405 results about "Bone mineral" patented technology

Disclosed herein are tissue-nonspecific alkaline phosphatase (TNAP) activators and uses thereof for promoting bone mineral deposition.

Disclosed is a pedicle screw used in spinal fusion surgery and a device for injecting bone cement into a spine having low bone mineral density by using the pedicle screw so as to enhance strength of the spine. The pedicle screw includes a screw rod fixedly inserted into a bone, a head section provided at an upper portion of the screw rod and formed at an inner portion thereof with a U-shaped recess and a screw part, and a coupling section coupled with the screw part of the head section. The coupling section is coupled with a rod support section including a bolt having a screw structure provided at an upper portion of the rod support section, a reverse U-shaped recess formed at a lower portion of the rod support section, and a pair of protrusions provided at lateral portions of the rod support section. The screw part of the head section is formed with a pair of guide slots. The screw rod is formed at an inner portion thereof with a hollow section, injection holes communicated with the hollow section are formed in the screw rod, and a feeding hole is formed in the U-shaped recess for feeding bone cement. The bone cement injection device has a cannula including an elongated body, a pedicle screw coupling member provided at one end of the elongated body so as to be fixed to the pedicle screw, and a handle provided at the other end of the elongated body and having an injector coupling member which is coupled to an inlet of an injector, and an impactor including an elongated cylindrical pressing rod inserted into the elongated body of the cannula and having a length longer than a length of the elongated body of the cannula, and a handle attached to one end of the elongated cylindrical pressing rod.

This invention pertains to chemometric methods for the analysis of chemical, biochemical, and biological data, for example, spectral data, for example, nuclear magnetic resonance (NMR) spectra, and their applications, including, e.g., classification, diagnosis, prognosis, etc., especially in the context of bone disorders, e.g., conditions associated with low bone mineral density, e.g., osteoporosis.

An antioxidant composition having enhanced oxidative stability, emulsion stability, and health benefits. The composition may include individual ingredients or a synergistic blend of non-reducing sugars, sugar polyols, medium-chain triglycerides, polysaccharides, polyphenols, phospholipids, chitosan, and alpha-casein, beta-casein, kappa-casein or protein fragments, glycopeptides, phosphopeptides. The composition may optionally be further utilized for the prevention of hypercholesterolemia or bone mineral loss.

This invention provides: 1) a method of treating androgen-deprivation induced osteoporosis and / or bone fractures and / or loss of Bone Mineral Density (BMD) in a male subject suffering from prostate cancer; 2) a method of preventing androgen-deprivation induced osteoporosis and / or bone fractures and / or loss of Bone Mineral Density (BMD) in a male subject suffering from prostate cancer; 3) a method of suppressing or inhibiting androgen-deprivation induced osteoporosis and / or bone fractures and / or loss of BMD in a male subject suffering from prostate cancer; and 4) a method of reducing the risk of developing androgen-deprivation induced osteoporosis and / or bone fractures and / or loss of BMD in a male subject suffering from prostate cancer, by administering to the subject a pharmaceutical composition comprising an anti-estrogen agent and / or its analog, derivative, isomer, metabolite, pharmaceutically acceptable salt, pharmaceutical product, hydrate, N-oxide, or any combination thereof as described herein.

An injectable bone mineral substitute material composition with the capability of being hardened in a body fluid in vivo, which comprises at least one calcium phosphate component and at least one calcium sulfate component as a dry mixture mixed with an aqueous liquid, and at least one accelerator, the at least one calcium sulfate component being particulate hardened calcium sulfate, which has a specified particle size that is in order to confer injectability to the composition. The invention also concerns the bone mineral substitute material produced from the composition as well as methods and uses thereof.

The invention refers to an injectable composition for a bone mineral substitute material, which comprises a dry powder mixed with an aqueous liquid. The powder comprises a first reaction component comprising a calcium sulphate hemihydrate with the capability of being hardened to calcium sulphate dihydrate when reacting with said aqueous liquid; a second reaction component, which comprise a calcium phosphate with the capability of being hardened to a calcium phosphate cement when reacting with said aqueous liquid; and at least one accelerator for the reaction of said first and / or second reaction component with said aqueous liquid. A method of producing an injectable bone mineral substitute material is also provided, wherein the composition is mixed in a closed mixing and delivery system for delivery.

