44 results about "Knee arthritis" patented technology

The invention relates to a knee joint health care device based on traditional Chinese medicine external therapy. The device comprises a belt body, a massage assembly, a moxibustion assembly, a traction assembly and a hot compress assembly. The massage assembly comprises magnetic beads, and the magnetic beads are arranged on the inner side of the belt body around the patella. The moxibustion assembly comprises laser probes, and the laser probes are installed at the positions, corresponding to inner and outer knee eyes, of the belt body. The traction assembly comprises air bags, and the air bags are embedded into the two sides of the belt body; the hot compress assembly comprises heating elements, and the heating elements are distributed on the lining part of the belt body. Compared with the prior art, convenient and safe knee joint nursing is achieved, and the family nursing requirements of knee arthritis patients are met.

The invention discloses a knee arthritis image measurement model system and method based on deep learning, particularly relates to the technical field of image processing, and is used for solving the problem of low image measurement accuracy. According to the method, the image preprocessing technology and the deep learning segmentation method are integrated, high-precision automatic segmentation and analysis are performed on the knee joint image, the contrast ratio and the resolution ratio of the image are enhanced, meanwhile, the image quality is further improved through biased field correction and non-local mean value noise reduction, and the image segmentation is performed by adopting the U-Net model, so that the image quality is improved. A complex structure in the joint is effectively recognized, segmentation precision is improved, a segmentation strategy is dynamically adjusted according to measurement influence information generated in the segmentation process, the processing flow is optimized in real time through different regulation and control signals, diagnosis efficiency and accuracy are improved, and therefore the automation level and reliability of medical image processing are improved, and the medical image processing efficiency is improved. Efficient and accurate support is provided for clinic, and the accuracy of osteoarthritis image measurement is improved.

The invention discloses a knee osteoarthritis dynamic grading prediction and intervention system and method based on a large model, and relates to the field of medical image analysis, and the method comprises the steps: obtaining a knee joint MRI image sequence and knee joint angle time sequence data of a patient; processing the MRI image sequence by using a pre-trained articular cavity segmentation model to obtain a joint fluid volume quantized value; aligning the knee joint angle time sequence to an image frame acquisition time point to generate a synchronous angle sequence; whether the average value of the liquid amount change rate sequence is lower than a preset stable threshold value or not is judged by calculating the liquid amount change rate sequence and the angle change quantity sequence, and if yes, a low-risk signal is output; otherwise, calculating a correlation coefficient between the liquid amount change rate and the angle change amount, outputting a moderate or severe gonitis prediction signal according to the value of the correlation coefficient, and further judging the mild or moderate risk of the gonitis according to the amplitude characteristics of the liquid amount change rate sequence; according to the invention, early gonitis lesion features can be identified, and the accuracy of grading prediction is improved.

This invention provides a traditional Chinese medicine composition for the prevention and treatment of knee arthritis. The active ingredients, by weight, include: 15-25 parts of Salvia miltiorrhiza, 8-15 parts of Ligusticum chuanxiong, 12-20 parts of Angelica sinensis, 7-15 parts of Lycopus lucidus, 15-30 parts of Poria cocos, 8-15 parts of Placenta hominis, 18-30 parts of Clematis chinensis, 15-25 parts of Spatholobus suberectus, 25-40 parts of Paeonia lactiflora, 12-20 parts of Rehmannia glutinosa, and 8-15 parts of Glycyrrhiza uralensis. Using Salvia miltiorrhiza, Ligusticum chuanxiong, Angelica sinensis, Lycopus lucidus, Poria cocos, Placenta hominis, Clematis chinensis, Spatholobus suberectus, Paeonia lactiflora, Rehmannia glutinosa, and Glycyrrhiza uralensis as raw materials, this invention follows the principle of "principal, assistant, adjuvant, and guide" in traditional Chinese medicine. The combined use of these herbs can tonify the liver and kidneys, promote blood circulation and remove blood stasis, and has a good therapeutic effect on knee arthritis caused by liver and kidney deficiency and qi stagnation and blood stasis.

This invention provides the application of a composition in the preparation of drugs for osteoarthritis, belonging to the field of arthritis technology. The composition comprises tofu glycosides, N-acetylcysteine, seaweed peptides, and PDGF. The combination of these drugs significantly enhances the chondrogenic differentiation and migration capacity of chondrocyte stem cells under inflammatory conditions. Furthermore, in an SD rat knee osteoarthritis model, chondrocyte stem cells treated with the enhanced culture medium reduced the Wakitani histological score from 8.83 to 2.17±0.98, demonstrating a superior repair effect compared to traditional methods. Therefore, this invention provides a foundation for the efficient treatment of osteoarthritis.

