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45 results about "Riboflavin" patented technology

Riboflavin (vitamin B2) is used to prevent or treat low levels of vitamin B2 in people who do not get enough of the vitamin from their diet.

Degradable plastic quality release and demolding residue traceability management method

The invention discloses a degradable plastic quality release and demolding residue traceability management method, and relates to the technical field of quality release traceability, and the method comprises the following steps: 1, doping a fluorescent whitening agent European in a polylactic acid matrix to form an inner channel, attaching a polyvinyl alcohol witness sheet to the edge of a cavity, and presetting riboflavin to form an outer channel, establishing a dual-channel ultraviolet detection position; 2, collecting two paths of intensity, calculating a ratio coefficient, and establishing mapping with surface residues to form red, yellow and green threshold values and a correction list; 3, a workpiece is judged through a black box, spray volume, wind shear and mold temperature instructions are automatically given, a witness piece is separated from warm water and confirmed through a background, and meanwhile a cavity-level demolding event is generated and bound with the digital link two-dimensional bar code; and step four, third-party compliance files are archived in a ticket-folder manner with quantiles as reference to a reconvergence threshold value, so that mold-crossing and line-crossing consistent release and verifiable traceability are realized, and food contact and compostable boundaries are considered. And the release efficiency and stability are improved.
Owner:ANHUI YONGHE ECOLOGICAL ENVIRONMENT TECHNOLOGY CO LTD

Use of safflower honey, or safflower honey extract, in increasing adh and aldh activity

ActiveCN117730986Bpromote alcohol metabolismHave a hangover effectUnknown materialsAldehyde active ingredientsBiotechnologyEthanol dehydrogenase
This invention relates to the field of functional food technology, and more particularly to the application of safflower honey, or safflower honey extract, in enhancing the activity of alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH). The invention has found that safflower honey, or safflower honey extract, can effectively enhance ADH and ALDH activity, thereby promoting alcohol metabolism and achieving a hangover-relieving effect. Further research on the extract revealed that a mixture of syringaldehyde, riboflavin, lutein, luciferin, and three p-coumaroyl spermidine plays a key role in enhancing ADH and ALDH activity, thus providing an application of this mixture in hangover relief. The application of safflower honey and its extract provided by this invention has high application value for developing foods and health products with hangover-relieving effects.
Owner:AAFUD HERBS (XINJIANG) CO LTD

Escherichia coli strain with high yield of riboflavin and construction method and application thereof

PendingCN121896258ABacteriaHydrolasesBiotechnologyRiboflavin
The invention discloses an escherichia coli strain with high yield of riboflavin as well as a construction method and application of the escherichia coli strain. A series of Escherichia coli strains with high yield of riboflavin are constructed, the constructed Escherichia coli with high yield of riboflavin is safe and harmless, glucose is used as a substrate for fermentation under the aerobic condition of a shake flask, the yield of riboflavin is 1117.8 mg / L, 1330.1 mg / L, 1430.8 mg / L, 1508.7 mg / L and 1640.8 mg / L in sequence, and the yields are 112.5 mg / g of glucose, 134.1 mg / g of glucose, 146.3 mg / g of glucose, 158.8 mg / g of glucose and 168.1 mg / g of glucose in sequence; when the strain SN04M is subjected to fed-batch fermentation in a 1L fermentation tank, the yield of riboflavin reaches 8.52 g / L, and the total yield is 189.9 mg / g glucose. According to the invention, the fermentation yield of riboflavin and the substrate utilization rate of riboflavin to glucose can be obviously improved.
Owner:TIANJIN UNIV

