Traditional Chinese medicine composition for activating blood and dispelling cold, application of traditional Chinese medicine composition, hot compress patch containing traditional Chinese medicine composition and preparation method of hot compress patch

Abstract

The invention belongs to the technical field of medicines, and relates to a traditional Chinese medicine composition for activating blood and dispelling cold, application, a hot compress patch containing the traditional Chinese medicine composition and a preparation method of the hot compress patch. The traditional Chinese medicine composition comprises Chinese redbud bark, cortex periplocae, radices trichosanthis, radix paeoniae rubra, notopterygium root, radix angelicae pubescentis, spina gleditsiae, negundo chastetree fruit, ligusticum wallichii, green fructus forsythiae, pawpaw, liquorice, gentiana macrophylla, radix angelicae, angelica sinensis, divaricate saposhnikovia root, zedoary, radix clematidis, gallnut, salvia miltiorrhiza, radix achyranthis bidentatae and centipede. The traditional Chinese medicine composition has a very good effect on treating muscle and bone diseases such as cervical spondylosis, lumbar spondylosis, osteoarthritis, knee arthritis, osteoporosis, piriformis syndrome or lumbar muscle degeneration, and is high in universality; and the traditional Chinese medicine has the advantages of quick effect, no discomfort, high patient acceptance and short treatment period.

Description

Technical Field

[0001] The invention belongs to the technical field of medicines, and relates to a Chinese medicine composition for promoting blood circulation and dispelling cold, an application thereof, a hot compress patch containing the composition, and a preparation method thereof. Background Art

[0002] Musculoskeletal diseases include muscle injuries and bone diseases. Musculoskeletal injuries include trauma and strain, while bone diseases include degenerative or metabolic bone diseases. Musculoskeletal diseases are common and frequently occurring diseases in orthopedics, and are also major and difficult diseases. For muscle injuries, Western orthopedics often only focus on open trauma, obvious fractures and dislocations. Apart from these, there is no better treatment. If patients with muscle injuries do not receive good treatment in the acute stage, they will often develop into chronic injuries, and then secondary strain of bones, joints and muscles will occur due to limb compensation, and eventually they will become ill due to overwork, which will bring difficulties to later diagnosis and treatment, and consume medical expenses and resources. For degenerative and metabolic bone diseases, the current conventional Western medicine anti-inflammatory and anti-osteoporosis drug therapies cannot fundamentally improve the prognosis of the disease. Moreover, long-term medication not only causes a huge medical burden, but also brings a series of systemic side effects. The rational use of traditional Chinese medicine technology can improve the functional status of patients, delay the progression of the disease, and improve the quality of life of patients.

[0003] Some of TCM's distinctive diagnostic and treatment techniques have unique advantages in the treatment of bone and muscle diseases. TCM's distinctive treatment plans, which mainly use special Chinese medicine packages for external application and traumatology techniques of various schools, are widely used in clinical practice and have certain therapeutic effects.

[0004] Chinese invention patent application CN110624078A discloses a tendon injury ointment and its preparation process. The preparation raw materials include Bauhinia bark, Vitex negundo, Salvia miltiorrhiza, Licorice, Chuanxiong, Notopterygium wilfordii, Angelica dahurica, Saposhnikovia divaricata, Atractylodes tetrandra, Forsythia suspensa, Gentiana macrophylla, Red Peony Root, Angelica dahurica, Angelica sinensis, Perennial Perilla bark, Clematidis, processed Strychnos nux vomica, Papaya, Radix Trichosanthis, Laurocapram, Achyranthes bidentata, Curcuma longa and maltose. The ointment can effectively relieve pain in body parts, but the Atractylodes tetrandra used in the ointment is prohibited for pregnant women, infants and children and those with renal insufficiency and lacks practical use value.

[0005] Chinese invention patent CN111084842B discloses an external Chinese medicine composition for treating scapulohumeral periarthritis, cervical spondylosis, lumbar disc herniation and osteoarthritis. The composition comprises the following raw materials in parts by weight: 55-65 parts of scutellaria baicalensis, 30-38 parts of rhubarb, 75-85 parts of dandelion, 22-28 parts of papaya, 20-30 parts of angelica, 20-30 parts of earthworm, 20-30 parts of zedoaria, 30-38 parts of areca nut, 30-40 parts of achyranthes bidentata, 30-40 parts of earthworm, 30-40 parts of blood scorpion, 50-60 parts of panax notoginseng, 33-40 parts of trichosanthes, 30-38 parts of knotweed, 30-40 parts of safflower, 50-60 parts of notopterygium wilfordii and 50-60 parts of angelica dahurica. It can effectively relieve frozen shoulder, with a total cure rate of up to 98%; however, its total cure rate for cervical spondylosis, lumbar disc herniation, and osteoarthritis is lower, and its universality is poor.

[0006] It can be seen that there are currently many types of Chinese herbal ingredients for common diseases of the bones and muscles. In order to give full play to the efficacy of each Chinese herbal ingredient and improve the universality and therapeutic effect of the preparation, the formula and preparation process of such Chinese herbal compositions and plasters still need to be further studied. Summary of the invention

[0007] The present invention aims at the problems existing in the prior art, and provides a Chinese medicine composition for promoting blood circulation and dispelling cold, its application, a hot compress patch containing the same, and a preparation method thereof. The composition adopts a variety of prescriptions for promoting blood circulation and dredge menstruation, dispelling wind and dampness, removing blood stasis and relieving pain, and warming meridians and dispelling cold, which has strong universality, quick effect, and safe ingredients without toxic side effects.

[0008] To achieve the above purpose, the technical solution adopted by the present invention is as follows:

[0009] The invention provides a Chinese medicine composition for promoting blood circulation and dispelling cold, which is characterized by comprising: bark of bauhinia, cortex perilla, root of trichosanthes, red peony root, notopterygium root, angelica root, gleditsia thorn, fruit of nephrite, ligusticum chuanxiong, forsythia suspensa, papaya, liquorice, gentiana macrophylla, angelica dahurica, angelica sinensis, siler, turmeric, clematis root, gallnut, salvia miltiorrhiza, achyranthes bidentata and centipede.

