80 results about "Colostrum" patented technology

The invention provides a polypeptide, and the sequence of the polypeptide is AEDVGDVAFVKNDT. The polypeptide provided by the invention can inhibit the human respiratory syncytial virus surface protein F so as to inhibit the fusion of the human respiratory syncytial virus surface protein F and a host cell membrane. The invention also provides the sheep colostrum. The sheep colostrum comprises the polypeptide with the antiviral function, so that the sheep colostrum is helpful for old people with relatively weak resistance to resist infection of human respiratory syncytial viruses and promotes repair of respiratory mucosa. The invention also provides a preparation method of the sheep colostrum. The preparation method is simple and can be used for industrial production. The invention also provides a preparation method of the polypeptide.

The invention provides modified milk powder capable of promoting bone health as well as a preparation method and application of the modified milk powder. The total protein content of the modified milk powder is 17-35 g / 100 g, the fat content of the modified milk powder is 1-32 g / 100 g, and the calcium content of the modified milk powder is 0.8-2.1 g / 100 g. Moreover, the modified milk powder contains bovine coloctrum and lactoferrin, the mass ratio of the bovine coloctrum to the lactoferrin is (5-100): 1 on the basis of the dry matter content, and the content of the lactoferrin in the modified milk powder is 2-400 mg / 100 g. The bovine colostrum and the lactoferrin are combined for preparing the milk powder, have a synergistic effect on promoting osteoblasts and inhibiting osteoclast proliferation, and are beneficial to bone health.

The invention discloses an enzymolysis preparation method of high-immunocompetence bovine coloctrum peptide, active peptide and application thereof, and belongs to the field of biotechnology and functional foods.The enzymolysis preparation method is characterized by comprising the steps that bovine coloctrum is degreased, trehalose is added into obtained supernate, first stirring is conducted, and first mixed liquid is obtained; wherein the supernate comprises whey protein and Ig; adding medium protease into the first mixed solution for hydrolysis to obtain enzymatic hydrolysate; wherein the enzymatic hydrolysate comprises a mixture of bovine colostrum hydrolyzed peptides, the Ig activity retention rate is larger than or equal to 90% through the targeted protection and directional enzymolysis technology, the beta-lactoglobulin peptide with the synergistic immune enhancement effect is obtained, the Ig and small molecule peptides in the product have the synergistic effect, the body immune regulation capacity and the intestinal immune function are remarkably improved, the immunity of the human body is improved, and the immunity of the human body is improved. The method can be widely applied to the fields of infant formulas, postoperative nutrition, functional drinks and the like.

The invention provides a bovine colostrum probiotic compound preparation as well as a preparation method and application thereof. The compound preparation provided by the invention comprises the bovine colostrum powder subjected to activity protection and the compound probiotics, and the bovine colostrum powder subjected to activity protection is obtained by adopting a microcapsule double-layer embedding and freeze-drying technology, so that the gastric acid retention rate (2h) of immune globulin in the bovine colostrum powder is greater than or equal to 90%, and IgG contained in the bovine colostrum powder is ensured to be efficiently delivered to intestinal tracts to play an immune regulation role. Wherein the compound probiotics comprise four stages of functional echeles formed by more than or equal to 6 strains, and the four stages of functional echeles comprise colon colonization major flora, gastric acid-resistant pioneer flora, antibacterial peptide secretion auxiliary flora and inflammation regulation backup flora. Through cooperation of the components in the compound preparation, the compound preparation has excellent immune enhancement and metabolic regulation functions.

The application discloses an Akkermansia muciniphila branched-chain amino acid metabolism gene nifJ and application thereof in colostrum IgA synthesis, and belongs to the technical field of genetic engineering. The application finds through in-vivo and in-vitro tests that the nifJ is a branched-chain amino acid metabolism gene of the Akkermansia muciniphila, regulates the metabolism process from branched-chain amino acids to branched-chain short-chain fatty acids, and plays a key role in the synthesis of maternal colostrum IgA. The research result of the application is expected to clarify the interaction relationship between the metabolic function of the Akkermansia muciniphila and a host, and reveal the action mechanism of the Akkermansia muciniphila in regulating the synthesis of maternal colostrum IgA, thereby providing a theoretical basis for improving the maternal colostrum IgA and further improving the maternal reproductive performance.