Bacillus high-yield strain for producing riboflavin and application thereof

The invention provides a bacillus high-yield strain for producing riboflavin and application of the bacillus high-yield strain, and belongs to the technical field of microbial fermentation. The bacillus strain is named as VB2-M-230602-66, the preservation unit is China Center for Type Culture Collection, the preservation date is December 1, 2023, and the preservation number is CCTCC NO: M20232421; according to the invention, the strain VB2-M-230602-66 with stable character is obtained by adopting physical mutagenesis separation and combining with shake flask screening of tolerance dose of a resistance marker, riboflavin can be produced through liquid fermentation, and the yield is stable; the bacterial strain has the biological characteristics that the bacterial strain is gram-positive bacteria through gram staining, the bacteria are cultured at 37 DEG C for 18 hours, the thalli are rod-shaped, 0.5-0.8 mu m * 2.0-5.4 mu m and are arranged in a single or paired manner, and bacterial colonies cultured on a solid culture medium are pale yellow, nearly circular, wet in surface, opaque and irregular in edge; the bacillus strain VB2-M-230602-66 provided by the invention is suitable for fermentation production of riboflavin (vitamin B2), has stable production performance, can obtain greater economic benefits, and is worthy of popularization.
Owner:NINGXIA QIYUAN PHARMA

Preparation method of sediment micro-ecological reconstruction and pollutant targeted fixation conditioning agent

This application relates to the field of water pollution control technology and discloses a method for preparing a sediment microecological reconstruction and pollutant-targeted immobilization conditioner. The method includes: modifying mesoporous silica with amino- and thiolated compounds and mixing it with biochar to obtain an adsorbent material; dispersing ferrous sulfate, sodium thiosulfate, and hydroxyapatite with the adsorbent material in a sodium alginate solution and adding it dropwise to a calcium chloride solution for cross-linking and chitosan coating to obtain microcapsules; compounding riboflavin, humic acid, carbon source nutrients, and adding signaling molecules to obtain a metabolic enhancer; compounding metalloenzyme inhibitors and activating them with microorganisms to obtain an activator; granulating and coating calcium carbonate, magnesium hydroxide, ferrous sulfate, sulfur powder, calcium peroxide, and sodium lactate to obtain buffer particles; mixing the adsorbent material, microcapsules, and buffer particles, spraying, adding the metabolic enhancer and activator, adding binders and pore-forming agents, granulating, drying, sieving, and spraying a protective film to obtain the conditioner. This application solves the technical problems of existing sediment conditioners, such as single function, uncontrolled release, and microecological imbalance.
Owner:SOUTH CHINA INST OF ENVIRONMENTAL SCI MEP

Limosilactobacillus reuteri strain with high riboflavin production and uses thereof

ActiveUS12674188B2BiotechnologyMicrobiology
The present invention to the identification of a novel isolated bacterial strain, the Limosilactobacillus reuteri strain which is characterized by a naturally occurring overproduction of riboflavin (vitamin B2) compared to other known strains of lactobacilli. Said strain of the Limosilactobacillus species is deposited under accession number LMG P-32020. In a further aspect, also the uses of said L. reuteri strain are disclosed herein. In particular, the use of said strain in food and feed industry, human and veterinary health, large-scale vitamin production, cosmetics and consumer care products is disclosed.
Owner:UNIVERSITEIT ANTWERPEN

Method for preparing food-grade Janus particles based on confinement template synergistic sequential curing

The invention discloses a method for preparing food-grade Janus particles based on confinement template synergistic sequential curing. The method comprises the following steps: firstly, dissolving riboflavin and hydrogen peroxide in a zein solution to serve as a water phase, and dispersing in an oil phase to prepare zein droplets; meanwhile, preparing sodium alginate liquid drops by taking a sodium alginate solution as a water phase; and mixing the two liquid drops to construct the Janus liquid drop based on a liquid drop collision method. Subsequently, the zein compartment in the Janus droplet is cured by ultraviolet irradiation; and further mixing the sodium alginate with calcium chloride liquid drops to solidify the sodium alginate compartment in the Janus liquid drops to obtain the food-grade Janus particles. The particle size of Janus liquid drops is reduced to nanoscale through gradient energy input, and food-grade Janus nanoparticles are constructed by using a sequential curing strategy. The construction method of the food-grade Janus particles is easy to operate and high in yield, and has good application prospects in the fields of food, medicine, cosmetics and the like.
Owner:OCEAN UNIV OF CHINA

