143results about How to "Good antithrombotic" patented technology

The present invention is directed to pharmaceutical compositions and methods of using combination therapies containing [4-(6-fluoro-7-methylamino-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-phenyl]-5-chloro-thiophen-2-yl-sulfonylurea, or a pharmaceutically acceptable salt thereof, for the treatment of thrombosis diseases.

A polymeric composition that generates nitric oxide and a process for rendering the surface of a substrate nonthrombogenic by applying a coating of the polymeric composition to the substrate are disclosed. The composition comprises: (1) a crosslinked chemical combination of (i) a polymer having amino group-containing side chains along a backbone forming the polymer, and (ii) a crosslinking agent containing functional groups capable of reacting with the amino groups; and (2) a plurality of nitric oxide generating functional groups associated with the crosslinked chemical combination. Once exposed to a physiological environment, the coating generates nitric oxide thereby inhibiting platelet aggregation. In one embodiment, the nitric oxide generating functional groups are provided by a nitrated compound (e.g., nitrocellulose) imbedded in the polymeric composition. In another embodiment, the nitric oxide generating functional groups comprise N2O2− groups covalently bonded to amino groups on the polymer.

A dripping pill of breviscapine is prepared from breviscapine and polyethylene glycol (PEG 4000) 5-8 times through conventional process. Its advantages are high curative effect and high biological utilization rate.

The invention provides an artificial blood vessel loaded with pseudo-ginseng medicines, and a preparation method and application for the artificial blood vessel. The artificial blood vessel sequentially consists of an inner layer, a middle layer and an outer layer which are closely connected with one another; the outer layer consists of nondegradable polymer materials; the middle layer consists of degradable high polymer materials and pseudo-ginseng powder distributed on the surface and / or the inside of the middle layer; the inner layer consists of degradable natural biological materials and pseudo-ginseng powder distributed on the surface and / or the inside of the inner layer; the mass percent of the pseudo-ginseng powder in the inner layer is larger than 5%; the content of the pseudo-ginseng powder in the middle layer is higher than that of the pseudo-ginseng powder in the inner layer; the outer layer is a nondegradable layer and is mainly used for protecting and replacing a blood vessel for a long time; the middle layer is a long-acting antithrombosis layer, can degrade high polymers, and can slowly release medicines so as to realize a long-acting antithrombosis effect; and the inner layer is a quick degrading layer, when the blood vessel is punctured and injured by a foreign object, the pseudo-ginseng medicines wrapped in the blood vessel are directly exposed on a wound, blood is stopped quickly, and the artificial blood vessel is particularly suitable for application to products such as hematodialysis.

The invention relates to a stent vessel for interventional therapy and a dedicated traction tool for implanting the stent vessel into a human body. The stent vessel comprises an artificial or animal vessel and support rings, wherein the support rings in three structures are used for fixation and respectively arranged at the outlet end and the inlet end of the artificial or animal vessel, and in the support rings, a detachable support ring with radial resilience force is further provided. The dedicated traction tool is especially suitable for dragging a Y-shaped stent into circuitous or narrow parts of the human body. The stent vessel provided by the invention is extremely flexible and easy to be implanted into a branch vessel until to the circuitous part. Because the main part and the branch of the stent vessel are integrated, the stent vessel is easy to position and safe and reliable without leakage after being implanted into the human body; and as the structure is simple and the cost is low, stent vessels in various diameters, variable diameters and lengths are be made, and the application range is wide because of no limit to lengths.

Disclosed is a antihypelipidemic and antihyperglycemic health food for preventing diseases including cardiovascular disease, diabetes, adjusting internal secretion, resisting osteoporosis and cancer, and beauty treatment. The raw materials include soybean powder 15-30 parts, pumpkin powder 15-30 parts, soybean isoflavones 0.5-1.5 parts, soybean saponin 2-5 parts, astragalus root 10-20 parts, wolfberry fruit 10-15 parts, kudzuvine root 10-15 parts, Chinese yam 10-15 parts, lotus plumule 6-10 parts, Siberian solomonseal rhizome 6-10 parts, cassia seed 6-10 parts, lily 5-8 parts, mulberry leaf 5-8 parts and ginseng 3-5 parts.

