63 results about "Bone mineral" patented technology

The invention discloses an eggshell membrane peptide for enhancing bone mineral density as well as a preparation method and application thereof, belongs to the technical field of egg by-product processing, and particularly relates to a preparation method of the eggshell membrane peptide for enhancing bone mineral density, which comprises the following steps: carrying out vacuum freeze drying and crushing on an eggshell membrane to obtain eggshell membrane powder; mixing the eggshell membrane powder with deionized water to obtain an eggshell membrane solution; adding keratinase, performing enzymolysis, and taking supernate; adding collagenase, carrying out enzymolysis, and centrifuging to take supernate, so as to obtain primary enzymatic hydrolysate; adding alkaline phosphatase, performing enzymolysis and centrifugation, and taking supernate to obtain enzymatic hydrolysate; and performing ultrafiltration and drying to obtain the eggshell membrane peptide. According to the eggshell membrane peptide for enhancing the bone mineral density, keratin cross-linking is destroyed through enzymolysis of keratinase, active peptide capable of stimulating osteoblast proliferation is released through enzymolysis of collagenase, phosphopeptide calcium binding sites are further activated through enzymolysis of alkaline phosphatase, calcium salt deposition is promoted, and the eggshell membrane peptide for enhancing the bone mineral density is provided.

The invention is suitable for the field of meat processing and production, and provides an intelligent recognition method and system for the three-dimensional contour of boned meat based on image recognition, and the method comprises the steps: carrying out the multi-modal image collection of frozen boned meat, and capturing a surface crack pattern; analyzing the crack pattern to construct a topological network model; reconstructing a bone-meat three-dimensional holographic model based on the topological network model, and marking joint, marrow cavity and bone mineral density abnormal areas; identifying potential skeleton weak points; generating a double-path cutting guide line; cooperative operation and visual presentation of the guide lines are controlled through dynamic compensation. Precise recognition and intelligent cutting guide of the internal skeleton structure of the boned meat are achieved, the segmentation precision and efficiency are improved, and the method is suitable for the field of meat processing and the like.

The invention discloses a dual-energy ray bone mineral density evaluation method based on a flat panel detector, and relates to the technical field of ray evaluation. Through a direct conversion mode of the flat panel detector, high-precision acquisition of low-energy and high-energy ray images is realized, and noise and resolution loss caused by traditional indirect imaging are remarkably reduced; primary correction and secondary correction are completed in the edge calculation nodes, so that the problems of discontinuous gray scale and distorted energy ratio of the boundary area of the skeleton and the soft tissue are effectively solved, and the authenticity of the image boundary is improved; and dynamic smoothing processing of the energy ratio is further combined to obtain a stable ratio image, so that the stability and repeatability of bone mineral density measurement are remarkably enhanced, and more accurate bone mineral density evaluation is realized.

The invention discloses an intelligent evaluation method for screening multiple diseases of lumbar vertebra based on deep learning, and relates to the technical field of intelligent screening of lumbar vertebra diseases, and the method comprises the steps: collecting multi-source data, and obtaining lumbar vertebra CT, MRI, bone mineral density images, clinical diagnosis and treatment data and operation related parameters; preprocessing data, denoising images, segmenting key structures, and standardizing non-image data; a deep learning model is constructed, image features are extracted through CNN branches, non-image features are processed through Transform branches, and disease classification, severity assessment and risk prediction are achieved in combination with multi-task learning; integrating the multi-modal features through a feature fusion optimization algorithm, and outputting an evaluation result; doctor interaction correction and model iteration are supported, and the generalization ability of the system is improved. According to the method, multi-source data are integrated, the accuracy and efficiency of lumbar vertebra multi-disease assessment are improved, postoperative risk prediction is optimized, clinical diversified requirements are met, and powerful support is provided for precise diagnosis and treatment and rehabilitation.

