5 results about "Biocompatibility Testing" patented technology

The utility model discloses a kind of for medical instrument biocompatibility test's extraction device, including mutually coordinated extraction bottle and sealing cover, further including extraction plate, the extraction plate has multiple micropores for extraction liquid to pass, multiple limit rods are evenly provided in peripheral side, the inner wall of the extraction bottle is equipped with the limit slot compatible with the positioning rod, one end of the limit slot is flush with the bottle mouth of the extraction bottle to form assembly end, the edge side of the other end is equipped with positioning slot, and the limit rod is detachably inserted into the limit slot by the assembly end, and by twist into the positioning slot. The utility model is optimized to the structure of existing extraction bottle, and the position of floating sample is fixed using additional extraction plate when extracting floating sample to ensure that sample and extraction liquid are in full contact, guarantee the accuracy of test.

This invention relates to the field of medical dressings and skin device fixation technology, and in particular to a dressing tape for fixing small devices on the skin surface. It comprises, from the inside out, a contact layer, a support layer, a fixation layer, and a functional modification layer. The contact layer is in direct contact with the skin, and the fixation layer is used to bond and fix the small device to the surface. The layers are bonded together using a gradient bonding process, where the bonding strength increases progressively from the contact layer to the fixation layer. The contact layer of this invention uses a silicone-hydrocolloid blend modified material, combining the ultra-low allergenicity of silicone with the skin-friendly and exudation-absorbing properties of hydrocolloids. It is further enhanced with a medical-grade toughening agent to improve extensibility. Biocompatibility testing shows no allergenicity or cytotoxicity, exhibiting ultra-low allergenicity and high skin-friendliness, making it suitable for all populations, including the general population, people with sensitive skin, and children. Removal causes no skin damage.

The invention relates to the field of polyurethane coatings, in particular to a low-VOC (volatile organic compound) antibacterial and antifouling waterborne polyurethane coating and a preparation process thereof. The invention provides a low-VOC (volatile organic compound) antibacterial and antifouling waterborne polyurethane coating and a preparation process thereof. The low-VOC antibacterial and antifouling waterborne polyurethane coating comprises 40-60 parts of waterborne polyurethane resin; 1-3 parts of a nano-silver antibacterial agent; 5-10 parts of fluorosilicone modified silicon dioxide; 0.5 to 1.5 parts of a photoinitiator; 20 to 30 parts of deionized water; 0.3 to 0.8 part of a leveling agent; 0.2 to 0.5 part of a defoaming agent; 0.1 to 0.3 part of a pH regulator; 2-4 parts of a coalescing agent; the waterborne polyurethane resin is a hydroxyl-terminated polyurethane prepolymer, and the molar ratio of an isocyanate group to a hydroxyl group of the hydroxyl-terminated polyurethane prepolymer is (1.5-2.0): 1. The medical safety is as follows: a USP Class VI biocompatibility test is passed; the food safety is as follows: the food passes an FDA 21 CFR 175.300 migration test; a nano-silver slow release technology is adopted, so that the antibacterial effect can last for more than 5 years; construction is convenient, the single-time spraying qualification rate is 97%, and the curing time is shortened by 35%. The contact angle is 148 degrees, and adhesion of various stains can be resisted.

The invention discloses a digital processing system for biocompatibility multi-parameter detection, and relates to the technical field of biomedical sensing, and the system executes, through a digital processing unit, physical interface integrity verification, gating decision making through matching of a detection signal and a response characteristic, and multi-parameter detection. Unreliable data is prevented from entering subsequent processing from the source; under the condition that an interface is reliable, multi-dimensional data cross scenario correction is executed, and main sensor signal deviation caused by instantaneous physiological environment fluctuation is intelligently corrected through real-time reading of an auxiliary sensor; and performing prospective compensation of time-dependent attenuation, dynamically selecting the most suitable aging model from the multi-model database, and performing feedback compensation. By establishing a progressive three-level confirmation and compensation architecture from a physical layer, a physiological layer to a time layer, multi-source uncertainty factors are eliminated, and physiological monitoring data with high reliability, high consistency and traceable process can be provided in the whole life cycle of the sensor.

The invention discloses a method for constructing a high-brightness non-conjugated luminescent molecule based on diethylenetriamine and application of the high-brightness non-conjugated luminescent molecule. According to the method, diethylenetriamine is taken as a core, and luminous micromolecules with an adjustable structure are efficiently synthesized through two-step reaction (p-toluenesulfonyl esterification and amine substitution / ion exchange). The obtained molecules present strong blue fluorescence at 430-440 nm, the absolute fluorescence quantum yield is up to 75%, and the molecules have significant aggregation-induced emission (AIE) characteristics. Experiments show that the smaller the ring structure is or the shorter the chain length is, the higher the fluorescence efficiency is, and the stability of molecules is excellent in the pH range of 3-10 and 0-60 DEG C. A biocompatibility test shows that the 24-hour survival rate gt to HeLa and MKN-45 cells is shown; and the method is successfully applied to imaging of living zebrafish. The invention breaks through the limitation that the traditional luminescent material depends on a conjugated structure, provides a low-cost and high-performance non-conjugated fluorescent molecule construction strategy, and has wide application prospects in the fields of biological imaging, optical sensing and the like.