250 results about "Colostrum" patented technology

The invention relates to the technical field of microorganisms, in particular to application of streptococcus non-lactolyticus GX-7 and a complex microbial inoculant thereof in sugarcane leaf silage, the strain GX-7 is separated from healthy pig manure by a research group, and through detection, the strain has good cholate resistance and is suitable for surviving in intestinal tracts, and the strain GX-7 has good cholate resistance and is suitable for being used as a feed additive. The antibacterial effect on pseudomonas fluorescens, listeria monocytogenes, salmonella choleraesuis and shigella flexneri is achieved; the strain has a good fermentation capability on sugarcane leaves, and the sugarcane leaves are inoculated with a complex microbial inoculant prepared from streptococcus non-lactolyticus GX-7 and streptococcus non-lactolyticus GX-2, so that a synergistic fermentation effect can be achieved; after the silage prepared from the complex microbial inoculant is fed to female buffalo in the gestation period, it is found that the silage can effectively increase the content of milk protein, milk total solids and milk non-fat solids in colostrum of the female buffalo and relieve diarrhea of the female buffalo, and the silage is safe and good.

The invention provides universal functional formula milk powder for cats and dogs and a preparation method thereof, and relates to the field of pet formula food. The formula milk powder consists of goat milk powder, colostrum powder, whey protein powder, lactoferrin powder, yolk powder, immune globulin powder, compound grease, compound minerals, compound vitamins, choline, taurine, compound prebiotics, compound probiotics, docosahexaenoic acid, arachidonic acid, casein phosphopeptides, L-glutamine and beta-galactosidase. And the goat milk powder, colostrum powder, whey protein powder, lactoferrin powder, yolk powder and immune globulin powder are subjected to low-temperature sterilization treatment by adopting an induced electric field or high-pressure microjet. The cat and dog formula milk powder overcomes the defects in the prior art, through compounding of basic nutritional ingredients and functional ingredients, a novel low-temperature sterilization technology is adopted for sterilization treatment, on the premise that the functionality of the formula milk powder is guaranteed, the nutritional value of the formula milk powder is reserved to a greater extent, and healthy growth and development of cats and dogs are promoted.

The invention provides a polypeptide, and the sequence of the polypeptide is AEDVGDVAFVKNDT. The polypeptide provided by the invention can inhibit the human respiratory syncytial virus surface protein F so as to inhibit the fusion of the human respiratory syncytial virus surface protein F and a host cell membrane. The invention also provides the sheep colostrum. The sheep colostrum comprises the polypeptide with the antiviral function, so that the sheep colostrum is helpful for old people with relatively weak resistance to resist infection of human respiratory syncytial viruses and promotes repair of respiratory mucosa. The invention also provides a preparation method of the sheep colostrum. The preparation method is simple and can be used for industrial production. The invention also provides a preparation method of the polypeptide.

The invention relates to the technical field of microorganisms, in particular to application of streptococcus non-lactolyticus GX-2 and a complex microbial inoculant thereof in peanut vine silage, and the strain GX-2 is suitable for surviving in the stomach and has an antibacterial effect on staphylococcus aureus, escherichia coli, pseudomonas fluorescens and listeria monocytogenes; the streptococcus non-lactolyticus GX-7 and the streptococcus non-lactolyticus GX-2 are prepared into a complex microbial inoculant, and then the complex microbial inoculant is inoculated into the peanut vines, so that the synergistic fermentation effect can be achieved at the mass ratio of 1: (1-3); after the gestational buffalo is fed with the silage prepared from the complex microbial inoculant, the silage is found to be capable of effectively increasing the contents of total milk solids and non-fat milk solids in the colostrum of the buffalo and relieving the diarrhea of the buffalo, and is safe and good.

