12 results about "Knee arthritis" patented technology

The application belongs to the technical field of biological medicine, and particularly relates to amniotic membrane mesenchymal stem cells for treating knee arthritis, and a preparation method and application thereof. The preparation method of the amniotic membrane mesenchymal stem cells comprises the following steps: (1) separating to obtain amniotic membrane tissue; (2) digesting the amniotic membrane tissue, filtering and centrifuging to obtain cell precipitate; (3) resuspending the cell precipitate, inoculating into a culture medium for culture, digesting, centrifuging, discarding supernatant, and obtaining P0 generation amniotic membrane mesenchymal stem cells; and (4) subculturing the P0 generation amniotic membrane mesenchymal stem cells in the culture medium to obtain amniotic membrane mesenchymal stem cells. By adding tiaprofenic acid and sappanin in the basic culture medium, the cell stemness of the amniotic membrane mesenchymal stem cells can be maintained, and the osteogenic differentiation ability of the amniotic membrane mesenchymal stem cells can be improved, so that the knee arthritis can be effectively treated. Meanwhile, the basic culture medium does not add fetal bovine serum, and the safety of clinical application is improved.

The invention belongs to the technical field of knee joint arbor treatment equipment, and particularly relates to a knee joint force line appliance which comprises a body and a pressure mechanism, the body comprises a main body supporting frame, a thigh binding assembly and a shank binding assembly, and the thigh binding assembly and the shank binding assembly are in sliding connection with the main body supporting frame; after sliding in place, the main body supporting frame is fixed, and then the main body supporting frame is bound to the thigh and the shank respectively; the pressure mechanism is located between the thigh binding assembly and the shank binding assembly, and the pressure mechanism applies adjustable pressure to the key position of a force line to adjust the form of the force line of the lower limb joint, reduce and improve the development speed of gonitis lesion and reduce knee joint pain. Gradient pressure is applied to the outer side, the lower limb force line is guided to be corrected towards the outer side, and joint load redistribution is achieved. The structure of the device adopts an arc-shaped fitting design conforming to ergonomics, and it is ensured that a pressure acting point is accurately located at a key position of a knee joint force line.

The invention discloses a Jinhuang powder external application paste and application thereof in preparation of drugs for treating gonitis synovitis, the external application paste is prepared from ten traditional Chinese medicines including turmeric, rheum officinale, golden cypress, radix angelicae, rhizoma arisaematis, pericarpium citri reticulatae, rhizoma atractylodis, mangnolia officinalis, liquorice and radices trichosanthis, honey, edible vegetable oil, paraffin oil and water through a specific emulsification process, the pH value is 6.0-7.0, and the viscosity is 3000-5000 mPa.s; standard random control clinical tests prove that the total effective rate of the external application ointment for treating gonarthromeningitis reaches 99.04%, the Lyshilm score is improved by 30.2 score, the VAS score is reduced by 5.39 score and is greatly superior to that of a diclofenac sodium control group, the adverse reaction occurrence rate is only 3.85%, the levels of serum TNF-alpha, IL-1beta and IL-6 and the synovial thickness can be greatly reduced, and the external application ointment has a good clinical application prospect. The method is suitable for K-L grading I-II and postoperative rehabilitation patients.

The invention provides application of combination of umbilical cord mesenchymal stem cells and peripheral blood PRP in treatment of gonitis. Specifically, the invention also provides a monoclonal antibody targeting IL-20, and the monoclonal antibody can effectively inhibit the amount of inflammatory factors IL-6 and IL-20 and promote the proliferation of cartilage cells. The OARSI score of the knee joint cartilage of a rat with osteoarthritis can be effectively reduced by using the monoclonal antibody alone or in combination with umbilical cord mesenchymal stem cells and peripheral blood PRP, and the monoclonal antibody has a relatively good treatment effect and a relatively good application prospect.

