The invention discloses comprehensive nutrition powder and a preparation method thereof. The comprehensive nutrition powder is characterized by comprising the following raw materials: vitamin B1, vitamin B2, vitamin B6, pantothenic acid, vitamin B12, vitamin C, vitamin A, vitamin K, vitamin D, vitamin E, biotin, folic acid, calcium, magnesium, iron, zinc, selenium, chromium, copper, manganese, corn fiber flour, inulin, soy isolate protein powder, black bean peel extract, Agaricus blazei Murill extract, soya bean lecithin, phaseolus calcaratus extract, L-carnitine, beta carotene, lycopene, citrus extract, vanadium, acerola cherry extract, grape seed extract, maltodextrin, essence, aspartame and acesulfame. The comprehensive nutrition powder refers to a rich nutrition food which is researched directionally, can be highly matched with low sugar diet and fitting exercise to form a conditioning scheme which specially aims at treating obesity and three highs, can achieve a comprehensive and obvious rehabilitation effect of weight loss and reduction of three highs, and is easy to popularize in a large scale.