This invention provides a bovine colostrum IgG nutritional supplement gummies and their preparation method, belonging to the field of functional food technology. The bovine colostrum IgG nutritional supplement gummies of this invention, through precise formulation of specific components, effectively improve the dispersion uniformity of whole-fat bovine colostrum freeze-dried powder in the gummy base, significantly retaining the activity of immunoglobulin G, giving the product a stable texture and good taste; further, combined with a special process adapted to the formula, high yield and high raw material utilization are achieved in industrial production. This product combines immune nutritional supplementation with convenient consumption, making it suitable for people of all ages and possessing good market application prospects.

This invention relates to the field of pet care product technology, and discloses a pet oral care spray and its preparation method. The preparation method employs a low-temperature gradient stepwise dissolution process: glucose oxidase is pre-dissolved at low temperature to obtain pre-solution A; bovine colostrum powder and lactoferrin are dissolved at low temperature to obtain protein pre-solution B; honey, folic acid, and vitamin D3 are dissolved at room temperature to obtain excipient pre-solution C; lysozyme is added to protein pre-solution B and stirred to dissolve; then pre-solution A and excipient pre-solution C are combined sequentially, the pH is adjusted, and purified water is added to make up the volume; the mixture is filtered through a microporous membrane for sterilization, and then filled and sealed under inert gas protection. This preparation method effectively protects the biological activity of each active protein and enzyme, achieving a long shelf life without the need for additional chemical preservatives. The resulting spray does not contain irritating ingredients such as alcohol and menthol, and is suitable for improving stomatitis, inhibiting plaque and tartar, and alleviating halitosis in pets of all ages and breeds.

The utility model discloses colostrum pasteurization machine, its technical scheme main points are: including: the placement box, the inside movable installation of placement box has the protective cover, and the bottom surface of protective cover has established two placement grooves, ultraviolet disinfection lamp, ultraviolet disinfection lamp fixedly connected in the inside of placement groove, heating component, heating component sets up in the inside of placement box, when the inside of placement box is in to the colostrum pasteurization machine disinfection after, at this time staff through using clean water to clean the inside of placement box, to this avoid colostrum residual liquid to adhere to the inner wall of placement box, when the inside of placement box is cleaned, start ultraviolet disinfection lamp again, so that ultraviolet disinfection lamp can carry out sterilization and disinfection to the microorganism and bacteria of the inside of placement box, avoid the microorganism and bacteria in clean water to adhere to the inside of placement box, influence subsequent pasteurization effect and nutrient composition, when the rotating rod drives several stirring vane to rotate, at this time several stirring vane can even mix the colostrum in the inside of placement box.

The invention discloses a primer pair of an SNP (Single Nucleotide Polymorphism) molecular marker related to the concentration of porcine colostrum immunoglobulin IgA (Immunoglobulin A) and application of the primer pair. According to the invention, the SNP marker which is extremely remarkably related to the IgA concentration of the porcine colostrum immunoglobulin is positioned at the 74703937th site of the No.16 chromosome of a porcine reference genome. The invention reveals that the SNP site has an obvious additive effect, that is, the colostrum IgA concentration of a favorable homozygote (GG) is obviously higher than that of a heterozygote (TG), and the heterozygote is obviously higher than that of an unfavorable homozygote (TT) (GG > TG > TT). The genetic characteristic means that in breeding practice, the frequency of G allelic genes is improved through continuous breeding, the colostrum quality of pig herds can be continuously improved, meanwhile, the optimal colostrum IgA phenotype and progeny disease resistance can be obtained by establishing a homozygous core group of the GG genotype, and the method has extremely high breeding upper limit and application value.

