46 results about "Endocranium" patented technology

The objective of the present invention is to provide a collagen material that possesses physical properties to an extent that allows suturing while still maintaining the biochemical properties inherently possessed by collagen, and retains its shape for a certain amount of time even after application to the body; its production process; and, a medical material on which it is based, examples of which include a artificial tube for nerve, artificial tube for spinal cord, artificial esophagus, artificial trachea, artificial blood vessel, artificial valve or alternative medical membranes such as artificial endocranium, artificial ligaments, artificial tendons, surgical sutures, surgical prostheses, surgical reinforcement, wound protecting materials, artificial skin and artificial cornea, characterized by filling or having inside a substance having biocompatibility that can be degraded and absorbed in the body into a matrix of a non-woven fabric-like multi-element structure of collagen fibers having ultra-fine fibers of collagen as its basic unit.

A cranial orthosis is contoured to match the curvature of the fronto-temporal, parietal and occipital areas of an infant's cranial vault to provide protection against the acquisition of postural cranial deformities as a result of the infant's sleeping in the supine position. The orthosis is designed to be of universal fit, as determined by the infant's fronto-occipital head circumference (FOC) measurement. Moreover, the interior dimensions of the orthosis can be enlarged to accommodate growth of the infant's head without requiring replacement. The orthosis is a molded plastic appliance in the form of a shell, headband or helmet having interior surfaces that are smoothly contoured to conform in shape to the surface curvature of the occipital, temporal and parietal areas of a healthy human infant having normal cranium size, shape and symmetry. The cavity is sized to provide a close, non-interfering fit of the conformed interior surfaces in facing relation to the occipital, fronto-temporal and parietal areas of the infant's cranial vault, thereby allowing the the infant's head weight forces to spread substantially uniformly across one or more of the conformed interior surfaces while the infant is resting on a sleep surface in the supine position.

An artificial dura biomedical device and a brain surgery method utilizing the same are disclosed. The steps includes: fixing an artificial dura to a partial skull; and fixing the partial skull with the artificial dura to a cut hole of a whole skull. The artificial dura biomedical device includes an artificial dura and a connecting element. The connecting element fixes the partial skull with the artificial dura.

The invention provides a biological repair tablet for endocranium and a preparation method thereof. The repair tablet uses small intestine submucosa tissues of inbred line animals without cell and DNA (deoxyribonucleic acid) components as the raw material, completely reserves the extracellular matrix component and structure, and has a micropore structure. The preparation method of the repair tablet comprises the following operation steps: determination of animal source, pretreatment and rough cleaning of small intestine tissues, virus inactivation, cell removal, DNA removal treatment, formation, packaging and sterilization. The biological repair tablet for endocranium prepared by the method uses an inbred line animal as an animal source, and thus, the hereditary features are pure, stable and uniform, thereby radically ensuring the stability and uniformity of different batches of products; and the biological repair tablet for endocranium has fewer animal source DNA residues, completely reserves the three-dimensional structure of natural ECM, and has the advantages of low immune source property and high infection resistance.

The invention discloses a composite collagen biological membrane and a preparation method thereof. Collagen in the composite collagen biological membrane is of a triple-helical structure; the composite collagen biological membrane is 0.2 to 0.9 cm in thickness, and is of a three-dimensional pore structure; the aperture of a multihole layer is 60 to 400 microns, and the aperture of a compact layer is 100 to 900 microns. The composite collagen biological membrane provided by the invention is formed by combining the compact layer with a relatively high collagen density and the multihole layer with relatively high porosity, so that the composite collagen biological membrane is high in mechanical strength, has suturing property and the advantages of biodegradability and low immunogenicity, and can be used as a substitute for an endocranium, a spinal membrane and the like.