The present invention relates to a diagnosis assistance device and method based on artificial intelligence processing of a radiographic image, wherein a disease diagnosis assistance device according to an embodiment of the present invention may comprise an information providing unit that constructs a diagnosis assistance model by learning a training radiographic image and additional information through a first feature processing unit, a second feature processing unit, and a feature fusion processing unit, determines a bone mineral density value and disease classification information with respect to a radiographic image to be diagnosed on the basis of the diagnosis assistance model, and provides disease diagnosis assistance information including the bone mineral density value, the disease classification information, and diagnosis basis information.

The invention discloses a fracture early warning method and system for bone mineral density analysis based on an MV-CT image. The method comprises the following steps: acquiring an MV-CT image, and sketching a skeleton contour based on the MV-CT image to obtain a skeleton contour map; calculating CT value data of the skeleton contour map, converting a pixel CT value of the skeleton contour map into pixel bone mineral density value data, and generating a bone mineral density three-dimensional distribution model; summarizing the bone mineral density three-dimensional distribution models under a plurality of time nodes to generate a bone mineral density change curve; generating a pseudo-color difference chart based on the bone mineral density three-dimensional distribution model; and carrying out fracture early warning based on the bone mineral density change curve and the pseudo-color difference chart. According to the method, visual bone mineral density change distribution can be obtained, accurate information of bone mineral density change during radiotherapy is further obtained, and early warning prompt is given to possible fracture parts.

An implant type or a process of implant fixation is automatically identified by processing surgical plan information. Further, bone mineral density information associated with a patient is determined by processing at least one image. The determined bone mineral density information and patient information representing at least demographics associated with the patient are processed, and a selection of a plurality of patients that previously underwent arthroplasty is made. Outcome information representing results of arthroplasty procedures is processed and a threshold is established representing a biomechanical tolerance. The bone mineral density information is processed to be determined associated with the patient is determined to be above or below the threshold.

The invention provides application of a composition containing butyric acid producing bacteria and vitamin K2 in preparation of a medicine for treating osteoporosis, and relates to the technical field of biological medicines, the composition comprises butyric acid producing bacteria and vitamin K2; wherein the butyric acid producing bacteria are selected from any one or more of clostridium butyricum, rosella and clostridium praeparatum; and the vitamin K2 is selected from any one or more of menadione-4 or menadione-7. The composition can play a synergistic effect through an intestine-bone axis, and compared with a single component, the composition can more remarkably improve the bone mineral density. The composition has comprehensive effects and high safety, provides a brand-new nutrition intervention strategy with a synergistic effect for prevention and treatment of osteoporosis, and provides a brand-new possibility for preparation of medicines related to osteoporosis.

An implant type or a process of implant fixation is automatically identified by processing surgical plan information. Further, bone mineral density information associated with a patient is determined by processing at least one image. The determined bone mineral density information and patient information representing at least demographics associated with the patient are processed, and a selection of a plurality of patients that previously underwent arthroplasty is made. Outcome information representing results of arthroplasty procedures is processed and a threshold is established representing a biomechanical tolerance. The bone mineral density information is processed to be determined associated with the patient is determined to be above or below the threshold.

The invention discloses a rehmannia neutral homogeneous polysaccharide as well as a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicine preparations. The polysaccharide mainly comprises galactose, glucose and fructose, the molar ratio of the galactose to the glucose to the fructose is 2.72: 1.17: 1.11, and the weight-average molecular weight of the polysaccharide is 2152 Da. The rehmannia neutral polysaccharide can play a role in treating osteoporosis by increasing bone mineralization amount and bone mineral density; the proliferation and directional osteogenic differentiation of the bone marrow mesenchymal stem cells BMSCs can be promoted, and the obvious application effect is achieved in the aspect of preparing the bone defect treatment medicine through the stem cells. The rehmannia neutral homogeneous polysaccharide shows a huge application prospect in the aspects of preparation of medicines for treating osteoporosis and stem cell treatment (especially bone regeneration treatment based on mesenchymal stem cells). A new candidate substance and a research direction are provided for developing an efficient and safe bone metabolism disease treatment strategy derived from traditional Chinese medicines.

