66 results about "Bergenin" patented technology

The invention discloses the applications of compounds, selected from quercetin, chrysophanic acid, digicitrine, formononetin, honokiol, berberine, kaempferol, bergenin, deoxyepinephrine and licochalcone A, as well as derivatives thereof, in preparation of medicines applied to methods that are used for promoting stem cell proliferation, delaying senescence of stem cells, promoting differentiation of the stem cells into osteoblasts, chondrocytes and adipocytes, enhancing the vascularization capability of the stem cells and / or improving exercise tolerance of mice. The invention also discloses that the compounds can be combined with vitamin C for application.

The invention belongs to the field of chemical research of traditional Chinese medicine, in particular to a method for extracting bergenin from traditional Chinese medicine rodgersia podophylla. In the prior art, methanol ultrasonic is used for extracting bergenin, which is not suitable for industrial production; in addition, a method for adopting lime water wastes time. In order to overcome the defects in the prior art, the invention adopts the technical scheme that the method for extracting bergenin from traditional Chinese medicine rodgersia podophylla comprises the following steps: taking traditional Chinese medicine rodgersia podophylla coarse powder as raw material; carrying out reflux extraction on the raw material for 3 times by alcohol of which the amount is 4-6 times of that of the raw material, wherein the first time lasts for 1-3 hours, and the second time and the third time respectively last for 0.5-1.5 hours; collecting extract, precipitating and filtering; recovering filtrate, and condensing to small volume; standing for devitrification; after the devitrificated crystal is dissolved by alcohol-carbinol mixed liquid at the volume ratio of 8:1-8:3, carrying out hot filtering; and after filtering, standing for devitrification. The method has simple technology, low cost, available raw material and high extraction efficiency and is favorable for industrial production.

An orally-disintegrating tablet of bergenin for treating cough, chronic trachetitis and other inflammations is prepared from bergenin, filler, disintegrant, flavouring, flow aid, lubricant, and optional adhesive or coating and effervescent agent.

The invention discloses a method for detecting the quality of An'erning granules. The method comprises a method for identifying cholic acid and bergenin and a method for determining content of glycyrrhizic acid, the bergenin and bilirubin. Experimental study proves that spots with different colors are displayed at a position, which corresponds to a color spectrum of a reference substance, in the color spectrum of a sample by the identification method in the quality detection method; and negative control is not interfered. Results show that the content determination method is used for determining the content of the glycyrrhizic acid and the bergenin in the An'erning granules, has a good linear relation, and high repeatability and stability, and can control the quality of An' erning granules accurately and strictly; and moreover, the accuracy of recovery tests is high.

The compound bergenin disperser tablet consists of bergenin in 82.0-90.0 wt%, chlorphenamine maleate 1.0-2.0 wt%, carboxymethyl starch sodium 5.0-10.0 wt%, magnesium stearate 0.5-2.0 wt%, superfine silica gel powder 0.5-1.5 wt%, sodium dodecyl sulfate 0.1-0.5 wt%, polyvinyl pyrrolidone 1.0-3.0 wt% and aspartame 0.1-0.5 wt%. The compound bergenin disperser tablet is prepared through micronizing the components, mixing, wet pelletizing and tabletting. It may be disintegrated fast within 2 min and has high bergenin and chlorphenamine maleate leaching speed.

The invention relates to a novel medicinal dosage for treating chronic bronchitis and common cold, and its preparing process, which comprises medicinal active constituents and medicinal auxiliary materials, wherein the active components of the medicament include Bergenin 8-42 wt% and chlorpheniramine 0.001-0.01 wt%, and balancing medicinal auxiliary materials.

The invention relates to the field of medicines and particularly relates to a bergenin derivative as well as a preparation method and application thereof. The bergenin derivative disclosed by the invention has a structure shown in the specification, wherein R1 represents one of a benzene ring, differently-substituted phenyl and pyridine and differently-substituted pyridine and aliphatic chain. The derivative is a dihydroisocoumarin type compound; the structure has one lactonic ring and can be applied to an anticancer drug.