The invention discloses a dissection type 3D printing net-shaped skull patch, and belongs to the technical field of skull repair. The skull patch comprises a skull patch edge matched with a brain injured part and a skull patch mesh structure, the skull patch edge is of a porous tentacle-free structure or pore-free tentacle-free structure or a pore-free tentacle structure. The skull patch mesh structure is formed by randomly weaving single-layer meshes or multi-layer meshes formed by beam structures. The skull patch is matched with the shape and dimension height of an original skull defect portion, and has the good anatomy and biological compatibility; meanwhile, the porous net-shaped design can effectively improve internal and external blood supply of the skull, after the skull patch is implanted, subcutaneous hematoma hematoma puncture drainage difficulty are likely to occur, the dropsy and infection occurrence rate can be lowered, and repairing and healing are promoted.

An apparatus and method to implant a seal in a skull base defect. The seal is implanted using apparatus with deployable elements which pass up the nasal cavity into the area of the sphenoid sinus where they deploy and expand into useful conformations. A disk is inserted through the skull base defect into an interior side of the skull at the base defect, with a stalk extending through the skull base defect. The stalk is held outward from the skull base defect, holding the disk against the interior side of the skull while a conical mold is filled with bone cement. Once the cement has cured, the apparatus is removed, leaving the insert in the skull with the stalk surrounded by a cone of bone cement, creating a water tight seal in said skull base defect.

The invention relates to a method and a device for pressure regulation and fixation of an epidural microstimulation (EMS) visual cortex neural prosthesis. The device consists of a pressure regulation plate, pressure regulation screws and a three-dimensional locating rack, wherein the pressure regulation plate can realize an interface between a microelectrode array chip and endocranium in a bone window; the pressure between a microelectrode array chip and an implanted endocranium region can be finely regulated through the pressure regulation screws; and the horizontal distance of a support and a shift port is regulated by a beam of the three-dimensional locating rack to improve effective transfer of a neuroelectricity stimulation signal in the endocranium and other nervous tissues and effectiveness of signal record. The device can effectively fix the EMS visual cortex neural prosthesis and effectively regulate the pressure between the microelectrode array chip and the endocranium, thereby ensuring accuracy, reality and stability of a microelectrode array chip stimulation signal and voltage signal record.

Disclosed is a dinosaur model with multi joint assembly that allows the user to grow creative idea and pursue self-lead learning during the assemblage of relatively many parts into the finished article and which is designed to allow free modification of actions and to provide a definite anatomical structure of dinosaur during the sequential assembly of a skeletal frame. It comprises: a skeletal frame in which skull, cervical vertebra, trunk skeleton, and tail bone units are sequentially connected through joints and the trunk skeleton unit is articulated with limb bone units; an integumental frame, responsible for appearance, comprising head integument, neck integument, trunk integument, tail integument, and limb integument units that are associated with the skull, the cervical vertebra, the trunk skeleton, the tail bone, and the limb bone units, respectively; and a connection member, intercalated between the skeletal frame and the integumental frame, for connecting the frames each other.

The invention provides a preparation method of a degradable endocranium repair stent compounded by a human amniotic membrane and bull dorsal aponeurosis. The preparation method comprises the following steps: (1) preparing an amniotic membrane; (2) preparing bull dorsal aponeurosis pieces; and (3) performing non-toxic crosslinking for amniotic membrane and bull dorsal aponeurosis pieces. The endocranium repair stent compounded by a human amniotic membrane and bull dorsal aponeurosis comprises the prepared amniotic membrane and the bull dorsal aponeurosis pieces; the prepared amniotic membrane and the bull dorsal aponeurosis pieces are subjected to non-toxic crosslinking to obtain the endocranium repair stent compounded by a human amniotic membrane and bull dorsal aponeurosis. According to the preparation method, the amniotic membrane processing method meets national standard, and the biological activity function of the amniotic membrane can be remained; the preparation of the bull dorsal aponeurosis pieces is different from the preparation of other collagen membranes, namely, the cell, nucleic acid and other immunogenicity substances can be removed without damaging the structure of the natural bull dorsal aponeurosis collagen, and the mechanical property is remained; in addition, the biosecurity is improved; and the two natural collagen membranes are subjected to non-toxic crosslinking and freezing and drying, and all functions meet the clinical requirements of repair of endocranium.

