57 results about "Craniocerebral trauma" patented technology

The invention belongs to the technical field of biological engineering, and relates to an NGF-Fc fusion protein and a preparation method thereof. The method comprises the following steps: constructing a human immune globulin IgG Fc and nerve growth factor (NGF) fusion gene expression vector through a genetic engineering means, transferring to a mammal cell to make the transferred mammal cell highly express and produce NGF-Fc fusion proteins, purifying, identifying and carrying out biological activity detection. The expression vector transferred mammal cell constructed in the invention can express bioactive NGF-Fc fusion proteins, so the expression level can be 150mg / L or above, and the obtained protein has good stability and long half life, and can be used to prepare drugs for treating Alzheimer's disease, diabetic peripheral neuropathy, Parkinson's disease, facial neuritis, craniocerebral trauma, trauma of spinal cord, acute cerebrovascular disease, encephalatrophy and other neurological diseases, and peripheral nerve injury acute cerebral vascular central nerve injuries induced by chemical drugs.

The brain protein hydrolysate injection is prepared with health swine brain and contains 16 kinds of free amino acids and small amount of peptides. It is used in treating sequelae of craniocerebral trauma and cerebrovascular disease, improving cerebral function, etc. It is prepared through washing, homogenizing, thermal changing, enzyme hydrolysis, freezing, ultrafiltering, sterilizing and other steps.

The invention discloses a patient transfer device capable of serving as a sickbed. The patient transfer device comprises a bearing unit, a lifting unit and a bracket unit, wherein the bearing unit comprises two vertical supports which are fixedly arranged and are vertically symmetric, and a horizontal transverse rod which is fixedly connected to the top ends of the vertical supports; the lifting unit comprises a lifting group and a translation group; the lifting group is such configured that a fixed pulley is connected to each of two ends of a lifting transverse rod which is horizontally arranged by virtue of a lifting rope, and the fixed pulleys are fixedly arranged on the horizontal transverse rod; the translation group comprises a translation sliding wheel which is arranged on the lifting transverse rod, and the translation sliding wheel is capable of sliding in a mode of translation along the lifting transverse rod; and the bracket unit, which is horizontally arranged, is connected to the lower end of the translation sliding wheel. The patient transfer device disclosed by the invention is applicable to patients who cannot be moved randomly due to fracture, spinal cord injury, cerebral hemorrhage, craniocerebral trauma and the like; the patient transfer device, after being used for transferring patients during and after operations, can serve as the sickbed; the patient transfer device is simple to operate; and the patient transfer device is capable of avoiding secondary injury to the patients and guaranteeing the comfort of the patients during moving to the greatest extent.

The invention relates to a traditional Chinese medicine preparation for treating craniocerebral trauma and neurologic impairment caused by craniocerebral operations, which can effectively improve cerebral damaged motor nerves. The traditional Chinese medicine preparation is prepared from ginseng, angelica, hoantchy roots, flastem milkvetch seeds, medlar, red sage roots, pearl powder, earthworm, rhizoma gastrodiae, panax notoginseng, grassleaf sweelflag rhizome, hemlock parsley and kudzuvine roots. The preparation method comprises the following steps that: (1) the ginseng, the panax notoginseng, the rhizoma gastrodiae, the kudzuvine roots and the earthworm are broken into particles; the particles are added with ethanol, heated, refluxed, extracted, heated, concentrated and dried to be powder; and herb residue is reserved on standby; (2) the angelica and the hemlock parsley are soaked in water, heated and distilled; volatile oil is extracted; and the herb residue is reserved on standby; (3) the herb residue and residual medicine are combined, added with water and decocted; decoction is combined, filtered, concentrated and spray-dried; and (4) the volatile oil is added with water and beta-cyclodextrin, ground, included, filtered, dried, ground, well mixed with dry powder, sequentially added and well mixed with pearl powder and dextrin, added with the ethanol and dried. The preparation has the advantages of advanced technique, reasonable composition, no toxic-side effect and remarkable treatment effect.