One-step photocured electrospun membrane material and preparation method thereof

PendingCN122358356AFiberMicro nano
This invention relates to the field of electrospun membranes, and more specifically to a one-step photocurable electrospun membrane material and its preparation method. The photocurable electrospun membrane material is prepared by mixing 5-20 parts of fiber-forming macromolecules, 10-40 parts of collagen, 0.05-3 parts of natural photosensitizer, and a solvent to form a spinning solution. Electrospinning is performed using either needle-type or non-needle-type methods. Simultaneously, the fibers are irradiated with 200-400 nm ultraviolet light in situ to achieve photocuring and cross-linking, thus obtaining a micro / nanofiber membrane in one step. The fiber-forming macromolecules are selected from biodegradable medical polymers, and the photosensitizers are biosafe components such as riboflavin and retinaldehyde. This invention completely solves the problems of uneven cross-linking, fiber morphology damage, collagen denaturation, and internal light filtering effects in traditional two-step methods. The resulting membrane has regular fiber morphology, uniform cross-linking, high mechanical strength, good water resistance, and complete retention of bioactivity. Furthermore, the process is simplified, complies with pharmaceutical quality management standards, and is suitable for medical applications such as tissue engineering and wound repair.
Owner:SUNNATECH SCI CO LTD

Preparation method and application of novel biomass carbon dots

PendingCN121735246ANanoopticsNano-carbonBiomass carbonMicrowave method
The invention discloses a preparation method and application of novel biomass carbon dots. The preparation method comprises the following steps: S1, adding apple branch powder into water, and uniformly mixing to obtain a mixed solution; and S2, putting the mixed solution obtained in S1 into a microwave oven for microwave treatment to obtain a reactant. S3, taking out reactants, cooling the reactants to room temperature, and adding water for centrifugal filtration treatment. And S4, collecting a supernatant obtained by treatment in S3, and purifying the supernatant. And S5, drying the purified product obtained in S4 to obtain the biomass carbon dots, and storing the prepared biomass carbon dots in an environment with a constant temperature of 4 DEG C for later use. Apple branches are used as precursors, the biomass carbon dots are synthesized through a microwave method, biocompatibility is good, toxicity is low, high-selectivity and high-sensitivity detection of Cr < 6 + > and riboflavin can be achieved, the synthesis process is economical, environmentally friendly, rapid, simple and convenient, and a new scheme is provided for the environment-friendly detection technology.
Owner:HEBEI NORMAL UNIVERSITY OF SCIENCE & TECHNOLOGY +1

Corneal cross-linking therapeutic drug delivery device

A device designed to assist in corneal cross-linking procedures. The device comprises a body portion having a top side and a bottom side, the latter characterized by a concave portion designed to be placed on the epithelium of the cornea to achieve a uniform pressure distribution. The device comprises a plurality of 50 micron high epithelium thorns on the bottom side, intended to create microperforations in the corneal epithelium when pressure is applied to the top side of the device. By creating these microperforations, the device helps to improve penetration of therapeutic agents, such as riboflavin, in corneal cross-linking procedures. The device is made of silica gel and is shaped like a contact lens, represents the innovative application of the microneedle technology in the ophthalmic field, and solves the key limitation related to the traditional drug delivery method leading to the eye.
Owner:马克洛巴诺夫

Dynamic membrane bioreactor, application thereof and selenium-containing wastewater treatment method

The invention belongs to the technical field of environmental treatment, and particularly relates to a dynamic membrane bioreactor, application thereof and a selenium-containing wastewater treatment method. The dynamic membrane bioreactor provided by the invention comprises a shell, a membrane assembly arranged in the shell and a filler dispersed in the shell, the membrane assembly comprises a porous support carrier and a dynamic biological membrane covering the surface of the porous support carrier; the filler comprises a carbon nanotube and / or immobilized riboflavin, and the immobilized riboflavin comprises an acidified carbon nanotube and riboflavin grafted on the surface of the acidified carbon nanotube. The reactor provided by the invention can slow down the pollution of the membrane module and prolong the efficient and stable operation period of the dynamic membrane bioreactor.
Owner:GUILIN UNIV OF ELECTRONIC TECH

