65 results about "Type II collagen" patented technology

The invention belongs to the technical field of microbial fermentation, and particularly relates to lactobacillus rhamnosus capable of maintaining bone health and improving local joint inflammation and a metagen and application of the lactobacillus rhamnosus. According to the invention, the probiotic NKU ML1-2 is subjected to fermentation culture, such that a post-generation product is prepared. Results of embodiments prove that the metagen product can enhance the oxidation resistance of cartilage and osteoblasts and promote the synthesis of anti-inflammatory factors and cartilage matrixes (type II collagen and proteoglycan), and has the potential of relieving oxidative stress and inflammatory response of local joints, relieving joint inflammation and delaying cartilage destruction. The prepared metagen product is high in safety and good in stability, and can be applied to preparation of medicines for preventing and / or treating osteoarthritis; the metagen product can also be used for promoting bone health, enhancing the antioxidant capacity of osteoblasts and / or chondrocytes, promoting osteoblast activity and / or promoting calcium absorption and fixation, and a new solution is provided for joint health management.

The invention relates to a diatomic iron-iron site nano-enzyme constructed by relieving oxidative stress and cartilage degeneration and used for targeted osteoarthritis treatment. According to the invention, a nitrogen-doped porous carbon anchored diatomic iron nano enzyme catalyst (Fe2-NCs) with Fe-Fe dimer coordination is developed by using a'subject-object 'strategy. The Fe2-NCs protect cartilage cells from oxidative stress induced apoptosis by modulating ROS and active nitrogen species (RNS) and promoting O2 release. In addition, Fe2-NCs restores mitochondrial function by inhibiting NOX4 expression, improving ATP production, and normalizing COXIV levels. In an in-vivo OA model, the Fe2-NCs can reduce the expression of a pro-inflammatory medium COX-2 through an NF-kappa B signal channel, inhibit the up-regulation of MMP-13 and delay the degradation of type II collagen. The invention provides a new theoretical framework and methodological approach for the treatment of osteoarthritis, and has important clinical and scientific significance.

The application discloses a functional composition for improving bone and joint health, a conditioner and application. The functional composition comprises a first active component and a second active component; the first active component comprises elastin peptide, haematococcus pluvialis and ergothioneine; and the second active component comprises one or more of houttuynia cordata and non-denatured type II collagen. The application realizes the protection effect on joint, cartilage and bone health by scientific matching of the components and synergistically improving the glycosaminoglycan level in chondrocytes and the osteocalcin level in osteoblasts. Meanwhile, the components in the functional composition for improving bone and joint health are natural and have good biocompatibility, and have no obvious side effects, so that the application provides a kind of drug or a substitute for the treatment and prevention of bone diseases.

The application provides a preparation method of non-denatured type II collagen for increasing bone density and improving bone elasticity, and belongs to the technical field of biotechnology. The application adopts EDTA-citric acid buffer containing beta-mercaptoethanol to decalcify cartilage, adopts supercritical CO2 extraction technology to defat, adopts alkaline protease and collagenase II to perform matrix directional enzymolysis, and performs gradient digestion; then three-phase centrifugal separation is adopted to separate non-denatured type II collagen, and biomimetic H column chromatography purification is adopted, so that non-denatured type II collagen with high extraction rate, high purity and high structural integrity can be obtained.

This invention relates to a compound nutritional composition and its application. The compound nutritional composition comprises the following components: 1 part by weight of turmeric; 0.002-5 parts by weight of enzymatically hydrolyzed bone powder; and 0.02-0.2 parts by weight of cartilage powder containing type II collagen or 0.02-10 parts by weight of collagen peptide powder. The compound nutritional composition provided in this application addresses the specific osteoarthritis issues of athletes. By constructing an articular cartilage cell inflammation model and conducting population testing, the intervention effects of the compound nutritional composition provided in this application on exercise-related oxidative stress, inflammatory response, and pain perception are systematically evaluated. The aim is to overcome the limitations of traditional broad-based formulations and develop precise nutritional solutions that combine component synergy with exercise physiological adaptability, providing athletes with more scientific and effective joint health protection.