The invention relates to the technical field of sheep colostrum peptide preparation devices, and discloses a sheep colostrum peptide preparation device and process based on immunity enhancement, the sheep colostrum peptide preparation device comprises a shell, the top of the shell is fixedly provided with a feeding box, and an electromagnetic valve pipe at the bottom of the feeding box is fixedly communicated with the top of the inner wall of the shell; a vertically-arranged electric cylinder is fixedly installed on the lower portion of the inner wall of the shell, and the movable end of the electric cylinder is fixedly installed at the center of the bottom of the lifting table. The lower end of the lower filter plate is rotatably attached to the side wall of the lifting table. According to the sheep colostrum peptide preparation device and process based on immunity enhancement, in the use process of the device, a to-be-filtered sheep colostrum raw material is extruded and disturbed by virtue of deformation and movement of the filtering structure, so that the filtering efficiency of the sheep colostrum raw material is improved, and filtered impurities are prevented from being intensively accumulated on the filtering structure; intercepted impurities can be automatically collected and cleaned.

The invention relates to a hypoallergenic bovine colostrum compound for pets. The milk powder comprises the following components in percentage by mass: 70%-95% of bovine colostrum, 10%-15% of protein hydrolysate, 1%-7% of a vitamin and trace element premix, 1%-8% of fructo-oligosaccharide, 0.01%-0.15% of sodium benzoate, 0.005%-0.015% of disodium ethylene diamine tetraacetate, 0.5%-1.5% of lactobacillus acidophilus, 0.1%-0.3% of lecithin, 0.2%-0.5% of glutamine, 0.1%-0.3% of beta-glucan, 0.3%-0.6% of arginine, 0.1%-0.3% of nano-hydroxyapatite, 0.05%-0.15% of a rosemary extract, 0.05%-0.1% of vitamin C and 1%-3% of a yolk immunoglobulin IgY and enzyme mixture. The bovine coloctrum provides immune support, the fructooligosaccharide regulates intestinal flora, the vitamin and trace element premix supplements trace elements and the like, and after enzymolysis and emulsification, nutrition is easy to absorb, the physiological state is rapidly regulated, and stress is relieved. The disodium ethylene diamine tetraacetate stabilizes the nutritional ingredients in the form of the nutritional paste, and can be effectively absorbed by the young pets in a stress state, so that the influence on the nutrient intake of the young pets due to the coagulation problem is avoided.

The invention belongs to the technical field of dairy product processing, and discloses camel milk composite nutrition powder beneficial to bone health, the camel milk composite nutrition powder is composed of the following raw materials by weight: 70%-75% of whole camel milk powder, 5%-15% of whey protein, 5%-20% of isomaltooligosacharide, 1%-10% of inulin, 0.02%-8% of milk mineral salt, 0.02%-5% of hydrolyzed yolk powder, and the balance water. The oral liquid is prepared from the following components in percentage by weight: 0.01%-0.5% of colostrum basic protein, 0.01%-1% of cartilage powder containing type II collagen, 0.01%-0.1% of N-acetylglucosamine, 0.01%-0.02% of sodium hyaluronate, 0.05%-5% of collagen peptide and 0.01%-1% of liquorice extract. According to the invention, a multi-dimensional health system is constructed by scientifically compounding a plurality of key components: milk mineral salt, colostrum basic protein and hydrolyzed egg yolk powder synergistically promote bone mineral density increase and bone metabolism balance; the II-type collagen cartilage powder, the N-acetylglucosamine and the sodium hyaluronate are combined to realize joint protection and skin repair; the six vitamins and the four minerals can accurately regulate and control the nutrition metabolism of the middle-aged and elderly people, especially can strengthen calcium absorption and oxidation resistance, and can significantly improve the bone health and improve the skin state.