Formula of organic mixed health-care beverage and preparation method of organic mixed health-care beverage

PendingCN121730369AMilk substitutesBiotechnologyPyridoxine
The invention discloses a formula of an organic mixed health-care beverage and a preparation method of the organic mixed health-care beverage. The raw materials comprise, by weight, 1-3 g of ginseng, 1-3 g of deer-horn glue, 2-5 g of folium cortex eucommiae, 2-5 g of gynostemma pentaphylla, 2-5 g of hawthorn, 2-5 g of ligusticum wallichii, 1-3 g of schisandra chinensis, 3-5 g of rhizoma polygonati, 2-5 g of radix ophiopogonis, 100-200 mg of algal oil, 200-300 mg of taurine, 150-200 mg of grape seed extract, 3-5 ml of perilla seed oil, 50-80 ml of yoghourt, 30-50 ml of walnut juice and 30-50 ml of peanut liquid. The selenium-enriched beverage is prepared from 30 to 50 milliliters of sweet almond liquid, 30 to 50 milliliters of black sesame liquid, 30 to 50 milliliters of mango juice, 50 to 100 milliliters of apple juice, 30 to 50 milliliters of tomato juice, 50 to 80 micrograms of selenium-enriched yeast, 25 to 50 milligrams of vitamin C, 125 to 25 milligrams of vitamin E, 0 to 15 milligrams of vitamin B1 {thiamine}, 15 milligrams of vitamin B2 {riboflavin}, 0 to 15 milligrams of vitamin B2 {pyridoxine}, 15 milligrams of vitamin B6 {pyridoxine}, 25 milligrams of vitamin B9 {folic acid}, 40 micrograms of vitamin B9 {folic acid}, and 0 to 75 milligrams of vitamin B12 {cobalamin}. After being taken by various people for a period of time, the health-care food is smooth and delicious in taste and free of adverse reaction through evaluation in multiple aspects, and the health-care effect and feeling state of the health-care food are better than those of the prior art. And the health-care tea is suitable for a wide range of people, is beneficial to market promotion, and enables more people to achieve the health-care effect of preventing diseases before diseases.
Owner:韩荣辉

Silk fiber material, preparation method and application

PendingCN121593333ADe-gumming silkLight/infra-red/X-rays fibre treatmentPolymer scienceCell adhesion
The invention relates to the technical field of silk fiber materials, and discloses a silk fiber material and a preparation method and application thereof.The preparation method comprises the steps that degummed fibroin fiber serves as a matrix, and the degummed fibroin fiber is mildly modified through genipin-mediated chemical crosslinking or riboflavin-mediated photo-crosslinking or the combination of genipin-mediated chemical crosslinking and riboflavin-mediated photo-crosslinking; the modified degummed fibroin fiber shows excellent cell adhesion and proliferation performance, the biocompatibility is remarkably improved, meanwhile, the excellent mechanical property of natural silk is reserved, and the degummed fibroin fiber is suitable for various biomedical application scene requirements; and the modified degummed fibroin fiber also has fluorescence luminescence characteristics obviously different from those before modification, and is beneficial to visual positioning and monitoring in specific application scenes. The method can be compatible with an existing textile process, and has popularization and application values.
Owner:NORTH SICHUAN MEDICAL COLLEGE

Culture medium, culture method and application of mouse hepatic sinus vascular endothelial cells