[0010] Preferably, the invention comprises, by weight: 5-15 parts of Bauhinia bark, 1-5 parts of Perennial Perilla bark, 1-8 parts of Radix Trichosanthis, 1-6 parts of Red Peony Root, 0.5-5 parts of Notopterygium root, 1-5 parts of Angelica dahurica, 0.1-4 parts of Gleditsia spinosa, 5-10 parts of Vitex negundo seeds, 0.5-5 parts of Ligusticum chuanxiong, 0.2-1.2 parts of Forsythia suspensa, 0.5-4 parts of Papaya, 0.2-0.8 parts of Licorice, 1-4 parts of Gentiana macrophylla, 0.5-1.5 parts of Angelica dahurica, 1.2-3 parts of Angelica sinensis, 1.5-2.5 parts of Saposhnikovia divaricata, 1-3 parts of Curcuma longa, 1-3 parts of Clematis chinensis, 0.5-2 parts of Galla chinensis, 0.5-5 parts of Salvia miltiorrhiza, 0.5-5 parts of Achyranthes bidentata and 0.1-1 parts of Scolopendra subspinipes.

[0011] More preferably, the invention comprises, by weight: 10-12 parts of Bauhinia bark, 1-3 parts of Perennial Perilla bark, 2-6 parts of Radix Trichosanthis, 1-3 parts of Red Peony Root, 1.5-2.5 parts of Notopterygium wilfordii, 1.5-2.5 parts of Angelica dahurica, 0.5-2 parts of Gleditsia sinensis, 7-9 parts of Vitex negundo, 1-3 parts of Ligusticum chuanxiong, 0.5-1 parts of Forsythia suspensa, 1-3 parts of Papaya, 0.4-0.6 parts of Licorice, 1-3 parts of Gentiana macrophylla, 0.8-1.2 parts of Angelica dahurica, 1.6-2.4 parts of Angelica sinensis, 1.8-2.2 parts of Saposhnikovia divaricata, 1.5-2.5 parts of Curcuma longa, 1.5-2.5 parts of Clematis chinensis, 0.8-1.2 parts of Gallnut, 1-3 parts of Salvia miltiorrhiza, 1-3 parts of Achyranthes bidentata and 0.3-0.8 parts of Scolopendra subspinipes.

[0012] Further preferably, the composition comprises, by weight: 8 parts of Bauhinia bark, 2 parts of Perennial Perilla bark, 4 parts of Radix Trichosanthis, 2 parts of Red Peony Root, 2 parts of Notopterygium root, 2 parts of Angelica dahurica, 1 part of Gleditsia sinensis Spinach, 8 parts of Vitex Ngawaiensis, 2 parts of Ligusticum chuanxiong, 1 part of Forsythia suspensa, 2 parts of Papaya, 0.5 parts of Licorice, 2 parts of Gentiana macrophylla, 1 part of Angelica dahurica, 2 parts of Angelica sinensis, 2 parts of Saposhnikovia divaricata, 2 parts of Curcuma longa, 2 parts of Clematis chinensis, 1 part of Galla chinensis, 2 parts of Salvia miltiorrhiza, 2 parts of Achyranthes bidentata and 0.5 parts of Scolopendra.

[0013] As some preferred technical solutions of the present invention, the mass ratio of the bark of Cercis chinensis, the fruit of Vitex negundo and the salvia miltiorrhiza is 10-15:5-10:1-5.

[0014] As some preferred technical solutions of the present invention, the mass ratio of Notopterygium wilfordii and Angelica dahurica is 1:1-1.5.

[0015] Each raw material of the present invention has the following effects:

[0016] Bauhinia bark is used to treat pain in tendons and bones, wind-cold-dampness arthralgia, numbness, paralysis and flaccidity, warm tendons, stop waist pain; promote blood circulation and qi, reduce swelling and detoxify. Persimmon bark is diuretic and reduces swelling, removes rheumatism, and strengthens tendons and bones. It is used for lower limb edema, palpitations and shortness of breath, wind-cold-dampness arthralgia, soreness of waist and knees, etc. Trichosanthes is mainly used to clear heat and promote body fluid, reduce swelling and discharge pus; "Southern Yunnan Materia Medica" records that "Trichosanthes is used to treat traumatic injuries and unbearable chest pain." Red peony root is mainly used to remove blood stasis, relieve pain, clear heat and cool blood, and reduce swelling. Notopterygium root can relieve cold, dispel wind and dampness, and relieve pain. It is used to treat colds caused by wind and cold, headaches and stiff necks, rheumatic arthralgia, and shoulder and back pain. Duhuo dispels wind and dampness, relieves pain. It is a wind-dampness and cold-dispelling medicine under the category of wind-dampness-dispelling medicine. Gleditsia sinensis is pungent, warm and salty, pungent and dispersing, can promote blood circulation and qi, soften and disperse nodules, warm and search for wind, promote blood circulation and remove blood stasis. Huangjingzi dispels wind and heat, benefits joints; treats rheumatism and pain. Chuanxiong promotes qi and relieves depression, dispels wind and dampness, promotes blood circulation and relieves pain. Qinglianqiao clears heat, detoxifies, disperses knots, and reduces swelling. Papaya has the effects of relaxing muscles and activating collaterals, dispelling dampness and harmonizing the stomach, and digestion. Licorice nourishes the spleen and replenishes qi, clears heat and detoxifies, dispels phlegm and relieves cough, relieves pain, and harmonizes various medicines. "Ben Jing" records that "it treats cold and heat evil spirits in the five internal organs and six organs, strengthens tendons and bones, grows muscles, doubles strength, treats wounds and swelling, and detoxifies." Qinjiao dispels wind and dampness, harmonizes blood and relaxes tendons, clears heat and promotes diuresis. It treats rheumatism and pain, tendon and bone cramps, etc. Baizhi dispels wind, dries dampness, reduces swelling, and relieves pain. Angelica is rich in volatile components, organic acids, sugars, vitamins, amino acids, inorganic elements, alkaline components, stigmasterol, sitosterol and other components, which can promote the formation of hemoglobin and red blood cells, relieve peripheral vascular smooth muscle spasm, increase blood flow, improve peripheral circulation, anti-thrombosis, analgesia, anti-inflammatory, and enhance immune function. Saposhnikovia divaricata is mainly used to treat exogenous wind-cold, headache, dizziness, stiff neck, wind-cold dampness, joint pain, limb spasm, and tetanus. Turmeric slices can break blood and promote qi circulation, promote menstruation and relieve pain. Clematis is used to treat rheumatic arthralgia, limb numbness, tendon spasm, flexion and extension difficulties, bone choking throat and other symptoms. Gallnut can restrain the lungs and reduce fire, astringe the intestines to stop diarrhea, stop bleeding, and detoxify. Salvia miltiorrhiza can remove blood stasis and relieve pain, promote blood circulation and promote menstruation, and clear the heart and relieve troubles. Achyranthes bidentata is used for waist and knee pain, weak tendons and bones; lower limb weakness. Centipede can relieve wind and calm spasms, attack poison and disperse knots.