The invention provides a calcium supplementing and calcium locking health care food. The calcium supplementing and calcium locking health care food comprises calcium, colostrum basic protein, chondroitin sulfate, D-glucosamine, vitamin D, casein phosphopeptides and the like, wherein the colostrum basic protein is obtained by degreasing, separating, concentrating, removing casein, alpha-lactoalbumin, beta-lactoglobulin and substances with molecular weights of more than 30 kDa and less than 1 kDa and drying at a low temperature; the biggest difference between the calcium supplementing and calcium locking health care food prepared by the method provided by the invention and the prior art is that the capacity of the bone tissue in actively absorbing osteoblast nutrition like calcium, ossein and the like can be effectively improved and effects of activating osteoblasts and inhibiting osteoclast activity to enhance bone mineral density and length and promote the health of the bone are obtained. The calcium supplementing and calcium locking health care food provided by the invention, which is a latest generation of domestic osteoarthrosis rehabilitation product, obtains breakthrough in the calcium supplementing effect, can be also used for helping the bone to preferably absorb the calcium in the food, has no toxic and side effect after being taken for a long time.

The invention relates to novel inulin products and compositions thereof, to their manufacture, to their use for modifying and modulating the bacterial flora and the fermentation pattern of inulin in the large intestine of humans, mammals or other vertebrates, to their use for providing improved inulin-associated nutritional effects / benefits, as well as to their use for the manufacture of consumer products and compositions for providing said effects / benefits in healthy, disfunctioned and diseased humans, mammals and other vertebrates. The novel inulin products consist of a particular mixture of an easily fermentable inulin (EFI) component and a hardly fermentable inulin (HFI) component. The nutritional effects / benefits include dietary fibre effects, improved mineral absorption, particularly calcium and magnesium, bone mineral density increase, reduction of bone mineral density loss, modulation of lipid metabolism, stimulation of the immune system, and anti-cancer effects. The novel inulin products are particularly suitable for the manufacture of a composition or a medicament for preventing, for postponing and / or for treating osteoporosis in humans, particularly in post-menopausal women and elderly people.

Method for radiographic imaging, in particular for measuring the bone mineral density of an osseous body, this method involving an operation which consists in determining the value of a composite index using, on the one hand, digitized radiological data, and, on the other hand, a three-dimensional generic model of said osseous body.

An antioxidant composition having enhanced oxidative stability, emulsion stability, and health benefits. The composition may include individual ingredients or a synergistic blend of non-reducing sugars, sugar polyols, medium-chain triglycerides, polysaccharides, polyphenols, phospholipids, chitosan, and alpha-casein, beta-casein, kappa-casein or protein fragments, glycopeptides, phosphopeptides. The composition may optionally be further utilized for the prevention of hypercholesterolemia or bone mineral loss.

An embodiment in accordance with the present invention provides a device and method for a quantitatively calibrated computed tomography scanner. The device includes a gentry configured for receiving a patient or part of a patient. The gentry includes an X-ray source and a detector positioned opposite said X-ray source, such that said detector receives the X-rays emitted from the X-ray source. Calibration phantoms are integrated with the gentry and / or a device within the scanner so as to allow for calibration in quantitative CT measurements of Hounsfield units and / or bone mineral density.

The invention belongs to the field of sports research, in particular to a scientific fitness guidance system. The system realizes the collection on the basic information of human bodies, test on comprehensive sports ability and comprehensive analysis and evaluation on conditions of body functions. The system comprises a total control analytic host machine which is respectively connected with a body composition tester, a balance capacity tester, a bone mineral density tester, a flexibility tester, a physical strength tester, a maximal oxygen uptake tester and a reaction time tester through a local area network; the contribution of the scientific fitness guidance system to the prior art is to simply and rapidly provide comprehensive human body experiment test data for establishing a test program and method of sports function of adults and an evaluation method of comprehensive sports ability and constructing a scientific sports fitness evaluation and guidance system of Chinese citizens; the scientific fitness guide system realizes one-time test on the comprehensive data of human bodies and can rapidly and accurately carry out the comprehensive analysis and evaluation on physical conditions by setting threshold values to finish the formulation of a personalized sports fitness guidance scheme.