This invention relates to the field of biomedical materials, providing non-denatured type II collagen ultrafine powder with cartilage tissue-targeted growth and structural repair functions, its bioactivity preservation preparation method, and its application in joints. The ultrafine powder has an average particle size of 0.5-50 μm, a triple helix structure integrity rate of not less than 85%, a thermal denaturation temperature of 38-48℃, and retains chondrocyte binding domains CB10, CB11, and MMP cleavage sites. The preparation method includes raw material pretreatment, time-limited enzymatic hydrolysis, graded purification, and ultra-low temperature ball milling. The product can be used for the repair and treatment of cartilage degenerative diseases such as osteoarthritis and cartilage damage.

The application provides a composition containing curcuma and type II collagen-containing cartilage powder and application thereof in joint maintenance, and relates to the field of food technology. The application provides a composition containing milk mineral salt, curcuma, type II collagen-containing cartilage powder, enzymatic bone powder, N-acetyl glucosamine and black pepper extract, which can significantly repair joint damage, significantly reduce cartilage damage indexes such as CTX-II and COMP, and can be used for preparing a joint maintenance medicine.

The invention discloses a functional composition capable of improving bone and joint health, a conditioner and application. The functional composition comprises a first active component and a second active component, the first active component is prepared from elastin peptide, haematococcus pluvialis and ergothioneine; the second active component is prepared from one or more of herba houttuyniae and non-denatured type II collagen. Through scientific compatibility of all the components, the levels of glycosaminoglycan in chondrocytes and osteocalcin in osteoblasts are synergistically improved, and the protection effect on joint, cartilage and skeleton health is achieved. Meanwhile, a plurality of components in the functional composition capable of improving the health of the bones and the joints are natural in source, good in biocompatibility and free of obvious side effects, and a medicine or an alternative scheme thereof is provided for treatment and prevention of the bone diseases.

The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to a composition for treating osteoarthritis and a preparation method thereof. The composition for treating osteoarthritis is prepared from the following raw materials in parts by weight: 1 to 3 parts of non-denatured type II collagen, 0.3 to 0.5 part of cowherb seed cyclic peptide A and 0.4 to 0.7 part of balanosine. According to the composition, through the synergistic effect of multiple active ingredients, the osteoarthritis symptom is jointly relieved, and joint tissue repair is promoted.

The invention relates to the technical field of nutritional supplement preparations for pets, in particular to a high-activity non-denatured II-type collagen pet joint dispersible tablet and a preparation method thereof. According to the technical scheme, the soft capsule is prepared from the following raw materials in percentage by weight: 4.0%-7.0% of non-modified II type collagen, 4.0%-6.0% of sodium chondroitin sulfate, 4.0%-6.0% of green lip mussel powder, 0.5%-1.5% of sodium hyaluronate, 30%-40% of microcrystalline cellulose, 12%-18% of sodium carboxymethyl starch, 15%-22% of sweet potato starch, 4.0%-6.0% of polyvinylpolypyrrolidone, 6.0%-10.0% of enzymolysis chicken liver powder, 2.0%-4.0% of yeast extract, 1.5%-3.5% of lactose goat milk powder and 0.3%-0.7% of magnesium stearate. A core active component structure is protected by virtue of nano embedding and a whole-course low-temperature process, and a dual joint maintenance path of immunoregulation and nutrition supplement is constructed.

Currently available non-denatured collagen products include powders and capsules that can optionally be incorporated into a final product that does not require heating or acidic conditions, or instead is consumed directly. This has been particularly problematic for administration to non-human mammals, such as pets and livestock, because when added as a dry powder to food or water, the supplements and capsules sink to the bottom of the bowl of food or liquid and remain unconsumed by the mammal, or in the case of capsules, can be difficult, if not impossible, to administer to the mammal.SOLUTION: The present disclosure relates to processed animal foods and / or treats comprising undenatured type II collagen. The undenatured type II collagen is introduced into the animal food and / or treat prior to processing and at least 30% or more of the undenatured collagen remains undenatured after processing of the animal food and / or treat.SELECTED DRAWING: None

The invention belongs to the technical field of biological medicines, and particularly relates to a drug-loaded nano-micelle as well as a preparation method and application thereof. According to the invention, bromoalkanes with different chain lengths are introduced to a leonurine phenolic hydroxyl group by adopting a total synthesis method to prepare a leonurine derivative, and the drug-loaded nano-micelle is prepared by applying triptolide (TP) and the leonurine derivative. The embodiment of the invention verifies that the drug-loaded nano-micelle can reduce in-vivo and in-vitro toxicity caused by triptolide and improve the treatment effect on a mouse arthritis model induced by type II collagen. The novel triptolide compatible medicine prepared by the invention is small in toxic and side effects and has a good curative effect on rheumatoid arthritis.