The utility model discloses a drying machine for bovine colostrum powder production, and relates to the technical field of drying machines. Comprising a drying main body, the drying main body is provided with a processing mechanism used for drying bovine colostrum powder production, the processing mechanism comprises a stirring assembly, an air feeder is turned on, the air feeder feeds air into an electric heater, the air is heated by the electric heater into hot air, and the hot air enters an arc pipe; then the hot air is evenly blown into all parts of the drying body through the vertical pipes and the nozzles evenly distributed on the arc pipes, when the vertical shafts rotate, the top ends of the vertical shafts drive the fan blade plates to rotate, and the hot air fed into the drying body through the nozzles flaps downwards through the fan blade plates, so that the hot air is better dispersed in the drying body; and the drying efficiency and uniformity are further improved, it is ensured that all parts of the materials can be subjected to the uniform hot air effect, the problem of local overheating or insufficient drying is solved, and the drying efficiency is improved.

The utility model relates to the technical field of drying devices, in particular to a colostrum immunoglobulin low-temperature drying device which comprises an upper-section tower body, and an extension drying assembly is arranged on the inner side of the upper-section tower body. The extended drying assembly comprises a spiral flow guide plate fixedly connected with the top of the inner wall of the upper-section tower body, and flow equalizing holes are formed in the inner side of the spiral flow guide plate. According to the utility model, through the arrangement of the extended drying assembly, irregular eddy current of the upper section of the tower body is converted into stable spiral airflow, the droplet retention time is prolonged, and the diversion cone forcibly divides central airflow, forces the airflow to deflect towards the tower wall, eliminates the short circuit phenomenon of the central airflow, and prolongs the droplet retention time; and through the arrangement of extending the drying assembly again, the flow guide cone and the annular spoiler jointly form a spiral airflow track, the fogdrop bypassing distance is increased, the Venturi effect is generated through the through hole gradual shrinkage type hole channel design, and turbulent mixing is enhanced while the airflow speed is reduced.

A colostrum collection device includes a lower funnel-shaped component and an upper bulb component integrated with the lower funnel-shaped component. The colostrum collection device also includes a cap for sealing the lower funnel-shaped component. The colostrum collection device may be attachable to a T-shaped adapter.

Provided are compositions and methods for alleviating symptoms or treating gluten-related diseases. In some embodiments, the compositions include colostrum from cows that are immunized with gluten or partially digested gluten.

The utility model provides an auxiliary feeding device for discarding small pandas, which comprises a young panda breeding box, a partition plate is arranged in the young panda breeding box, and a food luring trough is arranged in a female panda room and is arranged at the upper part of the partition plate; a through hole is formed in the partition plate and corresponds to the breast of a female animal; a fixing device is further arranged in the female animal chamber and comprises a fixing plate, the fixing plate is slidably mounted in the female animal chamber and provided with a push-pull assembly, and one end of the push-pull assembly extends out of the female animal chamber. According to the utility model, the breast of the female animal is exposed in the through hole by utilizing food, and the female animal is kept in the posture through the fixing device, so that an opportunity of directly contacting with colostrum is created for the discarded baby of the small panda, the discarded baby of the small panda can obtain the colostrum, and the feeding success rate of the discarded baby of the small panda is effectively improved.

The invention discloses application of an SNP (Single Nucleotide Polymorphism) marker influencing the colostrum yield of sheep in a PTPRK gene. The marker is located on a PTPRK gene of a sheep chromosome 8, the specific SNP marker site is C / T base mutation at the 488 bp position of SEQ ID NO: 1 in a sequence table, and the colostrum yield of TT and CT genotype sheep individuals at the site is remarkably higher than that of CC genotype individuals. Hu sheep is used as a research object, PCR is used for amplifying a DNA sequence of an eighth exon of a sheep PTPRK gene, the sequence has an SNP variation site, the colostrum yield of a specific genotype Hu sheep individual at the variation site is analyzed, and the Hu sheep individual is selected and reserved for breeding according to the colostrum yield, so that excellent individuals with high colostrum yield are rapidly screened, the breeding process of a high colostrum yield population is accelerated, and the breeding efficiency of the sheep PTPRK gene is improved. A marker resource is provided for marker-assisted selection breeding of the colostrum yield of the sheep.