The present invention provides a new application of tanshin polyphenolic acid B in preparing medicine for treating tumor. Extraneous research shows that tanshin polyphenolic acid B has the function of killing tumor cell and animal test shows its antineoplastic effect. In the present invention, the cation in the salt of tanshin polyphenolic acid B may be Fe ion, Na ion, K ion, Ca ion or Mg ion, preferably Mg ion. The said medicine may be in any medicine form, oral liquid, injection, tablet or capsule.

The present invention provides a catheter tube having excellent insertability into the body, excellent operability and an excellent anti-thrombogenic property, and also provide a catheter having the tube. A catheter tube comprising a mixture of an isobutylene block copolymer and a thermoplastic polyurethane resin, wherein the isobutylene block copolymer is composed of a polymer block mainly comprising isobutylene and a polymer block mainly comprising a monomeric component other than isobutylene; and a catheter using the tube.

The present invention provides a thrombin derivative, comprising an A chain and a B chain, the B chain having an amino acid sequence in which one or more kinds of active center amino acids selected from the group consisting of serine at position 205, glycine at position 203, aspartic acid at position 99, and histidine at position 43 in an amino acid sequence of a thrombin B chain are substituted, having the properties: (1) cleaving a thrombin substrate at the ratio of 10% or less when it is reacted with the thrombin substrate in 50 mM Tris-HCl (pH 7.4) containing 0.1 M NaCl at 37° C. for 3 hours, and (2) maintaining a structure of exosite I.

The invention relates to a heparin derivative polysaccharide mixture and a preparation method and a medicinal composition thereof. Specifically, the heparin derivative polysaccharide mixture of the invention is a degradation product of heparin or heparin ester or heparin ester salt and is characterized in that the weight-average molecular weight is 3,100 to 4,500 Daltons, the activity of anti-coagulation factor Xa is high, and the activity of anti-coagulation factor IIa is low. The heparin derivative polysaccharide mixture of the invention has excellent antithrombotic performance, low side effect, and has no residues of adverse components such as organic base and dermatan sulfate and the like.

The invention discloses a preparation method of Xinhui dried tangerine peel enzyme beverage. By adopting four industrial advanced unique processes such as natural fermentation and chelating process, low-high-pressure bidirectional homogenizing, high-temperature instantaneous sterilization and low-high-temperature canning, the specific nutritional ingredients of Xinhui orange, dried tangerine peel,rhizoma polygonati, fructus lycii, fructus crataegi and the like can be maximally reserved; and in the prepared Xinhui dried tangerine peel enzyme beverage, the content of crude polysaccharide and total flavonoids is increased, the extraction rate is high, the taste is good, and the tissue state stability is good.

The invention relates to a novel non-virus cationic gene vector and the process for preparation. The process for preparation comprises the following steps: firstly, utilizing an oxygen anion polymerization method to synthesize polycation type electrolyte and segmented copolymer which contains polycation type electrolyte, and then leading polycation type electrolyte and DNA to mutually compound in salting liquid whose PH is 7.4 and buffer solution, achieving the packing of polycation type electrolyte to DNA, and the surface of DNA / polycation compound which is formed is with positive charge, adding segmented copolymer MePEO-b-PMAA which contains polycation type electrolyte in a system, leading PMAA segment with negative charge to be absorbed on the surface of the DNA / polycation compound through electrostatic force action and hydrogen bond effect, achieving the packing to compounds. The novel non-virus cationic gene vector has the advantages of mild polymerization reaction condition, controllable molecular weight, narrow molecular weight distribution, simple process for preparing gene vector, high stability and bioavailability, low toxicity and the like.

