used for treating bone diseases related to endocrine diseases, metabolic disorders, nephropathy and the like, such as osteoporosis and osteoarthritis.

A machine-based learning system for predicting the presence of lesions indicative of axial spondyloarthritis in medical imaging data includes an image processor for receiving and processing one or more MRI image data set containing pelvic region and sacroiliac joint of a subject, and dividing said MRI image data set into a set of 3D voxels. The system also includes a voxel classifier for calculating for each of said the voxels one or more class probabilities of such voxel to contain a lesion of a particular type or being a non-lesion. The system also includes a lesion probability map generator for receiving the data produced by the voxel classifier and producing a probability intensity map for each of lesion types, in which one or more areas classified as lesion are highlighted; and an image display for displaying the output of the lesion probability map generator.

The present invention provides an aqueous pharmaceutical product comprising an anti-IL-17A antibody, and a use of the aqueous pharmaceutical product in the preparation of a drug for treating axial spondyloarthritis.

The invention discloses a plaster for treating osteoarthrosis and a preparation method thereof, and relates to the field of plasters for treating osteoarthrosis, and the plaster is prepared from the following raw materials: 14-18 parts of rhizoma atractylodis, 58-62 parts of garden balsam stem, 14-18 parts of cyathula officinalis, 8-12 parts of radix aucklandiae, 8-12 parts of gentiana macrophylla, 48-52 parts of clove root, 14-18 parts of cortex acanthopanacis, 8-12 parts of fructus cnidii, 98-102 parts of native copper, 14-18 parts of acorus gramineus, 8-12 parts of cinnamon, 48-52 parts of angelica sinensis and 48-52 parts of gastrodia elata. , 8-12 parts of Sichuan monkshood, 8-12 parts of pinellia ternate, 48-52 parts of myrrh, 48-52 parts of lycopodium clavatum, and 8-12 parts of dendrobe. The prepared plaster can be conveniently attached to the joint of a patient, stimulation of operations, anesthesia and the like is avoided, injury of the operations to the body is avoided, a series of toxic and side effects of oral medicines and the like are avoided, and the plaster is simple and effective to use; the cut plaster can be used for conveniently, simply, safely and effectively treating various osteoarthropathy such as cervical spondylosis, hyperostosis, lumbar disc herniation, rheumatism, rheumatoid, scapulohumeral periarthritis, arthritis, ankylosing spondylitis, fracture, traumatic injury and the like.

The present application relates to novel substituted indazoles, to processes for preparation thereof, to the use thereof alone or in combinations for treatment and / or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and / or prophylaxis of diseases, especially for treatment and / or prophylaxis of endometriosis and endometriosis-associated pain and other endometriosis-associated symptoms such as dysmenorrhoea, dyspareunia, dysuria and dyschezia, of lymphoma, rheumatoid arthritis, spondyloarthritis (especially psoriatic spondyloarthritis and Bekhterev's disease), lupus erythematosus, multiple sclerosis, macular degeneration, COPD, gout, fatty liver disorders, insulin resistance, neoplastic disorders and psoriasis.

The invention discloses an arthritis imaging scoring method, system and device and a storage medium, and the key points of the technical scheme are that periodic three-dimensional reconstruction is performed on a pre-constructed arthritis phantom to obtain a plurality of periodic three-dimensional images; determining an articular surface region in each three-dimensional image, and performing joint segmentation on each articular surface region to obtain a segmented image corresponding to each articular surface region; and performing feature extraction on each segmented image to obtain a target feature corresponding to each segmented image, and performing calculation according to each target feature and the corresponding score value to obtain an image evaluation result. Dynamic monitoring can be achieved, and the local pathological state of the joint can be comprehensively reflected.

