Traditional Chinese medicine ointment formula for treating gonitis and preparation method thereof

Abstract

The invention provides a traditional Chinese medicine ointment formula for treating gonitis and a preparation method thereof. Traditional Chinese medicine believes that knee arthralgia has symptoms of qi stagnation and blood stasis, liver and kidney deficiency and tendon and vessel obstruction. The symptoms include swelling and stabbing pain of knees, unfavorable flexion and extension, aggravated cold, soreness and weakness of waist and knees, dark tongue or ecchymosis and astringent pulse. In view of the problem, the traditional Chinese medicine ointment provided by the invention consists of trogopterus dung, corydalis tuber, Chinese angelica, white paeony root, pseudo-ginseng, safflower, peach kernel, nutgrass galingale rhizome, raw white mustard seed, eucommia bark, twotooth achyranthes root and honey-fried licorice root. The trogopterus dung breaks blood, the rhizoma corydalis promotes the circulation of qi, the rhizoma cyperi regulates the flow of qi, and the peach kernel and the safflower activate the blood, so that the effects of promoting the circulation of qi, activating blood and eliminating arthralgia are achieved. The traditional Chinese medicine composition is mainly used for promoting blood circulation to remove blood stasis, is supplemented by eucommia ulmoides and achyranthes bidentata to tonify the liver and kidney, eliminates evil without hurting vital energy, and accords with the pathogenesis of knee arthritis of deficiency in root and excess in superficies. The raw semen brassicae is pungent and dispersed and transdermal, and the radix achyranthis bidentatae guides the medicine to move downwards, so that the efficacy of the externally applied medicine reaches the muscles and bones, and the limitation of superficial efficacy of the traditional application is broken through.

Description

Technical Field

[0001] The invention belongs to the field of traditional Chinese medicine preparations, and particularly relates to a traditional Chinese medicine ointment prescription for treating knee arthritis and a preparation method thereof. Background Art

[0002] Knee arthritis is a condition based on degenerative pathological changes. It often affects middle-aged and elderly individuals, with symptoms including redness, swelling, and pain in the knee, pain climbing stairs, and knee soreness and discomfort when sitting or standing. Some patients may also experience swelling, snapping, and effusion. Left untreated, these conditions can lead to joint deformity. Other common knee joint conditions include synovitis, ligament injuries, meniscus injuries, loose bodies, popliteal cysts, patellar chondromalacia, pes anserine bursitis, and genu valgum / genu valgum.

[0003] Chinese patent application CN 108853390A discloses a traditional Chinese medicine preparation for treating knee arthritis. It is composed of small radix scutellariae, pittosporum bark, vine of green wind, vine of heather, Euonymus japonicus, stephensi, saururaceae root, trifoliate radix scutellariae bark, red scutellariae root, cyperus rotundus bark, dragon's blood, knotweed, dragon's blood lees, peach leaf, yew vine, cinnamomum camphora, five-fingered taro, and coix seed. It is claimed to eliminate wind, cold, and dampness that have penetrated the body, as well as blood stasis and phlegm that block the meridians, promote blood circulation and reduce swelling, relax tendons and activate the meridians, promote blood circulation in the affected area, and dredge the meridians, demonstrating significant therapeutic effects for knee arthritis.

[0004] Chinese patent application CN 105816550A discloses a traditional Chinese medicine combination for treating knee arthritis. The combination consists of raw Chuanwu (Chuanwu), raw Caowu (Aconiti Kusnezoffii), asarum, peach kernel, Achyranthes bidentata, Notopterygium wilfordii, Herba Lycopodii, Morinda officinalis, Clemati radix, Herba schoenopodii, Rhubarb, Chuanxiong (Ligusticum chuanxiong), Chinese angelica, Millettia reticulata, Pittosporum tobira bark, and mulberry branches. The combination is claimed to dispel wind and dampness, promote blood circulation, relax meridians and activate collaterals, and relieve pain. It can promote blood circulation, alleviate pain, and reduce discomfort. Raw Chuanwu also has anti-inflammatory properties, which can quickly eliminate inflammation and accelerate recovery.