[0017] The present invention also provides the use of any of the above-mentioned traditional Chinese medicine compositions in the preparation of medicines for treating tendon and bone diseases.

[0018] Furthermore, the bone and muscle diseases include cervical spondylosis, lumbar spondylosis, osteoarthritis, knee arthritis, osteoporosis, piriformis syndrome and / or lumbar muscle strain.

[0019] Furthermore, the medicine is an oral liquid or an external hot compress.

[0020] The present invention also provides a traditional Chinese medicine hot compress patch, comprising any of the above-mentioned traditional Chinese medicine compositions and a heating material.

[0021] Furthermore, the heating material includes at least two of iron powder, activated carbon, vermiculite, pansite and industrial salt.

[0022] The present invention also provides a method for preparing the above-mentioned Chinese medicine hot compress patch, comprising the following steps:

[0023] (1) taking Bauhinia bark, Perennial Cortex, Radix Trichosanthis, Red Peony Root, Notopterygium, Angelica dahurica, Gleditsia sinensis, Vitex negundo, Rhizoma Chuanxiong, Forsythia suspensa, Chaenomeles sinensis, Radix Glycyrrhizae, Radix Gentianae, Angelica dahuricae, Radix Angelicae Sinensis, Radix Saposhnikoviae, Rhizoma Curcumae, Radix Clematis, Galla chinensis, Salvia miltiorrhizae, Radix Achyranthis Bidentatae and Scolopendra subspinipes, and crushing and sieving to obtain raw material powder;

[0024] (2) adding the raw material powder to water for grinding and leaching to obtain a Chinese medicine composition;

[0025] (3) Mixing the Chinese medicine composition with the heating material to obtain

[0026] Furthermore, in step (2), the mass volume ratio of the raw material powder to water is 1:1-5 g / mL.

[0027] Furthermore, the mass ratio of the traditional Chinese medicine composition to the heating material is 1:0.2-0.5.

[0028] Compared with the prior art, the present invention has the following beneficial effects:

[0029] (1) Using multiple Chinese medicinal ingredients in synergistic combination, through the screening of Chinese medicinal ingredients and optimization of dosage, the Chinese medicinal composition has significant effects of promoting blood circulation and menstruation, dispelling wind and dampness, removing blood stasis and relieving pain, and warming the meridians and dispersing cold;

[0030] (2) The Chinese medicine composition has a rapid onset of action, effectively shortening the treatment period of musculoskeletal diseases such as cervical spondylosis, lumbar spondylosis, osteoarthritis, knee arthritis, osteoporosis, piriformis syndrome and / or lumbar muscle strain, and improving the quality of life of patients;

[0031] (3) The heating patch prepared by combining the Chinese medicine composition of the present invention with a suitable heating material in a certain ratio can be directly applied to the painful area without discomfort, and the patient acceptance is high; it has a good effect on the treatment of bone and joint related diseases such as cervical vertebrae, lumbar vertebrae, knee joints, hip joints, etc., and has strong universality;

[0032] (4) The Chinese medicine hot compress patch for promoting blood circulation and dispelling cold has a simple preparation process and high efficiency, which greatly reduces the production cost. DETAILED DESCRIPTION

[0033] In order to make the purpose, technical scheme and advantages of the embodiments of the present invention clearer, the technical scheme in the embodiments of the present invention will be clearly and completely described below. Obviously, the described embodiments are part of the embodiments of the present invention, rather than all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in the field without creative work are within the scope of protection of the present invention. It is worth noting that the raw materials used in the present invention are all common commercial products, and their sources are not specifically limited.

[0034] Example 1

[0035] A Chinese medicine composition comprises, by weight, 8 parts of Bauhinia bark, 2 parts of Perennial Perilla bark, 4 parts of Radix Trichosanthis, 2 parts of Red Peony Root, 2 parts of Notopterygium wilfordii, 2 parts of Angelica dahurica, 1 part of Gleditsia sinensis Spinosa, 8 parts of Vitex Ngauci, 2 parts of Ligusticum chuanxiong, 1 part of Forsythia suspensa, 2 parts of Chaenomeles sinensis, 0.5 parts of Licorice, 2 parts of Gentiana macrophylla, 1 part of Angelica dahurica, 2 parts of Angelica sinensis, 2 parts of Saposhnikovia divaricata, 2 parts of Curcuma longa, 2 parts of Clematis chinensis, 1 part of Galla chinensis, 2 parts of Salvia miltiorrhiza, 2 parts of Achyranthes bidentata and 0.5 parts of Scolopendra subspinipes.

[0036] A Chinese medicine hot compress patch for promoting blood circulation and dispelling cold, comprising the above-mentioned Chinese medicine composition and a heating material, wherein the heating material is iron powder, vermiculite powder and activated carbon in a mass ratio of 1:1:1 (wherein each patch contains 0.5g of the Chinese medicine composition).

[0037] Weigh the raw materials according to the above ratio, mix them, grind them and pass them through a 100-mesh sieve, mix them with water at a material-liquid ratio of 1:2, add them into a grinder, and grind them thoroughly to obtain a Chinese medicine composition. The Chinese medicine composition and the heating material are fully mixed and ground at a mass ratio of 1:0.4 to obtain the product.

[0038] Example 2

[0039] A Chinese medicine composition comprises, by weight, 12 parts of Bauhinia bark, 2 parts of Perennial Perilla bark, 5 parts of Radix Trichosanthis, 3 parts of Red Peony Root, 2.5 parts of Notopterygium wilfordii, 2.5 parts of Angelica dahurica, 1.5 parts of Gleditsia sinensis Spinach, 7 parts of Vitex negundo Fructus, 3 parts of Ligusticum chuanxiong, 0.5 parts of Forsythia suspensa, 1 part of Chaenomeles sinensis, 0.5 parts of Licorice, 1 part of Gentiana macrophylla, 1 part of Angelica dahurica, 1.8 parts of Angelica sinensis, 1.8 parts of Saposhnikovia divaricata, 2.5 parts of Curcuma longa, 2.5 parts of Clematis chinensis, 0.8 parts of Galla chinensis, 3 parts of Salvia miltiorrhiza, 3 parts of Achyranthes bidentata and 0.3 parts of Scolopendra subspinipes.