The invention discloses a culture medium, a culture method and application of mouse hepatic sinus vascular endothelial cells. Belongs to the technical field of cell culture. Components of the culture medium are optimized, in the aspect of growth factors, conventional VEGF / bFGF combination is broken through, liver cell growth factors and platelet-derived growth factors are creatively compounded with the growth factors, cell proliferation is driven, and liver-derived specific phenotypes and functional integrity of LSEC are maintained. An anti-oxidation system composed of N-acetylcysteine, ascorbic acid, alpha-tocopherol and riboflavin is constructed, active oxygen is synergistically removed through multiple mechanisms, and the activity and stability of cells in long-term culture are improved. Sodium pyruvate is additionally supplemented as an energy substrate, and taurine, glycine and other specific amino acids simulating the intrahepatic microenvironment provide energy and nutritional support for cell proliferation, and promote function maintenance. The efficient and stable in-vitro amplification and function maintenance of the LSEC are realized, and a solid foundation is laid for constructing a high-fidelity LSEC model.
Owner:INST OF BIOMEDICAL ENG CHINESE ACAD OF MEDICAL SCI

A system and method for applying acoustic wave therapy through epithelia

PCT designated stageWO2026089948A1Ultrasound therapyLaser surgeryEpitheliumShock wave
This disclosure provides methods, devices, and systems for treating biological tissue. The present implementations more specifically relate to techniques for applying acoustic wave therapy through an epithelium. In some aspects, an ophthalmic treatment apparatus may include an interface and an acoustic wave emitter. The interface is configured to provide fluid to an epithelium and the acoustic wave emitter is configured to generate acoustic waves in the fluid that radiate toward tissue for treatment under the epithelium. Example suitable acoustic waves include shock waves and / or cavitation waves. In some implementations, the fluid may include a riboflavin solution. In some implementations, the acoustic waves may be emitted via one or more spark gaps formed by one or more conductors wound around a shaft.
Owner:SHOCKWAVE MEDICAL INC

Umbilical cord mesenchymal stem cell with high expression of PD-L1, culture method and application of umbilical cord mesenchymal stem cell and method for promoting expression of PD-L1 through in-vitro energization

The invention relates to the technical field of cell biomedicine, in particular to umbilical cord mesenchymal stem cells with high PD-L1 expression, a culture method and application of the umbilical cord mesenchymal stem cells and a method for promoting PD-L1 expression through in-vitro energization. The umbilical cord mesenchymal stem cell in-vitro energizing inducer is based on a DMEM / F12 culture medium containing 3%-7% of human platelet lysis buffer, and further comprises the following components: a tumor necrosis factor alpha, interferon gamma, human serum albumin, transferrin, insulin, riboflavin, N-acetylcysteine and a vascular endothelial growth factor. The in-vitro energizing inducer reduces the content of a stimulating factor tumor necrosis factor alpha and interferon gamma, reduces immunogenicity abnormity caused by TNF-alpha, remarkably improves PDL1 expression and provides a basis for inflammation treatment. The influence of long-time stimulation on cell functions and activity is remarkably reduced through short-time factor-induced stimulation.
Owner:CHONGQING RUISHIKANG BIOMEDICINE CO LTD

Solid composition containing bromhexine

The present invention provides a solid composition comprising the following components: (a) bromhexine or a salt thereof; (b) a nonionic surfactant; and (c) a compound selected from the group consisting of vitamin antioxidants, phenolic antioxidants, meloxicam, and acetaminophen (wherein R1 represents a hydrogen atom or a hydrogen atom). The pharmaceutical composition does not contain ibuprofen, clemastine fumarate, dihydrocodeine phosphate, noscapine, racemic methyephedrine hydrochloride, anhydrous caffeine, bromhexine hydrochloride, tranexamic acid, riboflavin, benfotiamine, ascorbic acid, hesperidin, D-mannitol, low-substitution-degree hydroxy propyl cellulose, crystalline cellulose, hydroxy propyl cellulose and polyoxyethylene hydrogenated castor oil 60, and the pharmaceutical composition can be used for preparing the pharmaceutical composition. The invention relates to a solid composition of hydroxypropyl methylcellulose, talc, hydroxy propyl cellulose and light anhydrous silicic acid.
Owner:DAIICHI SANKYO HEALTHCARE