The invention relates to application of blackberry seed polysaccharide in the aspect of preparing antithrombotic drugs. The blackberry seed polysaccharide is obtained through the steps of obtaining crude polysaccharide by smashing blackberry seeds and using a water extraction and alcohol precipitation method, and then obtaining three polysaccharides respectively through DEAE-52 cellulose column chromatography and SephadexG-100 gel column chromatography. The in-vivo antithrombotic effect of the three polysaccharides is studied, and a result shows that the three polysaccharides have a good antithrombotic effect and can be separately used or combined to prepare the antithrombotic drugs.

This invention relates to a method for treating thrombosis by combined administration of a pitavastatin with aspirin.

The invention belongs to the field of biomedical engineering, and particularly relates to a preparing method of a biological source venous valve.In the preparing process, a biological material is cleaned, disinfected, subjected to cell lysis, cell digestion and nucleic acid digestion and then combined with heparin, and a covalence-ion-covalence heparin combining method is adopted in the combining process.The biological source venous valve prepared through the method is high in biophysical performance, antithrombus and anti-calcification performance and has certain clinical application and popularization prospects.

The invention provides an in-vivo enrichment device for circulating tumor cells. The in-vivo enrichment device comprises a catheter body capable of puncturing to a central vein through a peripheral vein, a plurality of sieve holes are formed in the catheter wall of the catheter body, the catheter body is filled with trapped particles of targeting circulating tumor cells, and a blind end is arranged at the front end of the catheter body. According to the in-vivo enrichment device for the circulating tumor cells, the inside of the catheter body is filled with assembling hydrophilic medicine or trapped particles of a specific antibody, the sieve holes are formed in the pipe wall of the catheter body, CTC in blood is continuously combined on the trapped particles inside the catheter body through specific targeting accordingly, and efficient and high-quality trapping of the CTC in blood is achieved; the in-vivo enrichment device has the advantages that the enrichment device is used in vivo, efficient trapping is achieved, and clinical application is convenient; the in-vivo enrichment device can provide molecular-gene diagnosis information based on the CTC for early diagnosis, targeting therapy, recurrence and metastasis detection, treatment evaluation and the like of tumor, and has quite-broad application prospects.

The compound orally taken thrombolytic preparation is used in treating retina venous blocking, vascular retina patholgoic change, coronary heart disease and angina pectoris. It is prepared with notoginseng, astragalus root, red sage and figwort as material and prepared in the forms of drip pills, granule, table, capsule or oral mixture liquid. The present invention has unique recipe and preparation process and obvious curative effect.

This invention discloses a method for manufacturing pineapple proteinase freeze-dried powders, which can solve the problem of low activity faced by conventional pineapple proteinase. The method comprises the steps of: washing pineapple stems with water, pressing to obtain juice, filtering, adsorbing the filtrate with zinc oxide, desorbing, ultrafiltering, concentrating and freeze-drying to obtain pineapple proteinase freeze-dried powders, whose enzyme activity can reach 600 million units per gram.

The invention discloses a single-chamber reciprocating blood pump with magnetic and elastic linkage. The technical scheme includes that the single-chamber reciprocating blood pump with magnetic and elastic linkage comprises a pump body, a storage cavity for blood storage is arranged in the pump body, the storage cavity gets larger or smaller with the change of compression, the pump body is externally coated and wound with a conductive coil, a magnet sliding along the lengthwise direction of the pump body is arranged in the inner cavity of the pump body, one end of the magnet is connected withthe storage cavity in an abutted manner, the magnet slides relative to the pump body to squeeze the storage cavity, one end of the magnet, away from the storage cavity is provided with a tension spring, and the conductive coil drives the magnet to move in a reciprocating manner along the lengthwise direction of the pump body in power supply or power failure. By the arrangement, the rhythm of heartbeat is simulated, and injury to target organs by continuous perfusion can be avoided.