The invention discloses a medicinal composition containing weinaolutong (7, 3', 4'-troxerutin) obtained by hydroxyethylating eldrin and brain extract which is extracted form brain tissue of mammalian except human. The medicinal composition contains 1 to 1000 parts of weinaolutong, by weight, and the weight of the weinaolutong in the medicinal composition is 0.1 to 200 times bigger than total nitrogen content in the brain extract. The invention also discloses preparation method and use of the medicinal composition. The medicinal composition can restrain platelet agglutination thereby preventing thrombosis, and can regulate and improve brain supersession, and is used for treating acute and chronic cerebrovascular disease and sequela such as brain dysfunctional caused by craniocerebral trauma and cerebrovascular disease; and can also be used for treating occlusive syndrome, arteriosclerosis, thrombosis phlebitis, capillary bleeding and dropsy caused by elevation of vascular permeability.

The invention discloses a pig blood protein-free extract preparation, pertaining to the technical field of biochemical drugs. The pig blood protein-free extract freeze-dried powder injection preparation is prepared by pig blood protein-free extract and an excipient, and the weight ratio of the pig blood extract and the excipient is 200: 30 to 500. The pig blood protein-free extract of the invention applies pig blood as a raw material source to replace calf blood in the preparation of drugs for the treatment of cerebral vascular diseases, the improvement of nervous function defects caused by cerebral ischemia and craniocerebral trauma and the treatment of peripheral blood disorder symptoms, thus producing the biochemical drugs with the same function, replacing the similar products with the calf blood source, becoming the best choice of drug for the treatment and the auxiliary treatment of cardiovascular and cerebrovascular diseases and having very wide range of clinical application prospect. The product of the invention adopts the pig blood as the raw material, compared with the similar calf blood products, the product has the product advantages of high safety and high biological activity; furthermore, as the raw material is easy to obtain, the cost is low, the production process is advanced, the period is short and the yield is high, the product of the invention has the price advantage compared with the similar calf blood products.

The invention discloses a craniocerebral trauma model system under the action of bullet impact or shock waves. According to the adopted the technical scheme, the model used in the craniocerebral trauma model system comprises preparation of a craniocerebral model and is applied to analysis of craniocerebral trauma conditions under the action of bullet impact or shock waves. The craniocerebral modelcomprises basic structures of scalp, skull, brain tissue and cerebrospinal fluid, and meanwhile, a brain tissue acceleration sensor, an intracranial pressure sensor and a skull stress strain sensor are implanted in the model. The sensors are connected with a data acquisition module through data lines in sensor connecting bases and data is transmitted to a data evaluation module after being processed by a data processing module. The craniocerebral trauma model can be used in the field of effectiveness evaluation of protection equipment, quantifies the protection effectiveness of the protectionequipment, and can carry out research on the injury and protection of the human head from the view point of simulating human mechanical indexes. The defects of biological tests are overcome, and thecredibility of data approaching a real person is improved.

The invention relates to the technical field of cooling devices, in particular to a novel cooling device for craniocerebral trauma nursing. The cooling device comprises a bed board, supporting legs are respectively connected with the four corners of the lower end of the bed board, and a reinforcing plate is fixedly connected between the lower portions of every two supporting legs; a long-strip-shaped plate is connected with the left side of the upper end of each reinforcing plate, an installing groove is formed in the middle of the upper end of the long-strip-shaped plate, and a lead screw isrotatably connected with the inside of each installing groove; the outer sides of the lead screws are in threaded connection with two lead screw slide bases with the opposite screwing directions, oscillating rods are hinged to the upper ends of the lead screw slide bases through hinge pins, and the upper ends of the oscillating rods are hinged to the bottom of the bed board through hinge pins; a groove is formed in the right end of the bed board, and a bearing plate is rotatably connected with the inside of the groove through a rotary shaft. The device is reasonable in structure design, convenient to use, high in practicability and functionality and more convenient to use.