The invention discloses a multi-mode ultrasonic coupling analysis system for measuring bone mineral density. The system comprises a shell, a foot placing groove, a sole supporting plate, a display screen, a first transducer, a second transducer, a clamping mechanism and a signal collecting and processing module, wherein the first transducer and the second transducer are oppositely arranged. A detachable double-state coupling piece is installed at the front end of the transducer, the coupling piece is provided with a first coupling face and a second coupling face which are equal in thickness but different in acoustic impedance, and the first coupling face and the second coupling face make contact with the skin in sequence when used. The device carries out bidirectional transmission measurement under multiple frequencies, the processing module averagely extracts transmission frequency dispersion characteristics through two-state difference and reciprocity, the center frequency, sharpness and sensitivity of a transmission window are obtained through fitting, and cortical-spongy transmission window indexes are formed and used for distinguishing osteoporosis phenotypes and longitudinal follow-up visit. According to the method, a traditional homogeneous model that QUS only depends on sound velocity and attenuation is broken through, frequency dispersion window characteristics of a cortical-cancellous double-layer structure are introduced into clinical quantitative indexes for the first time, and sensitivity to early osteoporosis and follow-up visit reliability are improved.

1. The name of the design product: dual-energy X-ray absorptiometry (medical whole body type). 2. The use of the design product: medical detection instrument for measuring bone mineral density of human body and obtaining relevant data. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view.

The invention relates to fermented milk containing human milk oligosaccharide 2-FL and having a bone mineral density improving function. The invention provides application of human milk oligosaccharide 2-FL in preparation of a composition for improving bone health, and further provides a composition which contains the human milk oligosaccharide 2-FL and has a function of improving bone health. The composition comprises human milk oligosaccharide 2-FL and a leavening agent, wherein the leavening agent is one or a mixture of more of streptococcus thermophilus, lactobacillus bulgaricus and a vitamin K2-producing leavening agent. Compared with other technical schemes of the same type for enhancing the bone mineral density, the calcium intake of a subject is not additionally increased, the risk that the subject suffers from organ calculi is reduced, the application range is wider, and the preparation method is suitable for being applied to various fermented milk products.

The invention relates to a bone volume evaluation system (100) based on magnetic resonance (MRI) patient scan data and / or at least one combined computed tomography (CT) data, comprising at least one processor module (110) and at least one memory module (120) for storing patient data. The processor module (110) is configured to process and / or analyze MRI patient scan data, at least one combination of CT data and / or simplified patient data, preferably to process the data combinations to determine at least one bone volume parameter of the first patient, including bone mineral density, fat percentage, calcium concentration, total bone trabecular interstitial density, etc. In addition, the invention also relates to a corresponding method 200 and a computer readable medium.

The invention provides an application of lurasidone or a pharmaceutically acceptable salt thereof in preparation of a medicine for preventing and / or treating diabetes individual bone injury healing disorder. The hyperglycemia environment causes excessive secretion of lipocalin-2 (LCN2) by activating a phosphopentose pathway of neutrophil, thereby inhibiting osteogenic differentiation of skeletal stem cells. According to the application of the lurasidone or the pharmaceutically acceptable salt thereof in the preparation of the medicine for preventing and / or treating the diabetic individual bone injury healing disorder, in the application provided by the invention, the lurasidone can specifically inhibit the metabolic pathway and the secretion of LCN2, remodel an immune microenvironment beneficial to repair, and promote the healing of the diabetic individual bone injury. The formation of callus under the condition of diabetes mellitus is obviously accelerated and the mineral density of bone is improved.

Surgical systems and methods involve a robotic manipulator configured to support and move a surgical tool, and a control system coupled to the robotic manipulator. The control system obtains a bone mineral density (BMD) map of a target bone and controls the robotic manipulator to move the surgical tool into contact with the bone at one or more points. Using the BMD map, the control system determines predicted BMD values of the target bone at the contact points. The control system calculates an estimated operational parameter of the surgical tool based on the predicted BMD values. The control system measures an actual operational parameter of the tool during interaction with the bone and compares it to the estimated operational parameter to identify any discrepancy. Upon detecting a discrepancy, the control system generates a corrective action or alert.

