99 results about "Bone mineral" patented technology

The invention relates to the technical field of osteoporosis diagnosis, and discloses an osteoporosis diagnosis method based on image recognition. The method comprises the following steps: acquiring bone density image data of a target object and bone structure image data of a target area based on medical imaging equipment, and determining a bone trabecula distribution condition of the target area according to the bone structure image data; constructing a three-dimensional bone mineral density model of the target object according to the bone mineral density image data, and determining an image analysis strategy by combining the three-dimensional bone mineral density model and the bone trabecula distribution condition; and an image analysis module acquires bone structure feature data of the target area according to the strategy, and identifies the bone density grade and the osteoporosis degree of the target area according to the feature data to obtain diagnosis data. According to the method, related data of the bone mineral density and the bone structure are integrated, comprehensive analysis is carried out in combination with the image recognition technology, an efficient and reliable new mode is provided for clinical diagnosis, the accuracy and objectivity of osteoporosis diagnosis are improved, and misdiagnosis and missed diagnosis are reduced.

The invention discloses a yolk protein source tripeptide with a function of improving osteoporosis and application of the yolk protein source tripeptide, and belongs to the technical field of biological medicines. The tripeptide is a tripeptide APW of which the amino acid sequence is Ala-Pro-Trp. The peptide fragment can be obtained through artificial synthesis or directional enzymolysis of defatted yolk powder. Functional verification shows that the tripeptide APW and the egg yolk protein hydrolysate containing the peptide fragment have the function of improving the bone mineral density, and in a zebra fish osteoporosis model, when the egg yolk protein hydrolysate is 20 mu g / mL, the bone mineral density is improved by 58%; when the tripeptide APW is 0.5 mu g / mL, the bone mineral density is increased by 23.4%; in a rat osteoporosis model, the bone mineral density of thighbone is increased by 3.39% after 10 mg / kg. D of egg yolk protein enzymatic hydrolysate is eaten. Moreover, the food-borne bioactive peptide is high in biological safety, so that the tripeptide APW and a yolk protein enzymolysis product containing the peptide fragment can be applied to preparation of medicines for treating osteoporosis or health-care foods for improving bone mineral density, and the tripeptide APW has a good market prospect and application potential.

The invention relates to the technical field of medical imaging, and discloses an image processing method and system for a dual-energy X-ray bone mineral densitometer, and the method comprises the steps: collecting a dual-energy X-ray image, and carrying out the light and dark field correction of original projection data; based on the corrected projection data, using an aluminum sheet to simulate bones and glass to simulate tissues, carrying out data fitting to obtain a bone mineral density value, and fitting a bone-aluminum conversion coefficient; preprocessing the image, wherein the preprocessing comprises Gaussian smooth filtering, threshold processing and corrosion operation; segmenting the image by using a region growing algorithm, and carrying out edge detection by using a Canny operator; extracting an ROI (Region of Interest), and determining the boundary of the ROI by searching coordinates meeting a preset threshold condition within a preset proportion range in the vertical direction of the image; and calculating the area of the ROI, the bone mineral density BMD and the bone mineral salt content. The accuracy of bone mineral density measurement is improved, the influence of noise and artifacts can be effectively reduced, and the target area is accurately extracted.

The invention belongs to the field of functional composite microbial preparations, and particularly discloses a microbial agent and GABA compounded composition and application thereof in promoting growth and development of children. The composition is prepared from a freeze-dried bacterial agent and a GABA (gamma-aminobutyric acid) compound, wherein the freeze-dried bacterial agent comprises lactobacillus johnsonii YH1136 and lactobacillus helveticus Helveticus; the GABA compound is prepared by loading GABA with the purity of greater than or equal to 98% on a nano cellulose carrier, and the loading rate is 20-35%. The composition realizes high survival rate of the microbial inoculum and targeted slow release of GABA through a freeze-drying process and enteric coating. Experiments show that the composition can significantly improve the serum GH / IGF-1 level, the bone mineral density and the body growth rate, and has a synergistic effect when combined with the vitamin D3. According to the invention, the problems of single strain function, low GABA utilization rate and gastric acid damage in the prior art are solved, and an efficient and safe solution is provided for children growth and development intervention.

