8 results about "Biocompatibility Testing" patented technology

The utility model discloses a kind of for medical instrument biocompatibility test's extraction device, including mutually coordinated extraction bottle and sealing cover, further including extraction plate, the extraction plate has multiple micropores for extraction liquid to pass, multiple limit rods are evenly provided in peripheral side, the inner wall of the extraction bottle is equipped with the limit slot compatible with the positioning rod, one end of the limit slot is flush with the bottle mouth of the extraction bottle to form assembly end, the edge side of the other end is equipped with positioning slot, and the limit rod is detachably inserted into the limit slot by the assembly end, and by twist into the positioning slot. The utility model is optimized to the structure of existing extraction bottle, and the position of floating sample is fixed using additional extraction plate when extracting floating sample to ensure that sample and extraction liquid are in full contact, guarantee the accuracy of test.

The invention relates to the technical field of balloon catheter testing, in particular to a balloon catheter biocompatibility testing device which comprises a closed protection mechanism, three sets of independent detection mechanisms arranged in the closed protection mechanism and a simulation regulation and control mechanism arranged in the closed protection mechanism and located among the three sets of independent detection mechanisms. A closed protection mechanism is arranged, a simulation regulation and control mechanism is arranged in the closed protection mechanism, a biological sample is clamped by utilizing the simulation regulation and control mechanism, the biological sample is tensioned in a gradual change degree in combination with the simulation regulation and control mechanism, and three independent simulation chambers are arranged outside the biological sample; after different detection media are selectively injected into the three simulation chambers, the balloon catheter extends into the biological sample and performs targeted test on the compatibility of the three pretreated parts after expanding, and the test result can be quickly transmitted outwards through the three simulation chambers, so that data acquisition is facilitated.

The utility model relates to the field of medical instruments, and discloses a balloon dilatation catheter biocompatibility testing device which comprises a box body, the top end of the outer wall of the box body is fixedly connected with two sets of fixing bases, the inner wall of the fixing base on the right side is provided with a limiting assembly, and the fixing bases are connected with a box cover in a clamped mode through the limiting assembly. A cable is rotationally connected to the inner side wall of the box cover, a hinge rod is hinged to the inner wall of the movable seat, two limiting blocks are fixedly connected to the inner side wall of the box body, a sliding frame is slidably connected to the inner wall of the box body, a clamping assembly is arranged in the sliding frame, and the sliding frame is connected with the machine body in a clamped mode through the clamping assembly. According to the utility model, by opening the box cover, the cable pushes the moving seat to move on the inner wall of the box body, so that the machine body is pushed to move up and down, the testing device can be conveniently taken out from the interior of the main body box through the box cover, and the purposes of convenience in carrying and high protectiveness are achieved.

This invention relates to the field of medical dressings and skin device fixation technology, and in particular to a dressing tape for fixing small devices on the skin surface. It comprises, from the inside out, a contact layer, a support layer, a fixation layer, and a functional modification layer. The contact layer is in direct contact with the skin, and the fixation layer is used to bond and fix the small device to the surface. The layers are bonded together using a gradient bonding process, where the bonding strength increases progressively from the contact layer to the fixation layer. The contact layer of this invention uses a silicone-hydrocolloid blend modified material, combining the ultra-low allergenicity of silicone with the skin-friendly and exudation-absorbing properties of hydrocolloids. It is further enhanced with a medical-grade toughening agent to improve extensibility. Biocompatibility testing shows no allergenicity or cytotoxicity, exhibiting ultra-low allergenicity and high skin-friendliness, making it suitable for all populations, including the general population, people with sensitive skin, and children. Removal causes no skin damage.