The invention discloses bergenin derivatives as well as a preparation method andapplication thereof. The structure of the compounds is as shown in a formula II, wherein R1 is selected from C3-C10 alkyl groups or naphthenic bases, and R1 is selected from H, the C3-C10 alkyl groups or the naphthenic bases. According to the preparation method of the bergenin derivatives, bergenin and bromoalkane are used as raw materials and react under the effect of a catalyst so as to generate the compounds as shown in the formula II. The bergenin derivatives disclosed by the invention are applied in the preparation of medicines for treating prostate cancers. A series of bergenin derivatives are synthesized by using the bergenin and the bromoalkane as raw materials; based on natural products easy to obtain, a synthetic method is simple and has relatively good operability and reaction yield. The bergenin derivatives have remarkable effects on prostate cancer treatment and provide reference for the application of the bergenin compounds in the prostate cancer treatment. The formula II is as shown in the specification.

The invention provides a bamboo shoot dietary fiber extraction method. The method comprises the following steps: taking bamboo shoot, crushing the bamboo shoot, adding water with the weight 20 times the weight of the bamboo shoot, decocting the bamboo shoot for 1 h, carrying out ultrasonic assisted cellulase enzymatic hydrolysis by adding cellulase with the mass being 2-6% of the mass of the above obtained bamboo shoot water decoction, deactivating enzymes, carrying out suction filtration, carrying out evaporative concentration on the above obtained filtrate to obtain a concentrate, and drying the concentrate to prepare bamboo shoot dietary fiber extract with high content of 5-deoxystrigol. The extract is combined with tripdiolide and bergenin to prepare a constipation treatment granule.

The invention relates to an assay method of metabolite of bergenin in an animal body. The method includes the following steps: adding acetonitrile into dosed blood plasma, dosed urine, dosed bile and dosed excrement sample to be assayed and non-dosed blank blood plasma, non-dosed urine, non-dosed bile and non-dosed excrement, mixing and spinning, centrifuging, clear-taking, drying and redissolving the samples to obtain liquid to be assayed, analyzing the liquid to be assayed through a high performance liquid chromatograph / quadrupole rod-time of flight / tandem mass spectrum (HPLC / Q-TOF / MS) method to obtain a total ions chromatogram of the liquid to be assayed, conducting contrast identification to the total ions chromatogram of a blank sample and the total ions chromatogram of a dosed sample, extracting ions and secondary fragments from the total ions chromatogram of the blank sample and the total ions chromatogram of the dosed sample, analyzing the ions and the secondary fragments, and obtaining that the metabolite of the bergenin in the animal body is a glucuronic acid combined product, a sulfuric combined product, hydrolysate and a methyl combined product. According to the assay method of the metabolite of the bergenin in the animal body, a high-sensitivity, strong-specificity, convenient and feasible HPLC / Q-TOF MS / MS method is first established and the metabolite of the bergenin in the animal body is successfully assayed through the HPLC / Q-TOF MS / MS method.

The invention discloses a children Kaihoujian spray as well as a preparation and quality standard inspection method thereof. The children Kaihoujian spray is prepared from four Chinese herbs such as ardisia crispa, radix sophorae subprostratae, periostracum cicada and menthol; in an identification process, the thin-layer identification of radix ardisiae crenataeis is corrected, in an original standard, the identification is performed by referring to bergenin, a test sample preparation method is complex, the original method is modified, a radix ardisiae crenataeis reference herb is added, so that the test sample preparation method is simplified, and the method is high in specificity and good in repetition and is listed in the standard text; the language description for identifying a mentholthin layer is standardized, and a reagent benzene used for the developing agent is replaced as methylbenzene; and the thin-layer identification of the radix ardisiae crenataeis is added, sophocarpidine is adopted as a reference, and by virtue of examination, the method is stable and good in repetition, thereby being listed in the standard text. In addition, the research is made for the thin-layeridentification of periostracum cicada.

