71 results about "Elastin peptides" patented technology

The invention provides a pharmaceutical composition for preventing and treating gingival atrophy and a preparation method and application thereof, and belongs to the technical field of biological medicine. The composition contains finless eel peptide, skipjack elastin peptide, quinoa rice extract, gleditsia sinensis rice extract, calendula extract, chamomile extract, chitosan, peach gum, hydroxyapatite and the like, and the finless eel peptide, the skipjack elastin peptide, the quinoa rice extract and the gleditsia sinensis rice extract are specific enzymatic hydrolysates. The monopterus albus peptide, the skipjack elastin peptide, the quinoa rice extract and the gleditsia sinensis rice extract jointly promote repair and regeneration of gingival tissues. The calendula extract, the chamomile extract and the chitosan have anti-inflammatory and antibacterial effects, so that gingival inflammation is relieved, and bacterial infection is prevented. And the chitosan and the calendula extract can accelerate the repair of damaged gingival tissues. The monopterus albus peptide, the skipjack elastin peptide and the hydroxyapatite are matched for use to jointly maintain the normal structure and function of gingiva. All the components have a synergistic effect, so that gingival atrophy can be effectively prevented and improved.

The invention provides an elastin peptide-containing composition as well as a preparation method and application thereof. The elastin peptide-containing composition comprises elastin peptide, camel milk active small molecule peptide and water lily oligopeptide in a mass ratio of 1: (1-3): (1.8-2.5). The elastin peptide, the camel milk active small molecule peptide and the water lily oligopeptide which are obtained through a specific treatment mode are compounded according to a specific proportion, synthesis of aquaporin AQP3 can be promoted, the content of sodium hyaluronate is increased, and the free radical scavenging activity is improved. The composition containing the elastin peptide can quickly and efficiently improve the skin state, repair the skin, delay the skin aging, enhance the skin function and recover the elasticity. The composition containing elastin peptide can promote the proliferation and growth of fibroblasts, improve the cell viability and promote the healing of skin wounds, and is non-toxic to cells.

The invention relates to the technical field of elastin peptides, in particular to a method for extracting elastin peptides from animal cartilage, which comprises the following specific steps: removing surface connective tissues and fat from animal cartilage, cleaning with normal saline, grinding and degreasing to obtain pretreated cartilage particles; putting the pretreated cartilage particles into a container, adding ionic liquid and stirring; after stirring is completed, centrifugally collecting precipitates; adding the precipitate into a phosphate buffer solution to form a suspension; adding an immobilized compound enzyme, and carrying out an enzymolysis reaction; after the enzymolysis is completed, raising the temperature for inactivation; filtering to obtain enzymatic hydrolysate; adding macroporous resin into the enzymatic hydrolysate, and filtering to obtain clear liquid; and carrying out ultrafiltration on the clear liquid to obtain the elastin peptide. The ionic liquid interacts with impurities in the animal cartilage, so that the impurities are easier to remove, a purer raw material environment is created for subsequent elastin peptide extraction, and the extraction efficiency is improved.

The invention discloses a bullfrog extracted biological collagen composition and a preparation method thereof in the technical field of collagen. The bullfrog extracted biological collagen composition comprises the following components in parts by weight: 1-1.5 parts of hydrophobic bullfrog source collagen peptide, 0.6-0.8 part of hydrophobic bullfrog source elastin peptide, 1-1.5 parts of polyglutamic acid and 1-1.5 parts of polylysine. Collagen and elastin in bullfrog skin and bullfrog cartilage are extracted in a combined mode through a three-enzyme co-production method, and after bullfrog source collagen peptide and bullfrog source elastin peptide are subjected to hydrophobic modification, polyglutamic acid and polylysine are added to form a collagen combination. The stability, the medicine carrying capacity and the slow release capacity of the composition can be improved.