The invention discloses a food beneficial to bone movement health and a preparation method thereof, and the food comprises the following components by weight: 3-5 parts of bone collagen; 0.3 to 0.5 part of non-denatured type II collagen; 7-9 parts of a cartilage extract; 0.4 to 0.6 part of rhizoma curcumae longae; 1-3 parts of mangosteen fruit powder; 0.8 to 1.0 part of sodium hyaluronate; 0.1 to 0.3 part of N-acetylglucosamine; 0.4 to 0.6 part of milk mineral salt; 0.02 to 0.04 part of vitamin D3 micro-capsule powder; and 0.16 to 0.18 part of casein phosphopeptides. The food disclosed by the invention is beneficial to comprehensive maintenance of skeleton movement health, has no side effect and is high in popularization value.

The application relates to the technical field of animal models, and discloses a construction method and application of an ectopic ossification arthritis animal model. 91‑115 After being mixed and emulsified with chicken type II collagen as an antigen, animals are immunized to obtain the animal model, which is referred to as a C2V7 model. The arthritis model constructed by the application has high success rate, short time consumption and easily-obtained modeling materials. The model can simulate the onset process of arthritis with obvious ectopic ossification characteristics such as ankylosing spondylitis, enthesial-related arthritis and psoriatic arthritis, objectively reflects the pathological process and pathological characteristics of ectopic ossification arthritis, and provides a new research platform for related research.

The application discloses a composition for promoting joint health, a preparation method and application, and relates to the field of food.The composition comprises the following components in parts by weight: animal protein: 20-80; non-denatured type II collagen: 0.2-1; sodium hyaluronate: 0.5-2; proteoglycan: 0.5-2; sour cherry extract: 3-10; and calcium beta-hydroxy-beta-methylbutyrate: 5-20.The application takes non-denatured type II collagen as a main efficacy component, and additionally adds animal protein, sodium hyaluronate, proteoglycan, sour cherry extract and calcium beta-hydroxy-beta-methylbutyrate, synergistically acts through the multiple efficacy components, relieves joint discomfort through multiple pathways, maintains muscle health, and enables the product to have the optimal effect of repairing joint damage, improving joint and skeletal muscle health.

1. The name of the design product: packaging box (non-denatured type II collagen chitosan oligosaccharide compound tablet). 2. The use of the design product: for packaging health care products. 3. The design points of the design product: the combination of shape, pattern and color. 4. The picture or photo that best indicates the design points: front view. 5. The design for which protection is sought includes color. 6. The bottom of the design product is a part that is not easily visible or invisible during use, and the top view is omitted.

This invention discloses a chitosan-based lidocaine formulation for intra-articular use and its preparation method. Belonging to the field of pharmaceutical formulation technology, the formulation is prepared from chitosan, carboxymethyl chitosan, lidocaine, chitosan-PNIPAM microspheres, sulfated trehalose, and excipients. The chitosan-PNIPAM used in this invention exhibits dual temperature and pH response. With temperature changes, PNIPAM possesses both hydrophobic contractile and hydrophilic swelling states, thereby controlling the lidocaine release rate. Simultaneously, when the pH decreases, chitosan repels PNIPAM, further disintegrating the microspheres to release the drug, thus achieving targeted analgesia. Sulfated trehalose, as a cartilage matrix synthesis promoter, can activate intracellular signaling pathways in chondrocytes, promoting the synthesis of type II collagen and proteoglycans. Simultaneously, the sulfate groups can form electrostatic complexes with the amino groups of chitosan, enhancing drug retention. The formulation of this invention can inhibit synovial cells, release cytokines, and synergistically with carboxymethyl chitosan, increase the inhibition rate of inflammatory factors by 40%-50%.

The application discloses a euphausia superba oil cartilage extract, a euphausia superba oil cartilage capsule and a preparation method. The euphausia superba oil cartilage extract is composed of the following raw materials in percentage by weight: cartilage collagen 40-60%; non-denatured type II collagen 0-5%; chicken cartilage extract 1-10%; chitosan oligosaccharide 0-10%; and the rest is euphausia superba oil. The compound formula design combines the euphausia superba oil, cartilage collagen, non-denatured type II collagen, chicken cartilage extract and chitosan oligosaccharide and other beneficial ingredients, which can produce positive effects on human cardiovascular health, joint health, skin health, immune system health and intestinal health and other aspects, meet the needs of human body in different physiological and health demands, help to improve the quality of life and promote health.