The invention discloses a craniocerebral trauma drilling exploration device comprising a frame. Rotating frames are arranged on the two sides of the front end of the frame correspondingly. The inner walls of the rotating frames are rotationally connected with a movable frame; and the surface of the movable frame is slidably connected with a sliding block. The top of the sliding block is fixedly connected with an electric cylinder; a movable end of the electric cylinder is fixedly connected with a connecting plate; the top of the connecting plate is fixedly connected with a driving motor; and adrill bit is fixedly connected to the output end of the driving motor. A rotating shaft is rotatably connected to the interior of the sliding block; a driving gear is fixedly connected to the middleof the rotating shaft; a rack is arranged on the surface of the movable frame; and the rack is in meshing transmission with the driving gear. The invention relates to the technical field of medical instruments. According to the craniocerebral trauma drilling exploration device, problems that the existing craniocerebral drill is in a handheld mode, flexible to use, low in drilling precision and stability, and prone to cause aggravation due to operation errors to affect the treatment rate are solved.

The invention relates to a citicoline sodium injection pharmaceutical composition and a preparation method thereof. Particularly, the invention belongs to the technical field of medicines, relates to a pharmaceutical composition for treating consciousness disturbance caused by acute craniocerebral trauma and brain surgery and particularly relates to an injection pharmaceutical composition for treating consciousness disturbance caused by acute craniocerebral trauma and brain surgery. More particularly, the invention relates to the citicoline sodium injection pharmaceutical composition and a preparation method of citicoline sodium injection. The citicoline sodium injection comprises citicoline sodium and injection water, wherein the injection water serves as a solvent, and the concentration of citicoline sodium is 0.01g / ml-1g / ml. The citicoline sodium injection has excellent pharmaceutical properties explained in the specification.

The invention relates to a portable rechargeable multifunctional skull drill and application thereof. The skull drill is a novel multifunctional neurosurgical electric tool, can be used for checking, diagnosing, preventing, treating and researching severe closed craniocerebral injury patients, particularly extremely severe craniocerebral injury patients, has simple structure, easy operation, low use cost, small volume, symmetrical force application, stable drilling, and improved utilization safety, and is more suitable for emergent treatment of pre hospitals, 120 ambulances, low level hospitals and emergency rooms in large size hospitals to provide possibility of early and super-early neurosurgical operation interference so as to greatly facilitate protraction of emergency medical treatment, achieve the aim of reducing the pre-hospital death rate of battling craniocerebral injury, and improve the effects and quality of the emergent medical treatment. The portable rechargeable multifunctional skull drill can be effectively combined into a complete set as a portable craniocerebral injury first-aid equipment kit which can be applied to field fight first aid for various battling craniocerebral injuries.

The invention provides an early warning method for a craniocerebral trauma specialized disease. The early warning method comprises the following steps: step 1, acquiring the consciousness level and various physiological index score values of a patient; step 2, obtaining a total score of each current index of the patient according to each score in the step 1; and step 3, outputting an early warning monitoring scheme corresponding to the total score of each current index of the patient according to the total score of each current index of the patient so as to remind the medical staff to monitor the patient according to the early warning monitoring scheme; the defect that medical staff can not achieve the purpose of early warning and judging the illness state of a patient by judging the illness state of the patient by themselves is overcome.

The invention relates to a traditional Chinese medicinal extract product prepared from traditional Chinese medicinal raw materials composed of root of large-flowered skullcap, cape jasmine and pseudo-ginseng, a traditional Chinese medicinal composition containing scutelloside, geniposide and panax notoginseng saponins, a medicine containing the traditional Chinese medicinal extract product or the traditional Chinese medicinal composition, and their clinical application. The traditional Chinese medicinal extract product, the traditional Chinese medicinal composition and the medicine containing the traditional Chinese medicinal extract product or the traditional Chinese medicinal composition can be used in emergency treatment and treatment of diseases such as cerebrovascular disease, intracranial infection, craniocerebral trauma, craniocerebral space-occupying lesion or intoxication and the like, which are mainly represented by brain edema.

A medicinal composition for treating cerebrovascular diseases, craniocerebral trauma, cerebral disfunction, arteriosclerosis, thrombophlebitis, etc is prepared from 7,3',4'-trihydroxyethyl rutin and the liquid extract of the brain of mammal except man.

The invention relates to dressing for craniocerebral trauma and a preparation method of the dressing. The dressing for craniocerebral trauma comprises a fixed layer, a backing layer as well as a waterabsorption layer and a drug layer which are arranged on the backing layer at an interval from outside to inside sequentially, wherein the drug layer comprises kaempferol-3-O-rhamnopyranoside, and a matrix of the drug layer is selected from alginate gel, cellulose gel, chitosan gel and the like. The dressing for craniocerebral trauma has the effect of promoting wound healing, and the effect of promoting wound healing is better when the matrix of the drug layer is chitosan gel containing chitosan oligosaccharide.