The invention provides a composition containing elastin peptide as well as a preparation method and application thereof, and relates to the technical field of food. The composition containing the elastin peptide is prepared from the following components in parts by weight: 5 to 10 parts of fish collagen peptide, 3 to 10 parts of tremella polysaccharide, 0.1 to 0.5 part of elastin peptide, 0.01 to 0.1 part of skipjack elastin peptide, 1 to 2 parts of hydrolyzed II-type collagen, 0.01 to 0.05 part of vitamin C, 1 to 5 parts of pomegranate concentrated powder, 1 to 5 parts of cranberry concentrated powder, 5 to 15 parts of lily powder and 1 to 3 parts of blueberry juice powder. The composition containing the elastin peptide is high in safety, and meanwhile, the effects of improving skin elasticity, improving skin moisture, delaying generation of wrinkles and resisting aging are achieved by remodeling internal skin tissues, increasing skin moisture, improving oxidation resistance and the like.

Relating to the field of biotechnology, disclosed are a recombinant human elastin peptide with anti-aging effects and a use thereof. The recombinant human elastin peptide comprises an amino acid sequence shown in SEQ ID NO:1 or a fragment of the amino acid sequence shown in SEQ ID NO:1, the fragment comprises 30% or more of SEQ ID NO:1, or a mutant of the amino acid sequence shown in SEQ ID NO:1 or the fragment of the amino acid sequence shown in SEQ ID NO:1. A disclosed method for producing elastin peptides by using a yeast expression system enables the targeted synthesis of highly effective protein fragments with 100% homology to human proteins, while achieving low costs and facilitating large-scale production, avoiding animal-derived sources and viral risks. This makes the recombinant human elastin peptide safe for use as an anti-aging and anti-photoaging active ingredient in cosmetics, while also supporting a use thereof in the field of biomedical materials.

The invention discloses a preparation method of elastin peptide, and relates to the technical field of natural elastin extraction.The preparation method comprises the following steps that S1, animal blood vessels are cleaned, subjected to impurity removal, cut into blocks and minced; s2, the diced and minced animal blood vessels are soaked in alkali liquor for degreasing, the animal blood vessels are fished out and cleaned after degreasing, water is added after cleaning, pulping is conducted, slurry is obtained, and the pH of the slurry is adjusted to 7.5-8.5; s3, adding elastinase and trypsin into the pulp, and performing enzymolysis to obtain enzymatic hydrolysate; s4, sequentially performing high-temperature enzyme deactivation, vacuum concentration, purification, refining and spray drying on the enzymatic hydrolysate to obtain powdery elastin peptide. The trypsin and elastinase adopted in the invention belong to basic proteins, can decompose proteins under alkaline conditions, and have the characteristics of high catalysis efficiency, action specificity, activity adjustability, diversity and the like.

The invention relates to the technical field of food preparation, and discloses a healthy food composition with breast enlarging efficacy, which comprises kudzuvine root, pawpaw, dandelion and Chinese angelica. The composition further comprises at least one of ginseng, red dates, colla corii asini, mulberries, black beans, red roses with double petals, collagen peptide, skipjack elastin peptide, fish collagen tripeptide, cubilose and saffron crocus extract. Compared with the prior art, the food composition capable of being used for breast enlargement, provided by the invention, has the advantages that all the components are selected from natural components, no additive is added, the breast enlargement effect is realized under the condition of ensuring no side effect and health hidden danger, and the vacancy in the existing market is made up.

The invention relates to the technical field of active peptides, and discloses a whitening and anti-wrinkle protein active peptide composition as well as a preparation method and application thereof. The whitening and anti-wrinkle protein active peptide composition is prepared from the following raw materials in parts by weight: 10 to 15 parts of elastin peptide, 11 to 14 parts of fish collagen peptide, 8 to 10 parts of fish maw small-molecule active peptide, 5 to 10 parts of cubilose peptide, 5 to 10 parts of sea cucumber peptide, 2 to 6 parts of Chinese fevervine herb active peptide, 1 to 3 parts of zingiber corianum active peptide and 1 to 5 parts of lycopene. According to the whitening and anti-wrinkle protein active peptide composition and the preparation method and application thereof, small-molecule active peptide in the prepared protein active peptide composition is beneficial to absorption of dermal cells, and meanwhile, through the synergistic effect of multiple active ingredients, the whitening and anti-wrinkle effects are effectively achieved, the skin quality is improved, and aging is delayed.