Provided is a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein (I) can inhibit TNFR1 and is expected to be useful as a therapeutic agent for treating, for example, inflammatory bowel disease, rheumatoid arthritis, juvenile rheumatoid arthritis, psoriasis, psoriatic arthritis, ankylosing spondylitis, non-radiographic axial spondyloarthritis, and hidradenitis suppurativa.The present disclosure also provides a pharmaceutical composition comprising the compound disclosed herein or a pharmaceutically acceptable salt thereof.The present disclosure also relates to a method of using the compound or a pharmaceutically acceptable salt thereof in the treatment and prevention of inflammatory bowel disease, rheumatoid arthritis, juvenile rheumatoid arthritis, psoriasis, psoriatic arthritis, ankylosing spondylitis, non-radiographic axial spondyloarthritis, and hidradenitis suppurativa, as well as a method of preparing a medicament for this purpose. [Formula 1] TIFF0007746628000195.tif82167

The invention belongs to the field of bone nutrition powder, and particularly relates to bone nutrition powder for assisting in relieving arthritis pain and a preparation process. In the preparation, the herba eupatorii extract and the kelp extract are matched to effectively improve the arthritis pain relieving effect of the preparation, and the lophatherum gracile, the raspberry, the motherwort and the purslane are adopted to further improve the arthritis pain relieving effect of the fermented product through the processes of fermentation and the like; the preparation is applied to preparation of the bone nutrition powder, and the bone nutrition powder for assisting in relieving arthritis pain is prepared from the bone nutrition powder, protein, fat, water-soluble dietary fibers, vitamins, mineral elements and chondroitin sulfate. The obtained bone nutrition powder can effectively provide nutrition, also has an excellent health care effect, assists in relieving arthritis pain, and is excellent in performance and relatively good in application prospect.

The invention belongs to the technical field of biological medicine, and particularly relates to a new Spp1 + Carmil1 + and Spp1 + Cav1 + macrophage subgroup, a screening method and application in diagnosis and treatment of rheumatoid arthritis (RA). Aiming at the function limitation of a traditional M1 / M2 classification model, the invention proves the following new subgroup pathological interaction mechanism: osteoclast (ACP5 +) specifically releases TNFSF11 (RANKL), and is co-localized with Spp1 + Carmil1 + and Spp1 + Cav1 + subgroup space; the Spp1 + Carmil1 + subgroup secretes IL-18, and space interaction exists between the Spp1 + Carmil1 + subgroup and Treg (Foxp3 +) and Th17 (Il17a +) cells. The invention provides a novel cell marker and a targeted treatment strategy for accurate diagnosis and treatment of RA.

A preparation method of the wine comprises the following steps: 1) weighing the following raw materials in parts by weight: 18-22 parts of raw radix astragali, 13-17 parts of rhizoma drynariae, 13-17 parts of dog bone, 1-5 parts of semen strychni, 1 part of ginseng, 13-17 parts of herba epimedii, 13-17 parts of caulis spatholobi, 3-7 parts of gecko, 1 part of radix salviae miltiorrhizae, 3-7 parts of rhizoma corydalis, 1-5 parts of asarum heterotropoides, 1 part of gynostemma pentaphylla and 3-7 parts of chili; and 2) processing the raw materials into powder, placing the powder in a pottery clay jar, soaking the powder in 50-degree grain white spirit for more than half a year, performing high-temperature fermentation in summer, leaching the liquid medicine, and removing medicine residues to obtain the finished product of the fermented wine for rheumatic bone impediment. The traditional Chinese medicine has the advantages that the traditional Chinese medicine is reasonable in raw material design and convenient to prepare, has a good effect on treating various arthritis such as rheumatism, ankylosing spondylitis, rheumatic arthritis, lumbar disc herniation and hyperostosis, and has a very good popularization prospect and a very good medical economic value.

The present disclosure relates to inhibitors of miR-574-5p (SEQ ID NO: 1) for use in intra-articular treatment of a disease selected from the group consisting of osteoarthritis (OA), rheumatoid arthritis (RA), psoriatic arthritis, ankylosing spondylitis, gout, juvenile arthritis, systemic lupus erythematosus (SLE), Sjögren's syndrome and osteoporosis.