The invention relates to a BMD (bone mineral density)-increased health food composite and a preparation method of the BMD-increased health food composite. The BMD-increased health food composite comprises 180-220 parts by weight of red deer bone, 120-160 parts by weight of D-glucosamine hydrochloride, 80-100 parts by weight of chondroitin sulfate, 25-45 parts by weight of achyranthes root extractive, 20-40 parts by weight of drynaria rhizome extractive, 15-35 parts by weight of herba epimedii extractive, 10-20 parts by weight of casein phosphopeptides, and clinically-acceptable auxiliary materials, so that the hard capsule, the troche, the granule, the powder, the tea bag agent and the soft capsule can be prepared. According to the invention, a calcium source can be compensated by the red deer bone, the symptom of the osteoarthropathy can be improved by the D-glucosamine hydrochloride and the chondroitin sulfate, the calcium absorption can be promoted by the casein phosphopeptides, and the functions of nourishing the liver and kidney and strengthening the bones and muscles can be achieved due to the compatibility of traditional Chinese medicines. The BMD can be effectively increased due to the joint compatibility of the raw materials; a finished product is simple in preparation technology; and the health food provided by the invention is exact in effects, safe, and free of toxic and side effects, and can be taken for a long term, so that the general flavone in every 100g in the content of effect ingredients of the health food composite is higher than 0.5g.

The key function of TNAP in bone is degradation of PPi to remove this mineralization inhibitor and provide free phosphate for apatite deposition. PC-1 is a direct antagonist of TNAP function. ANK also antagonizes TNAP-dependent matrix calcification. Specifically, the activity of PC-1 inhibits initial MV apatite deposition, but ANK inhibits propagation of apatite outside the MVs. Furthermore, loss of function of the two distinct skeletal TNAP antagonists, PC-1 and ANK, ameliorates TNAP deficiency-associated osteomalacia in vivo. Conversely, the hyperossification associated with both PC-1 null mice and ANK-deficient (ank / ank) mice is ameliorated by deficiency of TNAP in vivo.

From radiation images obtained by driving radiation tube with a plurality of tube voltages, including a normal tube voltage, a density gradient with respect to at least two sections of a reference substance having different radiation transmission characteristics is obtained for each of the plurality of tube voltages prior to obtaining a bone mineral density. If a radiation image captured for obtaining a bone mineral density is determined to have been captured under a tube voltage other than the normal tube voltage, an image signal representing the image and / or a bone mineral density analysis result is corrected so as to correspond to that which should have been obtained if the image had been captured under the normal tube voltage based on the relationship between the density gradient in the image and the density gradient in the radiation image captured under the normal tube voltage.

The invention relates to a troche for enhancing bone mineral density based on milk mineral salt as a raw material. Most calcium tablets are poor in taste and unsatisfactory in effect. Therefore, the troche provided by the invention is prepared by milk mineral salt, vitamin D3, casein phosphopeptides, whole milk powder, mannite, sodium carboxymethylcellulose and magnesium stearate. The invention further relates to a preparation method of the troche for enhancing bone mineral density based on milk mineral salt as the raw material. The troche for enhancing bone mineral density based on milk mineral salt as the raw material provided by the invention has various functions of milk mineral salt, vitamin D3, casein phosphopeptides and whole milk powder, and the bone density of users is increased. The troche is better in taste, smaller in use level and free from dependency, so that the troche is suitable for various crowds except infants.

The invention relates to the technical field of calcium supplement health products, and specially, relates to CBP calcium supplement electuary. The CBP calcium supplement electuary comprises: by weight, 14 to 18 parts of milk calcium, 1 to 2 parts of colostrum basic protein, 0.5 to 1 part of casein phosphoeptide, 0.5 to 0.7 parts of isoflavone, 0.00001 to 0.00002 parts of vitamin D, and 0.00001 to 0.00002 parts of vitamin K. Compared with the prior art, the CBP calcium supplement electuary contains isoflavone so that after the CBP calcium supplement electuary enters into a human body, isoflavone can combine with estrogen acceptors of osteocytes, and thus through the CBP calcium supplement electuary, sclerotin loss is reduced; calcium absorption capacities of human bodies are improved; bone mineral density is increased; osteoporosis can be prevented and improved; and real and good calcium supplement effects are obtained.