The invention discloses a convenient nursing bed used after craniocerebral trauma surgery. The convenient nursing bed comprises a bed plate, wherein the bottom corners of the bed plate are welded withsupport legs, a first guardrail and a second guardrail are respectively installed on the left and right sides of the top of the bed plate, the top right side screw of the bed plate is connected withtwo telescopic mechanisms which are symmetrical in front and rear, the top end of the telescopic mechanism on the rear side is connected with one end of a baffle plate, the top end of the telescopic mechanism on the front side is screwed to the other end of the baffle plate, the left side of the upper surface of the bed plate is provided with a rectangular hole, and the left side of an inner cavity of the rectangular hole is axially connected with a support plate. The convenient nursing bed can perform arm baffling for patients with different chest thicknesses, prevents the patient from touching the head while sleeping or inadvertently lifting the arm, and can prevent the wound from being damaged, and the patient's legs can move on a rotating mechanism to prevent the body from deteriorating, which greatly meets the needs of the patient's rehabilitation.

The invention relates to an endocranium fret saw for preventing acute encephalocele in a craniocerebral trauma operation. The endocranium fret saw comprises a casing pipe and a fret saw body, a line is marked on the inner side of the casing pipe, an opening is formed in the inner side of the middle of the casing pipe, and the fret saw body penetrates through the casing pipe. The endocranium fret saw has the advantages that the fret saw body is arranged, the endocranium is cut open by the fret saw body after the cranium is closed, brain tissue plumped backwards after the endocranium is cut open is blocked by sutured muscular layers and the scalp, the outside of the scalp can be bound by bandages, so that the intracranial and extracranial pressure difference is controlled, intracranial hypertension is released step by step, the brain tissue is prevented from being bulged outwards rapidly, and acute encephalocele is greatly avoided. After the cranium is closed, under the non-visual condition, the fret saw is used for cutting the endocranium open, the casing pipe separates the fret saw body from the brain tissue, and the brain tissue can be prevented from being hurt.

The invention relates to a traditional Chinese medicine treating hiccup after a craniocerebral trauma cerebral hemorrhage drainage operation, and mainly aims to overcome defects in the prior art. The traditional Chinese medicine is prepared from the following materials in parts by weight: 2-3 parts of Chinese thorowax, 2-3 parts of baical skullcap root, 2-3 parts of ginger processed pinellia, 3-5 parts of Indian buead, 2-3 parts of dried orange peel, 2-3 parts of immature bitter orange, 3-5 parts of radix salviae miltiorrhizae, 2-3 parts of red paeony root, 2-3 parts of curcuma aromatica, 2-3 parts of sweet flag, 3-6 parts of caulis bambusae in taeniam, 2-3 parts of arisaema cum bile, 3-5 parts of radix cyathulae, 2-4 parts of kaki calyx, 3-6 parts of inula flower, 3-6 parts of raddle, 0.2-0.6 part of pseudo-ginsheng powder, and 0.2-0.6 part of dragon's blood. The medicine is reasonable in medicine compatibility, and remarkable in curative effect; compared with the prior art, hiccup elimination coefficient of a curative group is higher than that of a control group by 38.96% after the medicine is taken for 3 days; total effective rate is higher by 41.79%.

The invention discloses a probiotic composition which comprises lactobacillus, oribacterium and rothia. The probiotic composition can be administered to regulate the intestinal flora so as to regulatethe sleep disorder of patients with craniocerebral trauma, the significance of the intestinal flora in regulation of the functions and behaviors of brain control is clarified, some theoretical basesare provided for preventing and treating the sleep disorder through intestinal microecological regulation, and the probiotic composition is used for guiding the prevention and treatment of the sleep disorder after clinical craniocerebral trauma.