[0005] Traditional Chinese Medicine (TCM) believes that knee arthritis is a syndrome characterized by qi stagnation and blood stasis, liver and kidney deficiency, and obstruction of tendons and vessels. Symptoms include knee swelling and stabbing pain, difficulty flexing and extending the knee, aggravated by cold, accompanied by soreness and weakness in the lower back and knees, a dark tongue with ecchymosis, and a wiry, wiry pulse. Therefore, it requires a differentiated and effective treatment. In light of this, the present invention proposes a traditional Chinese medicine ointment formula for treating knee arthritis that promotes qi and blood circulation, relieves pain, and tonifies the liver and kidneys. Summary of the Invention

[0006] The technical problem to be solved by the present invention is to provide a traditional Chinese medicine ointment for treating knee arthritis and a preparation method thereof. The various herbs in the traditional Chinese medicine ointment are used together to promote qi and blood circulation, relieve arthritis and pain, and nourish the liver and kidneys. When combined with the ointment application, it can have a good therapeutic effect on knee arthritis.

[0007] In order to achieve the above object, the technical solution adopted by the present invention is:

[0008] A traditional Chinese medicine ointment prescription for treating knee arthritis, comprising the following traditional Chinese medicine raw materials by weight:

[0009] Wulingzhi 8-12g, Yanhusuo 10-30g, Angelica 15-25g, White Peony 15-25g, Panax Notoginseng 5-15g, Carthamus 10-25g, Peach Kernel 10-25g, Cyperus 10-30g, Raw White Mustard Seed 8-12g, Eucommia ulmoides 15-25g, Achyranthes bidentata 15-30g, Roasted Licorice 5-10g.

[0010] As a preferred technical solution of the present invention, the Chinese medicine ointment for treating knee arthritis comprises the following Chinese medicine raw materials by weight:

[0011] 10g of Wulingzhi, 20g of Yanhusuo, 20g of Angelica sinensis, 20g of White Peony Root, 10g of Panax notoginseng, 20g of Carthamus tinctorius, 20g of Peach Kernel, 20g of Cyperus rotundus, 10g of Raw White Sinapis Seed, 20g of Eucommia ulmoides, 20g of Achyranthes bidentata, and 6g of Roasted Licorice Root.

[0012] This prescription is suitable for those with swollen and stiff knees, nighttime stabbing pain, and limited mobility. If localized redness, swelling, and burning sensation (damp-heat arthritis) are present, add Phellodendron amurense 5g and Coix seed 8g. If severe pain is caused by cold (cold-damp arthritis), add Cinnamon twig 3g and Asarum 6g for better efficacy.

[0013] This prescription treats knee arthritis, which can be caused by external wind, cold, and dampness, leading to arthritis over time, which depletes Qi and blood, affecting the liver and kidneys. Wind, cold, and dampness invade the joints, disrupting the smooth flow of Qi and blood, causing pain in the lower back and knees. Over time, this leads to difficulty flexing and extending the joints, or numbness. The kidneys govern the bones, and the liver governs the tendons. Prolonged damage to the bones and tendons inevitably depletes Qi and blood, damaging the liver and kidneys, resulting in soreness and weakness in the lower back and knees, and even palpitations and shortness of breath. This syndrome reflects a deficiency of the underlying cause and an excess of the superficial cause, requiring treatment that balances strengthening the body's vital energy and dispelling the pathogenic factors. It aims to alleviate arthritis and pain while also promoting Qi and blood circulation, nourishing the liver and kidneys.

[0014] In this formula, Wulingzhi (Five-spirit fat) effectively enters the liver meridian and blood circulation, dissolving blood stasis and relieving pain, and promoting blood circulation, making it a key herb for treating blood stasis and blood blockage in joints. Yanhusuo (Rhizoma Corydalis) promotes qi and blood circulation, specifically addressing general pain. It works in tandem with Wulingzhi, treating both qi and blood, and relieving blockage in the knees. Angelica sinensis nourishes and invigorates blood circulation, while white peony root softens the liver and alleviates urgency. Together, they harmonize liver blood to nourish the tendons and veins, addressing the dual mechanisms of "pain due to obstruction" and "pain due to lack of nourishment." These four herbs are collectively the main herb. Panax notoginseng dissolves blood stasis and relieves pain, while safflower and peach kernel promote blood circulation and promote menstruation. These three herbs enhance the main herb's ability to dissipate blood stasis and unclog the meridians, particularly effective in alleviating joint swelling and stiffness. Cyperus rotundus soothes the liver and regulates qi, promoting blood circulation, helping the main herb break down the congestion of qi and blood stasis in the knees. Raw white mustard seeds are pungent and warm, dissolving phlegm and dispersing nodules, with strong transdermal properties. External treatments can draw other herbs deeper into the skin, while also dispelling phlegm, dampness, and blockage. These five herbs are collectively the auxiliary herb. Eucommia ulmoides nourishes the liver and kidneys, strengthening tendons and bones. Achyranthes bidentata draws blood downward, strengthening the knees and improving gait. Together, they tonify and strengthen the body, addressing the root causes of liver and kidney deficiency and preventing chronic arthritis from damaging the body. Roasted licorice harmonizes the various herbs, relieving pain and mitigating the pungent properties of white mustard seeds, preventing burns when applied externally. Together, they serve as adjuvants. Achyranthes bidentata has a downward-moving nature, guiding the various herbs directly to the affected knees, making it a guiding herb.