This invention discloses a composition with bone-health-promoting functions and its applications, belonging to the field of microbial engineering. The composition comprises milk calcium, colostrum basic protein, and Bifidobacterium breve i1088 powder. The composition provided by this invention, which has a synergistic effect between milk calcium, colostrum basic protein, and Bifidobacterium breve i1088 powder, enhances the conversion rate of calcium from the blood to bone through the action of probiotics, thereby improving the actual utilization rate of calcium and effectively promoting bone health. Experimental data show that this composition significantly increases bone mineral density, bone volume fraction, and trabecular thickness in a female rat osteoporosis model, and significantly reduces trabecular spacing in the same model. The composition provided by this invention is suitable for promoting bone health and preventing and / or improving osteoporosis.

This invention relates to a method for preparing and applying a fat emulsion injection, belonging to the field of pharmaceutical technology. The preparation steps include preparing an oil phase using egg yolk lecithin with a specific PC and PE mass ratio as an emulsifier, mixing it with an aqueous phase to obtain a colostrum, homogenizing the colostrum, and then adding sodium oleate to obtain the fat emulsion injection. The fat emulsion injection prepared by the method of this invention has the characteristics of a low SPAN value and a small number of large-diameter emulsion particles.

The present application relates to the technical field of food processing, in particular to an emulsification stabilizer composition, a colostrum ice cream and a preparation method thereof. The present application provides an emulsification stabilizer composition, which can significantly improve the thermal stability and storage stability of immunoglobulin, and effectively reduce the content loss of immunoglobulin after heat treatment. The present application also provides a colostrum ice cream, which can guarantee the stability, flavor, taste and other conventional properties of the ice cream system, and can play a good thermal protection effect on immunoglobulin, effectively reduce the loss of immunoglobulin during the preparation and storage of the ice cream, effectively improve the content of immunoglobulin in the ice cream product, and has good application potential.

The invention relates to the technical field of lactose hydrolysis, in particular to a zero-lactose bovine colostrum lactase enzymolysis method suitable for lactose intolerant people. A zero-lactose bovine coloctrum lactase enzymolysis method suitable for lactose intolerant people comprises the following steps: adding lactase into cow milk, and carrying out hydrolysis reaction on lactose in bovine coloctrum to enable the hydrolysis rate of the lactose in the bovine coloctrum to be 100%, so as to obtain a zero-lactose emulsion; in the hydrolysis reaction process, the reaction temperature is 45-50 DEG C; the reaction time is 0.5 to 5 hours; the invention discloses a zero-lactose bovine colostrum lactase enzymolysis method suitable for lactose intolerant people, which improves the lactose hydrolysis efficiency by optimizing the lactase addition amount and reaction conditions without high-temperature heating, so that the lactose hydrolysis rate in the lactose hydrolysis process can reach 100% within a short time, and the lactose hydrolysis rate can reach 100% within a short period of time. Meanwhile, active ingredients in the bovine coloctrum are reserved to the maximum extent, and the hydrolyzed cow milk initially meets the market requirements of lactose-free dairy products.

The invention belongs to the technical field of biological peptide enzymolysis, and particularly discloses a sheep three-medullary peptide composition for assisting in improving memory and application of the sheep three-medullary peptide composition. The sheep three-medullary peptide composition is prepared from the following components in parts by mass: 40 to 50 parts of sheep three-medullary peptide, 20 to 35 parts of sheep colostrum peptide and 10 to 25 parts of casein hydrolyzed peptide. The invention discloses a sheep three-medullary peptide composition for assisting in improving memory and application thereof, which can obviously improve the level of acetylcholine in the brain and inhibit the activity of acetylcholin esterase to enhance nerve conduction, and can effectively relieve the damage of oxidative stress to brain tissues by improving the activity of SOD and GSH-Px and reducing the content of MDA.