The invention provides a human skull repairing scaffold which comprises a skull plate formed by a biodegradable polymer and bone growth factors adhered to the surface of the skull plate. The invention also provides a preparation method of the human skull repairing scaffold. After the human skull repairing scaffold provided by the invention is implanted into a human body, the self skull of a patient grows along the surface of the skull plate under the promotion of the bone growth factors, so that the skull injury part heals; because the self skull grows along the surface of the skull plate, the shape of the grown skull coincides with the shape of the original skull, so that malformation and other phenomena are not generated; and in addition, because the skull plate is formed by the biodegradable polymer, after the self skull grows to obtain a complete skull, the skull plate is slowly degraded and discharged out through human body absorption, metabolism and other means, so that the repaired skull injury part is completely formed by the growth of the self skull, no any other foreign bodies are left in the human body, and no any adverse effects are caused to the patient.

A training model for use in training to perform a medical procedure which is invasive of a skull, such as the insertion of an external ventricular drain or the evacuation of a subdural hematoma. The training model may comprise a base component defining a training component receptacle and a training component for mounting in the training component receptacle and comprising a skull section. Alternately, the training model may comprise the skull section or the training component in isolation. The skull section comprises an outer skull layer, a middle skull layer and an inner skull layer. The outer skull layer is constructed of an outer skull material which simulates osseous tissue when penetrated. The middle skull layer is constructed of a middle skull material which simulates marrow tissue when penetrated. The inner skull layer is constructed of an inner skull material which simulates osseous tissue when penetrated.

The invention discloses an implantable biological brain electrode multi-stage propulsion system and an operation method thereof. A bioelectrode is three-stage advancement, and comprises a positioningstage, an advancement stage and a conductive stage in turn. The positioning stage is used to fix the position of the electrode body and break through endocraniums and arachnoids. The tip reaches the outside of the arachnoids, so as to prevent inflammatory reaction caused by damaged tissues brought into the cerebral cortex by the electrode. The advancement stage is used to carry the conductive stage to a target implantation site in the cortex. The conductive stage is made of a core wire and a conductive biomaterial. A communicated porous structure is inside the conductive biomaterial. Nerve inducing factors are perfused onto the porous conductive biomaterial to realize inducing nerve cell synapse ingrowth and electroneurographic signal acquisition. Based on a biological neural interface made of a natural material, natural coupling and functional transition from a biologically active neural network organization to an information sensing device can be realized through the induction of nerve cell synapses, and technical and model foundations are provided for the perfect transition of a brain instruction terminal and an external information acquisition terminal.

A plaster for craniotomy is a silica gel plate-shaped body with two smooth surfaces. A plurality of cylindrical through holes are arranged on the plate-shaped body, and the thickness of the plate-shaped body is 1.5mm-2.0mm. The diameter of the bottom surface of each through hole is 3.0mm-4.0mm, and the distance between every two through holes is 10.0mm. The plaster can meet requirements for reducing bleeding and damage to brain tissue caused by operation separation during cranioplasty. By means of the plaster for the craniotomy, surgical dissection is conveniently performed during the cranioplasty, time is shortened, and bleeding is less. In addition, the plaster for the craniotomy is simple in structure and suitable for industrial production.

A method for single-stage cranioplasty reconstruction includes prefabricating a clear craniofacial implant, creating a cranial, craniofacial, and/or facial defect, positioning the clear craniofacial implant over the cranial, craniofacial, and/or facial defect, tracing cut lines on the clear craniofacial implant as it lies over the cranial, craniofacial, and/or facial defect, cutting the prefabricated clear custom craniofacial implant along the hand-marked lines for optimal fit of the clear implant within the cranial, craniofacial, and/or facial defect, and attaching the final clear craniofacial implant to the cranial, craniofacial, and/or facial defect with standard fixation methods of today.