The present invention is directed to pharmaceutical compositions and methods of using combination therapies containing [4-(6-fluoro-7-methylamino-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-phenyl]-5-chloro-thiophen-2-yl-sulfonylurea, or a pharmaceutically acceptable salt thereof, for the treatment of thrombosis diseases.

The invention provides the new application of salvianolic acid B, in particular the application of the salvianolic acid B to the preparation of medicament for treating tumor. The studies on the salvianolic acid B in vitro show that the salvianolic acid B can kill tumour cells, and the studies on the salvianolic acid B in the animal body proves that the salvianolic acid B can resist tumor. The cations in salvianolic acid B salt can be iron ions, calcium ions, sodium ions, potassium ions and preferentially magnesium ions. The medicament for treating tumor can be made into any form of liquid, injection, tablet or capsule in pharmaceutics.

The invention belongs to the technical field of high polymer materials, and particularly discloses a heat-resistant insulating resin composition. The heat-resistant insulating resin composition comprises the following raw materials in parts by weight: 60-80 parts of polypropylene resin, 22-35 parts of polyacrylate rubber, 15-26 parts of polyurethane rubber, 7-15 parts of polyisobutene grafted maleic anhydride, 15-30 parts of plasticizing agent, 5-10 parts of fire retardant, 5-10 parts of antioxidant, 3-6 parts of anti-aging agent, 4-8 parts of crosslinking agent and 1-2 parts of assistant crosslinking agent. The heat-resistant insulating resin composition disclosed by the invention has excellent mechanical property, flame retardant property and high temperature resistance.

The invention discloses a preparation method of a Xinhui pericarpium citri reticulatae enzyme beverage having anti-tumor and immunity enhancing functions. The preparation method includes steps of: 1)crushing a national geographical indication protection product, Xinhui pericarpium citri reticulatae and Xinhui tangerine whole fruits (including peel, pulp, segment membrane, and seeds) in a crushingsystem; 2) fermenting the crushed raw material through combination of natural fermentation and modern fermentation technology; 3) after the fermentation is completed, performing solid liquid separation and delivering the materials to a blending and homogenizing system for performing low- and high-pressure homogenization respectively; 4) after the homogenization, sterilizing and fill-packaging theproduct. In the invention, through double-direction fermentation, solid liquid separation, blending, low- and high-pressure homogenization, sterilization and medium / high-temperature fill-packaging, adifficult problem of food safety in the industry is completely solved, and the total flavones, crude polysaccharides, probiotics, probiotic active factors, and Xinhui tangerine metabolite, which arehigh in content in the Xinhui pericarpium citri reticulatae and Xinhui tangerine, are maintained as most as possible.

The shaft-less open impeller suitable for micro pump is one pollution-free and leak-less centrifugal mixed flow pump device suitable for continuous flow artificial heart. The impeller includes one vane combination and one vane holder, and the vane has pressure surface in the horizontal angle of 5-20 deg, conic upper end part of conic angle 40-60 deg, the ration between planar projection area of vane and outer circle area of the impeller of 0.4-0.8, and inlet angle and outlet angle of 45-50 deg. The impeller has effective inhibition of the secondary flow in the pressure surface of the vane, improved inside flow structure, reduced flow loss, small diameter and thus reduced damage to blood cell. The present invention may be also used in various kinds of centrifugal pump or mixed flow pump to improve the performance of the pumps.

One aspect of the invention contemplates a mutant E-WE thrombin precursor that contains the SEQ ID NO:1 amino acid residue sequence. Another aspect contemplates a thrombin precursor that contains the amino acid residue sequence Asp / Glu-Gly-Arg at positions 325, 326 and 327 based on the preprothrombin sequence. A third aspect contemplates a thrombin precursor that contains the SEQ ID NO:1 amino acid residue sequence as well as the amino acid residue sequence Asp / Glu Gly Arg at positions 325, 326 and 327 based on the preprothrombin sequence. Also contemplated is a composition that contains an effective amount of mutant thrombin dissolved or dispersed in a pharmaceutically acceptable carrier. A method is also disclosed for enhancing treating and preventing thrombosis in a mammal in need using that composition.