The invention discloses a method for preparing low-bitterness micromolecular bovine colostrum protein peptide powder by adopting a multi-stage membrane separation and enzyme membrane coupling combined technology, and belongs to the technical field of food processing. The preparation method comprises the following steps: firstly, dividing a colostrum component into components to be hydrolyzed by adopting a multi-stage membrane separation technology, namely casein intercepted by ceramic membrane microfiltration and lactoglobulin and lactalbumin filtered by an ultrafiltration membrane, and non-hydrolytic components, namely immune globulin and lactoferrin; the preparation method comprises the following steps: firstly, separating bovine coloctrum, then deeply hydrolyzing the separated lactoglobulin, milky white and casein flocculate with the molecular weight of less than 50kDa by adopting an enzyme membrane coupling technology, mixing with unhydrolyzed immunoglobulin and lactoferrin, and freeze-drying, so that the peptide content in the treated bovine coloctrum is more than 40%, the peptide content of 200-1000Da is more than 30%, the peptide content of 200-1000Da is more than 30%, and the peptide content of 200-1000Da is more than 30%. The preparation method is simple, the preparation dispersion time is within 10 s, no obvious bitter taste exists, the retention rate of immune globulin in bovine coloctrum reaches 90% or above, and the preparation method is suitable for large-scale industrial popularization.

The invention provides modified milk powder capable of promoting bone health as well as a preparation method and application of the modified milk powder. The total protein content of the modified milk powder is 17-35 g / 100 g, the fat content of the modified milk powder is 1-32 g / 100 g, and the calcium content of the modified milk powder is 0.8-2.1 g / 100 g. Moreover, the modified milk powder contains bovine coloctrum and lactoferrin, the mass ratio of the bovine coloctrum to the lactoferrin is (5-100): 1 on the basis of the dry matter content, and the content of the lactoferrin in the modified milk powder is 2-400 mg / 100 g. The bovine colostrum and the lactoferrin are combined for preparing the milk powder, have a synergistic effect on promoting osteoblasts and inhibiting osteoclast proliferation, and are beneficial to bone health.

The invention provides a nutritional composition for promoting children to grow tall and application of the nutritional composition. The invention firstly provides a composition which comprises zinc, lactoferrin, bovine colostrum and yeast beta-glucan, and the mass ratio of the zinc to the lactoferrin to the bovine colostrum to the yeast beta-glucan is (1.5-12): (16-800): (95-480): (14-75) according to the dry matter amount. The invention also provides a food containing the composition, and an application of the composition or the food in preparation of a product for promoting children to grow tall.

The present invention provides an ultra-nano encapsulation system and a preparation method thereof. The preparation method comprises: blending an active ingredient solution with an auxiliary agent to form a mixed colostrum, and then subjecting the mixed colostrum to a specific homogenization treatment to obtain the ultra-nano encapsulation system of the active ingredient; the solute of the active ingredient solution is selected from pharmaceutical active substances or cosmetic active ingredients; the solvent of the active ingredient solution comprises: caprylic / capric triglyceride or isopentyl glycol. The ultra-nano encapsulation system is prepared by the preparation method, and its particle size is less than or equal to 30 nm. The ultra-nano encapsulation system preparation technology route provided by the present invention is reasonable, the effect is outstanding, and it has high repeatability. The ultra-nano encapsulation system prepared by the present invention has the advantages of extremely small system particle size, small PDI, strong room temperature accelerated stability, strong high temperature accelerated stability, and active ingredients are not easy to precipitate, etc., and is particularly suitable for the fields of medicine, cosmetics, and skin care products.

The invention discloses a sheep colostrum composite powder composition capable of improving immunity and a preparation method of the sheep colostrum composite powder composition, and belongs to the technical field of milk composite powder. Comprising the following components in parts by weight: 15 to 20 parts of compound microcapsule probiotics, 200 to 300 parts of sheep colostrum dry powder, 20 to 25 parts of dissolution promoting polypeptide, 0.005 to 0.009 part of vitamin A, 0.003 to 0.006 part of vitamin D, 0.008 to 0.01 part of ascorbic acid, 0.003 to 0.005 part of vitamin K1, 0.006 to 0.009 part of vitamin B2 and 0.002 to 0.004 part of folic acid. According to the preparation method, the technical effects that the dissolution speed is increased, and caking and precipitation are not prone to occurring are achieved in a mode of preparing the dissolution-promoting polypeptide.