The invention relates to the field of polyurethane coatings, in particular to a low-VOC (volatile organic compound) antibacterial and antifouling waterborne polyurethane coating and a preparation process thereof. The invention provides a low-VOC (volatile organic compound) antibacterial and antifouling waterborne polyurethane coating and a preparation process thereof. The low-VOC antibacterial and antifouling waterborne polyurethane coating comprises 40-60 parts of waterborne polyurethane resin; 1-3 parts of a nano-silver antibacterial agent; 5-10 parts of fluorosilicone modified silicon dioxide; 0.5 to 1.5 parts of a photoinitiator; 20 to 30 parts of deionized water; 0.3 to 0.8 part of a leveling agent; 0.2 to 0.5 part of a defoaming agent; 0.1 to 0.3 part of a pH regulator; 2-4 parts of a coalescing agent; the waterborne polyurethane resin is a hydroxyl-terminated polyurethane prepolymer, and the molar ratio of an isocyanate group to a hydroxyl group of the hydroxyl-terminated polyurethane prepolymer is (1.5-2.0): 1. The medical safety is as follows: a USP Class VI biocompatibility test is passed; the food safety is as follows: the food passes an FDA 21 CFR 175.300 migration test; a nano-silver slow release technology is adopted, so that the antibacterial effect can last for more than 5 years; construction is convenient, the single-time spraying qualification rate is 97%, and the curing time is shortened by 35%. The contact angle is 148 degrees, and adhesion of various stains can be resisted.

The present invention relates to the field of balloon catheter testing technology, specifically a balloon catheter biocompatibility testing device, comprising a sealed protective mechanism, three groups of independent detection mechanisms arranged in the sealed protective mechanism, and a simulation control mechanism arranged in the sealed protective mechanism and located between the three groups of independent detection mechanisms. By setting up a sealed protective mechanism and a simulation control mechanism inside the sealed protective mechanism, the simulation control mechanism is used to clamp the biological sample, and the simulation control mechanism is combined with the biological sample to perform gradual tightening, and three independent simulation chambers are set outside the biological sample. After different detection media are selectively injected into the three simulation chambers, the balloon catheter is extended into the biological sample and the compatibility of the three pre-treated parts after expansion is targetedly tested, and the test results can be quickly transmitted to the outside through the three simulation chambers, thereby facilitating data collection.

The invention discloses a digital processing system for biocompatibility multi-parameter detection, and relates to the technical field of biomedical sensing, and the system executes, through a digital processing unit, physical interface integrity verification, gating decision making through matching of a detection signal and a response characteristic, and multi-parameter detection. Unreliable data is prevented from entering subsequent processing from the source; under the condition that an interface is reliable, multi-dimensional data cross scenario correction is executed, and main sensor signal deviation caused by instantaneous physiological environment fluctuation is intelligently corrected through real-time reading of an auxiliary sensor; and performing prospective compensation of time-dependent attenuation, dynamically selecting the most suitable aging model from the multi-model database, and performing feedback compensation. By establishing a progressive three-level confirmation and compensation architecture from a physical layer, a physiological layer to a time layer, multi-source uncertainty factors are eliminated, and physiological monitoring data with high reliability, high consistency and traceable process can be provided in the whole life cycle of the sensor.

The invention discloses a method for constructing a high-brightness non-conjugated luminescent molecule based on diethylenetriamine and application of the high-brightness non-conjugated luminescent molecule. According to the method, diethylenetriamine is taken as a core, and luminous micromolecules with an adjustable structure are efficiently synthesized through two-step reaction (p-toluenesulfonyl esterification and amine substitution / ion exchange). The obtained molecules present strong blue fluorescence at 430-440 nm, the absolute fluorescence quantum yield is up to 75%, and the molecules have significant aggregation-induced emission (AIE) characteristics. Experiments show that the smaller the ring structure is or the shorter the chain length is, the higher the fluorescence efficiency is, and the stability of molecules is excellent in the pH range of 3-10 and 0-60 DEG C. A biocompatibility test shows that the 24-hour survival rate gt to HeLa and MKN-45 cells is shown; and the method is successfully applied to imaging of living zebrafish. The invention breaks through the limitation that the traditional luminescent material depends on a conjugated structure, provides a low-cost and high-performance non-conjugated fluorescent molecule construction strategy, and has wide application prospects in the fields of biological imaging, optical sensing and the like.