The present invention provides a stem cell composition with knee joint injury repair function and a preparation method thereof, wherein the stem cell composition comprises mesenchymal stem cells and anti-NGF antibodies, wherein the anti-NGF antibodies comprise a heavy chain variable region with an amino acid sequence as shown in SEQ ID NO:1 and a light chain variable region with an amino acid sequence as shown in SEQ ID NO:2; and the mesenchymal stem cells are adipose mesenchymal stem cells that have been activated. The activated adipose mesenchymal stem cells are used in combination with the anti-NGF antibodies to promote knee arthritis repair, inhibit the expression of inflammatory factors, and relieve pain symptoms.

The invention provides a traditional Chinese medicine ointment formula for treating gonitis and a preparation method thereof. Traditional Chinese medicine believes that knee arthralgia has symptoms of qi stagnation and blood stasis, liver and kidney deficiency and tendon and vessel obstruction. The symptoms include swelling and stabbing pain of knees, unfavorable flexion and extension, aggravated cold, soreness and weakness of waist and knees, dark tongue or ecchymosis and astringent pulse. In view of the problem, the traditional Chinese medicine ointment provided by the invention consists of trogopterus dung, corydalis tuber, Chinese angelica, white paeony root, pseudo-ginseng, safflower, peach kernel, nutgrass galingale rhizome, raw white mustard seed, eucommia bark, twotooth achyranthes root and honey-fried licorice root. The trogopterus dung breaks blood, the rhizoma corydalis promotes the circulation of qi, the rhizoma cyperi regulates the flow of qi, and the peach kernel and the safflower activate the blood, so that the effects of promoting the circulation of qi, activating blood and eliminating arthralgia are achieved. The traditional Chinese medicine composition is mainly used for promoting blood circulation to remove blood stasis, is supplemented by eucommia ulmoides and achyranthes bidentata to tonify the liver and kidney, eliminates evil without hurting vital energy, and accords with the pathogenesis of knee arthritis of deficiency in root and excess in superficies. The raw semen brassicae is pungent and dispersed and transdermal, and the radix achyranthis bidentatae guides the medicine to move downwards, so that the efficacy of the externally applied medicine reaches the muscles and bones, and the limitation of superficial efficacy of the traditional application is broken through.

The application belongs to the field of medical image pattern recognition, and provides a knee osteoarthritis injury prediction method based on CT images, which comprises the following steps: step one, acquiring a group of healthy controls and a group of CT images of subjects with different degrees of knee joint damage; step two, pre-processing the X-ray images, cropping out the knee joint region, and converting the gray-scale images to L, a and b channels by using the LAB color model; step three, performing image enhancement on the images in the L channel by using adaptive histogram equalization; step four, integrating the three channels of L, a and b after enhancement; step five, performing denoising on the enhanced images; step six, marking the images of the healthy controls as 0, and marking the images of the patients with knee osteoarthritis as 1, 2, 3 and 4 according to the severity; and step seven, performing feature extraction by using a discriminative autoencoder; the method can reduce artificial errors, is an effective supplement for clinicians to judge knee osteoarthritis, and is expected to realize accurate prediction of knee osteoarthritis in areas where professional medical personnel are lacking.

The application belongs to the technical field of biological medicine, and particularly relates to amniotic membrane mesenchymal stem cells for treating knee arthritis, and a preparation method and application thereof. The preparation method of the amniotic membrane mesenchymal stem cells comprises the following steps: (1) separating to obtain amniotic membrane tissue; (2) digesting the amniotic membrane tissue, filtering and centrifuging to obtain cell precipitate; (3) resuspending the cell precipitate, inoculating into a culture medium for culture, digesting, centrifuging, discarding supernatant, and obtaining P0 generation amniotic membrane mesenchymal stem cells; and (4) subculturing the P0 generation amniotic membrane mesenchymal stem cells in the culture medium to obtain amniotic membrane mesenchymal stem cells. By adding tiaprofenic acid and sappanin in the basic culture medium, the cell stemness of the amniotic membrane mesenchymal stem cells can be maintained, and the osteogenic differentiation ability of the amniotic membrane mesenchymal stem cells can be improved, so that the knee arthritis can be effectively treated. Meanwhile, the basic culture medium does not add fetal bovine serum, and the safety of clinical application is improved.