The invention discloses application of black bean source oligopeptide in preparation of a product for preventing / treating osteoporosis, and belongs to the technical field of bioactive peptides. According to the black bean source oligopeptide helpful for improving osteoporosis, the black bean source oligopeptide comprises oligopeptide KGVG and / or oligopeptide KIGT; wherein the amino acid sequence of the oligopeptide KGVG is Lys-Gly-Val-Gly, and the amino acid sequence of the oligopeptide KIGT is Lys-Ile-Gly-Thr; the black bean source oligopeptide can directly up-regulate osteoblast activity, enhance expression of BMP-2 and Runx2, improve the level of bone formation marker osteocalcin, remarkably improve the bone density and bone microstructure of ovariectomized mice and enhance bone mechanical strength, is non-toxic to other tissues, can be used as an effective nutrition strategy for treating and relieving osteoporosis, and has broad application prospects. A scientific basis is provided for efficient utilization of the black bean source bioactive peptide.

The utility model discloses a household osteoporosis-sarcopenia combined monitoring and rehabilitation assisting device in the technical field of rehabilitation treatment, which comprises a leg sleeve, a portable ultrasonic bone mineral density instrument and a bioelectrical impedance analyzer, a plurality of grooves are arranged on the periphery of the leg sleeve, a plurality of electromagnets are fixedly connected in the leg sleeve along the periphery, and the electromagnets are connected with the bioelectrical impedance analyzer. A controller is fixedly connected in the leg sleeve, the controller is electrically connected with a data plug, and the portable ultrasonic bone mineral density instrument and the bioelectrical impedance analyzer are both in signal connection with a data socket. Through the arrangement of the leg sleeve, the electromagnet, the data plug and the data plugboard, the weight of the required balancing weight is determined according to data monitored by the portable ultrasonic bone mineral density instrument and the bioelectrical impedance analyzer, and then the balancing weight is attracted through the electromagnet, so that the weight of the balancing weight is adjusted. Through data, patients with osteoporosis and patients with sarcopenia can conveniently carry out aerobic training such as load-bearing jogging according to physical conditions, and therefore the recovery training effect is better achieved.

The invention discloses an osteoporosis pre-examination method based on multi-modal grading characteristics. The method comprises the steps that multi-source heterogeneous information such as bone mineral density, bone metabolism indexes, bone imaging and clinical medical history is collected, and the characteristics are extracted; inputting each modal feature into a depth potential space fusion model, and obtaining a preliminary fusion feature through mapping conversion and weight adjustment; inputting a cross-modal deep belief network for processing to obtain deep fusion features; and inputting an osteoporosis dynamic time sequence risk prediction model, outputting a risk time sequence prediction result in combination with historical time sequence features, and generating a pre-examination report containing risk indexes and feature contribution degrees. According to the method, through multi-model cooperation, deep fusion of multi-modal features, mining of deep association and combination of dynamic time sequence analysis, the defects that an existing method is poor in fusion effect and neglects time sequence changes are overcome, the pre-detection accuracy and the early warning capacity are improved, and a basis is provided for clinical decision making.

The invention provides application of xylotetraose or a composition of xylotetraose and nystose in preparation of an anti-osteoporosis product. The invention discloses the synergistic effect of the xylotetraose and the nystose in the aspect of osteoporosis resistance for the first time. When the zebrafish bone mineral composition and the zebrafish bone mineral composition are combined for use, the bone mineralization degree of zebrafish can be remarkably enhanced, the mineralization rate is increased, osteoblast activity is improved, bone metabolic disorder is effectively reversed, and the synergistic anti-osteoporosis potential of the zebrafish bone mineral composition is fully proved. Meanwhile, the invention also discloses the anti-osteoporosis effect of the xylotetraose for the first time, and the xylotetraose can promote bone mineralization, promote bone formation, inhibit bone resorption and regulate bone metabolism balance to a certain extent.