The utility model discloses a freeze dryer for preparing bovine colostrum freeze-dried powder, which comprises a freeze-drying chamber, a plurality of stirring pipes, an adjusting box and a lifting mechanism, the plurality of stirring pipes are arranged in the freeze-drying chamber through an air outlet mechanism and used for blowing and stirring bovine colostrum in the containers, and the adjusting box is arranged in the freeze-drying chamber. The adjusting box is arranged in the freeze-drying chamber through the moving mechanism and can drive the multiple stirring pipes to transversely move, the lifting mechanism is arranged in the freeze-drying chamber and used for longitudinally moving the adjusting box, the air outlet mechanism comprises a communicating pipe and an air pump, the communicating pipe communicates with one ends of the multiple stirring pipes, and the air pump is installed at the top end of the freeze-drying chamber; according to the freeze dryer for preparing the bovine colostrum freeze-dried powder, the bovine colostrum can make more uniform contact with the temperature in the freeze-drying chamber, and the freeze-drying efficiency of the bovine colostrum is improved.

The invention belongs to the technical field of biology, and particularly discloses a biological active peptide derived from buffalo colostrum and application of the biological active peptide in preparation of anti-inflammatory products, the biological active peptide is identified and obtained from the buffalo colostrum, the amino acid sequence of the biological active peptide is shown as SEQ ID NO: 1, and the biological active peptide is identified to have certain anti-inflammatory activity. The method can provide technical support for anti-inflammatory activity research of the buffalo colostrum and development of anti-inflammatory products related to the buffalo colostrum.

The embodiment of the invention discloses a fat emulsion preparation method, which comprises: (1) oil phase preparation: taking grease, and heating to obtain an oil phase; (2) preparing a water phase, namely heating water for injection, glycerol and a part of sodium hydroxide in the prescription to obtain the water phase; (3) preparing primary emulsion: mixing and shearing the oil phase and the water phase in proportion to obtain an oil-water mixed phase, circularly shearing uniformly, and filtering to obtain relatively stable primary emulsion; (4) front low-pressure homogenization: homogenizing the primary emulsion to obtain stable primary emulsion; (5) high-pressure homogenization: homogenizing the stable primary emulsion to obtain stable finished emulsion; (6) post-low-pressure homogenization: homogenizing the finished milk to obtain final milk; and (7) adding the residual sodium hydroxide in the prescription: adding the residual sodium hydroxide in the prescription into the final emulsion, and uniformly stirring to obtain the full-prescription fat emulsion.

The invention provides a polypeptide, and the sequence of the polypeptide is SVDGKENLI. The polypeptide is separated from sheep colostrum after fermentation of the lactobacillus rhamnosus D8A. The invention further provides application of the polypeptide, and the polypeptide can be applied to preparation of drugs for inhibiting neuraminidase, resisting viruses and promoting lung repair. The invention further provides sheep colostrum which comprises the polypeptide. The invention also provides a preparation method of the sheep colostrum, which comprises the following steps: filtering and pre-sterilizing the sheep colostrum, then carrying out secondary homogenization on the sheep colostrum, carrying out flash sterilization and cooling on the sheep colostrum subjected to secondary homogenization, then adding fructose, carrying out sterilization, inoculating a leavening agent comprising the rhamnosus lactobacillus D8A, and carrying out fermentation, so as to obtain the sheep colostrum. And then carrying out primary homogenization, concentration and freeze-drying to obtain the product.

The present application provides a nutritional composition for regulating immunity and application thereof. The present application firstly provides a composition comprising: zinc, lactoferrin, bovine colostrum and yeast beta-glucan, the mass ratio of zinc, lactoferrin, bovine colostrum and yeast beta-glucan is (2-10):(20-670):(140:400):(10-60) in the amount of dry matter. The present application also provides a food containing the composition, and application of the composition or food in preparing a product for regulating immunity.