The invention provides application of a composition in preparation of an osteoarthritis medicine, and belongs to the technical field of arthritis. The composition comprises helicid, N-acetylcysteine, seaweed oligopeptide and PDGF (Platelet Derived Growth Factor), and the chondrogenic differentiation capability and migration capability of cartilage stem cells in an inflammatory environment are remarkably enhanced through the combination of combined medicines. Besides, in an SD rat gonitis model, the Wakitani histological score of the cartilage stem cells treated by the enhanced culture medium is reduced from 8.83 to 2.17 + / -0.98, and the repairing effect is superior to that of a traditional method. Therefore, the invention provides a basis for efficient treatment of osteoarthritis.

The invention belongs to the technical field of knee joint arbor treatment equipment, and particularly relates to a knee joint force line appliance which comprises a body and a pressure mechanism, the body comprises a main body supporting frame, a thigh binding assembly and a shank binding assembly, and the thigh binding assembly and the shank binding assembly are in sliding connection with the main body supporting frame; after sliding in place, the main body supporting frame is fixed, and then the main body supporting frame is bound to the thigh and the shank respectively; the pressure mechanism is located between the thigh binding assembly and the shank binding assembly, and the pressure mechanism applies adjustable pressure to the key position of a force line to adjust the form of the force line of the lower limb joint, reduce and improve the development speed of gonitis lesion and reduce knee joint pain. Gradient pressure is applied to the outer side, the lower limb force line is guided to be corrected towards the outer side, and joint load redistribution is achieved. The structure of the device adopts an arc-shaped fitting design conforming to ergonomics, and it is ensured that a pressure acting point is accurately located at a key position of a knee joint force line.

The invention provides a method for treating arthritis by using mesenchymal stem cells subjected to limited induction in vitro. Osteoarthritis is a common joint degenerative disease and is mainly characterized by cartilage injury and inflammatory response. The traditional treatment method is difficult to realize cartilage regeneration, but mesenchymal stem cells (MSC) show a prospect in joint repair due to multidirectional differentiation potential and immunomodulatory effect. According to the invention, bergenin (KGN) is utilized in vitro to induce MSC to differentiate into chondrocytes, so that the chondrogenic ability of the cells is enhanced. The inducible MSC is injected into a rat gonitis model, cartilage repair is remarkably promoted, and inflammation is reduced. Experimental results show that the method can effectively relieve arthrocele, improve the motion function and reduce the pain sensitivity. The invention not only improves the treatment effect of MSC, but also provides a safe and effective new approach for treating arthritis, and has important clinical application value.

The present invention relates to the technical field of medical diagnostic systems, and specifically to an early diagnosis system and method for knee arthritis based on multimodal deep learning. The data collection module is used to collect and preprocess multimodal data including knee joint X-ray image data, MRI image data, and clinical evaluation data. The model construction module constructs a deep learning model by combining a convolutional neural network and a Transformer architecture, and uses a feature automatic learning module and a potential relationship mining module to achieve mapping from multimodal data to clinical evaluation phenotype labels. At the same time, the Grad-CAM interpretability method is integrated to understand the basis of model prediction, and diagnostic data is continuously collected and fed back to the data collection module for model optimization. The convolutional network is good at capturing local image features, while the Transformer architecture is good at modeling long-range dependencies. The combination of the two greatly improves the feature extraction and relationship modeling capabilities of the model.

The invention discloses a Jinhuang powder external application paste and application thereof in preparation of drugs for treating gonitis synovitis, the external application paste is prepared from ten traditional Chinese medicines including turmeric, rheum officinale, golden cypress, radix angelicae, rhizoma arisaematis, pericarpium citri reticulatae, rhizoma atractylodis, mangnolia officinalis, liquorice and radices trichosanthis, honey, edible vegetable oil, paraffin oil and water through a specific emulsification process, the pH value is 6.0-7.0, and the viscosity is 3000-5000 mPa.s; standard random control clinical tests prove that the total effective rate of the external application ointment for treating gonarthromeningitis reaches 99.04%, the Lyshilm score is improved by 30.2 score, the VAS score is reduced by 5.39 score and is greatly superior to that of a diclofenac sodium control group, the adverse reaction occurrence rate is only 3.85%, the levels of serum TNF-alpha, IL-1beta and IL-6 and the synovial thickness can be greatly reduced, and the external application ointment has a good clinical application prospect. The method is suitable for K-L grading I-II and postoperative rehabilitation patients.

