88 results about "Mineral density" patented technology

Compositions and methods relating to antibodies that specifically bind to TGF-beta binding proteins are provided. These methods and compositions relate to altering bone mineral density by interfering with the interaction between a TGF-beta binding protein sclerostin and a TGF-beta superfamily member, particularly a bone morphogenic protein. Increasing bone mineral density has uses in diseases and conditions in which low bone mineral density typifies the condition, such as osteopenia, osteoporosis, and bone fractures.

Compositions and methods relating to antibodies that specifically bind to TGF-beta binding proteins are provided. These methods and compositions relate to altering bone mineral density by interfering with the interaction between a TGF-beta binding protein sclerostin and a TGF-beta superfamily member, particularly a bone morphogenic protein. Increasing bone mineral density has uses in diseases and conditions in which low bone mineral density typifies the condition, such as osteopenia, osteoporosis, and bone fractures.

Disclosed are nutritional compositions and methods of using the compositions for treating or preventing osteoporosis. The compositions comprise (A) those dried fruit solids that inherently comprise flavonoids, hydroxycinnamic acids, and a fiber component of which at least about 20% by weight is soluble fiber, and (B) a soluble, indigestible oligosaccharide in addition to any soluble fiber inherently in the dried fruit solids. The dried fruit solids may also be characterized as those selected from dried plum, dried grape, dried date, or dried fig. The combination of dried fruit solids (e.g., dried plum solids) and soluble indigestible oligosaccharides (e.g., fructooligosaccharides) have been found to be surprisingly more effective in affecting bone mineral density than either component when used alone, thus allowing for reduced concentrations of such ingredients in a nutritional product form such as a beverage or solid nutritional bar.

The invention of this application relates to compositions and methods for the treatment and / or prevention of osteoporosis; improving and / or enhancing bone formation; and prevention and / or reducing bone mineral density loss. More particularly, the invention relates to a composition comprising vitamin K, in any form and betacryptoxanthin. A further aspect of this invention is a composition comprising vitamin K, in any form, betacryptoxanthin, and / or vitamin D and / or calcium.

A method for measuring a bone mineral density, by use of an x-ray image, in a bone mineral density measuring system, includes the steps of: (a) obtaining an X-ray image of bone; (b) setting a region of interest on the obtained X-ray image of bone; (c) calculating a background trend due to soft tissues, at a bone portion within the selected region of interest; and (d) calculating an index of the bone mineral density by removing the background trend due to the soft tissues, at the bone portion within the selected region of interest.

A bone mineral density meter comprises first input device which enters a sound of speed in a bone; second input device which enters a weight of the person to be measured; third input device which enters fat free mass of the person to be measured; arithmetic device which computes the bone mineral density based on data from said first input device and data from said second input device and said third input device; and display which displays a bone mineral density value computed by said arithmetic device. The present invention allows a bone mineral density to be safely estimated, at a low cost, and with proper accuracy and without having to worry about exposure to X-rays.

This invention provides for combinations of 5 alpha reductase inhibitors and SERMs. These combinations are useful in: 1) preventing prostate carcinogenesis in a subject; 2) preventing the recurrence of, suppressing, inhibiting or reducing the incidence of prostate carcinogenesis in a subject; 3) treating a subject with prostate cancer; 4) suppressing, inhibiting or reducing the incidence of prostate cancer in a subject; 5) treating a subject with pre-malignant lesions of prostate cancer; 6) suppressing, inhibiting or reducing the incidence of pre-malignant lesions of prostate cancer in a subject; 7) reducing the incidence, inhibiting, suppressing, preventing and / or treating androgen-deprivation induced conditions in men suffering from prostate cancer, such as androgen-deprivation induced osteoporosis, bone fractures, loss of bone mineral density (BMD), hot flashes and / or gynecomastia; and 8) treating polycystic ovarian syndrome and reducing the incidence, inhibiting, suppressing, preventing and / or treating diabetes, cardiovascular disease, breast cancer and endometrial cancer in women suffering from polycystic ovarian syndrome.

The invention discloses a gradient and porous magnesium alloy material used for bone defect repair. The preparation method of the gradient and porous magnesium alloy material comprises the steps of preparing a prefabrication body from magnesium alloy powder and an additive under a gradient pressure and sintering the prefabrication body by adopting a vacuum sintering process; the gradient and porous magnesium alloy material is characterized in that a plurality of pores communicating with each other are formed in each of the interior and the surface of the gradient and porous magnesium alloy material; the pores are in gradient distribution; the porosity size is in reverse proportion to the density of bone tissues around an implantation space in a specific direction, that is, a part with a higher cortical bone mineral density corresponds to a magnesium alloy part with a smaller porosity while a part with a lower trabecular bone mineral density corresponds to a magnesium alloy part with a higher porosity; an area with a higher porosity has a higher degradation velocity; an area with a lower porosity is conductive to strength increase thereof; the contact area between the body fluid and porous magnesium alloy is reduced; and the degradation velocity is more slowly; therefore the degradation velocity of magnesium alloy can be well matched with the bone tissue healing velocity as far as possible.

