The invention relates to the field of chemical engineering and provides a method for optimizing chemical intermittent production operation. The method comprises the steps of running state detection, production and detection data acquisition, comparison and judgment, operation parameter acquisition, operation parameter curing and the like. The invention further provides a chemical intermittent production operation system, a chemical production device, an intermittent production optimization system and a quality detection system. The intermittent production optimization system comprises a running state detection module, a data acquisition and storage module, a data query module, a data curing module and the like. The invention further provides an intermittent batch production control method for production control by taking a batch as a unit. After the original information islands, i.e., 'process operation data' and 'product quality inspection data', are organically combined based on a real-time database technology, the chemical intermittent production operation method is optimized, automatic reaction initiation is realized based on an optimum operation parameter, the product quality is guaranteed, and the production efficiency is improved.