The invention provides a foot bath bag composition and a preparation method thereof, and relates to the field of traditional Chinese medicinal materials. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 30 to 40 parts of fructus forsythiae, 35 to 45 parts of folium artemisiae argyi, 5 to 15 parts of flos carthami, 15 to 25 parts of caulis spatholobi, 25 to 35 parts of ramulus mori, 15 to 25 parts of herba leonuri, 15 to 25 parts of radix clematidis, 5 to 15 parts of fructus chaenomelis, 15 to 25 parts of rhizoma corydalis, 5 to 15 parts of caulis sargentodoxae, 5 to 15 parts of herba lycopodii, 15 to 25 parts of rhizoma chuanxiong and 5 to 15 parts of liquorice root. According to the traditional Chinese medicine composition, the traditional Chinese medicine composition is prepared by taking fructus forsythiae and folium artemisiae argyi as main components, extracting effective components through boiling, and absorbing the effective components in the composition through a foot bath mode, a sole Yongquan acupoint and skin, so that the traditional Chinese medicine composition has the effects of promoting blood circulation to remove blood stasis, diminishing inflammation and relieving pain, can effectively relieve pain caused by gonitis, femoral head necrosis and rheumatic arthritis, and is good in treatment effect.

The utility model discloses a knee osteoarthritis correction device, including base, stand column, crossbeam, damping telescopic link, two swing arm and two pedal, the base is placed on the ground, the lower end of stand column is fixedly connected with the base, the upper end of stand column is vertically connected with the middle of crossbeam, the two swing arms are symmetrically arranged on both sides of stand column, and the damping telescopic link is connected with the damping telescopic link. The upper ends of the two swing arms are rotationally connected with the two ends of the cross beam respectively, the two pedals are fixed to the lower ends of the two swing arms respectively, the damping telescopic rod is horizontally placed, and the two ends of the damping telescopic rod are rotationally connected with the middles of the two swing arms respectively. The pedal plates installed at the lower ends of the two swing arms are used for supporting the two feet of a patient to conduct internal and external shank swing exercise, meanwhile, the damping telescopic rods are used for providing resistance for shank swing, the knee arthritis patient can be helped to conduct rehabilitation training, and the knee joint rehabilitation effect is improved. In addition, the device has the advantages of simple structure, convenience in use, high reliability and the like.

1. The name of this design product: Comprehensive treatment device for knee arthritis. 2. Purpose of this design product: to assist doctors in treating knee osteoarthritis and correcting joint deformities. 3. The key point of the design of this product lies in its shape. 4. The picture or photo that best illustrates the design points: three-dimensional picture.

The present invention provides a new generation of stem cell therapeutic agents for treating knee arthritis and their preparation process. The present invention is the first to discover that the therapeutic agent can effectively reduce serum levels of IL-1β, TNF-ɑ, and IL-6 in patients with knee arthritis, inhibit their secretion, alleviate knee arthritis damage, and improve and promote cartilage tissue repair.

The invention discloses a pharmaceutical composition for preventing and treating joint inflammation / relieving pain and a preparation method thereof. The pharmaceutical composition comprises the following components: 1, glucosamine sulfate 2KCL (99%), 2, chondroitin sulfate, 3, methylsulfonylmethane (MSM), 4, type II collagen, 5, a morinda officinalis root extract, 6, a herba epimedii extract, 7, a sambucus williamsii extract, 8, a rhizoma drynariae extract, 9, a turmeric root extract, 10, hyaluronic acid and 11, chitosan. The pharmaceutical composition can be prepared into tablets, capsules, dispersible tablets, chewable tablets, effervescent tablets, buccal tablets and other oral preparations. The composition has the effect of preventing and relieving knee joint inflammation / pain.

The invention provides application of combination of umbilical cord mesenchymal stem cells and peripheral blood PRP in treatment of gonitis. Specifically, the invention also provides a monoclonal antibody targeting IL-20, and the monoclonal antibody can effectively inhibit the amount of inflammatory factors IL-6 and IL-20 and promote the proliferation of cartilage cells. The OARSI score of the knee joint cartilage of a rat with osteoarthritis can be effectively reduced by using the monoclonal antibody alone or in combination with umbilical cord mesenchymal stem cells and peripheral blood PRP, and the monoclonal antibody has a relatively good treatment effect and a relatively good application prospect.