The invention discloses a special diet and a preparation process thereof, and the special diet comprises the following raw materials: 500-600 parts of a red date concentrated solution, 350-400 parts of purified water, 40-60 parts of collagen peptide, 4-6 parts of lycium ruthenicum primary pulp, 0.5-1.5 parts of donkey-hide gelatin oligopeptide powder, 0.5-1.5 parts of longan powder, 3-5 parts of gamma-aminobutyric acid essence, 0.5-1.5 parts of elastin peptide, 0.5-1.5 parts of cubilose peptide, and 0.5-1.5 parts of collagen tripeptide. And 0.5 to 1.5 parts of epigallocatechin gallate. According to the special diet disclosed by the invention, the matching of the red date concentrated solution and the lycium ruthenicum primary pulp not only provides abundant natural antioxidant substances, but also enhances the blood replenishing and beautifying functions of the product, and the combination of the collagen peptide, the elastin peptide and the collagen tripeptide provides multi-level nourishing protection and the like for skin and joint health. The whole preparation process is accurate and controllable in technological parameters, high in production efficiency and suitable for large-scale production, and the obtained product has the remarkable characteristics of being fine and smooth in taste, definite in effect and good in stability and can meet the diversified requirements of different people for functional dietary supplements.

The invention relates to the technical field of bioengineering, and discloses an elastin peptide fusion protein as well as a preparation method and application thereof. Based on the elastin with an amino acid sequence such as SEQ ID NO.8, high-yield expression of the elastin is realized through pichia pastoris GS115. According to the elastin, bovine lactoferrin peptide with a natural antibacterial function is fused, bovine lactoferrin N-leaf small peptide, bovine lactoferrin peptide and elastin peptide with an amino acid sequence as shown in SEQ ID NO.8 are fused, on the premise that the high expression quantity of the fusion protein is guaranteed, the fusion protein is endowed with more functions, and the fusion protein has the advantages of being capable of resisting bacteria and resisting bacteria. Therefore, the fusion protein can be applied to cosmetics, such as artificial blood vessels and other medical equipment products, and the elastin has good biocompatibility and a natural preservative function.

The invention relates to the technical field of functional drinks, in particular to a polypeptide synergistically strengthened cubilose collagen composite drink with a breast enlarging function and a preparation method of the polypeptide synergistically strengthened cubilose collagen composite drink. The drink contains fish collagen tripeptide, elastin peptide, cubilose peptide, pueraria mirifica isoflavone, red clover isoflavone and saffron crocus extract. A lipidosome delivery system is adopted to entrap polypeptide to form a nano-scale compound, nano-emulsion entraps phytoestrogen, and berry polyphenol and lipidosome-polypeptide form a stable ternary compound. Through the multi-way synergistic effect that phytoestrogen activates a mammary gland estrogen receptor, polypeptide promotes connective tissue collagen synthesis and cubilose peptide activates a growth factor signal, mammary gland development is remarkably promoted, the breast enlarging effect is achieved, the bioavailability reaches 85% or above, and the retention rate of active ingredients stored at normal temperature for 24 months is larger than 90%.

The invention belongs to the technical field of functional food, and particularly relates to a moisturizing, freckle-removing, whitening and antioxidant composition as well as a preparation method and application thereof, and the composition comprises the following raw materials: elastin peptide, fish collagen peptide, soybean peptide, tremella polysaccharide, aronia melanocarpa fruit powder, acerola cherry powder, Cuanshania cerasus pollen, rice bran oil powder and casei casei CN1566. The freckle-removing and whitening mask can improve the skin quality and achieve the freckle-removing and whitening effects.

The present invention relates to the field of biotechnology and discloses a recombinant human elastin peptide with anti-aging efficacy and its application in a composition thereof. The recombinant human elastin peptide comprises the elastin peptide amino acid sequence SEQ ID: 1 or a fragment thereof, wherein the fragment comprises 30% of SEQ ID: 1, or a fragment comprises more than 30% of SEQ ID: 1, or a mutant of the above sequence. The recombinant human elastin peptide can be directed to synthesize a protein of a highly effective fragment, with a 100% human homologous sequence, while being low-cost, easy to mass-produce, avoiding animal sources, and avoiding viral risks. This allows the recombinant human elastin peptide to be safely used in cosmetics as an anti-aging and anti-photoaging ingredient, while also providing support for its application in the field of biomedical materials.