The invention relates to a method of preparing an air freshener, which is mainly characterized by perilla leaf, bergenin, Chinese arborvitae, woad, cablin patchouli herb, fineleaf schizonepeta herb, silver flower, chrysanthemum, argy wormwood leaf, atractylodes rhizome, virgate wormwood herb and platycodon root. The invention is easy in preparation and convenient in use, not only has the functions of environment purification and foreign flavour elimination, but also achieves the objectives of preventing and curing epidemic diseases, such as cold, hepatitis, cephalitis, etc, meanwhile, can kill the bacteria on contact tools (such as telephones, microphones, bathing necessities, door and window handles, etc.), and is an ideal air freshener at home and in public places.

The invention relates to a method for identifying Japanese ardisia herb in a Chinese patent medicine for treating heat asthma. The method comprises the following steps: a test article solution is prepared, wherein a macroporous adsorption resin column is adopted for absorption, and eluting is carried out by ethanol with the mass concentration being 35%; and a reference substance solution is prepared, wherein bergenin is taken as a control sample, a thin layer chromatography is adopted, wherein a polyamide film is used for unfolding, a mixed solution of ethyl acetate-acetic acid is taken as an unfolding agent. An experiment result is negative and free of interference. According to the method for identifying Japanese ardisia herb in the Chinese patent medicine for treating heat asthma provided by the invention, the repeatability is good, the specificity is high, spots are clear, and stable Chinese patent medicine quality can be effectively ensured.

The invention belongs to the technical field of traditional Chinese medicines, and discloses a preparation method and application of a herba ardisiae japonicae alcohol extract. The preparation method comprises the following steps: after drying and crushing a herba ardisiae japonicae medicinal material at low temperature, weighing 0.1g of the crushed herba ardisiae japonicae medicinal material, and adding 0.1mL of methanol; after carrying out vortex oscillation, carrying out ultrasonic treatment and cooling; then weighing the weight, and supplementing the reduced weight with the methanol; uniformly shaking and filtering; taking subsequent filtrate and preserving for later use; weighing a bergenin reference substance, and adding the methanol to prepare a solution; determining the content of bergenin in the herba ardisiae japonicae alcohol extract by adopting an ultra-high performance liquid chromatography. According to the preparation method and the application of the herba ardisiae japonicae alcohol extract, the content of the bergenin in the herba ardisiae japonicae alcohol extract is 9.88mg / g and accords with quality standards; herba ardisiae japonicae can be used for reducing the quantity of lipid droplets in ST-2 and C3H10 cells which are obtained by inducing adipogenesis differentiation, and for inhibiting mRNA expression of adipogenesis differentiation characterization genes PPARgamma, C / EBPalpha and aP2; interventional treatment of the herba ardisiae japonicae can be used for effectively reducing the weight of C57BL / 6 mice fed by high fat diet.

The invention discloses a method for detecting active ingredient content in Yushangling Capsule, including the following steps: (1) reference substance solution is prepared; (2) testing substance solution is prepared; (3) standard curve is drawn; (4) the active ingredient content in Yushangling Capsule is measured. The invention screens the active ingredient content in Yushangling Capsule through lots of experiments; moreover, the invention screens the method for extracting bergenin from made medicine of Yushangling Capsule and ensures that the bergenin is suitable for high efficient liquid phase chromatogram detection after technical treatment; meanwhile, conditions for chromatogram detection are established. The method can effectively detect the active ingredient content in Yushangling Capsule and can effectively control product quality to ensure curative effect of product; therefore, the method can be widely used in production control in pharmaceutical factory.

The invention discloses a method of extracting and purifying bergenin from cissus pteroclada hayata. The method comprises the steps that the cissus pteroclada hayata is smashed and screened, ethanol solution is added according to the mass-to-volume ratio of 1 to 8-20 for reflux extraction, solid-liquid separation is conducted to obtain filtrate, the filtrate is concentrated, macroporous resin is added into the concentrated solution for static adsorption, the macroporous resin subjected to adsorption is placed on a pillar, impurities are removed and elution is conducted with distilled water and ethanol solution in sequence, the eluant is collected and concentrated to obtain crude bergenin, and the crude bergenin is recrystallized with ethanol to obtain pure bergenin. According to the method, sources of raw materials are wide, price is low, production cost is low, production conditions are moderate, and pollution to the environment is light.