The invention relates to the technical field of medical rehabilitation, in particular to a training device for postoperative rehabilitation of knee arthritis patients, which comprises a fixing plate, leg lifting assemblies are symmetrically arranged on the fixing plate, sliding groove assemblies are arranged between the leg lifting assemblies and the fixing plate, and pedal assemblies are symmetrically arranged on the sliding groove assemblies; symmetrical air bag assemblies are arranged on the inner sides of the leg lifting assemblies, a reset assembly is further fixedly connected to the fixing plate, the air bag assemblies communicate with the two ends of the reset assembly correspondingly, and the reset assembly is used for pushing the air bag assemblies to reset based on sensing information of the air bag assemblies so as to correct the posture of a patient. Elastic assemblies used for sensing the inward turning or outward turning condition of the foot sole of the patient during rehabilitation training are symmetrically arranged on the side, close to the pedal assembly, of the fixing plate, one end of each elastic assembly is fixedly connected with the pedal assembly, and the other end of each elastic assembly is hinged to the reset assembly. Through a closed-loop feedback mechanism of air bag induction and mechanical linkage, real-time detection and dynamic correction of abnormal postures of multiple joints of the lower limb are achieved.

The application relates to a knee joint pneumatic decompression type orthopedic brace with a sensor, which comprises an orthopedic body, a fastener, an air bag unit, a first pressure sensor, a second pressure sensor and an angle sensor, wherein when the ratio of the plantar pressure transmitted by the first pressure sensor and the second pressure sensor is 0.5-2.0, the air pump does not work; when the ratio of the plantar pressure transmitted by the first pressure sensor and the second pressure sensor is not 0.5-2.0, the air pump controls the air inflation of the air bags located on the two sides of the knee joint; and when the bending angle of the knee joint transmitted by the angle sensor is 60-150 DEG, the air pump controls the air inflation of the air bags located on the back side of the knee joint. Compared with the prior art, the application can accurately and real-timely adjust the pressure of the medial and lateral sides of the knee joint and the pressure of the patellofemoral joint, correct the force line during the walking or movement of the knee joint, and relieve the symptoms of knee arthritis.

The invention relates to the technical field of traditional Chinese medicine, and provides a medicine film for relieving the symptoms of knee arthritis that can be used at home and a preparation method thereof, comprising main ingredients and auxiliary ingredients, wherein the main ingredients include the following raw materials by weight: 10-50g of gynostemma pentaphyllum, 20-50g of sappan wood, 10-35g of mountain conch, 10-30g of processed rhubarb, 10-50g of clematis, 10-30g of radix scutellariae, 20-50g of corydalis, 10-30g of liquorice, 9-20g of asarum, 10-50g of millettia reticulata, and 15-60g of honeysuckle vine; and the auxiliary ingredients include vaseline and beeswax. The medicine film can effectively disperse the stasis in the human body through the coordinated use of the main ingredients, disperse the stasis and reduce swelling, activate blood circulation and remove stasis, relieve pain, promote blood circulation, improve the stasis state of local tissues, and dredge meridians. Through the use of auxiliary ingredients, Chinese medicine can be directly applied to the lesion site, with rapid onset of effect, quick results, no sensitization, and no allergic reactions; it can be used continuously, is easy to use, has no odor, no foreign body sensation, and does not stain the skin or clothing.

The present application relates to the technical field of knee joint rehabilitation equipment, and is a rehabilitation treatment device for knee joint osteoarthritis, comprising a treatment bed, two foot fixing assemblies and two first driving assemblies. The top surface of the first end of the treatment bed is provided with a backrest, and the top surface of the second end of the treatment bed is provided with two guide grooves, and the two foot fixing assemblies are arranged in the two guide grooves respectively. The inside of the treatment bed is provided with an assembly cavity, and the two first driving assemblies are arranged in the assembly cavity, and the output ends of the two first driving assemblies are connected with the two foot fixing assemblies respectively. When the present application is used, not only the posture of the patient can be standardized, but also uniform and appropriate force joint traction can be implemented, safe joint surface separation and effective treatment can be realized, and the rehabilitation speed of the knee joint of the patient can be accelerated. The present application aims to help patients with knee osteoarthritis to increase the range of motion of the knee joint, release the joint negative pressure, relieve pain and improve the quality of life.