The invention belongs to the technical field of cartilage extracts, and particularly relates to application of a salmon nasal cartilage extract in preparation of a product for improving bone mineral density. The preparation method of the extract comprises the following steps: 1) performing low-temperature extraction on salmon nasal cartilage homogenate by using guanidine hydrochloride, centrifuging, and dialyzing to intercept total protein with the molecular weight of more than 8000; 2) adding precooled acetone into the total protein for fractional precipitation, and freeze-drying to obtain fractional precipitation protein; 3) dissolving the fractional precipitation protein in diluted hydrochloric acid, adding trypsin, and carrying out light-shielding enzymolysis to obtain an enzymatic hydrolysate; and (4) carrying out hydroxyapatite ion chromatography on the enzymatic hydrolysate, and carrying out ultrafiltration to intercept components with the molecular weight of less than 3kDa, so as to obtain the salmon nasal cartilage extract. The extract can significantly improve the multiplication capacity of embryo osteogenesis cell strains, can improve the bone mineral density value of shin bones of SD rats, has wide application prospects in the fields of food, health care products and medicines, and is especially suitable for development of bone health related products.

The invention discloses application of NUAK1 as a biomarker in clinical diagnosis and prevention of osteoporosis and a kit of the NUAK1, and belongs to the technical field of biological medicines. Targeted verification experiments show that the NUAK1 as the biomarker is applied to preparation of targeted drugs for treating osteoporosis and evaluation of the curative effect of the drugs, and meanwhile, the NUAK1 as the biomarker has the effect equivalent to that of other traditional detection methods in clinical detection of osteoporosis; in addition, the NUAK1 is obviously up-regulated before osteoporosis clinical symptoms such as reduction of bone mineral density of a patient, and the NUAK1 has important significance on early diagnosis and prognosis of osteoporosis.

The invention discloses a bone mineral density measuring system and method.The bone mineral density measuring system comprises a support module, an X-ray generating module, a detector module and a processing module.The support module is used for carrying a host to move to a target position; the X-ray generation module adopts a PWM mode to control a high-voltage generator to carry out high-low voltage switching, the voltage and current of an X-ray tube are adjusted, X-rays are rapidly output, and the X-rays irradiate and penetrate through the forearm of a patient. According to the bone mineral density measuring system and method, the PWM control high-low energy X-ray rapid switching technology and the large-size detector are adopted, so that the detector can synchronously capture the attenuation difference of the bone to different energy rays in single scanning, the imaging time is shortened, full coverage of a key area at the far end of the forearm is ensured, and the accuracy of bone mineral density measurement is improved. The image resolution and the micro-structure capturing capacity are improved, meanwhile, positioning errors caused by forearm positioning deviation or shaking during shooting are eliminated, and the accuracy and reliability of diagnosis results are improved.

A method for training a medical image performed by a medical image processing apparatus for processing a medical image for a body is provided. The method for training a medical image includes preparing a first input data set including a training chest X-ray image, and a bone enhancement image or a bone extraction image acquired from the training chest X-ray image; preparing a label data for the first input data set including osteoporosis information or bone mineral density information corresponding to the training chest X-ray image; and training an artificial neural network model using the first input data set and the label data.

The invention relates to medicinal oral liquid of glycosaminoglycan and a preparation method, and belongs to the technical field of biological medicines.The oral liquid adopts glycosaminoglycan-rich collagen peptide, cod collagen oligopeptide powder, skipjack elastin peptide-Y, fish maw oligopeptide powder, fish collagen tripeptide, apple concentrated juice, white birch juice and the like as effective active ingredients, the apple concentrated juice is obtained by sequentially carrying out step-by-step enzymolysis on green apples through bromelain, ficin and trypsin; the white birch juice is obtained by carrying out anaerobic fermentation on white birch juice through lactobacillus brevis and lactobacillus cellosus. All the components are matched for use, so that the food has very good effects of reducing blood fat, increasing bone mineral density, improving immunity, resisting fatigue and the like, and the action effect is rapid and effective.