The invention relates to a spine bone structure and bone mineral density automatic measurement method based on a CT image. The method comprises the following steps: performing CT scanning on a phantom with known bone mineral density to obtain a real bone mineral density calculation formula; all CT images in the DICOM format are read, DICOM analysis is carried out, and three-dimensional CT value data and other main information of all the images are obtained; performing outer contour segmentation on the whole spine in the CT image by using a deep learning network to obtain an outer contour of each vertebral body in the image; the method comprises the following steps: carrying out preliminary segmentation on cortical bones and cancellous bones by adopting a dynamic threshold method aiming at each vertebral body, selecting a preliminarily segmented cancellous bone region, using a maximum connected domain algorithm in a three-dimensional direction, retaining a maximum connected region, and further measuring the bone mineral density, namely calculating overall topology parameters, the bone mineral density and the bone mineral content of the current vertebral body; calculating the rubbing parameters, the bone mineral density and the bone mineral content of the current vertebral cortical bone and cancellous bone; and measuring the content of the cross section of the cone.

The invention discloses an eggshell membrane peptide for enhancing bone mineral density as well as a preparation method and application thereof, belongs to the technical field of egg by-product processing, and particularly relates to a preparation method of the eggshell membrane peptide for enhancing bone mineral density, which comprises the following steps: carrying out vacuum freeze drying and crushing on an eggshell membrane to obtain eggshell membrane powder; mixing the eggshell membrane powder with deionized water to obtain an eggshell membrane solution; adding keratinase, performing enzymolysis, and taking supernate; adding collagenase, carrying out enzymolysis, and centrifuging to take supernate, so as to obtain primary enzymatic hydrolysate; adding alkaline phosphatase, performing enzymolysis and centrifugation, and taking supernate to obtain enzymatic hydrolysate; and performing ultrafiltration and drying to obtain the eggshell membrane peptide. According to the eggshell membrane peptide for enhancing the bone mineral density, keratin cross-linking is destroyed through enzymolysis of keratinase, active peptide capable of stimulating osteoblast proliferation is released through enzymolysis of collagenase, phosphopeptide calcium binding sites are further activated through enzymolysis of alkaline phosphatase, calcium salt deposition is promoted, and the eggshell membrane peptide for enhancing the bone mineral density is provided.

The invention is suitable for the field of meat processing and production, and provides an intelligent recognition method and system for the three-dimensional contour of boned meat based on image recognition, and the method comprises the steps: carrying out the multi-modal image collection of frozen boned meat, and capturing a surface crack pattern; analyzing the crack pattern to construct a topological network model; reconstructing a bone-meat three-dimensional holographic model based on the topological network model, and marking joint, marrow cavity and bone mineral density abnormal areas; identifying potential skeleton weak points; generating a double-path cutting guide line; cooperative operation and visual presentation of the guide lines are controlled through dynamic compensation. Precise recognition and intelligent cutting guide of the internal skeleton structure of the boned meat are achieved, the segmentation precision and efficiency are improved, and the method is suitable for the field of meat processing and the like.

The invention discloses a method and device for intelligently achieving implant anchorage position generation, and the method comprises the steps: carrying out the fusion of oral cavity CBCT data and oral scanning model data, obtaining a fusion three-dimensional model, and carrying out the registration of the oral cavity CBCT data and the oral scanning data based on a non-rigid I CP algorithm during the fusion; performing feature point extraction on the fused three-dimensional model to obtain a feature point heat map, performing risk region division on the fused three-dimensional model to obtain a risk region, determining a bone mineral density grading map based on the fused three-dimensional model, and dividing a tooth root three-dimensional safety boundary; determining at least one target feature point based on the feature point heat map, the risk area, the bone mineral density grading map and the tooth root three-dimensional safety boundary, and determining implant anchorage position information corresponding to the target feature point based on the target feature point; and screening out an optimal implant anchorage target position from the implant anchorage position information. The purpose of intelligently determining the position of the implant anchorage is achieved, and the defects in the related technology are overcome.

