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Nepeta is a genus of flowering plants in the family Lamiaceae. The genus name is reportedly in reference to Nepete, an ancient Etruscan city. There are about 250 species. The genus is native to Europe, Asia, and Africa, and has also naturalized in North America.
Iridoid synthase mutants with improved specificity and activity and uses thereof
The application discloses a mutant of iridoid synthetase with improved specificity and enzyme activity and application thereof. The mutant of iridoid synthetase is obtained by mutation of wild-type iridoid synthetase NmISY2 derived from Nepeta mussinii. The mutant has higher catalytic activity to 8-oxogeranial, and the enzyme activity to geranial is obviously decreased. The ratio of the enzyme activity of the mutant to 8-oxogeranial and geranial is up to 293 times, which is greatly improved compared with the parent iridoid synthetase. The mutant can be used for heterologous synthesis and in-vitro synthesis of iridoid compounds and derivatives, and has a good application prospect.
Owner:ZHEJIANG UNIV