1results about How to "Good antithrombotic" patented technology

This invention discloses a biodegradable polyurethane elastomer, its preparation method, and a force-electro-coupled artificial blood vessel, belonging to the field of biomedical materials. The process includes: mixing soft segment glycol and functionalized chain extender 1 under nitrogen protection, reacting under stirring and heating conditions, and then cooling to obtain reactant a; adding diisocyanate to continue the reaction to obtain a polyurethane prepolymer; dissolving functionalized chain extender 2 in solvent a, adding it dropwise to the prepolymer to obtain reactant b, precipitating it in solvent b and vacuum drying to obtain the biodegradable polyurethane elastomer. This invention uses bioactive molecules with anticoagulant and anti-inflammatory effects as functionalized chain extenders, endowing the biodegradable polyurethane elastomer with a stable structure and piezoelectric properties. The artificial blood vessel can achieve continuous dynamic regulation of the regenerative microenvironment throughout the entire degradation cycle, continuously releasing anticoagulant and anti-inflammatory bioactive molecules, which has significant clinical application value.