The invention provides a nutrition enhancer beneficial to bone health of middle-aged and elderly people, a preparation method of the nutrition enhancer and application of the nutrition enhancer in preparation of medial care food, and belongs to the field of nutritious food. The nutrient supplement comprises a plant fermentation product, osteopontin peptide, collagen peptide, N-acetylglucosamine and calcium, vitamins and mineral substances can be added, and the plant fermentation product is obtained by performing anaerobic fermentation on rhizoma drynariae and chestnuts through a complex microbial inoculant composed of lactobacillus reuteri and bifidobacterium longum subsp. Longum; the collagen peptide is prepared by performing enzymolysis on bovine bones through alkaline protease and flavourzyme; the hydrogel is prepared by adopting a sodium alginate-calcium chloride-carboxymethyl chitosan micro-capsule embedding process. An in-vitro experiment shows that the nutrition enhancer can remarkably promote osteoblast proliferation, differentiation and mineralization; animal experiments show that the bone mineral density of osteoporosis model mice can be effectively improved. The nutrition enhancer disclosed by the invention is suitable for preparing care food and bone health products, and has a remarkable effect of improving bone health of middle-aged and elderly people.

The invention discloses a dual-energy ray bone mineral density evaluation method based on a flat panel detector, and relates to the technical field of ray evaluation. Through a direct conversion mode of the flat panel detector, high-precision acquisition of low-energy and high-energy ray images is realized, and noise and resolution loss caused by traditional indirect imaging are remarkably reduced; primary correction and secondary correction are completed in the edge calculation nodes, so that the problems of discontinuous gray scale and distorted energy ratio of the boundary area of the skeleton and the soft tissue are effectively solved, and the authenticity of the image boundary is improved; and dynamic smoothing processing of the energy ratio is further combined to obtain a stable ratio image, so that the stability and repeatability of bone mineral density measurement are remarkably enhanced, and more accurate bone mineral density evaluation is realized.

The invention discloses an intelligent evaluation method for screening multiple diseases of lumbar vertebra based on deep learning, and relates to the technical field of intelligent screening of lumbar vertebra diseases, and the method comprises the steps: collecting multi-source data, and obtaining lumbar vertebra CT, MRI, bone mineral density images, clinical diagnosis and treatment data and operation related parameters; preprocessing data, denoising images, segmenting key structures, and standardizing non-image data; a deep learning model is constructed, image features are extracted through CNN branches, non-image features are processed through Transform branches, and disease classification, severity assessment and risk prediction are achieved in combination with multi-task learning; integrating the multi-modal features through a feature fusion optimization algorithm, and outputting an evaluation result; doctor interaction correction and model iteration are supported, and the generalization ability of the system is improved. According to the method, multi-source data are integrated, the accuracy and efficiency of lumbar vertebra multi-disease assessment are improved, postoperative risk prediction is optimized, clinical diversified requirements are met, and powerful support is provided for precise diagnosis and treatment and rehabilitation.

The present invention relates to a diagnosis assistance device and method based on artificial intelligence processing of a radiographic image, wherein a disease diagnosis assistance device according to an embodiment of the present invention may comprise an information providing unit that constructs a diagnosis assistance model by learning a training radiographic image and additional information through a first feature processing unit, a second feature processing unit, and a feature fusion processing unit, determines a bone mineral density value and disease classification information with respect to a radiographic image to be diagnosed on the basis of the diagnosis assistance model, and provides disease diagnosis assistance information including the bone mineral density value, the disease classification information, and diagnosis basis information.

The invention discloses a fracture early warning method and system for bone mineral density analysis based on an MV-CT image. The method comprises the following steps: acquiring an MV-CT image, and sketching a skeleton contour based on the MV-CT image to obtain a skeleton contour map; calculating CT value data of the skeleton contour map, converting a pixel CT value of the skeleton contour map into pixel bone mineral density value data, and generating a bone mineral density three-dimensional distribution model; summarizing the bone mineral density three-dimensional distribution models under a plurality of time nodes to generate a bone mineral density change curve; generating a pseudo-color difference chart based on the bone mineral density three-dimensional distribution model; and carrying out fracture early warning based on the bone mineral density change curve and the pseudo-color difference chart. According to the method, visual bone mineral density change distribution can be obtained, accurate information of bone mineral density change during radiotherapy is further obtained, and early warning prompt is given to possible fracture parts.