[0040] A Chinese medicine hot compress patch for promoting blood circulation and dispelling cold comprises the Chinese medicine composition and a heating material, wherein the heating material is iron powder and panthenite powder in a mass ratio of 1:1.

[0041] Weigh the raw materials according to the above ratio, mix them, grind them and pass them through a 100-mesh sieve, mix them with water at a material-liquid ratio of 1:3, add them into a grinder, and grind them thoroughly to obtain a Chinese medicine composition. The Chinese medicine composition and the heating material are fully mixed and ground at a mass ratio of 1:0.5 to obtain the product.

[0042] Example 3

[0043] A Chinese medicine composition comprises, by weight, 15 parts of Bauhinia bark, 1 part of Perennial Perilla bark, 1 part of Radix Trichosanthis, 5 parts of Red Peony Root, 5 parts of Notopterygium wilfordii, 5 parts of Angelica dahurica, 0.5 part of Gleditsia sinensis Spinosa, 10 parts of Vitex negundo, 1 part of Ligusticum chuanxiong, 0.5 part of Forsythia suspensa, 0.5 part of Chaenomeles sinensis, 0.8 part of Licorice, 1 part of Gentiana macrophylla, 1.5 parts of Angelica dahurica, 3 parts of Angelica sinensis, 1.5 parts of Saposhnikovia divaricata, 1 part of Curcuma longa, 1 part of Clematis chinensis, 2 parts of Galla chinensis, 5 parts of Salvia miltiorrhiza, 0.5 part of Achyranthes bidentata and 1 part of Scolopendra subspinipes.

[0044] A Chinese medicine hot compress patch for promoting blood circulation and dispelling cold comprises the Chinese medicine composition and a heating material, wherein the heating material is iron powder and activated carbon in a mass ratio of 1:1.

[0045] Weigh the raw materials according to the above ratio, mix them, grind them and pass them through a 100-mesh sieve, mix them with water at a material-liquid ratio of 1:1, add them into a grinder, and grind them thoroughly to obtain a Chinese medicine composition. The Chinese medicine composition and the heating material are fully mixed and ground at a mass ratio of 1:0.2 to obtain the product.

[0046] Example 4

[0047] A Chinese medicine composition comprises, by weight, 7.5 parts of Bauhinia bark, 2 parts of Perennial Perilla bark, 4 parts of Radix Trichosanthis, 2 parts of Red Peony Root, 2 parts of Notopterygium wilfordii, 2 parts of Angelica dahurica, 1 part of Gleditsia sinensis Spinosa, 10 parts of Vitex Ngadophylla, 2 parts of Ligusticum chuanxiong, 1 part of Forsythia suspensa, 2 parts of Chaenomeles sinensis, 0.5 part of Licorice, 2 parts of Gentiana macrophylla, 1 part of Angelica dahurica, 2 parts of Angelica sinensis, 2 parts of Saposhnikovia divaricata, 2 parts of Curcuma longa, 2 parts of Clematis chinensis, 1 part of Galla chinensis, 0.5 part of Salvia miltiorrhiza, 2 parts of Achyranthes bidentata and 0.5 part of Scolopendra subspinipes.

[0048] A Chinese medicine hot compress patch for promoting blood circulation and dispelling cold comprises the Chinese medicine composition and a heating material, wherein the heating material is iron powder, vermiculite powder and activated carbon in a mass ratio of 1:1:1.

[0049] Weigh the raw materials according to the above ratio, mix them, grind them and pass them through a 100-mesh sieve, mix them with water at a material-liquid ratio of 1:2, add them into a grinder, and grind them thoroughly to obtain a Chinese medicine composition. The Chinese medicine composition and the heating material are fully mixed and ground at a mass ratio of 1:0.4 to obtain the product.

[0050] Example 5

[0051] A Chinese medicine composition comprises, by weight, 8 parts of Bauhinia bark, 2 parts of Perennial Perilla bark, 4 parts of Radix Trichosanthis, 2 parts of Red Peony Root, 3 parts of Notopterygium wilfordii, 1 part of Angelica dahurica, 1 part of Gleditsia sinensis Spinosa, 8 parts of Vitex Ngawaiensis, 2 parts of Chuanxiong, 1 part of Forsythia suspensa, 2 parts of Chaenomeles sinensis, 0.5 part of Licorice, 2 parts of Gentiana macrophylla, 1 part of Angelica dahurica, 2 parts of Angelica sinensis, 2 parts of Saposhnikovia divaricata, 2 parts of Curcuma longa, 2 parts of Clematis chinensis, 1 part of Galla chinensis, 2 parts of Salvia miltiorrhiza, 2 parts of Achyranthes bidentata and 0.5 part of Scolopendra subspinipes.

[0052] A Chinese medicine hot compress patch for promoting blood circulation and dispelling cold comprises the Chinese medicine composition and a heating material, wherein the heating material is iron powder, vermiculite powder and activated carbon in a mass ratio of 1:1:1.

[0053] Weigh the raw materials according to the above ratio, mix them, grind them and pass them through a 100-mesh sieve, mix them with water at a material-liquid ratio of 1:2, add them into a grinder, and grind them thoroughly to obtain a Chinese medicine composition. The Chinese medicine composition and the heating material are fully mixed and ground at a mass ratio of 1:0.4 to obtain the product.

[0054] Example 6

[0055] A Chinese medicine composition comprises, by weight, 8 parts of Bauhinia bark, 2 parts of Perennial Perilla bark, 4 parts of Radix Trichosanthis, 2 parts of Red Peony Root, 2 parts of Notopterygium wilfordii, 2 parts of Angelica dahurica, 1 part of Gleditsia sinensis Spinosa, 8 parts of Vitex Ngauci, 2 parts of Ligusticum chuanxiong, 1 part of Forsythia suspensa, 2 parts of Chaenomeles sinensis, 0.5 parts of Licorice, 2 parts of Gentiana macrophylla, 1 part of Angelica dahurica, 2 parts of Angelica sinensis, 2 parts of Saposhnikovia divaricata, 2 parts of Curcuma longa, 2 parts of Clematis chinensis, 1 part of Galla chinensis, 2 parts of Salvia miltiorrhiza, 2 parts of Achyranthes bidentata and 0.5 parts of Scolopendra subspinipes.