The invention relates to the technical field of biological medicine and food processing, and discloses a sheep bone marrow peptide composition for activating osteoblasts to be rich in bone repair factors, the sheep bone marrow peptide composition has an ordered assembly structure mediated by electrostatic adsorption, and the sheep bone marrow peptide composition is prepared from the following raw materials in parts by weight: 1000-1500 parts of sheep bone marrow peptide powder; 250 to 350 parts of sweet orange fruit powder; 450 to 700 parts of a non-denatured type II collagen protein; 800 to 1200 parts of hydrolyzed type II collagen protein; 1-10 parts of ginseng peptide powder; 1-10 parts of Chinese wolfberry fruit peptide powder; and 5 to 15 parts of stevioside. According to the invention, an interface proton buffer layer is constructed by utilizing the zwitterionic characteristics of the hydrolyzed type II collagen, and a microenvironment with high buffer capacity is formed on the surface of the non-denatured type II collagen, so that the permeation of gastric acid hydrogen ions is effectively blocked, and the local pH value of core protein is kept stable.

This document presents a novel composition and method for treating osteoarthritis using a cannabinoid-based nanoplatform administered via intra-articular injection. The composition includes phytocannabinoids such as CBG and CBC, along with hyaluronic acid, type II collagen, and calcium gluconate, embedded within a nanoplatform designed to enhance bioavailability and ensure controlled release in the synovial space. Tailored for osteoarthritis patients, the treatment alleviates joint pain, stiffness, reduced mobility, inflammation, sensations of friction, muscle weakness, and joint deformity. Cannabinoids act through multiple mechanisms, including interaction with CB1 and CB2 receptors, cytokine modulation, inhibition of NF-κB, and activation of the TRPV1 receptor, providing a potent anti-inflammatory effect. The formulation aims to halt cartilage degeneration, reduce pain, and slow osteoarthritis progression. The production process uses nanoemulsification techniques to create particles smaller than 200 nm, with pre-sterilization through membrane filtration, ensuring both efficacy and safety.

An oral anti-aging combination based on the triple interaction of NAD + -SIRT1-GH, characterized in that it comprises the following components: NAD + -Precursor, resveratrol or an esveratrol-containing reagent, astaxanthin, grape seed extract, vitamin C, L-citrulline, L-ornithine, hydrolyzed collagen, hydrolyzed type II collagen, a zinc chelate and sodium hyaluronate.

This invention discloses a tissue regeneration-promoting filler material and its preparation method. The filler material is made by dispersing composite microspheres in a type I collagen gel, using type II collagen as the microsphere wall material and hydroxyapatite as the core material. The tissue regeneration-promoting filler material prepared by this invention is used for filling areas such as eyebrow wrinkles, eyebrow subcutaneous support, malar fat and buccal fat pads, tear troughs, nasolabial folds, nose, lips, chin, and mandibular periosteum. It provides significant mechanical support and, based on exogenous collagen supply, continuously stimulates the formation and rearrangement of endogenous collagen, meeting the needs of cosmetic surgery.

The invention discloses a nutritional composition for promoting osteogenesis, protecting articular cartilage and improving joint inflammation, and belongs to the technical field of bone health products. According to the invention, the components in the formula and the proportion thereof are systematically researched and analyzed to construct a nutritional composition formula system which takes yak bone collagen peptide as a main material and shark cartilage powder as an auxiliary material, and is added with an effective amount of non-denatured type II collagen and vitamin K2 to promote osteogenesis, protect articular cartilage and improve joint inflammation. On the basis of research on bioactive substances in combination with the modern nutriology theory, the best combination between bone collagen peptide and cartilage powder, between vitamin K2 and bone collagen peptide and between non-denatured type II collagen and bone collagen is found through tests, the synergistic effect is achieved, and the bone nutrition effect is extremely good. Functional tests and testee people prove that the nutritional composition has the effects of promoting osteogenesis, protecting articular cartilage and improving joint inflammation.

