3results about How to "Good antithrombotic" patented technology

The invention relates to the technical field of artificial blood vessels, in particular to a preparation method of an anti-thrombus small-caliber artificial blood vessel with a double-layer structure, which comprises the following steps: step 1, synthesizing phosphorylcholine-containing dihydric alcohol MPCDL with an anti-biofilm adsorption effect; 2, preparing different types of polycarbonate polyurethane PCU-MPC containing phosphorylcholine groups by regulating and controlling the molar ratio of the MPCDL synthesized in the step 1 to 1, 4-butanediol, and adding the PCU-MPC into the inner layer of the small-caliber artificial blood vessel; step 3, preparing a PCU-MPC / fibroin blend synthesized in the step 2 by regulating and controlling the proportion of the water-insoluble fibroin powder; and 4, preparing the small-caliber artificial blood vessel with a double-layer structure, which takes PCU as an outer layer and takes the PCU-MPC / fibroin blend prepared in the step 3 as an inner layer, by utilizing an electrostatic spinning technology, so as to maximize the antithrombotic effect of the small-caliber artificial blood vessel. The antithrombotic small-caliber artificial blood vessel prepared by the invention has excellent biocompatibility, protein adsorption resistance, antithrombotic performance, high strength and high elasticity, and can be used for repairing or replacing lesion blood vessels.

The invention belongs to the technical field of medicines, and relates to a traditional Chinese medicine composition for activating blood and dispelling cold, application, a hot compress patch containing the traditional Chinese medicine composition and a preparation method of the hot compress patch. The traditional Chinese medicine composition comprises Chinese redbud bark, cortex periplocae, radices trichosanthis, radix paeoniae rubra, notopterygium root, radix angelicae pubescentis, spina gleditsiae, negundo chastetree fruit, ligusticum wallichii, green fructus forsythiae, pawpaw, liquorice, gentiana macrophylla, radix angelicae, angelica sinensis, divaricate saposhnikovia root, zedoary, radix clematidis, gallnut, salvia miltiorrhiza, radix achyranthis bidentatae and centipede. The traditional Chinese medicine composition has a very good effect on treating muscle and bone diseases such as cervical spondylosis, lumbar spondylosis, osteoarthritis, knee arthritis, osteoporosis, piriformis syndrome or lumbar muscle degeneration, and is high in universality; and the traditional Chinese medicine has the advantages of quick effect, no discomfort, high patient acceptance and short treatment period.

This invention discloses a biodegradable polyurethane elastomer, its preparation method, and a force-electro-coupled artificial blood vessel, belonging to the field of biomedical materials. The process includes: mixing soft segment glycol and functionalized chain extender 1 under nitrogen protection, reacting under stirring and heating conditions, and then cooling to obtain reactant a; adding diisocyanate to continue the reaction to obtain a polyurethane prepolymer; dissolving functionalized chain extender 2 in solvent a, adding it dropwise to the prepolymer to obtain reactant b, precipitating it in solvent b and vacuum drying to obtain the biodegradable polyurethane elastomer. This invention uses bioactive molecules with anticoagulant and anti-inflammatory effects as functionalized chain extenders, endowing the biodegradable polyurethane elastomer with a stable structure and piezoelectric properties. The artificial blood vessel can achieve continuous dynamic regulation of the regenerative microenvironment throughout the entire degradation cycle, continuously releasing anticoagulant and anti-inflammatory bioactive molecules, which has significant clinical application value.