[0056] A Chinese medicine hot compress patch for promoting blood circulation and dispelling cold comprises the Chinese medicine composition and a heating material, wherein the heating material is iron powder and vermiculite powder in a mass ratio of 1:1.

[0057] Weigh the raw materials according to the above ratio, mix them, grind them and pass them through a 100-mesh sieve, mix them with water at a material-liquid ratio of 1:2, add them into a grinder, and grind them thoroughly to obtain a Chinese medicine composition. The Chinese medicine composition and the heating material are fully mixed and ground at a mass ratio of 1:0.4 to obtain the product.

[0058] Example 7

[0059] A Chinese medicine composition comprises, by weight, 8 parts of Bauhinia bark, 2 parts of Perennial Perilla bark, 4 parts of Radix Trichosanthis, 2 parts of Red Peony Root, 2 parts of Notopterygium wilfordii, 2 parts of Angelica dahurica, 1 part of Gleditsia sinensis Spinosa, 8 parts of Vitex Ngauci, 2 parts of Ligusticum chuanxiong, 1 part of Forsythia suspensa, 2 parts of Chaenomeles sinensis, 0.5 parts of Licorice, 2 parts of Gentiana macrophylla, 1 part of Angelica dahurica, 2 parts of Angelica sinensis, 2 parts of Saposhnikovia divaricata, 2 parts of Curcuma longa, 2 parts of Clematis chinensis, 1 part of Galla chinensis, 2 parts of Salvia miltiorrhiza, 2 parts of Achyranthes bidentata and 0.5 parts of Scolopendra subspinipes.

[0060] A Chinese medicine hot compress patch for promoting blood circulation and dispelling cold comprises the Chinese medicine composition and a heating material, wherein the heating material is iron powder and vermiculite powder in a mass ratio of 1:1.

[0061] Weigh the raw materials according to the above ratio, mix them, grind them and pass them through a 100-mesh sieve, mix them with water at a material-liquid ratio of 1:2, add them into a grinder, and grind them thoroughly to obtain a Chinese medicine composition. The Chinese medicine composition and the heating material are fully mixed and ground at a mass ratio of 1:0.5 to obtain the product.

[0062] Example 8

[0063] A Chinese medicine composition comprises, by weight, 8 parts of Bauhinia bark, 2 parts of Perennial Perilla bark, 4 parts of Radix Trichosanthis, 2 parts of Red Peony Root, 2 parts of Notopterygium wilfordii, 2 parts of Angelica dahurica, 1 part of Gleditsia sinensis Spinosa, 8 parts of Vitex Ngauci, 2 parts of Ligusticum chuanxiong, 1 part of Forsythia suspensa, 2 parts of Chaenomeles sinensis, 0.5 parts of Licorice, 2 parts of Gentiana macrophylla, 1 part of Angelica dahurica, 2 parts of Angelica sinensis, 2 parts of Saposhnikovia divaricata, 2 parts of Curcuma longa, 2 parts of Clematis chinensis, 1 part of Galla chinensis, 2 parts of Salvia miltiorrhiza, 2 parts of Achyranthes bidentata and 0.5 parts of Scolopendra subspinipes.

[0064] A Chinese medicine hot compress patch for promoting blood circulation and dispelling cold comprises the Chinese medicine composition and a heating material, wherein the heating material is iron powder, vermiculite powder and activated carbon in a mass ratio of 1:1:1.

[0065] Weigh the raw materials according to the above ratio, mix them, grind them and pass them through a 100-mesh sieve, mix them with water at a material-liquid ratio of 1:2, add them into a grinder, and grind them thoroughly to obtain a Chinese medicine composition. The Chinese medicine composition and the heating material are fully mixed and ground at a mass ratio of 1:0.2 to obtain the product.

[0066] Comparative Example 1

[0067] The only difference from Example 1 is that the Chinese medicine composition does not contain Gleditsia sinensis, Galla chinensis and Centipede;

[0068] Specifically: the Chinese medicine composition includes, by weight: 8 parts of Bauhinia bark, 2 parts of Perennial Perilla bark, 4 parts of Radix Trichosanthis, 2 parts of Red Peony Root, 2 parts of Notopterygium wilfordii, 2 parts of Angelica dahurica, 8 parts of Vitex Ngauji, 2 parts of Ligusticum chuanxiong, 1 part of Forsythia suspensa, 2 parts of Papaya, 0.5 parts of Licorice, 2 parts of Gentiana macrophylla, 1 part of Angelica dahurica, 2 parts of Angelica sinensis, 2 parts of Saposhnikovia divaricata, 2 parts of Curcuma longa, 2 parts of Clematis chinensis, 2 parts of Salvia miltiorrhiza and 2 parts of Achyranthes bidentata.

[0069] A Chinese medicine hot compress for promoting blood circulation and dispelling cold is provided, wherein the Chinese medicine composition described above is substituted for the Chinese medicine composition of Example 1, and the preparation method is the same as that of Example 1.

[0070] Comparative Example 2

[0071] The only difference from Example 1 is that the Chinese medicine composition does not contain Gleditsia sinensis, Galla chinensis and Scolopendra subspinipes; instead, they are replaced by 2.5 parts of processed Strychnos nux vomica.

[0072] Specifically: the Chinese medicine composition includes, by weight: 8 parts of Bauhinia bark, 2 parts of Perennial Perilla bark, 4 parts of Radix Trichosanthis, 2 parts of Red Peony Root, 2 parts of Notopterygium wilfordii, 2 parts of Angelica dahurica, 2 parts of Processed Strychnos nux vomica, 8 parts of Vitex negundo, 2 parts of Ligusticum chuanxiong, 1 part of Forsythia suspensa, 2 parts of Papaya, 0.5 parts of Licorice, 2 parts of Gentiana macrophylla, 1 part of Angelica dahurica, 2 parts of Angelica sinensis, 2 parts of Saposhnikovia divaricata, 2 parts of Curcuma longa, 2 parts of Clematis chinensis, 2 parts of Salvia miltiorrhiza and 2 parts of Achyranthes bidentata.

[0073] A Chinese medicine hot compress for promoting blood circulation and dispelling cold is provided, wherein the Chinese medicine composition described above is substituted for the Chinese medicine composition of Example 1, and the preparation method is the same as that of Example 1.