The invention discloses a protective agent as well as a preparation method and application thereof. The protective agent is prepared from inulin, fructo-oligosaccharide and erythritol. According to the protective agent provided by the invention, the inulin, the fructo-oligosaccharide and the erythritol are compounded to form a mixed protective agent, so that the heat resistance of functional protein in the bovine colostrum processing process can be improved, and the protective agent has a good protective effect on immune globulin (Ig-G) and lactoferrin (LF) in the processing process. Moreover, the three components all have probiotic effects, so that the development of high-value bovine coloctrum functional products is facilitated, and the comprehensive benefits of the bovine coloctrum are improved.

The invention discloses an enzymolysis preparation method of high-immunocompetence bovine coloctrum peptide, active peptide and application thereof, and belongs to the field of biotechnology and functional foods.The enzymolysis preparation method is characterized by comprising the steps that bovine coloctrum is degreased, trehalose is added into obtained supernate, first stirring is conducted, and first mixed liquid is obtained; wherein the supernate comprises whey protein and Ig; adding medium protease into the first mixed solution for hydrolysis to obtain enzymatic hydrolysate; wherein the enzymatic hydrolysate comprises a mixture of bovine colostrum hydrolyzed peptides, the Ig activity retention rate is larger than or equal to 90% through the targeted protection and directional enzymolysis technology, the beta-lactoglobulin peptide with the synergistic immune enhancement effect is obtained, the Ig and small molecule peptides in the product have the synergistic effect, the body immune regulation capacity and the intestinal immune function are remarkably improved, the immunity of the human body is improved, and the immunity of the human body is improved. The method can be widely applied to the fields of infant formulas, postoperative nutrition, functional drinks and the like.

The present invention discloses a method for preparing Lactobacillus casei and a preparation thereof. The Lactobacillus casei was deposited in the China General Microbiological Culture Collection Center on July 6, 2022, with a deposit number of CGMCC No. 25194. The preparation method of the double-layer emulsion probiotic preparation comprises the following steps: (1) vortexing Lactobacillus casei and a probiotic protective agent solution to uniformly disperse them to form an inner water phase W1; (2) dissolving ursolic acid in oil to form an oil phase O, and mixing the oil phase O with the inner water phase W1 by high-speed shearing to obtain an oil-in-water type colostrum W1 / O; (3) using a suspension of colloidal particles as an external water phase W2, adding the external water phase W2 to the colostrum W1 / O, and mixing by medium-speed shearing to obtain a double-layer emulsion probiotic preparation with a W1 / O / W2 type double emulsion structure.

1. The name of the product of this design: colostrum collector and its main body. 2. Purpose of the product of this design: This product of this design is a container for collecting, storing and feeding colostrum. 3. The key design point of this design product lies in the local shape for which protection is sought. 4. The picture or photo that best illustrates the key points of the design: Design 1 Stereoscopic drawing 1. 5. Designate Design 1 as the base design. 6. The product of this design is a slender object, and its length is omitted. 7. Other situations that require explanation: In Design 3, the parts that are not required to be protected are indicated by dotted lines.

The invention discloses sheep colostrum immune globulin powder and a preparation process thereof, and relates to the technical field of protein powder. The sheep colostrum immune globulin powder is prepared from the following components in parts by weight: 200 to 250 parts of a sheep colostrum raw material, 350 to 400 parts of whole milk powder, 330 to 370 parts of skimmed milk powder, 30 to 50 parts of prebiotics, 8 to 12 parts of acerola cherry powder, 0.8 to 1.2 parts of lactoferrin, 0.4 to 0.6 part of N-acetylneuraminic acid and 0.3 to 0.5 part of probiotics. Diversified nutritional requirements of a human body are fully considered, various nutritional ingredients are matched with one another and have a synergistic effect, the nutritional ingredients can be better absorbed and utilized by the human body, comprehensive nutritional support is provided for consumers, and the requirements of daily nutritional supplement, physique enhancement, immunity improvement and the like are met.