The invention relates to the technical field of biological medicines and functional nucleic acid molecules, and discloses pearl mussel source miRNA and application thereof, a biological preparation and application thereof. The pearl mussel source miRNA is miRNA derived from a pearl mussel pallium exosome, contains a sequence shown in SEQ ID NO: 1, and can be modified by phosphorylation, locked nucleic acid and the like to enhance the stability. The biological preparation containing the miRNA can be used for preparing a medicine for preventing and / or treating osteoporosis or functional food for promoting bone mineralization, and the bone mineral density and the bone microstructure are improved by promoting osteoblast proliferation, differentiation and mineralization. According to the invention, marine biological resources which are natural in source and high in safety are utilized, and new active ingredients and technical schemes are provided for prevention and treatment of osteoporosis.

This invention discloses a multi-objective optimization-based method for preoperative tibial prosthesis localization in ankle replacement surgery, primarily addressing the problems of poor accuracy and low reliability in existing ankle prosthesis localization methods. The method includes: 1) acquiring and processing medical CT images and prosthesis model data of the affected lower limb, completing prosthesis standard position calibration and establishing a local coordinate system; 2) segmenting bone tissue, extracting three-dimensional models of the tibia, fibula, and talus, and including HU bone mineral density values; 3) standardizing the skeletal model, labeling anatomical landmarks, and constructing an orthogonal standard coordinate system; 4) pre-calculating relevant data of the distal tibial articular surface; 5) generating initial candidate solutions through grid search and constraint filtering; 6) obtaining the Pareto front by combining the NSGA-II-CDP algorithm and constraint dominance principles; 7) recommending the optimal solution and generating a visual model through multi-stage compromise solution filtering and multi-criteria decision-making. This invention can unify anatomical orientation, improve computational efficiency, and achieve accurate and efficient localization.

This invention relates to the application of SRGN in the treatment and diagnosis of osteoporosis, belonging to the field of biomedical technology. This invention reveals for the first time the key role of SRGN in the pathogenesis of osteoporosis, suggesting its potential as a novel therapeutic or diagnostic target for osteoporosis. Furthermore, this invention designs a novel neutralizing antibody against SRGN, 12E2, which effectively blocks the interaction between SRGN and SIGLEC15, showing significant inhibitory effects on osteoclast formation in both in vivo and in vitro models. In animal experiments, SRGN neutralizing antibody 12E2 or... Srgn Knockout significantly improved bone mineral density in mice. This invention provides novel molecular targets and strategies for the treatment or diagnosis of osteoporosis, and has promising clinical application prospects.

The invention discloses an application of a bone marrow mesenchymal stem cell outer vesicle for inhibiting miR-221-3p and a preparation method of the bone marrow mesenchymal stem cell outer vesicle. Rat bone marrow mesenchymal stem cell outer vesicles (rBMSCs-EVs) are extracted, rBMSCs-EVs (miR-221-3pin-EVs are used for cells, and antiagomiR-221-3p-EVs are used for animals) for inhibiting miR-221-3p are prepared, and in-vitro osteogenic induction differentiation experiments define that the miR-221-3pin-EVs can remarkably inhibit fluorine-induced osteogenic differentiation enhancement. Meanwhile, the fact that the antagomiR-221-3p-EVs can improve the phenomena of bone mineral density increase, bone trabecula number increase, bone trabecula thickening and the like of a sclerotic bone fluorosis rat model in vivo is further proved, and the antagomiR-221-3p-EVs has important significance on clinical treatment of a patient with the bone fluorosis.

The invention relates to the field of medicines, and particularly discloses application of bile acid in preparation of a medicine for treating osteoporosis. Research finds that the content of hyodeoxycholic acid (HDCA) in an old individual is remarkably reduced, and the bone mineral density and the bone microstructure can be improved by supplementing the HDCA. Animal experiment results show that the HDCA can significantly inhibit bone mass loss and improve bone quality through oral administration and intragastric administration, and the effect of the HDCA depends on a bile acid receptor TGR5. HDCA is provided as an active component for treating osteoporosis for the first time, and a new drug candidate and an action mechanism can be provided for prevention and treatment of osteoporosis.