The invention relates to a bone mineral density increase health capsule and a preparation method thereof. The capsule is composed of a capsule body and a content closed in the capsule body. The content is characterized in that the content comprises 15-30wt% of calcium carbonate, 8-20wt% of chondroitin sulfate, 10-25wt% of D-glucosamine hydrochloride, 0.02-0.2wt% of vitamin K1, 10-20wt% of a collagen polypeptide, 5-15wt% of momordica saponin, 5-15wt% of soybean isoflavone, 5-20wt% of sheep bone marrow peptide powder, 0.1-0.5wt% of vitamin D3 and 0.5-1wt% of an auxiliary material magnesium stearate; and the preparation method comprises the following steps: uniformly stirring the content, sending the uniformly stirred content to a capsule filling machine for filling the content to capsule shells, polishing, choosing, and packaging to obtain the bone mineral density increase health capsule. The health capsule has the advantages of synergistic effect of the above components, common improvement of the absorption of calcium by human bodies, bone mineral density increase, safety, reliability, obvious effect, and carrying and administrating convenience. The preparation method of the health capsule has the advantages of reasonable technology and strong operability.

The invention relates to novel inulin products and compositions thereof, to their manufacture, to their use for modifying and modulating the bacterial flora and the fermentation pattern of inulin in the large intestine of humans, mammals or other vertebrates, to their use for providing improved inulin-associated nutritional effects / benefits, as well as to their use for the manufacture of consumer products and compositions for providing said effects / benefits in healthy, disfunctioned and diseased humans, mammals and other vertebrates.The novel inulin products consist of a particular mixture of an easily fermentable inulin (EFI) component and a hardly fermentable inulin (HFI) component.The nutritional effects / benefits include dietary fiber effects, improved mineral absorption, particularly calcium and magnesium, bone mineral density increase, reduction of bone mineral density loss, modulation of lipid metabolism, stimulation of the immune system, and anti-cancer effects. The novel inulin products are particularly suitable for the manufacture of a composition or a medicament for preventing, for postponing and / or for treating osteoporosis in humans, particularly in post-menopausal women and elderly people.

The present invention relates to the use of natural isotopes 44Ca / 42Ca87Sr / 86Sr as biomarkers to measure changes in bone mineral balance and loss.

The invention provides an establishment method, an establishment device, and a manufacturing system for a 3D porous support model, and relates to the technical field of medical science. The establishment method for a 3D porous support model comprises: according to CT image data of skeleton lesion or defect positions, obtaining outline data of a to-be-established support and bone mineral density distribution of each corresponding pixel point of the to-be-established support in the CT image data, selecting an element of a topological structure type in minimum structure, and based on the selectedtopological type structure element and the outline data, generating an uniform porosity initial support model, using the corresponding bone mineral density distribution of each pixel point, adjustingthe porosity of each structure element and micropore size in the initial support model, to generate a 3D porous support model like cancellous bone corresponding to the to-be-established support. A porous support printed according to the 3D porous support model like cancellous bone satisfies a bionic microstructure having biomechanical characteristics on bone defect positions, and satisfies cell migration, differentiation, and multiplication and other cell growth microenvironment.

The invention discloses a preparation method of three-marrow powder, which comprises the following steps: 1. extracting effective ingredients such as compound phosphatide of brain marrows, bone marrows and spinal cords of animals by using an extraction technology, and then preparing the effective ingredients into a three-marrow extract powder by using a low-temperature freeze drying technology; 2. carrying out biological enzymolysis on animal bones to extract effective ingredients such as bone collagen protein polypeptide, and preparing the effective ingredients such as bone collagen protein polypeptide into animal bone extract powder by using a high-pressure spray method; 3. after the animal bones subjected to enzymolysis are dried, preparing the animal bones into animal full-bone nutrition powder by using a superfine grinding technology; and 4. after the three-marrow extract powder, the animal bone extract powder and the animal full-bone nutrition powder are mixed in certain proportion, supplementing vegetable origin food to the obtained mixture so as to prepare various series of three-marrow function foods through scientific matching. Produced three-marrow powder can economically and effectively improve the physiological function of a human body, and can enhance the immunity, improve the bone mineral density and reduce the bone mineral loss.