A computer-implemented method for evaluating a medical image exhibiting air, fat, a bone, and a motion rod. The computer-implemented method includes automatically performing the following: identifying, from the medical image, intensities of the bone, the motion rod and at least one of: air or fat; obtaining a bone mineral density equivalent value of the motion rod and the at least one of the air or the fat; determining a bone mineral density calibration factor based on a relationship between the identified intensities and a bone mineral density equivalent values of the motion rod and the at least one of the air or the fat; and determining the bone mineral density of the bone within the medical image based on the bone mineral density calibration factor.

The invention provides a bone mineral density acquisition method, an X-ray imaging system and a storage medium. The bone mineral density obtaining method comprises the steps that at least one X-ray image of a detected object is obtained through an X-ray imaging system, the at least one X-ray image is an original image or a medical image obtained after image processing, the at least one X-ray image is processed on the basis of a trained learning network, and the bone mineral density is obtained. The result comprises at least one of a T value of bone mineral density and classification, and at least one of an abnormal bone position, an abnormal probability and an abnormal prompt, and the abnormality means that the T value exceeds a threshold range.

An implant type or a process of implant fixation is automatically identified by processing surgical plan information. Further, bone mineral density information associated with a patient is determined by processing at least one image. The determined bone mineral density information and patient information representing at least demographics associated with the patient are processed, and a selection of a plurality of patients that previously underwent arthroplasty is made. Outcome information representing results of arthroplasty procedures is processed and a threshold is established representing a biomechanical tolerance. The bone mineral density information is processed to be determined associated with the patient is determined to be above or below the threshold.

The invention provides application of a composition containing butyric acid producing bacteria and vitamin K2 in preparation of a medicine for treating osteoporosis, and relates to the technical field of biological medicines, the composition comprises butyric acid producing bacteria and vitamin K2; wherein the butyric acid producing bacteria are selected from any one or more of clostridium butyricum, rosella and clostridium praeparatum; and the vitamin K2 is selected from any one or more of menadione-4 or menadione-7. The composition can play a synergistic effect through an intestine-bone axis, and compared with a single component, the composition can more remarkably improve the bone mineral density. The composition has comprehensive effects and high safety, provides a brand-new nutrition intervention strategy with a synergistic effect for prevention and treatment of osteoporosis, and provides a brand-new possibility for preparation of medicines related to osteoporosis.

An implant type or a process of implant fixation is automatically identified by processing surgical plan information. Further, bone mineral density information associated with a patient is determined by processing at least one image. The determined bone mineral density information and patient information representing at least demographics associated with the patient are processed, and a selection of a plurality of patients that previously underwent arthroplasty is made. Outcome information representing results of arthroplasty procedures is processed and a threshold is established representing a biomechanical tolerance. The bone mineral density information is processed to be determined associated with the patient is determined to be above or below the threshold.

The invention discloses a rehmannia neutral homogeneous polysaccharide as well as a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicine preparations. The polysaccharide mainly comprises galactose, glucose and fructose, the molar ratio of the galactose to the glucose to the fructose is 2.72: 1.17: 1.11, and the weight-average molecular weight of the polysaccharide is 2152 Da. The rehmannia neutral polysaccharide can play a role in treating osteoporosis by increasing bone mineralization amount and bone mineral density; the proliferation and directional osteogenic differentiation of the bone marrow mesenchymal stem cells BMSCs can be promoted, and the obvious application effect is achieved in the aspect of preparing the bone defect treatment medicine through the stem cells. The rehmannia neutral homogeneous polysaccharide shows a huge application prospect in the aspects of preparation of medicines for treating osteoporosis and stem cell treatment (especially bone regeneration treatment based on mesenchymal stem cells). A new candidate substance and a research direction are provided for developing an efficient and safe bone metabolism disease treatment strategy derived from traditional Chinese medicines.