The invention discloses a traditional Chinese medicinepreparation for treating mental disordersassociated with craniocerebral trauma. The traditional Chinese medicine thinks that traumatic mental disorders are formed by qi-stagnation and blood stasis, effects on direct pouring of blood of five internal organ essences and vital energy of six hollow organs caused by hemorrhage of blood vessels or blood vesselstasis caused by trauma or pulse vessel oppression of blood stasis blocks out of the blood vessel, resulting in deficiency of warm qi and moistened blood of the fix hollow organs. The traditional Chinese medicines, such as kadsura rootbark, schisandra propinqua, astilbe chinensis root, snakeroot, fiveleaf akebia fruit, jasminum grandiflorum, allium macrostemon, scarlet kadsura root and ixora chinensis root are selected to be decocted with water into decoction. A clinical test proves that the total effective rate reaches 82.0%; the curative effect is superior to that of a control group; and the traditional Chinese medicinepreparation is worthy of clinical popularization and application.

A method for treating sensorineural hearing loss caused by different factors, such as hyperbilirubinemia, birth injuries, viral and bacterial infections, ototoxic medications, Usher's syndrome, craniocerebral trauma with a fracture of the base of the scull and the pyramid of the temporal bone, and neurinomas. The method includes administering donepezil hydrochloride (ARICEPT®) in a dosage of 2.5 to 5 mg for an adult, one to two times a day, for 3 to 15 courses of treatment of 20-25 days each. For a child, the dosage is reduced to a range of 0.625 to 1.25 mg.

The invention relates to a traditional Chinese medicine preparation for treating craniocerebral trauma and neurologic impairment caused by craniocerebral operations, which can effectively improve cerebral damaged motor nerves. The traditional Chinese medicine preparation is prepared from ginseng, angelica, hoantchy roots, flastem milkvetch seeds, medlar, red sage roots, pearl powder, earthworm, rhizoma gastrodiae, panax notoginseng, grassleaf sweelflag rhizome, hemlock parsley and kudzuvine roots. The preparation method comprises the following steps that: (1) the ginseng, the panax notoginseng, the rhizoma gastrodiae, the kudzuvine roots and the earthworm are broken into particles; the particles are added with ethanol, heated, refluxed, extracted, heated, concentrated and dried to be powder; and herb residue is reserved on standby; (2) the angelica and the hemlock parsley are soaked in water, heated and distilled; volatile oil is extracted; and the herb residue is reserved on standby;(3) the herb residue and residual medicine are combined, added with water and decocted; decoction is combined, filtered, concentrated and spray-dried; and (4) the volatile oil is added with water andbeta-cyclodextrin, ground, included, filtered, dried, ground, well mixed with dry powder, sequentially added and well mixed with pearl powder and dextrin, added with the ethanol and dried. The preparation has the advantages of advanced technique, reasonable composition, no toxic-side effect and remarkable treatment effect.

The invention discloses a traditional Chinese medicinal enema for treating constipation after craniocerebral trauma. According to traditional Chinese medicine, craniocerebral trauma may cause dysfunction of internal organs, disturbance of middle jiao and qi activity, combination of phlegm and heat as well as elimination and burning of body fluid, and subsequently the symptom of dry stool or constipation appears. The enema disclosed by the invention is prepared from the following traditional Chinese medicines having functions of clearing heat and hollow viscera, removing blood stasis and stimulating menstrual flow, restoring consciousness and inducing resuscitation, and eliminating phlegm and freeing channels: haloragis micrantha, patience dock root, delavay schefflera root, twig and leaf of taperleaf Japanese spiraea, garden balsam, woolyfruit stylophorum herb, coral ardisia leaf, laxflower embelia root, radix ampelopsis, calamus and Chinese honeylocust root and bark, by decocting with water. Upon clinical tests, total effective rate of the enema reaches 96.0%, which is significantly better than that of a control group; and the enema is significant in curative effect and low in recurrence rate.

The invention provides a traditional Chinese medicine for treating qi-stagnation and blood-stasis type craniocerebral trauma syndrome and a preparation method of the traditional Chinese medicine. The traditional Chinese medicine is prepared from the following raw herbal materials: meconopsis horridula, rauwolfia, fructus tribuli purus, red sage root, ixeris sonchifolia hance, aspidistra elatior, herb or root of common rockvine, zanthoxylum nitidum dc, mysorethorn, style pachysandra herb, ipomoea cairica, heterophyllous wing seedtreeroot and beechey fig root. The traditional Chinese medicine disclosed by the invention is exact in curative effect in treating qi-stagnation and blood-stasis type craniocerebral trauma syndrome, and small in toxic or side effect.