The invention provides an identification method for a fingerprint spectrum of a salvia miltiorrhiza medicinal material. The method consists of: preparation of a test solution, measurement of a fingerprint spectrum, determination of a control fingerprint spectrum, and identification of a salvia miltiorrhiza medicinal material fingerprint spectrum. By high performance liquid chromatography (HPLC) fingerprint spectrum measurement and analysis on the salvia miltiorrhiza medicinal material, 5 characteristic peaks of the salvia miltiorrhiza medicinal material are determined, and the common characteristic peaks constitute fingerprint features of the salvia miltiorrhiza medicinal material and can serve as the control fingerprint spectrum of the salvia miltiorrhiza medicinal material. The salvia miltiorrhiza medicinal material needing identification can be compared with the control fingerprint spectrum to inspect the situation of the common characteristic peaks so as to identify quality. With the characteristics of simplicity, good repeatability, obvious characteristic peaks, accuracy and reliability, etc., the method provided by the invention is conducive to identifying the quality of the salvia miltiorrhiza medicinal material.

The invention relates to a polysaccharide mixture derived from heparin, a preparation method thereof, and a pharmaceutical composition thereof. Specifically, the polysaccharide mixture derived from heparin is a degradation product of heparin quaternary ammonium salt, and is characterized by a weight average molar mass of 1500-4200 Dalton, a high anticoagulin Xa activity, and a low anticoagulin IIa activity. Also, a content of polysaccharide with a weight average molar mass higher than 5000 Dalton in the mixture is below 5%. The polysaccharide mixture derived from heparin is advantaged in excellent performances, low side-effect, and no harmful component residuals of organic base, dermatan sulfate and the like.

This invention discloses a method for manufacturing pineapple proteinase freeze-dried powders, which can solve the problem of low activity faced by conventional pineapple proteinase. The method comprises the steps of: washing pineapple stems with water, pressing to obtain juice, filtering, adsorbing the filtrate with zinc oxide, desorbing, ultrafiltering, concentrating and freeze-drying to obtain pineapple proteinase freeze-dried powders, whose enzyme activity can reach 600 million units per gram.

The invention discloses a ginkgolide B composite medicine eluting stent which is a stent of which the surface is covered with a medicine coating containing ginkgolide B, sirolimus and polylactic acid, wherein the ratio of ginkgolide B to sirolimus to polylactic acid is 1 to (0.6-1.4) to (0.5-1.5); and each 10mm stent respectively contains 8-12mcg of ginkgolide B and 7-10mcg of sirolimus. The composite medicine eluting stent is capable of promoting vascular endothelial cell growth, resisting thrombus and resisting vascular restenosis. The medicine coating is smooth and evenly covers the stent surface; the thickness of the medicine coating is 5-10 microns; the medicine slow-release time of the medicine coating is greater than or equal to 28 days; and the medicine release rate can reach 85%. The ginkgolide B composite medicine eluting stent disclosed by the invention has good effects of resisting thrombus, promoting endothelialization of intravascular stent and resisting vascular restenosis, and can be used as a choice of a new generation of coronary medicine stent.

The invention discloses compounds of the general formula I and provides a preparation method of the compounds which have good antithrombotic activity, wherein, R represents CH (CH3) CH 2CH3, CH (CH3)2, CH2CH (CH3)2 , CH3, H, CH2C6H5, CH2C6H4-OH-p, indole-5-group-CH2, imidazole-4-group-CH2-, CH2CH2SCH3, CH2COCH3, CH2CH2CO2CH3, CH2CH2CO2H, CH2OH, CH (OH)CH3, CH2CH2CH2NHC(NH) NH2, CH2CONH2, CH2CH2CONH2, CH2SH, CH2CH2CH2CH2NHCBz or CH2CH2CH2CH2NH2.