The invention discloses a multi-mode ultrasonic coupling analysis system for measuring bone mineral density. The system comprises a shell, a foot placing groove, a sole supporting plate, a display screen, a first transducer, a second transducer, a clamping mechanism and a signal collecting and processing module, wherein the first transducer and the second transducer are oppositely arranged. A detachable double-state coupling piece is installed at the front end of the transducer, the coupling piece is provided with a first coupling face and a second coupling face which are equal in thickness but different in acoustic impedance, and the first coupling face and the second coupling face make contact with the skin in sequence when used. The device carries out bidirectional transmission measurement under multiple frequencies, the processing module averagely extracts transmission frequency dispersion characteristics through two-state difference and reciprocity, the center frequency, sharpness and sensitivity of a transmission window are obtained through fitting, and cortical-spongy transmission window indexes are formed and used for distinguishing osteoporosis phenotypes and longitudinal follow-up visit. According to the method, a traditional homogeneous model that QUS only depends on sound velocity and attenuation is broken through, frequency dispersion window characteristics of a cortical-cancellous double-layer structure are introduced into clinical quantitative indexes for the first time, and sensitivity to early osteoporosis and follow-up visit reliability are improved.

1. The name of the design product: dual-energy X-ray absorptiometry (medical whole body type). 2. The use of the design product: medical detection instrument for measuring bone mineral density of human body and obtaining relevant data. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view.

The invention provides a vertebral body end plate three-dimensional rotation posture and bone mineral density evaluation method based on end plate calibration, which comprises the following steps: based on a small number of CT images of spinal malformation patients after end plate region labeling and a large number of non-labeled CT images of any patients, performing end plate region labeling on the CT images of the spinal malformation patients; performing supervised training and unsupervised training on the neural network model of the teacher-student architecture to obtain a centrum endplate segmentation model; performing centrum end plate region segmentation on a to-be-evaluated centrum CT image by using the centrum end plate segmentation model to obtain an upper bony end plate and a lower bony end plate; obtaining a three-dimensional rotating posture of the vertebral body end plate based on the end plate region mask corresponding to the bony end plate; and measuring the volume bone density of the cancellous bone area in the vertebral body based on the three-dimensional rotation attitude of the vertebral body end plate. The problems that in the prior art, a vertebral body end plate segmentation method cannot be suitable for a spine malformation patient, three-dimensional space posture evaluation of a spine vertebral body cannot be achieved, and the consistency of vertebral body bone mineral density measurement is poor due to the fact that the three-dimensional posture of the malformed spine is not considered are solved.

The invention relates to fermented milk containing human milk oligosaccharide 2-FL and having a bone mineral density improving function. The invention provides application of human milk oligosaccharide 2-FL in preparation of a composition for improving bone health, and further provides a composition which contains the human milk oligosaccharide 2-FL and has a function of improving bone health. The composition comprises human milk oligosaccharide 2-FL and a leavening agent, wherein the leavening agent is one or a mixture of more of streptococcus thermophilus, lactobacillus bulgaricus and a vitamin K2-producing leavening agent. Compared with other technical schemes of the same type for enhancing the bone mineral density, the calcium intake of a subject is not additionally increased, the risk that the subject suffers from organ calculi is reduced, the application range is wider, and the preparation method is suitable for being applied to various fermented milk products.

The invention belongs to the technical field of pharmaceutical compositions, and particularly relates to a composition helpful for improving bone mineral density and application thereof. The composition comprises sheep milk casein peptide, collagen tripeptide, sea cucumber peptide and osteopontin, can achieve the effects of improving bone mineral density and preventing and treating osteoporosis, integrates functionality and nutrition, and has wide application prospects in the aspect of promoting calcium absorption.

The invention relates to a bone volume evaluation system (100) based on magnetic resonance (MRI) patient scan data and / or at least one combined computed tomography (CT) data, comprising at least one processor module (110) and at least one memory module (120) for storing patient data. The processor module (110) is configured to process and / or analyze MRI patient scan data, at least one combination of CT data and / or simplified patient data, preferably to process the data combinations to determine at least one bone volume parameter of the first patient, including bone mineral density, fat percentage, calcium concentration, total bone trabecular interstitial density, etc. In addition, the invention also relates to a corresponding method 200 and a computer readable medium.