Traditional Chinese medicine ointment is prepared, standardized positioning of a permanent magnet is achieved, the traditional Chinese medicine ointment is coated in cooperation with a silk-screen printing technology (the precision is + / -0.2 mm), it is ensured that the magnet position deviation of each batch of products is smaller than or equal to + / -0.5 mm, the ointment thickness deviation is smaller than or equal to + / -0.1 mm, and the product percent of pass reaches 98% or above; a 50-60 DEG C constant-temperature curing process can enhance the binding force between the paste body and the base material, prevent the paste body from falling off, prolong the shelf life of the product to 24 months, meet large-scale production requirements, and aim at common elderly gonitis (corresponding to inner knee eyes and outer knee eyes), scapulohumeral periarthritis (corresponding to shoulder and shoulder) and lumbocrural pain (corresponding to shenshu and large bowel shu) through an acupoint adaptive design of a positioning mold. Precise correspondence of different arthralgia can be achieved, the patch structure does not need to be replaced, the use difficulty of old patients is reduced, and the patch is suitable for various scenes such as home nursing and rehabilitation assistance.

The present application belongs to the technical field of prosthesis manufacturing, and aims to provide a knee joint prosthesis design method, system, electronic device and product. The present application firstly constructs an initial prosthesis design model for a specified KBD knee osteoarthritis patient, then obtains knee joint image data of the specified KBD knee osteoarthritis patient, and obtains an image feature set according to the knee joint image data. Subsequently, multiple sets of the image feature set are divided into a training set, a validation set and a test set, and a final prosthesis design model is obtained based on the training set, the validation set and the test set. The final prosthesis design model is used to obtain a knee joint prosthesis structure model matched with the specified KBD knee osteoarthritis patient, and then a knee joint prosthesis matched with the specified KBD knee osteoarthritis patient is manufactured. Thus, the adaptation between the knee joint prosthesis and the skeleton of the specified KBD knee osteoarthritis patient can be improved, and the comfort of the patient after installing the knee joint prosthesis and the service life of the prosthesis can be improved.

The invention discloses a traditional Chinese medicine formula for treating knee arthritis and a preparation process, relates to the technical field of knee arthritis, and aims to solve the problem of treating knee arthritis. The raw materials of the traditional Chinese medicine are composed of the following components, calculated by weight: 13.3-16.7 parts of processed aconite root, 7.3-10.7 parts of longan root, 2.8-6.2 parts of cloves, 2.8-6.2 parts of nutmeg, 25.3-28.7 parts of jujube, 2.8-6.2 parts of yak heart, 2.8-6.2 parts of agarwood, 2.8-6.2 parts of costus root, 2.8-6.2 parts of white cloud osmanthus, and 28.3-31.7 parts of terminalia chebula, which are ground and taken with water.

The invention relates to the technical field of pharmacy, in particular to biomimetic mineralized peptide-graphene bone joint health-care paste as well as a preparation system and a preparation method thereof. The health-care cream comprises an olibanum serratum resin extract, thyme flower / leaf oil and other extracts, hexanediol, p-hydroxyacetophenone, triethanolamine, chlorphenesin and a biomimetic mineralized peptide-graphene composite material. The graphene oxide layer is introduced into the bone joint health-care ointment, so that the conductivity of a medicine carrying system is improved, directional migration of calcium ions and phosphorus ions is promoted, and the mineralization process is accelerated; in addition, the bone targeting peptide is modified on the surface of the carrier, so that the traditional Chinese medicine extract, phosphorus ions and calcium ions are effectively and efficiently permeated into the bone joint part, and the bone joint treatment effect is improved. The health-care ointment can quickly resist inflammation, relieve pain, promote cartilage / bone repair and promote microcirculation, so that microcrack new sites are increased, continuous anti-inflammation is realized, and pain, stiffness and structural damage caused by gonitis, scapulohumeral periarthritis and rheumatism are remarkably improved.

The invention relates to the technical field of knee joint repair, and particularly provides a stem cell preparation for knee joint injury repair as well as a preparation method and application thereof. The NGF monoclonal antibody 4G13 and the bone marrow mesenchymal stem cells are combined for knee joint injury repair for the first time, and test analysis shows that the preparation can effectively reduce the levels of IL-1beta, TNF-alpha and IL-6 in serum of a patient suffering from gonitis, inhibit secretion of the IL-1beta, the TNF-alpha and the IL-6, repair knee joint inflammatory injury, improve and promote cartilage tissue repair, and have a good application prospect in knee joint injury repair. Good application prospects are realized.