The invention discloses a pregnant sow feed for increasing birth weight of piglets and improving placenta inflammation of sows, and relates to the technical field of biology. The pregnant sow feed comprises a lysozyme oligomer and a basic ration. The pregnant sow feed for increasing birth weight of piglets and improving placenta inflammation of sows provided by the invention is used for dynamically feeding sows in the pregnancy stage, meets the nutrition and energy requirements of the sows from the late pregnancy stage to delivery, and is fed for several times two days before delivery, so that the dystocia condition of the sows can be relieved, the stillbirth rate can be effectively reduced, and the survival rate of the sows is increased. The lysozyme content in colostrum and serum is increased, the anti-inflammatory factor expression of placenta is obviously promoted, the birth weight of piglets is obviously increased, the stillbirth rate is reduced, and the reproductive performance of sows is improved.

The invention relates to the technical field of immune functions, in particular to a construction method of a microRNA regulation and control network for influencing calf immunity establishment. According to the method, the expression profiles of microRNA in colostrum and finished milk are obtained, the microRNA with high expression and obvious difference in colostrum compared with the finished milk is found, target gene prediction is carried out on the differentially expressed microRNA, gene annotation and enrichment analysis are carried out on the obtained target gene, the target gene enriched by the MAPK pathway related to immunoregulation in the enrichment analysis result is screened, and the immunoregulation related MAPK pathway related to the immunoregulation is screened to obtain the immunoregulation related MAPK pathway related to the immunoregulation related to the immunoregulation related to the immunoregulation related to the immunoregulation related to the immunoregulation related to the immunoregulation related to the immunoregulation. And a network regulation relation graph of the immune-related target gene and the microRNA regulated by the immune-related target gene is obtained, so that the key node target gene regulated by the microRNA in milk in the MAPK pathway and the correlation between the key node target gene and the microRNA are screened out, and a technical support is provided for further research and development of feed additives or regulating agents for industrially improving the immunity of the calves.

The invention discloses a sports nutrition solid food for supplementing protein and a preparation method, and belongs to the technical field of foods.The sports nutrition solid food is prepared from, by weight, 31-60 parts of compound amino acid powder, 10-15 parts of isomaltitol, 1-6 parts of taurine, 1-5 parts of Chinese yam peptide, 5 parts of glycine, 5 parts of gamma-aminobutyric acid, 5 parts of L-lysine hydrochloride and 1 part of yeast protein powder. The formula comprises the following components in parts by weight: 1-3 parts of whey protein powder, 1-2 parts of hydroxymethyl propyl cellulose, 0.1-1 part of yeast extract, 0.1-1 part of yeast beta-glucan, 2-6 parts of bovine colostrum powder, 0.5 part of stevioside, 0.1 part of zinc glycinate, 0.1 part of ferrous lactate, 0.5 part of essence and 2-3 parts of magnesium stearate. The compound amino acid powder, the Chinese yam peptide, the glycine, the L-lysine hydrochloride, the yeast protein powder, the whey protein powder, the yeast extract and the bovine colostrum powder are compounded, so that protein consumed by a human body after exercise can be comprehensively supplemented.

The invention relates to the technical field of high-activity immune globulin liquid extraction, in particular to a preparation method for extracting high-activity immune globulin liquid from bovine colostrum. The invention discloses a preparation method for extracting high-activity immune globulin liquid from bovine coloctrum, which comprises the following steps: performing primary separation, secondary separation, filtration, ultrafiltration concentration and sterilization on degreased bovine coloctrum to obtain the high-activity immune globulin liquid, the primary separation comprises the following steps: adjusting the pH value of the defatted bovine colostrum to 4.6-4.7, and sieving to remove casein, so as to obtain whey; and the secondary separation comprises the following steps: adjusting the pH value of the whey to 3.8-4.0, uniformly mixing, and sieving to remove denatured protein to obtain an immunoglobulin liquid. The high-activity immune globulin liquid containing IgG, IgA, IgM, lactoferrin, lactoperoxidase, IGF-beta, lysozyme, lactose and protein, which is prepared by adopting the method disclosed by the invention, can be used for effectively improving the immunity of a human body.