The invention provides an application of lurasidone or a pharmaceutically acceptable salt thereof in preparation of a medicine for preventing and / or treating diabetes individual bone injury healing disorder. The hyperglycemia environment causes excessive secretion of lipocalin-2 (LCN2) by activating a phosphopentose pathway of neutrophil, thereby inhibiting osteogenic differentiation of skeletal stem cells. According to the application of the lurasidone or the pharmaceutically acceptable salt thereof in the preparation of the medicine for preventing and / or treating the diabetic individual bone injury healing disorder, in the application provided by the invention, the lurasidone can specifically inhibit the metabolic pathway and the secretion of LCN2, remodel an immune microenvironment beneficial to repair, and promote the healing of the diabetic individual bone injury. The formation of callus under the condition of diabetes mellitus is obviously accelerated and the mineral density of bone is improved.

Surgical systems and methods involve a robotic manipulator configured to support and move a surgical tool, and a control system coupled to the robotic manipulator. The control system obtains a bone mineral density (BMD) map of a target bone and controls the robotic manipulator to move the surgical tool into contact with the bone at one or more points. Using the BMD map, the control system determines predicted BMD values of the target bone at the contact points. The control system calculates an estimated operational parameter of the surgical tool based on the predicted BMD values. The control system measures an actual operational parameter of the tool during interaction with the bone and compares it to the estimated operational parameter to identify any discrepancy. Upon detecting a discrepancy, the control system generates a corrective action or alert.

The invention discloses application of black bean source oligopeptide in preparation of a product for preventing / treating osteoporosis, and belongs to the technical field of bioactive peptides. According to the black bean source oligopeptide helpful for improving osteoporosis, the black bean source oligopeptide comprises oligopeptide KGVG and / or oligopeptide KIGT; wherein the amino acid sequence of the oligopeptide KGVG is Lys-Gly-Val-Gly, and the amino acid sequence of the oligopeptide KIGT is Lys-Ile-Gly-Thr; the black bean source oligopeptide can directly up-regulate osteoblast activity, enhance expression of BMP-2 and Runx2, improve the level of bone formation marker osteocalcin, remarkably improve the bone density and bone microstructure of ovariectomized mice and enhance bone mechanical strength, is non-toxic to other tissues, can be used as an effective nutrition strategy for treating and relieving osteoporosis, and has broad application prospects. A scientific basis is provided for efficient utilization of the black bean source bioactive peptide.

The invention discloses a preparation method of a biological tibial prosthesis, and relates to the technical field of prosthesis preparation. The preparation method of the biological tibial prosthesis comprises the following steps: acquiring image data of a tibial plateau of a patient; establishing a platform model according to the image data; acquiring bone mineral density data of a plurality of unit areas on the platform model; based on the multiple pieces of bone mineral density data, bone nail parameters of the multiple unit areas are determined respectively, and the bone nail parameters comprise the number of bone nails; and preparing the tibial prosthesis according to the platform model and the plurality of bone nail parameters. According to the preparation method of the biological tibial prosthesis, the tibial prosthesis adapting to the bone density distribution condition of a tibial plateau of a patient can be prepared, and the stability of the tibial prosthesis in the early stage of implantation is improved.

The utility model discloses a household osteoporosis-sarcopenia combined monitoring and rehabilitation assisting device in the technical field of rehabilitation treatment, which comprises a leg sleeve, a portable ultrasonic bone mineral density instrument and a bioelectrical impedance analyzer, a plurality of grooves are arranged on the periphery of the leg sleeve, a plurality of electromagnets are fixedly connected in the leg sleeve along the periphery, and the electromagnets are connected with the bioelectrical impedance analyzer. A controller is fixedly connected in the leg sleeve, the controller is electrically connected with a data plug, and the portable ultrasonic bone mineral density instrument and the bioelectrical impedance analyzer are both in signal connection with a data socket. Through the arrangement of the leg sleeve, the electromagnet, the data plug and the data plugboard, the weight of the required balancing weight is determined according to data monitored by the portable ultrasonic bone mineral density instrument and the bioelectrical impedance analyzer, and then the balancing weight is attracted through the electromagnet, so that the weight of the balancing weight is adjusted. Through data, patients with osteoporosis and patients with sarcopenia can conveniently carry out aerobic training such as load-bearing jogging according to physical conditions, and therefore the recovery training effect is better achieved.