The application discloses a functional composition for improving bone and joint health, a conditioner and application. The functional composition comprises a first active component and a second active component; the first active component comprises elastin peptide, haematococcus pluvialis and ergothioneine; and the second active component comprises one or more of houttuynia cordata and non-denatured type II collagen. The application realizes the protection effect on joint, cartilage and bone health by scientific matching of the components and synergistically improving the glycosaminoglycan level in chondrocytes and the osteocalcin level in osteoblasts. Meanwhile, the components in the functional composition for improving bone and joint health are natural and have good biocompatibility, and have no obvious side effects, so that the application provides a kind of drug or a substitute for the treatment and prevention of bone diseases.

The invention discloses an acidic high-content collagen beverage, which is prepared from the following raw materials in percentage by mass: 30 to 34 percent of collagen peptide, 8 to 12 percent of collagen tripeptide, 0.05 to 0.3 percent of elastin peptide, 0.01 to 0.05 percent of hyaluronic acid, 0.1 to 0.3 percent of grape seed extract, 0.05 to 0.1 percent of xylooligosaccharide, 0.01 to 0.03 percent of sweetening agent, 0.8 to 1.5 percent of acidulant and the balance of water. The pH value of the acidic high-content collagen beverage is less than or equal to 4.6. The acidic high-content collagen beverage disclosed by the invention has the characteristics of excellent taste, high collagen content, acidity, no bad flavor and stable quality.

The invention discloses a multifunctional special dietary food skin beautifying and shaping formula and application, and belongs to the technical field of beauty treatment. The multifunctional special dietary food at least comprises collagen peptide, collagen tripeptide, skipjack elastin peptide, carob bean extract, phosphatidylserine, casein hydrolytic peptide, nicotinamide, rice bran oil powder, haematococcus pluvialis, cranberry powder, oriental cherry flower powder, pig blood peptide powder, red date peptide powder and cattle spleen peptide. The health-care product can comprehensively supplement nutrition recovered after exercise, has the effects of beautifying, shaping and removing wrinkles, can effectively relieve pressure and regulate emotion, and also has the effects of improving female physiological health, strengthening the spleen and stomach and enhancing immunity.

The present invention provides a process for extracting collagen tripeptide (CTP) from collagenase hydrolysate, comprising the following steps: performing two enzymatic hydrolysis on the pretreated collagen raw material, filtering, and adopting specific magnetic microsphere separation and molecular imprinting polymer microsphere medium solid phase extraction purification. The present invention can obtain a high-content (up to 80%) collagen tripeptide composition product (Gly-X-Y, including Gly-Pro-Hyp). The present invention has the advantages of high separation efficiency, low cost, and suitability for industrial-scale production. Studies have shown that the compound use of collagen tripeptide and elastin peptide in a ratio of 16:1 to 24:1 can significantly increase the content of elastin and collagen in the skin, and significantly increase the content of hyaluronic acid and hydroxyproline, while reducing the content of MMP3 and inhibiting skin inflammatory factors.

The invention discloses a functional composition capable of improving bone and joint health, a conditioner and application. The functional composition comprises a first active component and a second active component, the first active component is prepared from elastin peptide, haematococcus pluvialis and ergothioneine; the second active component is prepared from one or more of herba houttuyniae and non-denatured type II collagen. Through scientific compatibility of all the components, the levels of glycosaminoglycan in chondrocytes and osteocalcin in osteoblasts are synergistically improved, and the protection effect on joint, cartilage and skeleton health is achieved. Meanwhile, a plurality of components in the functional composition capable of improving the health of the bones and the joints are natural in source, good in biocompatibility and free of obvious side effects, and a medicine or an alternative scheme thereof is provided for treatment and prevention of the bone diseases.