The invention relates to the technical field of knee joint repair, and particularly provides a stem cell preparation for knee joint injury repair as well as a preparation method and application thereof. The NGF monoclonal antibody 4G13 and the bone marrow mesenchymal stem cells are combined for knee joint injury repair for the first time, and test analysis shows that the preparation can effectively reduce the levels of IL-1beta, TNF-alpha and IL-6 in serum of a patient suffering from gonitis, inhibit secretion of the IL-1beta, the TNF-alpha and the IL-6, repair knee joint inflammatory injury, improve and promote cartilage tissue repair, and have a good application prospect in knee joint injury repair. Good application prospects are realized.

The present invention discloses a preparation method of a Zhuang medicine Luoqianyu cataplasm and its application in the treatment of knee arthritis. The preparation method includes extracting effective medicinal components such as volatile oils, alkaloids, organic acids, and flavonoids from the Zhuang medicine Luoqianyu formula, mixing the extracted medicinal components with a cataplasm forming matrix and stirring evenly, then coating on non-woven fabric, and drying and forming, etc. The Zhuang medicine Luoqianyu cataplasm prepared by the method of the present invention for treating knee arthritis not only has a smooth surface without granular feeling, a soft paste body, good quality, but also has a large drug loading capacity, fast onset, good curative effect, high bioavailability, convenient use, easy preservation, can continuously exert the medicinal effect for a long time, is suitable for long-term use by middle-aged and elderly people, and can better exert the curative effect of the Zhuang medicine Luoqianyu formula.

This invention discloses a dynamic grading prediction and intervention system and method for knee osteoarthritis based on a large model, relating to the field of medical image analysis. The system includes: acquiring a patient's knee MRI image sequence and knee joint angle time-series data; processing the MRI image sequence using a pre-trained joint cavity segmentation model to obtain a quantitative value of joint fluid volume; aligning the knee joint angle time-series to the image frame acquisition time point to generate a synchronized angle sequence; calculating the fluid volume change rate and angle change sequence, determining whether the average value of the fluid volume change rate sequence is lower than a preset stability threshold, and outputting a low-risk signal if it is; otherwise, calculating the correlation coefficient between the fluid volume change rate and angle change, and outputting a moderate or severe knee osteoarthritis prediction signal based on its value; further determining the mild or moderate risk of knee osteoarthritis based on the amplitude characteristics of the fluid volume change rate sequence. This invention can identify early knee osteoarthritis lesion characteristics and improve the accuracy of grading prediction.

The invention relates to the technical field of medical preparations, in particular to a preparation method of exosomes for intervening gonitis, which comprises the following steps: S1, preparing and activating adipose tissue-derived stem cell exosomes to obtain exosomes of which the surfaces are modified with azide groups; s2, dandelion polysaccharide is prepared and activated, and DBCO modified dandelion polysaccharide is obtained; s3, clicking chemical connection to obtain a target exosome; s4, purification: purifying the target exosome through an ultracentrifugation method, and resuspending to obtain the exosome for intervening in gonitis. Compared with a traditional simple physical mixing mode of exosomes and active ingredients, chemical bonding is more stable and efficient, and the excellent gonitis intervention effect can be achieved.

1. Name of the product in this design: Wearable laser therapy device. 2. Purpose of this product design: It is mainly used for anti-inflammatory and pain relief, and has therapeutic and improving effects on knee arthritis, rheumatoid arthritis, musculoskeletal injuries, soft tissue and sprains, wounds and ulcers; the straps can be adjusted to fit different parts of the body for treatment. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: a 3D model.

To provide a knee joint inflammation detection device and the like that can accurately specify the three-dimensional position of inflammation of the knee joint from a plurality of sensors attached to the front and back of the knee.SOLUTION: A knee joint inflammation detection device comprises: AE sensors 12 that each detect an elastic wave generated from a knee joint part during the movement of the knee joint part as an ultrasonic detection signal; and an inflammation position calculation unit 33 that, based on the detection signals, specifies the presence or absence of inflammation occurring in the knee joint of a subject 11 and the position of the inflammation. During examination, the subject 11 is attached with a plurality of front sensors that are attached to surround a joint part of the femur and the tibia when seen from the front of the knee of the subject 11, and a plurality of rear sensors that are attached to the back of the knee on the outside and / or the back of the knee on the inside of the subject 11.SELECTED DRAWING: Figure 1