[0074] Comparative Example 3

[0075] The only difference from Example 1 is that the amount of each raw material in the Chinese medicine composition is different;

[0076] Specifically: the Chinese medicine composition includes, by weight: 3 parts of Bauhinia bark, 4 parts of Perennial Perilla bark, 6 parts of Radix Trichosanthis, 4 parts of Red Peony Root, 5 parts of Notopterygium, 3 parts of Angelica dahurica, 1 part of Gleditsia Spinosa, 3 parts of Vitex Ngawaii, 5 parts of Ligusticum chuanxiong, 3 parts of Forsythia suspensa, 6 parts of Papaya, 08 parts of Licorice, 4 parts of Gentiana macrophylla, 5 parts of Angelica dahurica, 5 parts of Angelica sinensis, 4 parts of Saposhnikovia divaricata, 5 parts of Curcuma longa, 5 parts of Clematis, 1 part of Galla chinensis, 5 parts of Salvia miltiorrhiza, 6 parts of Achyranthes bidentata and 0.5 parts of Scolopendra.

[0077] A Chinese medicine hot compress for promoting blood circulation and dispelling cold is provided, wherein the Chinese medicine composition described above is substituted for the Chinese medicine composition of Example 1, and the preparation method is the same as that of Example 1.

[0078] Comparative Example 4

[0079] The only difference from Example 3 is that the heating material is iron powder, and the mass ratio of the Chinese medicine composition to the heating material is 1:0.8.

[0080] A Chinese medicine hot compress patch for promoting blood circulation and dispelling cold, using the above-mentioned heating material to replace the heating material in Example 1, and the preparation method is the same as that in Example 1.

[0081] Comparative Example 5

[0082] The only difference from Example 3 is that the heating material is activated carbon, and the mass ratio of the Chinese medicine composition to the heating material is 1:1.

[0083] A Chinese medicine hot compress patch for promoting blood circulation and dispelling cold, using the above-mentioned heating material to replace the heating material in Example 1, and the preparation method is the same as that in Example 1.

[0084] 1. Effects on traumatic bruises and swelling in the plantar area of ​​mice

[0085] 150 healthy adult C57BL / 6 mice were randomly divided into 13 groups, with 10 mice in each group, half of which were female and half were male. A cylinder with an inner diameter of 3.2 cm and a length of 27 cm was used to vertically press the left hind foot of the mouse, and then a 200 g weight was used to vertically hit the plantar part of the mouse's foot from top to bottom from the inside of the cylinder, causing acute traumatic bruising and swelling of the left hind foot plantar part.

[0086] 48 hours after modeling, the Chinese medicine patches prepared in Examples 1-8 and Comparative Examples 1-5 were respectively pasted on the swollen bruises on the left hind paw of the corresponding experimental group mice, and the patch was applied once a day for 6 hours each time for 3 consecutive days to observe the disappearance time of the bruises (starting from the end of modeling); and 2 hours after the last patch, the mice were killed, and the left and right feet were cut off 4 mm above the ankle joint and weighed. The difference was the swelling degree, and the data of 10 mice were averaged. The results are shown in Table 1.

[0087] Table 1

[0088] Swelling degree (mg) Bruising disappearance time (h) Example 1 32.1 23.6 Example 2 38.4 30.2 Example 3 33.2 29.4 Example 4 40.3 25.6 Example 5 36.4 28.7 Example 6 35.6 27.9 Example 7 32.8 25.6 Example 8 42.3 32.5 Comparative Example 1 90.4 72.3 Comparative Example 2 74.6 66.5 Comparative Example 3 52.9 43.2 Comparative Example 4 35.2 25.5 Comparative Example 5 39.6 24.4

[0089] It can be seen from the above table that the swelling degree of the ankle joints of mice using the Chinese medicine hot compress of Examples 1-5 is about 40 mg, and the lowest is only 32.1 mg; the time for the ecchymosis to disappear does not exceed 30 hours. However, the swelling degree of the ankle joints of mice in Comparative Example 1 is as high as 90.4 mg, and the time for the ecchymosis to disappear is as long as 72.3 hours, indicating that after the Chinese medicine hot compress lacks some Chinese medicine ingredients, even if the total amount of Chinese medicine is constant, the effect is still significantly reduced; the swelling degree of the ankle joints of mice in Comparative Examples 2 and 3 and the time for the ecchymosis to disappear also show different degrees of increase, indicating that the replacement of some Chinese medicine ingredients and the change of dosage will affect the recovery of traumatic stasis swelling; in addition, Comparative Examples 4 and 5 only use a single heating material. When the amount of Chinese medicine ingredients is the same, after the heating material adopts a single ingredient, its dosage must be increased by 8-10 times relative to the use of two materials to achieve the corresponding effect.

[0090] 2. Impact on the recovery of local tissue damage

[0091] 150 healthy adult C57BL / 6 mice were randomly divided into 15 groups, namely control group, model group and experimental group 1-13, with 10 mice in each group, half of which were female and half were male. The mice in the model group and experimental group were anesthetized, and after skin preparation and disinfection, a longitudinal incision of about 0.5 cm was made below the right knee joint of the mice. A 22G / 0.41mm intramedullary fixation needle was inserted from the patellar tendon, and the muscles and fascia were separated at the upper 1 / 3 of the tibia. After the tibia was cut with a saw blade, the surface of the tibia was immediately rinsed with 0.9% saline, and then the intramedullary fixation needle was completely inserted and aligned. The incision was sutured layer by layer to make a mouse right tibial shaft fracture model.

[0092] 72 hours after modeling, the Chinese medicine patches prepared in Examples 1-8 and Comparative Examples 1-5 were respectively applied to the right tibial shaft fracture of the corresponding experimental group mice, and the patches were applied once a day, each time for 6 hours, for 3 consecutive days. Plasma was collected 2 hours after the last administration, and the pain-related neuropeptide substance P (SP), calcitonin gene-related peptide (CGRP), tumor necrosis factor TNF-α and interleukin (IL-β) were detected. The results are shown in Table 2.