The invention discloses a traditional Chinese medicine preparation used for treating silicosis, a preparation method and an application thereof. The traditional Chinese medicine preparation comprises the following raw materials by weight: 1250-2500 parts of Glechoma longituba, 750-1250 parts of gentrin knotweed, 30 parts of bergenin, 500-1000 parts of mulberry bark, 250-750 parts of fritillaria cirrhosa, 250-750 parts of stemona, 1-1.75 parts of auxiliary material magnesium stearate, 3.5-17.5 parts of powdered steatile, 3.5-17.5 parts of starch or 3.5-17.5 parts of dextrin, 3.5-17.5 parts of microcrystalline cellulose or 3.5-17.5 parts of mixture of starch, dextrin and microcrystalline cellulose. The traditional Chinese medicine preparation has the functions of invigorating blood circulation and dissipating binds, eliminating phlegm by cooling, as well as relieving cough and asthma. The tablet prepared by the traditional Chinese medicine preparation can be used for symptoms of cough, chest distress, short breath and hypodynamia due to silicosis; and can be used for acute attack sputum and heat cough patients of acute bronchitis and chronic bronchitis.

The invention belongs to the technical field of traditional Chinese medicines and particularly relates to a preparation method of Shuangyang pharyngitis tablets and an application of the Shuangyang pharyngitis tablets to preparation of a cell proliferation medicine of anus sarcoma cells S-180. The Shuangyang pharyngitis tablets are prepared from the following bulk drugs: 468.7g of wild tobacco leaves, 468.7g of sheepear inula herbs, 312.5g of herba ardisiae japonicae, 312.5g of folium elaeagni, 312.5g of bombyx batryticatus, 312.5g of schizonepeta and 312.5g of mints. The Shuangyang pharyngitis tablets are prepared by supercritical extraction and the content of bergenin is greatly improved.

The invention discloses a preparation method and application of a zinc germanate nanorod modified functionalized graphene composite material, which comprises the following steps: adding PDDA into GO dispersion liquid, after half an hour, adding GeO2 and Zn (CH3COO)2.H2O into the mixed liquid, and carrying out ultrasonic treatment on the mixed liquid for 1 hour to fully mix the GeO2 and the Zn (CH3COO)2.H2O; transferring into a reaction kettle, reacting for 24 hours under the condition of 200 DEG C, centrifuging, washing and drying an obtained reaction product to obtain Zn2GeO4-PDDA-GR nanocomposite material; dispensing 5[mu]L of Zn2GeO4-PDDA-GR dispersion liquid by using a pipette on the surface of the bare glassy carbon electrode and dried under an infrared lamp to obtain the nano sensorZn2GeO4-PDDA-GR / GCE. When the sensor is used for detecting bergenin in an actual sample bergenin tablet, the sensor has the advantages of high sensitivity, low detection limit and the like, and also has the characteristics of good selectivity, high reproducibility and stability.

The invention provides a bergenin osmotic pump tablet. The bergenin osmotic pump tablet is prepared by coating bergenin, a penetration enhancer and an auxiliary material suppressant tablet core with a controlled release film and punching, wherein the penetration enhancer is polyethylene oxide PEO and mannitol, the tablet core contains 8.3-37.5wt% of bergenin, 3.5-45wt% of polyethylene oxide PEO and 20-45wt% of mannitol. The invention also provides a preparation method of the bergenin osmotic pump tablet. The invention improves the solubility of a slightly soluble drug of the bergenin by utilizing a Beta-cyclodextrin inclusion technology, and further the bergenin is prepared into a single layer osmotic pump type controlled release tablet so as to decrease the drug release speed, reduce the dosage frequency, improve the bioavailability and greatly simplify the process; compared with the common bergenin tablet, the solubility of the prepared bergenin solid dispersoid osmotic pump tablet is obviously enhanced, and the drug is released according to a zero order release speed, and the blood drug level is more moderate and stable, thereby improving the bioavailability, enhancing the clinic curative effects, reducing the dosage frequency and increasing medicine-taking compliance of a patient so that the bergenin is applied more widely in medicine.