Weight management composition

The invention provides a method of promoting weight management in a mammal comprising administering to the mammal a composition comprising at least one weight loss agent and at least one mitochondrial enhancer. The weight loss agent can be selected from the group consisting of psyllium, guar gum, capsaicin, chitosan, caffeine, gamboge, mume, capsaicin, yohimbine, butterfly pea, glucomannan, African mango, guarana, pyruvate, carnitine, beta-glucan, fucoxanthin, raspberry ketone, white kidney bean, kola nut, chromium, ginseng, psyllium, St. John's wort, dandelion, hydroxycitric acid, conjugated linoleic acid, green tea, black tea, coffee bean extract, forskolin, and bitter orange. The mitochondrial enhancer can be selected from the group consisting of beetroot extract, nitrate, idebenone, nicotinamide riboside, elamipretide, vitamin C, vitamin D, vitamin E, thiamine, riboflavin, magnesium, calcium, phosphate, phospholipid, creatine, pyruvate, coenzyme Q10, NADH, niacin, L-carnitine, dichloroacetate, curcumin, schisandrin, and resveratrol. Compositions for weight management are also provided.
Owner:ASERKIN CO LTD

Small-molecule protein environment air disinfecting and deodorizing preparation and application thereof

ActiveCN121797080BBiocideGas treatmentActive agentSodium ascorbate
The present application relates to the technical field of environmental purification and odor removal, and discloses a small-molecule protein environmental air disinfection and odor removal preparation and application thereof.The preparation is made of core protein components, sodium citrate, sorbitol, an anti-browning agent, L-sodium ascorbate, riboflavin, cyclodextrin or cyclodextrin derivatives, a surfactant, a preservative and deionized water, wherein the core protein components are enzymatic products with a molecular weight less than or equal to 20 kDa, and the preparation is prepared by establishing an anti-browning buffer environment, dissolving functional components, slowly adding the core protein components to make them disperse and dissolve, and finally adjusting the pH value and setting the volume.The core protein components with a molecular weight less than or equal to 20 kDa have more active sites, and can enhance the capture and combination capacity with indoor air chemical pollutants, and can act on bacterial cell structures or virus activity, so as to realize the multifunctional air purification effect of pollutant removal and biological disinfection and inactivation.
Owner:ZHEJIANG FUSKAI BIOTECHNOLOGY CO LTD

A controlled removal and rapid identification method for chromium(VI) ions in vanadium(V) aqueous solution

This invention belongs to the field of fine chemical synthesis and solution separation and purification, and relates to a method for the controllable removal and rapid identification of chromium(VI) ions in vanadium(V) aqueous solutions. Utilizing a macroporous organic adsorbent, chromium(VI) ions are continuously adsorbed through multiple contact-separation processes under non-equilibrium conditions at low pH to achieve controllable removal of chromium ions, thereby increasing the vanadium-chromium ratio in the solution and improving the purity of the vanadium product. Then, biodegradable riboflavin is used as a probe, and ultraviolet spectroscopy is employed to rapidly identify the remaining chromium(VI) ions in the vanadium(V) aqueous solution. This method achieves high chromium removal efficiency; by controlling appropriate chromium removal conditions, controllable purification can be achieved, providing technical support for online monitoring and intelligent production.
Owner:DALIAN UNIV OF TECH +1

Dynamic carbon accounting method for biological fermentation of vitamins and application of dynamic carbon accounting method