The invention discloses a pleura/meninges patch and a preparation method thereof. The preparation method comprises the following steps: S1, dissolving squid cartilage chitosan to form a glue solution, wherein the deacetylation degree of the squid cartilage chitosan is greater than 60% and the molecular weight of the squid cartilage chitosan is greater than 0.5*10<6>; and S2, coating the glue solution to obtain the pleura/meninges patch. The pleura/meninges patch prepared by the method is capable of effectively promoting regeneration and rehabilitation of pleura and endocranium of a human body, is finally degraded and absorbed in vivo, and has relatively high clinical application value.

The invention relates to the technical field of medical equipment, in particular to a visual function restoration system. Compared with the existing visual restoration system based on visual cortex stimulation, the visual function restoration system of the invention performs electrical stimulation on visual cortex by endocranium; and an implant is placed on the endocranium, the endocranium does not need to be opened in the operation process, thus avoiding risks such as operation infection, cerebrospinal fluid leakage and the like. The visual function restoration system comprises an image acquisition module, an image information extraction and compression coding module, an electrical stimulation signal generation module and a microelectrode array, wherein the image information extraction and compression coding module acquires image information by the image acquisition module, and then generates digital image and a control signal corresponding to the image information by compression coding processing; the electrical stimulation signal generation module controls the microelectrode array to output a corresponding electrical stimulation signal according to the control signal output by the image information extraction and compression coding module; and the microelectrode array is used for outputting the electrical stimulation signal.

The invention discloses a novel biological endocranium patch which is prepared from I-type collagen, has a unique fiber structure, can absorb cerebrospinal fluid without increasing the volume, has a nutrition protection effect on nervous tissues, is good in biocompatibility, and can induce the growth of fibroblast cells and has an effect of guiding the regeneration of tissues, and meanwhile, an endocranium repairing method is simple and practicable, well in effect, and cannot increase the postoperation infection rate, so that the novel biological endocranium patch is an effective endocranium repairing material.

The invention relates to a monitoring method, in particular to an intracranial pressure monitoring method. The intracranial pressure monitoring method comprises the following steps that the head of apatient is subjected to a minimally-invasive craniotomy, a monitoring probe is implanted under endocranium or in brain parenchyma or ventricle; a power supply in the monitoring probe is controlled tosupply power to the monitoring probe in a remote control mode, so that the intracranial pressure is monitored by an intracranial pressure sensor of the monitoring probe in real time; an intracranial pressure signal monitored by the intracranial pressure sensor is converted by a signal converter arranged in the monitoring probe, and the converted signal is stored in a storage in the monitoring probe; a center control system in the monitoring probe is remotely controlled, the center control system is utilized for transmitting a control signal to a signal transmitter, so that the signal transmitter extracts the digital signal stored in the storage, and the extracted digital signal is transmitted to an external display device in a wireless signal transmission mode. The display device receivesand processes the digital signal and is converted into data with the mmH2O unit, and the data is displayed on a display screen.

The invention relates to an endocranium fret saw for preventing acute encephalocele in a craniocerebral trauma operation. The endocranium fret saw comprises a casing pipe and a fret saw body, a line is marked on the inner side of the casing pipe, an opening is formed in the inner side of the middle of the casing pipe, and the fret saw body penetrates through the casing pipe. The endocranium fret saw has the advantages that the fret saw body is arranged, the endocranium is cut open by the fret saw body after the cranium is closed, brain tissue plumped backwards after the endocranium is cut open is blocked by sutured muscular layers and the scalp, the outside of the scalp can be bound by bandages, so that the intracranial and extracranial pressure difference is controlled, intracranial hypertension is released step by step, the brain tissue is prevented from being bulged outwards rapidly, and acute encephalocele is greatly avoided. After the cranium is closed, under the non-visual condition, the fret saw is used for cutting the endocranium open, the casing pipe separates the fret saw body from the brain tissue, and the brain tissue can be prevented from being hurt.