The invention relates to a technical solution of an implantable electrical stimulation ear vagus nerve coma awakening system comprising an electrode line and a low frequency pulse generator, wherein SOC chips are distributed on one side of the electrode line, the other side of each of the SOC chip is connected with an external controller, a remote controller is mounted on one side inside the external controller, and a mobile phone control unit is fixed at the other end of the remote controller. The technical solution of the implantable electrical stimulation ear vagus nerve coma awakening system has the advantages that it is showed through a number of clinical studies that the electrical stimulation ear vagus nerve has a significant awakening effect on coma patients caused by craniocerebral trauma and the like. The technical scheme of the system can promote the accelerated flow of cerebral blood flow, promote the release of neurotransmitters, promote the recovery of advanced neurological functions, promote the probability of awakening, and increase the speed of recovery. The technical solution can effectively restore the language and motor function of comatose patients, reduce thedisability rate of patients and improve the life quality of patients, and clinical recovery is good.

The invention belongs to the technical field of medicine preparation, and particularly relates to a medicine for treating consciousness disorder and a preparation method of the medicine. The preparation method is as follows: S1, adding water for injection into a container A, adding citicoline sodium according to a prescription amount, keeping the temperature at 5-100 DEG C, then adding the water for injection to prepare a citicoline sodium concentrated solution, adjusting the pH value with 0.1-3mol / L hydrochloric acid or sodium hydroxide solution, then adding activated carbon, keeping the temperature for 5-55 minutes, and then performing filtering and decarburizing by using a filtering device; And S2, adding the water for injection into a container B, performing heating to 5-100 DEG C, then adding mannitol according to a prescription dosage, performing stirring while heating until the mannitol completely dissolves, then adding the water for injection at the temperature of 5-100 DEG C, adding activated carbon accounting for 0.03-0.3% (w / v) of the total volume of the mannitol solution, keeping the temperature for 5-55 minutes, and then performing filtering and decarburizing by using a filtering device. The influence of the pH value and the temperature on the stability and the effect of the medicine is reduced, and the curative effect of treating acute craniocerebral trauma and brain postoperative consciousness disturbance can be improved.

The invention discloses a traditional Chinese medicinal composition for treating pediatric epilepsy during an attack period. The pediatric epilepsy is induced by craniocerebral trauma, birth injury or collateral damage, and is represented as stagnation of blood stasis and obstruction in collaterals, therefore the symptom may result in sudden faint. For the reason, the traditional Chinese medicinal composition is a traditional Chinese medicinal preparation prepared from the following traditional Chinese medicines: campsis grandiflora, laxflower pottsia root, euphorbia humifusa, wilson passion flower, white-flowered agapetes, winter jasmine, red rhodobryum, yichang meadow rue, Japanese peristrophe herb and vittaria flexuosa which function as promoting blood circulation and dissolving stasis, relieving convulsion and treating epilepsy. A clinical test in the hospital shows that the traditional Chinese medicinal composition is significant in curative effect and achieves a total effective rate of 95.8%, so that the traditional Chinese medicinal composition is worthy of clinical popularization and application.

The invention relates to a traditional Chinese medicinal extract product prepared from traditional Chinese medicinal raw materials composed of root of large-flowered skullcap, cape jasmine and pseudo-ginseng, a traditional Chinese medicinal composition containing scutelloside, geniposide and panax notoginseng saponins, a medicine containing the traditional Chinese medicinal extract product or the traditional Chinese medicinal composition, and their clinical application. The traditional Chinese medicinal extract product, the traditional Chinese medicinal composition and the medicine containing the traditional Chinese medicinal extract product or the traditional Chinese medicinal composition can be used in emergency treatment and treatment of diseases such as cerebrovascular disease, intracranial infection, craniocerebral trauma, craniocerebral space-occupying lesion or intoxication and the like, which are mainly represented by brain edema.