[0093] Table 2

[0094] SP(pg / mL) CGRP (pg / mL) TNF-α(ng / mL) IL-β (ng / mL) Control group 26.784±1.550 53.541±2.185 1.115±0.125 0.112±0.021 Model Group 13.217±0.994** 18.325±1.803** 2.258±0.183** 0.325±0.048** Example 1 <![CDATA[24.150±1.142 ## ]]> <![CDATA[42.450±2.017 ## ]]> <![CDATA[1.154±0.119 ## ]]> <![CDATA[0.145±0.024 ## ]]> Example 2 <![CDATA[22.152±1.040 ## ]]> <![CDATA[39.367±1.895 ## ]]> <![CDATA[1.172±0.121 ## ]]> <![CDATA[0.148±0.028 ## ]]> Example 3 <![CDATA[23.478±1.137 ## ]]> <![CDATA[40.291±1.942 ## ]]> <![CDATA[1.203±0.209 ## ]]> <![CDATA[0.151±0.031 ## ]]> Example 4 <![CDATA[22.561±1.084 ## ]]> <![CDATA[36.471±2.014* ## ]]> <![CDATA[1.235±0.150 ## ]]> <![CDATA[0.153±0.025 ## ]]> Example 5 <![CDATA[23.225±1.179 ## ]]> <![CDATA[38.425±2.106* ## ]]> <![CDATA[1.308±0.143 ## ]]> <![CDATA[0.149±0.028 ## ]]> Example 6 <![CDATA[23.561±1.144 ## ]]> <![CDATA[41.573±1.855 ## ]]> <![CDATA[1.195±0.129 ## ]]> <![CDATA[0.155±0.033 ## ]]> Example 7 <![CDATA[22.187±1.120 ## ]]> <![CDATA[40.922±1.884 ## ]]> <![CDATA[1.178±0.201 ## ]]> <![CDATA[0.152±0.031 ## ]]> Example 8 <![CDATA[21.179±1.133 # ]]> <![CDATA[42.018±2.110 ## ]]> <![CDATA[1.217±0.078 ## ]]> <![CDATA[0.146±0.029 ## ]]> Comparative Example 1 <![CDATA[17.171±1.105* #& ]]> <![CDATA[21.425±1.132** #&& ]]> <![CDATA[1.875±0.155 #&& ]]> <![CDATA[0.244±0.044 #&& ]]> Comparative Example 2 <![CDATA[17.045±1.119* #& ]]> <![CDATA[23.794±1.224** #&& ]]> <![CDATA[1.745±0.148 #&& ]]> <![CDATA[0.261±0.048 #&& <!-- 7 -->]]> Comparative Example 3 <![CDATA[15.432±1.152** && ]]> <![CDATA[26.877±1.138** #&& ]]> <![CDATA[1.533±0.133 #& ]]> <![CDATA[0.223±0.039 #& ]]> Comparative Example 4 <![CDATA[20.195±1.120 ## ]]> <![CDATA[40.315±2.150* ## ]]> <![CDATA[1.252±0.124 ## ]]> <![CDATA[0.155±0.022 ## ]]> Comparative Example 5 <![CDATA[21.524±1.108 ## ]]> <![CDATA[38.247±2.084* ## ]]> <![CDATA[1.270±0.117 ## ]]> <![CDATA[0.143±0.025 ## ]]>

[0095] Remark: * Compared with the control group, P < 0.05; ** Compared with the control group, P < 0.01; # Compared with the model group, P < 0.05; ## Compared with the model group, P < 0.01;& Compared with Example 1, P < 0.05; && Compared with Example 1, P < 0.01.

[0096] Related studies have shown that SP and CGRP play a positive role in accelerating bone formation and inhibiting bone resorption. It can be seen from the above table that compared with the control group, the levels of SP and CGRP in the plasma of mice in the model group decreased significantly, indicating that the modeling was successful. Compared with the model group, the levels of SP and CGRP in mice in Examples 1-8 and Comparative Examples 4-5 were significantly improved (P < 0.01), indicating that the hot compress of the present invention can effectively repair tibial shaft fractures, but in Comparative Examples 4 and 5, under the same dosage of Chinese medicine components, the dosage of heating materials is relatively high, which is easy to affect the uniformity of the Chinese medicine components, thereby affecting the efficacy; compared with Example 1, the SP content of mice in Comparative Examples 1-3 has significant differences, and the CGRP content has extremely significant differences, indicating that the lack or replacement of Chinese medicine ingredients in the hot compress of the present invention, as well as changes in dosage, have a greater impact on the recovery of fractured mice.

[0097] In addition, inflammatory factors IL-1β and TNF-α are closely related to cartilage damage, and cartilage damage can lead to increased TNF-α and IL-1β. As can be seen from the above table, compared with the control group, the plasma TNF-α and IL-1β levels of mice in the model group were significantly increased, indicating that the modeling was successful. Compared with the model group, the TNF-α and IL-1β levels of mice in Example 1-8 groups were significantly decreased (P < 0.01), indicating that the hot compress of the present invention can effectively repair cartilage damage; compared with Example 1, the TNF-α and IL-1β levels of mice in the comparative example 1-2 groups were significantly different (P < 0.01), indicating that the Chinese medicine components in the hot compress have a significant effect on its repair of cartilage damage; the TNF-α and IL-1β levels of mice in the comparative example 3 group were also significantly different (P < 0.05), which shows that the amount of Chinese medicine components also has a certain degree of effect on cartilage damage. The present invention fully exerts the effect of each component by regulating the composition and dosage of the Chinese medicine components in the hot compress.

[0098] 3. Observation of clinical efficacy on volunteers with osteoarthritis

[0099] 200 clinical patients were selected as volunteers, aged 35-65 years old, and their X-rays showed different degrees of knee osteoarthritis, cervical disc herniation, lumbar disc herniation and osteoporosis. They were divided into 4 groups according to their symptoms, and each group was randomly divided into 2 groups, namely the control group and the treatment group. There was no significant difference in age, gender, and severity of the disease among the groups, which was comparable.

[0100] Treatment method: The control group applied the moxibustion paste on the painful area; the experimental group applied the Chinese medicine hot compress patch prepared in Example 1 of the present invention on the painful area; once a day, each time for 6 hours, for 5 consecutive days.

[0101] Efficacy criteria: According to the efficacy evaluation criteria of the "Guidelines for Clinical Research of New Chinese Medicines" and the efficacy criteria for diagnosis of TCM diseases and syndromes, the clinical efficacy is divided into four types, including clinical cure, marked effect, effectiveness and ineffectiveness. Changes in joint pain: no change, relief, significant relief and disappearance are scored as 0, 1, 2 and 3 points respectively; changes in joint swelling: no change, improvement and disappearance are scored as 0, 1 and 2 points respectively; changes in joint activity: no change, improvement and normal are scored as 0, 1 and 2 points respectively; changes in walking function: no change, improvement, significant improvement and normal are scored as 0, 1, 2 and 3 points respectively.

