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Preparation and application of Shuangyang pharyngitis tablets

A technology of Houbi and Tong tablets, which is applied to medical preparations containing active ingredients, pharmaceutical formulas, plant raw materials, etc., can solve the problems of large dosage for patients, many impurities, rough process, etc., and achieve small dosage and reduced dosage , The effect of taking the dose without bitterness

Inactive Publication Date: 2014-05-21
滕邵玲
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the prior art, there is no report on the use of supercritical methods for the extraction and preparation of Shuangyanghoubitong granules, and there is no report on the application of Shuangyanghoubitong granules in the preparation of drugs for inhibiting the proliferation of anal sarcoma cells S-180 cells. However, the extraction of volatile oil and the method of decocting in water are rough and backward in technology, and there are many impurities, which lead to excessive dosage for patients and are inconvenient to take, which seriously affects the clinical application of this product.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Take 468.7g of wild tobacco leaves, 468.7g of sheep's ear chrysanthemum, 312.5g of short tea, 312.5g of goat's milk leaves, 312.5g of silkworm, 312.5g of nepeta, and 312.5g of mint. Goat milk leaves, silkworm, Nepeta, and mint are crushed into fine powder and added to CO 2 In the supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer to the total extraction solvent is 5%, the extraction pressure is 25MPa, the temperature is 40°C, and the CO 2 The flow rate is 2ml / g crude drug·min, the extraction time is 360min, and the supercritical extract is obtained. The supercritical extract is added to starch and 70% ethanol to make granules, dried, and compressed into 200 tablets, each weighing 0.5g.

[0028] After testing, the content of petracenin in the finished product is 17.5mg / tablet.

Embodiment 2

[0030] Take 468.7g of wild tobacco leaves, 468.7g of sheep's ear chrysanthemum, 312.5g of short tea, 312.5g of goat's milk leaves, 312.5g of silkworm, 312.5g of nepeta, and 312.5g of mint. Goat milk leaves, silkworm, Nepeta, and mint are crushed into fine powder and added to CO 2 In the supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer to the total extraction solvent is 4%, the extraction pressure is 30MPa, the temperature is 30°C, and the CO 2 The flow rate is 1ml / g crude drug min, and the extraction time is 400min to obtain a supercritical extract, which is added to starch and 70% ethanol to make granules, dried, and pressed into tablets to make 200 tablets, each weighing 0.5g.

[0031] After testing, the content of petracenin in the finished product is 15.2mg / tablet.

Embodiment 3

[0033] Take 468.7g of wild tobacco leaves, 468.7g of sheep's ear chrysanthemum, 312.5g of short tea, 312.5g of goat's milk leaves, 312.5g of silkworm, 312.5g of nepeta, and 312.5g of mint. Goat milk leaves, silkworm, Nepeta, and mint are crushed into fine powder and added to CO 2 In a supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer to the total extraction solvent is 6%, the extraction pressure is 20MPa, the temperature is 50°C, and the CO 2 The flow rate is 3ml / g crude drug·min, the extraction time is 300min, and the supercritical extract is obtained. The supercritical extract is added to starch and 70% ethanol to make granules, dried, and pressed into tablets to make 200 tablets, each weighing 0.5g.

[0034] After testing, the content of petracenin in the finished product is 10.8mg / tablet.

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PUM

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Abstract

The invention belongs to the technical field of traditional Chinese medicines and particularly relates to a preparation method of Shuangyang pharyngitis tablets and an application of the Shuangyang pharyngitis tablets to preparation of a cell proliferation medicine of anus sarcoma cells S-180. The Shuangyang pharyngitis tablets are prepared from the following bulk drugs: 468.7g of wild tobacco leaves, 468.7g of sheepear inula herbs, 312.5g of herba ardisiae japonicae, 312.5g of folium elaeagni, 312.5g of bombyx batryticatus, 312.5g of schizonepeta and 312.5g of mints. The Shuangyang pharyngitis tablets are prepared by supercritical extraction and the content of bergenin is greatly improved.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and relates to a preparation method and application of Shuangyanghoubitong Tablets, in particular to a preparation method of Shuangyanghoubitong Tablets and its use in the preparation of drugs for inhibiting the proliferation of anal sarcoma cells S-180 cells Applications. Background technique [0002] The standard number of Shuangyang Houbitong Granules is WS-10287 (ZD-0287)-2002, which is recorded in the Department of Ophthalmology, Otorhinolaryngology and Dermatology of the National Compilation of Chinese Patent Medicine Standards. Made from wild tobacco leaves 468.7g, sheep's ear chrysanthemum 468.7g, dwarf tea 312.5g, goat's milk leaves 312.5g, silkworm 312.5g, Nepeta 312.5g, and mint 312.5g as raw materials, it has the functions of clearing away heat and reducing phlegm, relieving cough and calming Breathing effect. It is used for sore throat caused by acute sore thro...

Claims

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Application Information

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IPC IPC(8): A61K36/81A61K9/20A61P35/00A61K35/64
Inventor 滕邵玲唐俊玲周建娣
Owner 滕邵玲
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