The invention provides gel based on collagen liposome. The gel comprises the following components in parts by mass: 2 parts of shikonin liposome; 2 parts of collagen peptide liposome; 1 part of elastin peptide liposome; and 1 part of carbomer. According to the gel based on the collagen liposome provided by the invention, the alkannin liposome compound gel has an obvious cleaning capability, namely, the alkannin liposome compound gel has a very strong anti-oxidation capability. The alkannin liposome compound gel has an obvious cleaning effect on H2O2 (hydrogen peroxide). The alkannin liposome compound gel has an excellent itching relieving effect. The alkannin liposome compound gel has the effect of resisting eczema. The alkannin liposome compound gel also has an inhibition effect on staphylococcus aureus and escherichia coli. The invention further provides a preparation method of the gel based on the collagen lipidosome and application of the gel based on the collagen lipidosome in the aspect of drugs for treating skin diseases.

The invention relates to the technical field of biological medicines, and particularly discloses an elastin peptide, a composition containing the elastin peptide and application of the elastin peptide to preparation of a product with an effect of promoting hair growth. The elastin peptide has the following amino acid sequence: VGAPI. The composition containing the elastin peptide comprises the elastin peptide and an extract, the elastin peptide has the following amino acid sequence: VGAPI. Researches show that the elastin peptide (the amino acid sequence is VGAPI) and the composition containing the elastin peptide have the effect of promoting hair growth; therefore, when being used as an active ingredient for preparing medicines or daily chemical products with an effect of promoting hair growth or an effect of treating alopecia, the compound has important application value.

To suppress an unpleasant odor when an iron compound and collagen peptide or elastin peptide are formulated in an oral liquid composition.SOLUTION: The oral liquid composition comprises (A) an iron compound, (B) at least one peptide selected from the group consisting of collagen peptide and / or elastin peptide, and (C) at least one plant extract selected from the group consisting of lemon balm extract, Houttuynia cordata extract, artichoke extract and rosemary extract.SELECTED DRAWING: None

A method and compositions of treatment for improving skin health and sleep quality using supplementation, comprising the step of applying a supplement formulation to a human subject via a selected administration route, the supplement formulation comprising therapeutically effective amounts of a hormone supplement, a plurality of collagen peptides, and a plurality of elastin peptides. The hormone supplement may comprise either HGH or IGF-1, or precursors or analogues thereof, and the collagen peptides may be sourced from a plurality of animal-based sources, which may include at least one of chicken bone, bovine hide, or fish tissues.

The invention discloses a high-content astaxanthin beverage and a preparation method thereof. The product contains 0.6-2% of astaxanthin microcapsule powder or astaxanthin aqueous solution, and also contains fish collagen peptide, skipjack elastin peptide, sodium hyaluronate, nicotinamide, honey, vitamin B6, pectin, lactic acid, citric acid, fermented kiwi fruit juice, fermented pineapple juice, fermented lemon juice and the like. By optimizing the formula and the process, the problems of low astaxanthin content, poor stability and single nutrition function in the existing astaxanthin beverage are successfully solved, and the astaxanthin beverage with higher quality and higher efficiency is provided for consumers.

The invention discloses a composition for repairing pelvic floor muscle and regenerating elastic fiber and a preparation method thereof, and relates to the technical field of pelvic floor muscle repairing, the composition is prepared from the following raw materials by weight: 10-50 parts of collagen peptide, 5-30 parts of elastin peptide, 5-40 parts of metagen, and 20-100 parts of a traditional Chinese medicine extract group, according to the composition for repairing pelvic floor muscles and regenerating elastic fibers and the preparation method of the composition, fish collagen peptide, deep sea gill fish elastin peptide, metabiotics and a traditional Chinese medicine extract group are used as raw materials, so that a composition system with multiple target points and a synergistic effect is constructed; according to the present invention, the pelvic floor muscle structure and the elastic fiber are systematically repaired and regenerated, the problems of urine leakage, pelvic floor muscle relaxation and the like are effectively improved, the lactic acid bacteria powder VGA1 and the casei paracasei are adopted to carry out liquid-state and solid-state combined fermentation, and the cell-penetrating peptide, the targeting peptide and other active substances are effectively enriched, such that the pelvic floor muscle structure and the elastic fiber are effectively repaired and regenerated; therefore, the bioavailability and the targeting effect efficiency of the functional components in the composition are improved.