Described herein are methods and compositions for using microbial agents (probiotics) and agents that promote growth of certain microbes (prebiotics) for management (including prevention and treatment) of musculoskeletal disorders, including osteoporosis, osteopenia, Paget's disease, stunting, osteoarthritis, osteomyelitis, and delayed or non-union fractures.

The present invention discloses a long-acting GGG triple-target agonist. The compound of the present invention simultaneously achieves excellent agonist ability at the nM level for the three targets of GLP-1 / GIP / GCGR, and can fully excite the corresponding target organ tissue cells. The compound of the present invention can promote insulin secretion and lower blood sugar; it can also inhibit food intake, delay gastric emptying, increase energy consumption, and ultimately observe a weight loss effect. The compound of the present invention can reduce pancreatic β-cell apoptosis, increase the number of pancreatic β-cells, and improve pancreatic cell function. The compound of the present invention can also improve blood lipids, reduce liver fat accumulation, and inhibit the development of liver inflammation. The compound or composition of the present invention can be used to prevent and / or treat metabolic disorders and related complications. The compound or composition of the present invention can be used to treat bone diseases related to endocrine diseases, metabolic disorders, kidney disease, etc., such as osteoporosis and osteoarthritis.

The present application relates to the prevention and treatment of osteoarticular diseases, in particular osteoarthritis (OA), by inhibition of acetylcholinesterase (AChE). Specifically, this application provides a disease progression-modifying drug for the treatment of osteoarthritis, i.e., an acetylcholinesterase inhibitor, in particular a dimeric acetylcholinesterase inhibitor. The dimer targets both the enzymatic triad and non-enzymatic peripheral sites of acetylcholinesterase, thereby enhancing protection of articular cartilage and subchondral bone.

A method for modeling temporomandibular joint osteoarthritis, 6-week-old rats are selected, the rats are confirmed to have entered an anesthetized state before surgery, the rat's mandibular incisors are first checked and confirmed to be normal, the first arm of the device is sleeved on one side of the mandibular incisor, and the palatal side of the maxillary incisor is made to touch the slope surface of the second arm of the device, the device is checked and confirmed to not affect the rat's mandibular movement and occlusion, not significantly raise the bite, have no early contact, and the upper and lower jaw relationship is relatively stable; the device and the mandibular incisor sleeved with the device are fixed; then the rat is put back into the cage, and soft food or powdered feed is given after waking up; the device is removed after being fed for 8 weeks or more. It is verified that the condylar process of the rat changes significantly, the overall condylar process is significantly reduced, the subchondral bone is destroyed, and the expression of the cartilage matrix is also reduced. Thus, a TMJOA rat model exhibiting mandibular retrusion is formed.

The disclosure is directed to pharmaceutical products and stable liquid compositions of IL-17 antibodies and antigen-binding fragments thereof, e.g., AIN457 (secukinumab), and processes of making these pharmaceutical products and compositions. The disclosure is also directed to the use of these pharmaceutical products and liquid compositions (e.g., as part of a kit having instructions for use) for the treatment of various IL-17-mediated disorders (e.g., autoimmune disorders, such as psoriasis, ankylosing spondylitis, psoriatic arthritis, and rheumatoid arthritis).

Described herein are methods and compositions for using microbial agents (probiotics) and agents that promote growth of certain microbes (prebiotics) for management (including prevention and treatment) of musculoskeletal disorders, including osteoporosis, osteopenia, Paget's disease, stunting, osteoarthritis, osteomyelitis, and delayed or non-union fractures. Also described herein are methods and compositions for using probiotics and prebiotics for management of inflammation, and symptoms of menopause.

The present disclosure relates to viscosupplements and uses thereof, for example, in viscosupplementation of a mammalian joint and / or in methods of treating osteoarthritis. For example, the viscosupplements can comprise hyaluronic acid and / or a derivative thereof and crystalline nanocellulose, in a physiologically acceptable buffered saline.