The invention relates to an essence for improving skin elasticity and skin aging and a preparation method and application thereof, the essence comprises the following components: 0.1%-10% of ginseng extract, 0.1%-5% of coenzyme Q10, 0.1%-1% of chia seed extract, 0.5%-3% of type I collagen, 0.01%-1% of type II collagen, 1%-5% of type III collagen, 0.1%-3% of type V collagen, 0.001%-0.1% of palmitoyl pentapeptide-4, 0.1%-5% of panthenol, and the balance of water. The green tea mask comprises the following components in percentage by weight: 0.1%-2% of green tea extract, 0.1%-2% of allantoin, 0.5%-5% of nicotinamide, 0.05%-2% of vitamin B6, 0.05%-3% of tocopheryl acetate, 0.01%-1% of Biotin biotin, 0.5%-5% of elastin, 0.5%-5% of squalane and the balance of deionized water. The essence can comprehensively recover collagenous fiber structures and functions of skin through various collagens (such as type I, type III, type II and type V), palmitoyl pentapeptide-4 and coenzyme Q10 for promoting generation of elastic fibers are added, skin elasticity and compactness are enhanced, collagen synthesis and metabolism are supported by the aid of components such as nicotinamide and biotin, and the essence has the effects of whitening skin, whitening skin and whitening skin. The absorption effect and the stability of the formula are improved, and the formula is suitable for various skin-care products.

This invention relates to methods for purifying type II collagen from cartilage tissue. The present invention also relates to a type II collagen composition, and the use of the type II collagen composition as a dietary supplement or treatment for cartilage-related disorders. Methods of treating or preventing cartilage-related disorders are also provided.

The invention provides bionic bio-ink for articular cartilage defect repair and a preparation method thereof.The bionic bio-ink is composed of type II collagen, hyaluronic acid, chondroitin sulfate and geniposide, the bionic bio-ink takes a natural matrix component, a rheology modifier and a mild cross-linking agent as a core system, and through precise matching and synergistic effect, the bionic bio-ink can be used for repairing articular cartilage defects. The cell compatibility and the printing precision are both considered, and the problems that existing ink is low in bionic degree and poor in differentiation effect are effectively solved. All the components of the bionic bio-ink are natural sources or low-toxicity reagents, the risk of immunological rejection is avoided, in-vitro degradation products are small molecular polysaccharide and amino acid which can be metabolized and absorbed by a human body, and inflammatory response is avoided.

The application discloses a composition with the effect of auxiliary treatment of arthritis and a preparation method and application thereof, and the composition comprises the following preparation raw materials in parts by weight: non-denatured type II collagen 5-15 parts, curcuma longa extract 56.8-100 parts, frankincense extract 18.7-39.8 parts, sophora flower bud extract 15-28.5 parts, chondroitin sulfate 20-30 parts, glyceryl behenate 15-25 parts, chitosan 3-7.5 parts, sodium deoxycholate 3-8 parts, polyethylene glycol-15 hydroxystearate 5-15 parts, anti-knotting agent 1-3 parts, curing agent 5-15 parts and filling agent 15-25 parts. The application can treat arthritis through the trinity of immune-mechanical-metabolic pathways, and the effect is remarkable and fast, and has a certain residual effect.

The invention discloses an ergothioneine-non-denatured II-type collagen peptide pet anti-aging rehabilitation composition with anti-oxidation, joint repair and intestinal regulation functions and application thereof, and belongs to the technical field of pet health and nutrition. The composition consists of ergothioneine, non-denatured type II collagen peptide, prebiotics, metabiotics, vitamin E, vitamin C and the balance of a carrier acceptable for pets. According to the invention, the ergothioneine with high bioavailability, the non-denatured II type collagen peptide and the metagen are combined and applied to the anti-aging field of pets for the first time, and a triple pathway synergistic anti-aging model is innovatively constructed, namely, the effect is achieved by regulating intestinal flora, activating an endogenous antioxidant system and regulating immune inflammation balance. The composition is clear in action mechanism, remarkable in effect and high in safety, and a scientific and effective new nutrition intervention scheme is provided for delaying the pet aging process and promoting postoperative rehabilitation.

The present invention provides a use of a ugonin compound for the treatment of joint-related diseases by enhancing chondrogenesis. More specifically, the chondrogenesis is mediated by the ugonin compound’s ability to promote the increase of aggrecan and type II collagen, which is achieved through the inhibition of miR-3074-5p and the activation of the MAPK signaling pathway.