The application discloses a colostrum powder digestion-released bone formation active peptide and application thereof, the amino acid sequence of the bone formation active peptide is HLVDEPQ, and the bone formation active peptide is derived from bovine colostrum within 24 hours after a cow gives birth to a calf. It is found through a simulation digestion experiment that after the bovine colostrum enters the human gastrointestinal tract, the specific active polypeptide with high target affinity for preventing osteoporosis can be accurately released only by virtue of the natural digestion pathway of the human body without additional in-vitro enzymolysis, the material basis for improving bone metabolism of the bovine colostrum is determined from a molecular level, it is fully proved that the natural bovine colostrum itself can serve as a safe and efficient bone formation functional food, and definite material basis and solid theoretical basis are provided for development of a high-target bone health auxiliary preparation.

The present application relates to a kind of preparation method of immunoglobulin powder and its application, the preparation method includes the following steps: collecting bovine colostrum, using cell survival technology is frozen;Frozen bovine colostrum is thawed, carries out milk fat separation, and obtains defatted bovine colostrum;Defatted bovine colostrum and composite rennet are mixed and are curdled, and then broken, obtain whey;The composite rennet includes aspartic protease, papain and bromelain;Whey is ultrafiltrated, and immunoglobulin solution is obtained;Immunoglobulin solution is vacuum freeze-dried, and the immunoglobulin powder is obtained.The preparation method provided by the present application is low temperature all the way, the activity of immunoglobulin is retained to the greatest extent, the use of composite rennet solves the problem of curd failure, and each link cooperates to improve the curd effect, realizes the preparation of high-efficiency, high-purity and high-quality immunoglobulin powder.

The invention discloses application of a molecular marker in an LIFR gene for sheep colostrum yield trait breeding. The marker is located on an LIFR gene of a sheep chromosome 16, the specific SNP marker is that a G / A base at the 528bp position of SEQ ID NO: 1 in a sequence table is mutated, and the colostrum yield of a GG genotype sheep individual is remarkably higher than that of an AA genotype individual. According to the invention, Hu sheep is taken as a research object, PCR is utilized to amplify the DNA sequence of the 13th exon of the Hu sheep LIFR gene, the colostrum yield of variation site specific genotype sheep individuals is analyzed, and the sheep individuals are selected and reserved for breeding according to the colostrum yield, so that excellent individuals with high colostrum yield are rapidly screened, the breeding process of high colostrum yield population is accelerated, and the breeding efficiency is improved. A marker resource is provided for marker-assisted selection breeding of the colostrum yield of the sheep.

The present application provides a Bifidobacterium breve. The strain has high yield of acetoin and has milk clotting function. The present application provides a fermenting agent comprising the Bifidobacterium breve. The preparation method of the fermenting agent is also provided. The present application also provides a fermented ovine colostrum, which contains a plurality of functional polypeptides. The present application also provides a preparation method of the fermented ovine colostrum. The method can simultaneously ensure high retention rate of nutrients in the ovine colostrum. The present application also provides a polypeptide. The polypeptide can inhibit angiotensin converting enzyme activity, improve vascular endothelial function or inhibit platelet aggregation, and has cardiovascular protection ability. The present application also provides a polypeptide composition. The present application also provides application of the Bifidobacterium breve, the polypeptide and / or the fermented ovine colostrum in the field of food or medicine for helping to enhance immunity.

The invention discloses a preparation method of a novel ultrasonic contrast agent capable of protecting unstable artery plaques, which adopts a preparation method of improved perfluoropropane lipid microspheres and comprises the following steps: preparing a lipid mixed solution and preparing a curcumin stock solution, then constructing a curcumin-lipid mixed system to obtain a curcumin-lipid mixed solution; slowly dropwise adding the curcumin-lipid mixed solution into a calcium chloride solution, and simultaneously starting a high-speed shearing emulsifying machine to form milk white colostrum; and carrying out ultrasonic refining treatment, adding perfluoropropane for loading, carrying out high-pressure homogenization treatment, collecting to obtain a perfluoropropane lipid microsphere finished product, and sealing and storing in a dark place. The lipidosome ultrasonic contrast agent prepared by the method not only can well fulfill the aim of ultrasonic contrast contrast, but also can more effectively kill new vessels of unstable plaques of arteries and reduce the vulnerability index in the ultrasonic cavitation treatment effect, and the preparation method is relatively simple and has very important significance and wide prospects.