A method of computing oral bone mineral density using a panoramic x-ray system. A reference phantom having a known density is provided. A digital panoramic image of a body part and the reference phantom is obtained by irradiating the body part and the reference phantom. The reference phantom is disposed in a location free from anatomical features and in the same scan line as the body part. A relationship is established between a region of the image corresponding to a portion of the body part and a region of the image corresponding to the reference phantom. Bone mineral density is calculated based upon the established relationship and the known density of the reference phantom.

The present invention relates to a dual energy X-ray apparatus and method for osteoporosis assessment and monitoring. The present invention takes a bone densitometry reading of a patient's wrist to assess osteoporosis and monitor bone loss condition by repeat measurements along with therapy. The bone densitometry system has an X-ray source, dual energy detectors, an arm-rest to place the patient's arm, a motion system to move the source-detector gantry along the patient's forearm, and a computer with a database to archive the wrist image, calculate the bone mineral density, maintain a history of patient information, and generate patient history reports.

The present invention relates to compositions comprising two sustained-release formulations, the first capable of releasing the gonadotropin-releasing hormone component and the second capable of releasing the estrogenic component. Compositions of the present invention can be used for improved androgen ablation therapy of prostate cancer to minimize loss of bone mineral density and frequency and severity of hot flashes by maintaining low adequate estrogen levels during treatment .

The invention relates to novel inulin products and compositions thereof, to their manufacture, to their use for modifying and modulating the bacterial flora and the fermentation pattern of inulin in the large intestine of humans, mammals or other vertebrates, to their use for providing improved inulin-associated nutritional effects / benefits, as well as to their use for the manufacture of consumer products and compositions for providing said effects / benefits in healthy, disfunctioned and diseased humans, mammals and other vertebrates. The novel inulin products consist of a particular mixture of an easily fermentable inulin (EFI) component and a hardly fermentable inulin (HFI) component. The nutritional effects / benefits include dietary fibre effects, improved mineral absorption, particularly calcium and magnesium, bone mineral density increase, reduction of bone mineral density loss, modulation of lipid metabolism, stimulation of the immune system, and anti-cancer effects. The novel inulin products are particularly suitable for the manufacture of a composition or a medicament for preventing, for postponing and / or for treating osteoporosis in humans, particularly in post-menopausal women and elderly people.

The present invention provides a system for improving the accuracy of the measurement of the osteoporosis condition of the human body parts especially bones using more than three parameters, viz., the broadband ultrasonic attenuation (BUA) quantity, the velocity of ultrasound (SOS) in the bone, the broadband ultrasonic back scattering (BUB) intensity, and the Width of received maximum (WORM) values are calculated from received ultrasound signals. The accuracy of each measured diagnostic parameter is improved by measuring the tissue thickness and the squish amount in the coupling pad instead of assuming constant thickness for the tissue. The several operating modes of the device are controlled and the frequency and the timing of the emitted ultrasounds signals are adjusted by using a field programmable gate array. The error generated in the measurement of the bone mineral density due to the variation in the anatomy and the size of the foot, is removed by using a removable footpad. The present invention provides a mechanism to replace the gel pads easily. The generation of cross infection is prevented by using the disposable and replaceable coupling pads.

A method of measuring Bone Mineral Density (BMD) including providing a model of a plurality of constituents of at least a portion of a subject body, the model including at least one bone constituent, injecting electric current into the portion of the subject body using a current injection electrode, such that at least part of the current flows through the at least one bone constituent, measuring a value of electric potential at a surface of the subject body using a pickup electrode, using a value of the injected electric current as input to a model of the at least a portion of a subject body, and calculating a value of conductance of the bone constituent corresponding to a value of the injected electric current and the measured value of the electric potential. Related apparatus and methods are also described.

A method and apparatus for using a flat panel detector to determine bone mineral density are provided. The apparatus includes a dual energy X-ray emitter, a flat panel detector for receiving X-rays sent from the X-ray emitter, and may optionally include an image corrector, adapted to emit corrected image information. The apparatus also includes a basis material decomposer that includes a calibration database, the decomposer being adapted to create a bone image and a soft tissue image. The apparatus further includes a bone mineral density calculator that is adapted to compute bone mineral density from the first image, and a display for displaying at least the computed bone mineral density. A method for using a flat panel detector to detect multiple disease states is also provided. The method includes emitting X-rays from a dual energy X-ray source through an area of a patient's body sought to be imaged and receiving X-rays with a flat panel detector. The method also includes generating multiple images, using dual energy X-ray absorptiometry, to detect for a first disease state and a second disease state and analyzing the images for the first and second disease states. The first disease state includes lung cancer, breast cancer, pneumonia, chronic obstructive pulmonary disease, tuberculosis, bone fracture or an abnormally sized or shaped organ and the second disease state comprises osteoporosis.

