This invention provides a
microemulsion gel of
traditional Chinese medicine (TCM) compound essential oils, its preparation method, and its application, relating to the technical field of TCM compound
essential oil preparations. Following TCM theory and based on the principle of
syndrome differentiation and treatment, this invention yields a
microemulsion gel of TCM compound essential oils composed of
Bupleurum chinense
essential oil, Citrus reticulata peel
essential oil,
Ligusticum chuanxiong essential oil,
Murraya paniculata essential oil, and
Nardostachys chinensis essential oil, which has the functions of soothing the liver and regulating qi, promoting
blood circulation and relieving pain. Based on single-factor experiments, this invention uses
response surface methodology to optimize the formulation of the TCM compound essential oil
microemulsion gel, ultimately obtaining a uniform, stable, and easily spreadable microemulsion gel. The TCM compound essential oil microemulsion gel of this invention can effectively improve depressive-like behavior in mice under chronic unpredictable stress and reduce the levels of
inflammatory factors in the CUMS mouse model, effectively improving the
bioavailability of active ingredients in
plant essential oils. This invention provides reference and guidance for the development of new dosage forms for the prevention and treatment of depression and the application of TCM essential oils.