This invention discloses an oral liquid containing astaxanthin and its preparation method, which is prepared from raw materials comprising the following weight percentages: 0.5%~2% astaxanthin burst beads, 8%~12% collagen peptides, 0.1%~0.3% sodium hyaluronate, 0.01%~2% elastin peptides, 0.01%~0.05% spermidine, 0.005%~0.02% ergothioneine, and 0.001%~0.01% pyrroloquinoline quinone. The astaxanthin burst beads are prepared using astaxanthin oil as the core material and sodium alginate and chitosan as the wall material. This invention, by using astaxanthin burst beads with higher stability and bioavailability in the oral liquid, combined with other ingredients, can improve the user's skin moisture content and elasticity index, reduce wrinkle depth, reduce skin yellowing, and better exert the effects of the oral liquid.

The present invention belongs to the technical field of active substance extraction, and specifically relates to a low-fat, low-cost, high-purity and high-quality elastin peptide and a preparation method thereof. The present invention uses a mixture of alkali solution and sodium carbonate solution, the overall concentration is low, it is more environmentally friendly, and the degreasing effect is better using microwave heating technology. The present invention uses microsphere immobilized protease, and the enzyme preparation can be fully recovered and reused multiple times, which greatly reduces production costs. The elastase hydrolysate is separated, purified and refined using ion exchange resin series chromatography technology to efficiently remove other impurities, and the prepared elastin peptide has a higher purity. The present invention uses high-voltage pulsed electric field technology (PEF) for sterilization, which has a better sterilization effect, avoids the influence of traditional heat sterilization methods on the color and taste of the product, and better maintains the quality of the elastin peptide.

The invention provides a preparation method and application of a camptothecin-elastin-like peptide conjugate capable of being self-assembled, and belongs to the field of nano-drugs. The camptothecin self-assembled prodrug is synthesized through a drug-connexon conjugate, and the obtained camptothecin self-assembled prodrug can be self-assembled in an aqueous solution through pi-pi interaction among camptothecin molecules to form a one-dimensional nanotube structure. The camptothecin self-assembled prodrug adopts the design concept of self-assembled prodrug, camptothecin is used as a structural unit, the camptothecin self-assembled prodrug with hydrophilic and hydrophobic balance is obtained by simply connecting hydrophilic polypeptides with different sequences, the prodrug has high drug loading capacity and improved solubility, and a clearly defined one-dimensional nano structure can be formed by simply dissolving the prodrug in water. The method has the advantages that the method is simple and easy to operate, the repeatability is excellent, the tumor inhibition effect is obviously superior to that of clinical medicine irritecan in in-vivo anti-tumor treatment, nearly 90% of tumor growth inhibition can be achieved, the biological safety is good, and the method has important significance in nano-medicine production preparation and clinical conversion.

The invention relates to a preparation method of instant fish maw with an anti-oxidation function, and belongs to the technical field of instant food processing, and the preparation method comprises the following steps: S1, preparing materials: preparing fish maw, rock candy, juicy peach powder, acerola cherry powder, roxburgh rose powder, skipjack elastin peptide, oat powder and the balance of pure milk; s2, cleaning the fish maw: soaking the fish maw and cleaning the fish maw; s3, blending and homogenizing: putting the pure milk into a stirring tank, stirring and heating, after the temperature reaches 45 DEG C, adding materials from the upper part of the stirring tank, after all the materials are added, continuously heating and stirring for 30-35 minutes, after heating is completed, filtering, pumping into a homogenizer for homogenizing, and after homogenizing is completed, preparing to be filled; s4, filling: preheating a filling machine, and filling bottles with the soaked and cleaned fish maw and the homogenized feed liquid; and S5, capping, sterilizing, cooling and carrying out quality inspection to obtain the instant fish maw with the anti-oxidation function. Double VC essence and protein are compounded, the underlying logic of skin aging is focused, and the effect of the fish maw is enhanced.