[0015] This prescription has three key features: Harmonizing Qi and Blood: Wulingzhi (Schizonepeta tenuifolia) dissolves blood, and Yanhusuo (Rhizoma Corydalis) promotes Qi flow. Combined with Cyperus rotundus (Roxb. Root) regulates Qi, and Peach Kernel (Safflower) invigorates blood circulation, achieving the combined effect of "Qi circulates and blood activates, leading to the spontaneous resolution of pain and numbness." It also addresses both attack and tonification: Primarily promoting blood circulation and removing blood stasis, supplemented by Eucommia ulmoides and Achyranthes bidentata to nourish the liver and kidneys, dispelling pathogenic factors without harming the body's health. This approach addresses the underlying pathogenesis of knee arthritis, characterized by both internal and external attraction: Raw white mustard seeds disperse through the skin, while Achyranthes bidentata guides the drug downward, allowing the externally applied medicine to penetrate the tendons and bones, transcending the superficial effects of traditional patch therapy.

[0016] The invention also proposes a preparation method of the Chinese medicine paste, which comprises crushing the various Chinese medicines in the Chinese medicine compound into powder and mixing them evenly; using an appropriate amount of white vinegar or white wine to prepare a paste before applying, and applying the paste on a non-woven fabric to prepare a plaster. DETAILED DESCRIPTION

[0017] Example 1

[0018] A traditional Chinese medicine ointment for treating knee arthritis, comprising the following traditional Chinese medicine raw materials by weight:

[0019] 10g of Wulingzhi, 20g of Yanhusuo, 20g of Angelica sinensis, 20g of White Peony Root, 10g of Panax notoginseng, 20g of Carthamus tinctorius, 20g of Peach Kernel, 20g of Cyperus rotundus, 10g of Raw White Sinapis Seed, 20g of Eucommia ulmoides, 20g of Achyranthes bidentata, and 6g of Roasted Licorice Root.

[0020] The various Chinese medicinal herbs in the Chinese medicinal compound are crushed into powder and mixed evenly; before application, an appropriate amount of white vinegar or white wine is used to prepare a paste, which is then applied on non-woven fabric to prepare a pain patch.

[0021] Example 2

[0022] Typical Cases

[0023] Case 1

[0024] Patient Lv, female, 74 years old, was treated on February 27, 2025. The patient had a history of chronic low back pain, and intermittent diagnosis and treatment in other hospitals occasionally relieved. One month ago, the patient's low back pain recurred, accompanied by pain in the right knee joint. Walking about 500 meters became unbearable, the pain worsened at night, and it was aggravated by cold. Physical examination showed mild swelling of the right knee joint, tenderness of the inner and outer knee eyes (+), patellar grinding test (+), and joint motion of 0°-110° (pain arc: when the knee is flexed 60°-90°). Diagnosis 1. Lumbar disc herniation; 2. Right knee osteoarthritis. The treatment should be to promote blood circulation, remove blood stasis and relieve pain, and nourish the liver and kidneys. A knee arthritis pain patch (prepared with reference to the method of Example 1, the same below) was applied to the affected part, once a day. After 20 days of treatment, the patient's right knee joint swelling disappeared, the pain was greatly reduced, he could walk normally, the pain disappeared at night, and the effect was satisfactory.

[0025] Case 2

[0026] Ms. Li, 71, was admitted to the hospital on March 2, 2025, with symptoms of paroxysmal dizziness lasting over 10 years and recurring within a week. The admission diagnoses included 1. lacunar infarction, 2. hypertension, and 3. type 2 diabetes. On the second day of hospitalization, the patient complained of pain in the left knee joint after exposure to cold. Physical examination revealed no redness or swelling in the left knee joint, normal skin temperature, tenderness over the medial and lateral knee joints (+), mild limitation of joint motion (flexion), and a positive varus stress test. Treatment was to promote blood circulation, remove stasis, and relieve pain. A knee arthritis pain patch was applied to the affected area daily. After two weeks of treatment, the patient reported a significant reduction in left knee pain and normal joint motion.