[0102] The sum of the scores of the four observation indicators is 0.1, 2.5, 6.8 and 9.10, which represent ineffectiveness, effectiveness, marked effectiveness and clinical cure respectively. Total effective rate = (number of cured cases + number of marked effectiveness + number of effective cases) / total number of patients × 100%

[0103] It can be seen from the above results that the composition of the present invention has a high therapeutic efficacy for cervical spondylosis, lumbar disc herniation, rheumatoid arthritis, osteoporosis and other musculoskeletal diseases, and has excellent therapeutic effects and strong universality.

[0104] Finally, it should be noted that the above content is only used to illustrate the technical solution of the present invention, rather than to limit the scope of protection of the present invention. Simple modifications or equivalent substitutions of the technical solution of the present invention by ordinary technicians in this field do not deviate from the essence and scope of the technical solution of the present invention.

Claims

1. A Chinese medicine composition for promoting blood circulation and dispelling cold, characterized in that: The ingredients include, by weight: 5-15 parts of Bauhinia bark, 1-5 parts of Perennial Perilla bark, 1-8 parts of Radix Trichosanthis, 1-6 parts of Red Peony Root, 0.5-5 parts of Notopterygium root, 1-5 parts of Angelica dahurica, 0.1-4 parts of Gleditsia spinosa, 5-10 parts of Vitex negundo seeds, 0.5-5 parts of Ligusticum chuanxiong, 0.2-1.2 parts of Forsythia suspensa, 0.5-4 parts of Papaya, 0.2-0.8 parts of Licorice, 1-4 parts of Gentiana macrophylla, 0.5-1.5 parts of Angelica dahurica, 1.2-3 parts of Angelica sinensis, 1.5-2.5 parts of Saposhnikovia divaricata, 1-3 parts of Curcuma longa, 1-3 parts of Clematis chinensis, 0.5-2 parts of Galla chinensis, 0.5-5 parts of Salvia miltiorrhiza, 0.5-5 parts of Achyranthes bidentata and 0.1-1 parts of Scolopendra subspinipes.

2. The Chinese medicine composition according to claim 1, characterized in that: The ingredients include, by weight: 6-10 parts of Bauhinia bark, 1-3 parts of Perennial Perilla bark, 2-6 parts of Radix Trichosanthis, 1-3 parts of Red Peony Root, 1.5-2.5 parts of Notopterygium wilfordii, 1.5-2.5 parts of Angelica dahurica, 0.5-2 parts of Gleditsia sinensis, 7-9 parts of Vitex negundo, 1-3 parts of Ligusticum chuanxiong, 0.5-1 parts of Forsythia suspensa, 1-3 parts of Papaya, 0.4-0.6 parts of Licorice, 1-3 parts of Gentiana macrophylla, 0.8-1.2 parts of Angelica dahurica, 1.6-2.4 parts of Angelica sinensis, 1.8-2.2 parts of Saposhnikovia divaricata, 1.5-2.5 parts of Curcuma longa, 1.5-2.5 parts of Clematis chinensis, 0.8-1.2 parts of Gallnut, 1-3 parts of Salvia miltiorrhiza, 1-3 parts of Achyranthes bidentata and 0.3-0.8 parts of Scolopendra subspinipes.

3. The Chinese medicine composition according to claim 2, characterized in that: The ingredients include 8 parts of Bauhinia bark, 2 parts of Perennial Perilla bark, 4 parts of Radix Trichosanthis, 2 parts of Red Peony Root, 2 parts of Notopterygium wilfordii, 2 parts of Angelica dahurica, 1 part of Gleditsia sinensis Spinach, 8 parts of Vitex Ngawaiensis, 2 parts of Ligusticum chuanxiong, 1 part of Forsythia suspensa, 2 parts of Papaya, 0.5 part of Licorice, 2 parts of Gentiana macrophylla, 1 part of Angelica dahurica, 2 parts of Angelica sinensis, 2 parts of Saposhnikovia divaricata, 2 parts of Curcuma longa, 2 parts of Clematis chinensis, 1 part of Galla chinensis, 2 parts of Salvia miltiorrhiza, 2 parts of Achyranthes bidentata and 0.5 part of Scolopendra subspinipes.

4. The Chinese medicine composition according to claim 1, characterized in that: The mass ratio of the bark of Cercis chinensis, the fruit of Vitex negundo and Salvia miltiorrhiza is 10-15:5-10:1-5; the mass ratio of Notopterygium wilfordii and Angelica dahurica is 1:1-1.

5.

5. Use of the Chinese medicine composition according to any one of claims 1 to 4 in the preparation of drugs for treating myositis.

6. The use according to claim 5, characterized in that: The bone and muscle diseases include cervical spondylosis, lumbar spondylosis, osteoarthritis, knee arthritis, osteoporosis, piriformis syndrome and / or lumbar muscle strain; the medicine is a Chinese medicine oral liquid or an external hot compress.

7. A Chinese medicine hot compress patch, characterized in that: It comprises the Chinese medicine composition described in any one of claims 1 to 4 and a heating material.

8. The Chinese medicine hot compress patch according to claim 7, characterized in that: The heat-generating material includes at least two of iron powder, activated carbon, vermiculite, pansite and industrial salt.

9. The method for preparing the Chinese medicine hot compress patch according to claim 7 or 8, characterized in that: The following steps are involved: (1) taking Bauhinia bark, Perennial Cortex, Radix Trichosanthis, Red Peony Root, Notopterygium, Angelica dahurica, Gleditsia sinensis, Vitex negundo, Rhizoma Chuanxiong, Forsythia suspensa, Chaenomeles sinensis, Radix Glycyrrhizae, Radix Gentianae, Angelica dahuricae, Radix Angelicae Sinensis, Radix Saposhnikoviae, Rhizoma Curcumae, Radix Clematis, Galla chinensis, Salvia miltiorrhizae, Radix Achyranthis Bidentatae and Scolopendra subspinipes, and crushing and sieving to obtain raw material powder; (2) adding the raw material powder to water for grinding and leaching to obtain a Chinese medicine composition; (3) Mix the Chinese medicine composition with the exothermic material to obtain the product.

10. The preparation method according to claim 9, characterized in that: In step (2), the mass volume ratio of the raw material powder to water is 1:1-5 g / mL; the mass ratio of the traditional Chinese medicine composition to the heating material is 1:0.2-0.5.

Images