The invention discloses a method for preparing high-activity bovine colostrum immune globulin through combination of multistage membrane filtration and ion exchange resin adsorption, and belongs to the technical field of bovine colostrum powder processing. According to the preparation method of the bovine coloctrum immune globulin, specifically, acidizing precipitation, ultrafiltration and nanofiltration separation, ion exchange resin selective adsorption and other means are adopted for pretreated bovine coloctrum for cooperation, so that the extraction rate and purity of the immune globulin are remarkably improved; meanwhile, active ingredients such as micromolecular growth factors and amino acid in the bovine coloctrum are effectively reserved, so that the final product is rich in high-activity immune globulin, other important nutritional ingredients in the bovine coloctrum are reserved, and the overall nutritional value and market competitiveness of the product are improved.

The present application relates to the technical field of protein separation and purification, and specifically discloses a method for extracting bovine colostrum immunoglobulin. The method comprises the following steps: centrifugal degreasing: degreasing the bovine colostrum by centrifugation, followed by filtering the intermediate layer to obtain colostrum whey; ammonium sulfate salting out: diluting the colostrum whey, then adding a saturated ammonium sulfate solution, stirring, standing, centrifuging, removing the supernatant A, adding phosphate buffer to the precipitate A, stirring evenly, adding a saturated ammonium sulfate solution, standing, centrifuging, removing the precipitate B, adding a saturated ammonium sulfate solution to the supernatant B, centrifuging, removing the supernatant C, and obtaining the precipitate C; and purification: desalting the precipitate C using a gel column, concentrating it by ultrafiltration, and separating it by column chromatography to obtain the bovine colostrum immunoglobulin.

The invention provides a bovine colostrum probiotic compound preparation as well as a preparation method and application thereof. The compound preparation provided by the invention comprises the bovine colostrum powder subjected to activity protection and the compound probiotics, and the bovine colostrum powder subjected to activity protection is obtained by adopting a microcapsule double-layer embedding and freeze-drying technology, so that the gastric acid retention rate (2h) of immune globulin in the bovine colostrum powder is greater than or equal to 90%, and IgG contained in the bovine colostrum powder is ensured to be efficiently delivered to intestinal tracts to play an immune regulation role. Wherein the compound probiotics comprise four stages of functional echeles formed by more than or equal to 6 strains, and the four stages of functional echeles comprise colon colonization major flora, gastric acid-resistant pioneer flora, antibacterial peptide secretion auxiliary flora and inflammation regulation backup flora. Through cooperation of the components in the compound preparation, the compound preparation has excellent immune enhancement and metabolic regulation functions.

The invention belongs to the technical field of milk powder formulas, and particularly relates to milk powder for promoting growth and development of children and a preparation method thereof. Comprising the following components: raw milk, whole milk powder, dried skim milk, lactose, isomaltooligosacharide, fructo-oligosaccharide, galactooligosaccharide, colostrum basic protein, whey protein powder, cattle spleen peptide powder, comprehensive fruit powder, hydrolyzed yolk powder, phosphatidylserine, xanthophyll, compound vitamins, compound minerals, choline chloride, L-carnitine, calcium carbonate, milk mineral salt and lactoferrin. The composition is prepared from docosahexaenoic acid grease, plant lactobacillus YBT5 and plant lactobacillus SG5; in the preparation method of the milk powder, a dry-wet mixing method is adopted to obtain the milk powder. According to the formula, reasonable nutrients are selected, a comprehensive and balanced proportion is adopted, nutrition of children can be balanced, growth and development of the children can be promoted, and the milk powder is simple in preparation method, convenient to operate and suitable for large-scale production.