[0027] Case 3

[0028] Ruan Moumou, male, 67 years old, was diagnosed on March 3, 2025. The patient suffered a cerebral infarction 3 years ago, which left him with poor right limb activity. He underwent intermittent rehabilitation treatment during the period, and his limb activity improved. One month ago, he developed swelling and pain in the right knee joint and sought treatment in our department. Physical examination showed that the muscle strength of the right upper limb was level 3, the muscle strength of the right lower limb was level 4, the muscle tone was normal, the right knee joint was slightly swollen, the medial and lateral knee eye tenderness (+), the inversion stress test (+), and the patellar grinding test (+). The patient had a long course of cerebral infarction and was deficient in qi and blood. Due to the low muscle strength of the affected lower limb, the knee joint was poorly stable and more susceptible to injury than normal joints. After completing the auxiliary examination, a knee arthritis pain patch was applied to the affected part once a day. After 2 weeks of treatment, the patient reported that the pain in the right knee joint had improved and he was able to walk continuously.

[0029] Case 4

[0030] Liu Moumou, female, 71 years old, was admitted to the hospital for treatment on February 25, 2025. The patient was admitted to the hospital for treatment because of "difficulty in right half body movement and unstable walking for more than 4 years, which worsened for 1 week". The patient suddenly developed weakness in the right lower limb 4 years ago, and weakness in the right upper limb movement 3 days later. She was sent to the hospital for examination and diagnosed with "cerebral infarction". After the condition stabilized, she was left with difficulty in right half body movement, and had undergone comprehensive rehabilitation treatment many times. One week ago, the patient felt weakness in both lower limbs and pain in both knees. The pain worsened when she walked and the pain worsened at night. Physical examination showed that the knee joints were swollen and the joint line was tender (+). In response to the patient's symptoms of pain in both knees, knee arthritis pain patches were applied to the affected area once a day. After 3 weeks of treatment, the patient's knee pain improved and the joint swelling was reduced.

[0031]

Case 5

[0032] Yang Moumou, male, 57 years old, was admitted to the local hospital on February 24, 2025. One year ago, the patient was admitted to the local hospital with "left basal ganglia cerebral infarction" and his condition stabilized after relevant treatment. He still had weakness in right limb movement and his speech was not clear. One week ago, he came to our department for further rehabilitation treatment. During the period, he complained of pain and discomfort in the right knee joint. Physical examination showed mild swelling of the right knee joint, tenderness (+) on the medial and lateral knee eyes, patellar grinding test (+), and joint motion of 0°-110° (pain arc: when the knee is flexed 70°-90°). The patient was given a knee arthritis pain patch applied to the affected area once a day. After 2 weeks of treatment, the patient's right knee joint pain was significantly relieved, the range of motion was normal, and the swelling disappeared.

[0033] The above content is merely an example and explanation of the concept of the present invention. Those skilled in the art may make various modifications or additions to the described specific embodiments or replace them in a similar manner. As long as they do not deviate from the concept of the invention or exceed the scope defined by the claims, they should all fall within the scope of protection of the present invention.

Claims

1. A Chinese medicinal ointment for treating knee arthritis, characterized in that Including the following weights of Chinese medicine raw materials: Wulingzhi 8-12g, Yanhusuo 10-30g, Angelica 15-25g, White Peony 15-25g, Panax Notoginseng 5-15g, Carthamus 10-25g, Peach Kernel 10-25g, Cyperus 10-30g, Raw White Mustard Seed 8-12g, Eucommia ulmoides 15-25g, Achyranthes bidentata 15-30g, Roasted Licorice 5-10g.

2. The Chinese medicinal ointment for treating knee arthritis according to claim 1, characterized in that Including the following weights of Chinese medicine raw materials: 10g of Wulingzhi, 20g of Yanhusuo, 20g of Angelica sinensis, 20g of White Peony Root, 10g of Panax notoginseng, 20g of Carthamus tinctorius, 20g of Peach Kernel, 20g of Cyperus rotundus, 10g of Raw White Sinapis Seed, 20g of Eucommia ulmoides, 20g of Achyranthes bidentata, and 6g of Roasted Licorice Root.

3. The Chinese medicinal ointment for treating knee arthritis according to claim 2, characterized in that It also includes the following weights of Chinese medicinal raw materials: 5g of Phellodendron amurense and 8g of Coix seed.

4. The Chinese medicinal ointment for treating knee arthritis according to claim 2, characterized in that It also includes the following weights of Chinese medicinal raw materials: 3g of cinnamon twig and 6g of asarum.

5. A method for preparing the Chinese medicinal ointment according to any one of claims 1 to 4, characterized in that: Crush each Chinese medicine into powder and mix them evenly; before applying, use an appropriate amount of white vinegar or white wine to make a paste, and apply it on non-woven fabric to make a plaster.