The invention provides a dynamic carbon accounting method for biological fermentation of vitamins and application of the dynamic carbon accounting method, and belongs to the technical field of carbon emission control. Comprising the following steps: constructing a dynamic carbon balance equation of biological fermentation vitamins to track input, conversion and output of carbon elements in a fermentation tank in real time; establishing a detection sensor matrix to collect process data corresponding to each parameter in the equation in real time; a long-short-term memory network model is trained based on historical fermentation batch data, input quantities comprise dissolved oxygen, pH, oxygen uptake rate and feeding rate which are collected in real time, and output is real-time carbon conversion efficiency; in the fermentation process, various parameters in the equation are calculated by using process data collected by a detection sensor matrix, and the calculated value of the fixed carbon amount of riboflavin carbon synthesis in unit time is dynamically corrected by using the real-time carbon conversion efficiency output after model training, so that the corrected riboflavin carbon generation rate is obtained. According to the invention, the dynamic correction of the carbon conversion efficiency is realized, and the real-time performance and precision of carbon accounting are improved.
Owner:CHINA UNIV OF MINING & TECH (BEIJING) +2

Construction method of meibomian gland dysfunction animal model and animal model

The invention discloses a meibomian gland dysfunction animal model construction method and an animal model, the construction method comprises the following steps: 1, animal anesthesia: adopting an inhalation anesthesia mode to carry out general anesthesia, and keeping eyelids in a slightly closed state; step 2, eye anesthesia: performing surface anesthesia on the left eye and / or the right eye of the animal to serve as a tested eye; step three, meibomian gland collagen crosslinking: applying riboflavin mixed liquid to the eyelid margin of the tested eye, then irradiating the eyelid margin with 365nm ultraviolet light to induce meibomian gland dysfunction, and placing for 7-10 days; and 4, repeating the operation process in the step 3 to obtain the meibomian gland dysfunction animal model. According to the method, the meibomian gland collagen crosslinking technology that the riboflavin and hydrogen peroxide mixed solution is smeared on the eyelid margin and the 365nm ultraviolet light irradiates the eyelid margin is utilized to induce meibomian gland dysfunction, the modeling time is short, and the operation is simple.
Owner:西安市人民医院(西安市第四医院)

Composite bag for improving wooden meat of broiler chickens and preparation method and application of composite bag

The invention discloses a compound bag for improving wooden meat of broiler chickens as well as a preparation method and application of the compound bag, and belongs to the field of animal feed additives. The compound bag is prepared from the following components in parts by mass: 100 to 150 parts of a humic acid copper chelate, 200 to 300 parts of a humic acid iron chelate, 200 to 300 parts of a humic acid manganese chelate, 150 to 200 parts of a humic acid zinc chelate, 50 to 100 parts of a humic acid cobalt chelate, 50 to 100 parts of a humic acid selenium chelate, 1 to 2 parts of vitamin E, 5 to 10 parts of vitamin C, 1 to 2 parts of nicotinamide, 1 to 2 parts of riboflavin, 1 to 2 parts of thiamine and 100 to 150 parts of a carrier. The prepared compound bag has the effects of humic acid and trace elements, and the humic acid can activate feed absorption, resist bacteria and diminish inflammation, astringe and stop diarrhea, treat nutritional diarrhea and protect intestinal health; trace elements and vitamins can meet the growth requirements of the broiler chickens, resist oxidative stress and improve the immunity; humic acid chelation can change the trace element absorption form and improve the trace element utilization rate. And the occurrence rate of the wooden meat of the broiler chicken is controlled below 2%.
Owner:SHANDONG ASIA-PACIFIC HIGHVARVE ORGANISMS SCI & TECH CO LTD +3

A medium additive for mesenchymal stem cells and use thereof

This invention relates to the field of cell culture technology, and more particularly to a culture medium additive for mesenchymal stem cells and its application. The culture medium additive of this invention, using water as a solvent, comprises the following components at the following concentrations: 0.5-1.5 mg / L rhTXNDC5 protein, 10-20 mg / L vascular endothelial cadherin 5, 10-20 mg / L vascular endothelial cadherin 11, 10-20 mg / L recombinant human long-acting insulin-like growth factor-1, 400-600 mg / L dextran, 200-400 mg / L riboflavin, 300-500 IU / L superoxide dismutase, 10-20 mg / L ethanolamine, and 1-3 mg / L progesterone. Adding this culture medium additive to serum-free culture medium can increase the yield of mesenchymal stem cells and accelerate the emergence time of umbilical cord mesenchymal stem cells.
Owner:CHONGQING RUISHIKANG BIOMEDICINE CO LTD