The invention discloses a medicine composition for treating pneumonia. The medicine composition is prepared from garlic, coptidis rhizomes, magnetite, Chinese siphonostegia herb, radix sophorae flavescentis, germacrone and bergenin according to a proportion. The medicine composition can be prepared into various dosage forms according to conventional preparation technologies and is significant in treatment effect when used for treating pneumonia.

The invention discloses a synergistic bio-composite insecticidal pesticide for gardening and a preparation method thereof. The pesticide is prepared from, by weight, 16-25 parts of extract liquid of euphorbia helioscopia, 8-14 parts of bergenin std., 6-11 parts of extract of pyrethrum cinerariifolium, 7-11 parts of attapulgite powder, 3-5 parts of sophora flavescens alkaloids, 4-7 parts of chili,2-6 parts of folium artemisiae argyi, 15-21 parts of euphorbia nematocypha, 7-12 parts of tea saponin, and 6-12 parts of pumpkin leaves. In the invention, by means of effective ratio of the extract liquid of euphorbia helioscopia, the bergenin std., the extract of pyrethrum cinerariifolium, the attapulgite powder, the sophora flavescens alkaloids, the chili, the folium artemisiae argyi, the euphorbia nematocypha, the tea saponin and the pumpkin leaves, the pesticide is produced. The preparation method is simple. The pesticide has significant effect of killing pests and has no residue, is freeof polluting soil, water source and crops, can be degraded in natural environment, is free of damage on human and animals and generation of drug resistance in pests, is prepared from natural raw materials and is toxic-free, and has good insecticidal effect when being directly applied to flowers.

The invention provides a method for extracting quercitrin and bergenin from herba ardisiae japonicae. The method comprises specific steps as follows: the herba ardisiae japonicae is crushed, ethyl ether is added for reflux extraction, filtration is performed, and a filtrate I and filter residues I are obtained; the filter residues I are added to a trichoderma fermentation broth and an aspergillusniger fermentation broth for fermentation, ethanol is added for reflux extraction, filtration is performed, and a filtrate II is obtained; the filtrate II is concentrated under reduced pressure and then mixed with methanol, the mixture is loaded on a macroporous resin column, elution is performed with methanol, and an eluate is obtained; the eluate is concentrated under reduced pressure and left to stand overnight at 4-8 DEG C, crystallization and recrystallization are performed, and pure bergenin and quercitrin are obtained.

The invention relates to the field of Chinese herbal medicine, in particular to an extraction method and an extraction system for bergenin. The extraction method includes placing medicinal material powders in an extracting tank, adding ethanol in the extracting tank, heating to enable effective components in the medicinal material powders to be dissolved in the ethanol, heating until the ethanol boils to obtain a mixture, filtering the mixture to obtain a first filter liquor, subjecting the first filter liquor to evaporation and concentration to obtain an extracting liquor and a first gas which has a major component of the ethanol, keeping a first filtering medium in the extracting tank, cooling the first gas to a first liquid, real-timely adding the first liquid in the extracting tank, subjecting the extracting liquor to recrystallization, performing centrifugal separation to obtain a bergenin crude product, and refining the bergenin crude product. The extraction system comprises a coarse extraction device and a refining device, and the coarse extraction device includes a first heating device, a circulating concentration extraction unit, a first recrystallization device and a first solid-liquid separation device. According to the extraction method and the extraction system for the bergenin, low cost and high efficiency production is achieved.

The invention belongs to the technical field of the research and development of medical products, relating to preparation of bergenin in aruneus dioicus. A preparation method comprises the steps of: pulverizing dried aruneus dioicus, soaking for 10-12 hours in 50 percent of alcohol, carrying out ultrasound for 1-1.5 hours with the temperature of 30 DEG C and the power of 80W, repeating 3 times, filtering by using gauze, merging filtrate, concentrating, blending and suspending by using water, sequentially extracting by using petroleum ether, ethyl acetate and n-butyl alcohol, concentrating the recovered extracting solvent to obtain four parts, dissolving an ethyl acetate part by using methanol, blending a sample by using silicagel, loading on a silicagel column, assembling the column by using chloroform, carrying out gradient elution by using chloroform-methanol, merging similar fractions, concentrating, further carrying out chromatography by using the silicagel column, merging similar fractions, concentrating, separating out crystal and obtaining a bergenin monomer by using a recrystallization method. The bergenin has the main effect of relieving a cough and eliminating phlegm, also has the effects of anti-inflammation, liver protection, anti-ulcer, immune improvement and the like and can be further used for the research and development of corresponding preparation products used for clinical applications.