The invention belongs to the technical field of oral liquid, and provides DHA algae oil oral liquid and a preparation method thereof. The preparation method comprises the following steps: mixing sodium hexametaphosphate, disodium hydrogen phosphate, sodium caseinate, starch sodium octenylsuccinate and water, and refrigerating to obtain a water phase; mixing docosahexaenoic acid, caprylic capric triglyceride, essence and vitamin E oil to obtain an oil phase; adding the oil phase into the water phase, stirring at a high speed, and homogenizing the primary emulsion to obtain an embedded emulsion; and mixing the embedding emulsion, sucralose, sweet orange essence and water to obtain the DHA algae oil oral liquid. The DHA algal oil oral liquid forms a double-layer nano-emulsion structure, and the DHA algal oil nano-emulsion oral liquid with the double-layer structure has good thermal stability, freeze-thaw stability, salt, acid and alkali tolerance and long-term storage stability, and provides technical reference for development of DHA high-stability products and application of the DHA high-stability products in food processing.

The invention discloses a nutritional composition capable of regulating appetite and body weight of people after chemotherapy and improving taste perception capability and application thereof. The nutritional composition provided by the invention contains milk powder, soybean protein, concentrated whey protein, bovine colostrum powder, hydrolyzed yolk, a red bean extract, a Chinese date extract, lily freeze-dried powder, broccoli freeze-dried powder, a radish seed extract, a peach kernel extract, xanthan gum and Arabic gum. The food can obviously increase appetite of people after chemotherapy and restore weight, and is helpful for treating or improving symptoms such as inappetence, weight loss and weakness of chemotherapy patients. When being applied to paclitaxel (PTX)-induced taste disorder model animals, the paclitaxel protein can improve the taste perception capability, increase the cross sectional area of a taste bud, remarkably repair taste structural damage, reduce the level of proinflammatory factors in serum and relieve hepatotoxicity caused by a chemotherapeutic drug PTX; and moreover, the water solubility and the stability are better, adhesion and layering are avoided, and stable storage is facilitated.

The application discloses a preparation method of an immune protein extract of colostrum with tumor inhibition efficacy, and comprises the following steps: (1) raw material selection; (2) flocculation of casein; (3) sugar removal; (4) ultrafiltration membrane filtration; (5) directional hydrolysis; (6) cation exchange resin adsorption; (7) desalination; and (8) freeze drying. The extract of the application is rich in hydrophobic amino acid and alkaline amino acid hydrolysis fragments of the immune protein of colostrum, and has stronger antioxidant, immune enhancement and tumor inhibition activities. Different from common immune proteins of colostrum, the extract plays the anti-tumor activity as a result of the combined action of its double effects of immune enhancement and tumor cell growth inhibition.

The application discloses an Akkermansia muciniphila branched-chain amino acid metabolism gene nifJ and application thereof in colostrum IgA synthesis, and belongs to the technical field of genetic engineering. The application finds through in-vivo and in-vitro tests that the nifJ is a branched-chain amino acid metabolism gene of the Akkermansia muciniphila, regulates the metabolism process from branched-chain amino acids to branched-chain short-chain fatty acids, and plays a key role in the synthesis of maternal colostrum IgA. The research result of the application is expected to clarify the interaction relationship between the metabolic function of the Akkermansia muciniphila and a host, and reveal the action mechanism of the Akkermansia muciniphila in regulating the synthesis of maternal colostrum IgA, thereby providing a theoretical basis for improving the maternal colostrum IgA and further improving the maternal reproductive performance.

This invention provides a bovine colostrum IgG nutritional supplement gummies and their preparation method, belonging to the field of functional food technology. The bovine colostrum IgG nutritional supplement gummies of this invention, through precise formulation of specific components, effectively improve the dispersion uniformity of whole-fat bovine colostrum freeze-dried powder in the gummy base, significantly retaining the activity of immunoglobulin G, giving the product a stable texture and good taste; further, combined with a special process adapted to the formula, high yield and high raw material utilization are achieved in industrial production. This product combines immune nutritional supplementation with convenient consumption, making it suitable for people of all ages and possessing good market application prospects.