The invention discloses a multi-scale multi-component digital core construction method and system based on image fusion, and belongs to the field of petrophysics and petroleum logging, and the method comprises the following steps: S1, preparing a core slice, i. e., carrying out imaging and mineral component analysis on the slice to obtain a mineral type, a micropore development degree and a mineral density sequence in imaging; S2, extracting two-dimensional pores in MAPS imaging, determining core pore diameter size distribution characteristics, further determining a proper scanning area, and drilling a sub-sample for X-ray CT scanning; S3, reconstructing the sample subjected to X-ray CT scanning to obtain a three-dimensional grey-scale map, and performing multi-threshold segmentation to obtain a multi-component three-dimensional digital rock core; and S4, adding the pores extracted by the MAPS into the multi-component digital rock core to obtain the multi-scale multi-component digital rock core. The problem of contradiction between the scanning sample size and the scanning resolution can be effectively solved, and the application of the digital rock physics technology in unconventional reservoir evaluation is expanded.

There are provided a method and support device for measuring jawbone mineral density using a jawbone X-ray image. The method for measuring jawbone mineral density includes: obtaining a jawbone X-ray image using a support device for jawbone; defining a region of interest from the obtained jawbone X-ray image; and measuring jawbone mineral density from the defined region of interest. Therefore, the support device for measuring jawbone mineral density may be useful to measure jawbone mineral density with a jawbone X-ray imaging device, which has been widely used in dental clinics, by using the method.

The invention relates to a porosity calculating method. Porosity calculation in principle requires coal quality analysis data of a researched zone, with the data including coal industrial components (ash, volatile components, fixed carbon and a sulfur content) and a coal rock apparent density. Main calculation steps include acquiring the bulk density of a coal sample, acquiring industrial component data (ash, volatile components, fixed carbon and a sulfur content) of the coal sample, and performing porosity calculation through combination of known organic matter density and mineral density data and through a calculation formula provided in the method. Through the method, porosity of coal rock can be calculated simply in a large scale, and the method is beneficial to research of earthquake rock physics.

A method and system for determining the bone mineral density of a body extremity. An image of a body extremity is acquired using a mammography x-ray system whereby a bone mineral density can be performed on the image. The system for determining the bone mineral density of a body extremity includes: a support for supporting the body extremity; a detector for capturing an image of the body extremity; and an x-ray source adapted to project an x-ray beam through the body extremity toward the detector, the x-ray source having a voltage of no more than about 45 kVp and having a target / filter combination of rhodium / rhodium, molybdenum / molybdenum, molybdenum / rhodium, or tungsten / rhodium.

The present invention relates to a method for estimating the Bone Mineral Density (BMD) using image data collected in emergency situation, i.e. without following specific protocols. In particular, the invention discloses a method for assessing the risk of bone fractures using as one indicator a BMD of one or more bones. The BMD is calculated using a universal constant which provides a value of BMD having a certain error in respect to its true value. However this error does not substantially affect the assessment of the risk of fracture of one or more bones.

In general, various embodiments of the present invention comprise an external fixation device, an internal fixation device, and a lower extremity stabilizer. The external fixation device is connected to the lower extremity stabilizer and the external fixation device is adjustably connected to the internal fixation device. The internal fixation device is capable of being attached to at least one bone in a patient's foot, ankle, and / or lower extremity. The system is capable of simultaneously compressing and stabilizing at least one bone for treating Charcot neuroarthropathy, fractures, revisional foot and ankle surgery including but not limited to malunions, nonunions, delayed unions, fibrous unions, avascular necrosis, resected osteomyelitis, incorporated autogenous and / or allogenic bone grafts for arthrodesis procedures, pseudoarthrosis and bones with decreased mineral density and cortical stiffness, and / or the like for any reconstructive and / or elective foot and ankle surgery where a compression arthrodesis is needed. The external fixation device and / or lower extremity stabilizer can be removed after a certain period of time, leaving the internal fixation system within the body for prolonged stabilization and maintenance of the arthrodesis site(s).

The present invention relates to a composition for the inhibition or prevention of a bone mineral density reduction, or food and drink for use in such application, comprising isoxanthohumol or an isomerized hop extract as an active ingredient. According to the present invention, a bone mineral density reduction can be inhibited or prevented while avoiding a problem of side effect which may be induced by using an estrogen preparation.