Storage solution including an aqueous culture medium and methods of preservation of live allografts

A live tissue storage solution is formed of an aqueous culture medium including additives, inorganic salts and nutrients. The additives preferably include amino acids including but not limited to L-Arg, L-Cys, Gly, L-His, L-Ile, L-Lys, L-Leu, L-Met, L-Phe, L-Ser, L-Try, L-Try, and L-Val. The inorganic salts preferably include calcium chloride, sodium chloride, magnesium sulphate, sodium bicarbonate, sodium phosphate. The nutrients preferably include glucose, choline, folic acid, nicinamide, riboflavin, which are known to maintain cell culture. Examples include Dulbecco's Modified Eagle Medium DMEM or Minimal Essential Medium MEM with or without serum. The culture medium contains additives to reduce, inhibit, or mitigate lipid oxidation, lipotoxicy, lipid-induced responses, and lipid inflammation.
Owner:RESTORATION BIOLOGICS LLC

Oral composition for Anti-inflammation in aging tissues

PCT designated stageWO2026134296A1Cosmetic preparationsAntipyreticQuercitrinPyridoxine
The main purpose of the present inventors is to provide a technique for suppressing inflammation, in particular, in aging tissues within the oral cavity. The present inventors have found that an oral composition containing at least one selected from the group consisting of β-glycyrrhetinic acid, glycyrrhizic acid, ascorbic acid, tocopherol nicotinate, tocopherol acetate, pyridoxine, cobalamin, retinol, retinol acetate, riboflavin, phylloquinone, calciferol, anthraquinone, menaquinone-4, and L-aspartic acid, and chemically acceptable salts thereof, quercetin, genistein, fisetin, nobiletin, kaempferol, apigenin, and naringenin, and glycosides thereof, and methyl hesperidin can suppress inflammation, in particular, in aging tissues within the oral cavity.
Owner:SUNSTAR INC

A method of promoting advanced glycosylation end product formation

The application relates to a method for promoting generation of advanced glycation end products, comprising the following steps: preparing a reaction solution by mixing proteins, reducing sugar and riboflavin in a buffer solution; making the reaction solution undergo photo-thermal synergistic reaction to obtain a solution rich in the advanced glycation end products; and monitoring the generation amount of the advanced glycation end products by using fluorescence spectroscopy during the reaction process. The application uses the natural photosensitizer riboflavin to produce active ingredients under light conditions, accelerates the glycosylation reaction of bovine serum albumin and glucose, and effectively solves the problem of slow generation rate of the advanced glycation end products under normal temperature conditions.
Owner:HEBEI ACADEMY OF AGRI & FORESTRY SCI INST OF GENETICS & PHYSIOLOGY

Method for preparing benzoic acid through selective cracking of polystyrene in field of waste plastic recovery

The invention discloses a method for preparing benzoic acid through selective cracking of polystyrene in the field of waste plastic recovery, and belongs to the technical field of benzoic acid preparation. The method comprises the following steps: adding waste plastics, riboflavin tetraacetate, scandium trifluoromethanesulfonate and an additive into a solvent, and stirring in room-temperature air under the irradiation of a blue LED to obtain a mixture; and continuing to add riboflavin tetraacetate, scandium trifluoromethanesulfonate, thiourea and a solvent into the mixture, continuing to stir in room-temperature air under the irradiation of a blue LED, and adding an internal standard agent to remove the solvent to obtain benzoic acid. The method is mild in condition, green, efficient, high in substrate compatibility, capable of treating high-molecular-weight polystyrene and mixed waste plastics, outstanding in selectivity, capable of achieving gram-level conversion and excellent in yield, and lays a foundation for industrial application.
Owner:TIANSHUI NORMAL UNIV