Gradient and porous magnesium alloy material used for bone defect repair

Abstract

The invention discloses a gradient and porous magnesium alloy material used for bone defect repair. The preparation method of the gradient and porous magnesium alloy material comprises the steps of preparing a prefabrication body from magnesium alloy powder and an additive under a gradient pressure and sintering the prefabrication body by adopting a vacuum sintering process; the gradient and porous magnesium alloy material is characterized in that a plurality of pores communicating with each other are formed in each of the interior and the surface of the gradient and porous magnesium alloy material; the pores are in gradient distribution; the porosity size is in reverse proportion to the density of bone tissues around an implantation space in a specific direction, that is, a part with a higher cortical bone mineral density corresponds to a magnesium alloy part with a smaller porosity while a part with a lower trabecular bone mineral density corresponds to a magnesium alloy part with a higher porosity; an area with a higher porosity has a higher degradation velocity; an area with a lower porosity is conductive to strength increase thereof; the contact area between the body fluid and porous magnesium alloy is reduced; and the degradation velocity is more slowly; therefore the degradation velocity of magnesium alloy can be well matched with the bone tissue healing velocity as far as possible.

Description

technical field [0001] The invention relates to the technical field of medical devices, in particular to a gradient porous magnesium alloy material for bone defect repair. Background technique [0002] Surgical implant materials for human hard tissue repair or replacement have a wide range of clinical application requirements. Magnesium alloys with good biocompatibility, biodegradability and in vivo absorption are the research hotspots in recent years. Among biomaterials and medical devices, the most promising applications are materials for the repair and replacement of hard tissues such as bones, teeth, and joints. The main reasons are: magnesium has good biocompatibility, can be completely degraded without secondary surgery, the density of magnesium alloy is not much different from that of human bone, and the elastic modulus is close to that of bone, avoiding the stress shielding effect. [0003] However, how to prepare porous magnesium alloy materials is a difficult pro...

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Problems solved by technology

The problems of above-mentioned conventional method are: (1) because the chemical property of magnesium and magnesium alloy is comparatively active, it is easy to react with other substances to denature, and it is easy to corrode. The preparation process is complex; (2) A large number of foaming agents and pore-forming agents are introduced in the process of preparing porous magnesium, so oxides or inclusions are easily formed in porous magnesium and porous magnesium alloy materials, affecting their performance

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