The invention belongs to the field of building materials, and specifically relates to an antibacterial coating and a preparation method thereof. The antibacterial coating is prepared from the following main raw materials in parts by weight: lupeol, palmatine hydrochloride, coptisine, bergenin, citronellol, rutin, ursolic acid, nanometer Chlorite-schist powder, titanium dioxide, trimethylolpropane,hydrogenated castor oil and manganese acetate. According to the invention, the lupeol, the palmatine hydrochloride, the citronellol, the rutin and the ursolic acid with antibacterial effects are added into the antibacterial coating to improve antibacterial properties of the coating and reduce propagation of bacteria on the surface of the coating; and after the antibacterial coating is coated ontothe surface of a building which is in an environment with easy propagation of bacteria, the building is insusceptible to mildewing.

The invention provides Chinese astilbe herb ultra-fine powder decoction pieces which comprise Chinese astilbe herb ultra-fine powder and auxiliaries, and the particle size of the Chinese astilbe herb ultra-fine powder is smaller than or equal to 75 microns.The invention further provides a preparation method of the Chinese astilbe herb ultra-fine powder decoction pieces.The method includes the steps that 1, the Chinese astilbe herb decoction pieces are crushed and sieved, and a Chinese astilbe herb plus sieve component and a Chinese astilbe herb minus sieve component are obtained; 2, the obtained minus sieve component is subjected to superfine grinding, and the Chinese astilbe herb ultra-fine powder is obtained; 3, the Chinese astilbe herb ultra-fine powder is mixed with the auxiliaries, and the Chinese astilbe herb ultra-fine powder decoction pieces are obtained.According to the Chinese astilbe herb ultra-fine powder decoction pieces, the dissolution rate of the effective ingredient bergenin in Chinese astilbe herb ultra-fine powder particles is remarkably improved, the dissolution rate can reach 35.12 mg / g to the maximum, the problem that it is difficult to transfer main ingredients, particularly the bergenin in Chinese astilbe herbs is solved, and thus bioavailability of medical materials is improved.

The present invention is related to a novel gastroretentive swellable oral dosage form for sustained or delayed release of bergenin, a active constituent of Bergenia ciliata extract / fraction and a process for preparing the same wherein the extract is wet-granulated using excipients i.e. biodegradable polymers and / or non-biodegradable polymers alone or in combination, and the said granules are either filled into a capsule or compressed into a tablet. The said formulation comprising a granulated extract of bergenin-rich Bergenia ciliata with polymers has resulted in a sustained release of extract in the stomach over a period of 16-24 hrs. The said formulations are useful for the treatment of inflammatory diseases.

The invention discloses a B-crystal form of a compound of bergenin shown in a formula (I), a preparation method of a new crystal-form solid matter sample of the bergenin and a pharmaceutical composition containing a new crystal form of the bergenin, and discovers absorption and plasma drug concentration features of a new crystal-form solid matter of the bergenin in an organism after oral solid administration. The new crystal-form solid matter changes the absorption rate of active constituents of the original crystal-form solid drug in the organism, enhances the plasma drug concentration in the organism and strengthens the advantages of the drug in clinical disease treatment.

The invention discloses a crystal C form of the compound of bergenin shown in formula (I), a preparation method of the solid matter sample of the new crystal form of the bergenin, and a pharmaceutical composition containing the new crystal form of the bergenin. The invention finds the characteristics of absorption and blood concentration of the new crystal form solid matter of the bergenin in living organisms after solid oral administration. The new crystal form solid matter changes the absorption rate of the effective components of the original crystal form solid medicines in living organisms, enhances the blood concentration in the living organisms, and achieves the dominant prevention and cure effects of medicines in clinic disease treatment.