The invention discloses a yak lactoprotein polypeptide nutrition powder applicable to middle-aged and aged people and a preparation method of the powder. The powder consists of the following raw materials by weight percent: 22-28% of yak lactoprotein polypeptide powder, 8-10% of sodium caseinate, 15-20% of whey protein, 8-10% of defatted milk powder, 0.11-0.14% of taurine, 0.2-0.5% of alpha-linolenic acid, 1.0-2.0% of calcium lactate, 0.10-0.12% of zinc gluconate, 0.08-0.10% of ferrous lactate, dietary fiber (10-14% of polydextrose and 6-10% of fructo-oligose), 10-14% of maltodextrin, 0.2-0.3% of compound vitamins and 2-3% of apple powder. Raw materials of ordinary type yak lactoprotein full-nutrition powder are reasonably matched, nutrient substances required by the middle-aged and aged people are comprehensively supplemented, the mineral substance adsorption can be prompted by the rich casein phosphopeptides, the bone mineral density is improved, the osteoporosis is prevented, and through mutual matching and synergistic effects of components, the normal health problems of the middle-aged and aged people are substantially solved, and the physical and psychological health of the middle-aged and aged people are effectively maintained.

The invention relates to a combination of donkey-hid gelatin and calcium and a preparation method thereof, which pertains to the preparation field of medical nutrition. Iron-deficiency and calcium deficiency exist at the same time, when a person supplements the calcium in a large dosage, the calcium inhibits the body to absorb the iron elements and impacts the effect of blood enriching; in order to overcome the problem, the invention discloses a formula of the combination of donkey-hid gelatin and calcium; the formula not only comprises donkey-hid gelatin, calcium lactate, calcium gluconate, but also the iron-supplementing agent of ferrous fumarate, the calcium and iron absorption enhancer of casein phosphopeptide and excipients acceptable by pharmacology. The combination realizes the purpose of supplementing the calcium and the iron at the same time, thus having the advantages of reducing types of medicines taken by a patient, improving nutritional anemia, enhancing bone mineral density and reducing economic burden of the patient.

The present invention relates to parathyroid hormone (PTH) antagonists. More particularly, the present invention provides for pharmaceutical compositions, kits and combinations comprising the PTH antagonist. The present invention also provides for methods for preventing, treating or delaying a disease or disorder associated with excessive bone mineral, e.g., calcium, loss or for preventing, treating or delaying the effect of a PTH agonist using the PTH antagonist. The present invention further provides for methods for identifying a subject having or at risk of having osteoporosis or decreased bone density, or for identifying a subject in need of PTH antagonist treatment, or for monitoring a subject undergoing treatment for osteoporosis or decreased bone density, by determining and / or monitoring PTH antagonist level or a comparative value between PTH agonist and PTH antagonist. The present invention further provides for methods for identifying an agent suitable for preventing, treating or delaying osteoporosis by identifying a compound that enhances the PTH antagonist activity.

A bone healing combination material includes a matrix carrying cultivated bone-forming cells which may be osteocytes, osteoblasts, stromal stem cells or stem cells committed to differentiation into bone-forming osteoblasts. The matrix is a purified collagen matrix material derived from natural collagen-containing animal tissue, a porous bone mineral matrix material derived from natural bone having a crystal structure substantially that of natural bone and being substantially free from endogenous organic material, or a combination of purified collagen matrix material and porous bone mineral matrix material.

This invention pertains to chemometric methods for the analysis of chemical, biochemical, and biological data, for example, spectral data, for example, nuclear magnetic resonance (NMR) spectra, and their applications, including, e.g., classification, diagnosis, prognosis, etc., especially in the context of bone disorders, e.g., conditions associated with low bone mineral density, e.g., osteoporosis.

The present invention provides a system for improving the accuracy of the measurement of the osteoporosis condition of the human body parts especially bones using more than three parameters, viz., the broadband ultrasonic attenuation (BUA) quantity, the velocity of ultrasound (SOS) in the bone, the broadband ultrasonic back scattering (BUB) intensity, and the Width of received maximum (WORM) values are calculated from received ultrasound signals. The accuracy of each measured diagnostic parameter is improved by measuring the tissue thickness and the squish amount in the coupling pad instead of assuming constant thickness for the tissue. The several operating modes of the device are controlled and the frequency and the timing of the emitted ultrasounds signals are adjusted by using a field programmable gate array. The error generated in the measurement of the bone mineral density due to the variation in the anatomy and the size of the foot, is removed by using a removable footpad. The present invention provides a mechanism to replace the gel pads easily. The generation of cross infection is prevented by using the disposable and replaceable coupling pads.