417 results about "Thrombosis" patented technology

The present invention discloses a prosthetic heart valve comprising at least two valve components, a sealant covering the valve components, and an edge-sealing structure. A space is formed between the valve components covered with the sealant. The edge-sealing structure has a closed end face and connects the ends of the sealant to form a closed space within the space. The prosthetic heart valve provided by the present invention can reduce the risk of thrombosis between the valve components. Because the edge-sealing structure is flexible, it has little effect on the compression and gripping of the prosthetic valve, and the addition of the edge-sealing structure does not affect the normal function of the prosthetic valve.

The invention discloses a sublingual collateral feature extraction and pathological analysis system and method, and relates to the technical field of traditional Chinese medicine tongue diagnosis. Dynamic pressure is applied to the sublingual through a miniature ultrasonic array arranged in a tongue depressor, and meanwhile, an annular polarization multispectral light source is started; an ultrasonic echo signal, a photoacoustic pressure wave and an anti-reflection multispectral image are collected to generate a time-space synchronous fusion data set, and further through a compressed sensing reconstruction algorithm, a biomechanical feedback engine, an acousto-optic thrombus analysis module and the like, the thrombus is reconstructed. According to the four-dimensional pathological risk assessment map generation method and system, the limitation of traditional static detection is overcome, dynamic coupling assessment of blood vessel biomechanical characteristics and thrombosis is achieved, and the risk assessment map generation method and system have the advantages of being high in accuracy, high in accuracy and high in reliability. And the clinical applicability and the diagnosis efficiency of sublingual vein analysis are remarkably improved.

The invention discloses a deep venous thrombosis early warning method and system based on multi-modal physiological signals, and relates to the technical field of health monitoring. The method is used for realizing thrombus early recognition and graded early warning. The method comprises the following steps: synchronously acquiring physiological signals of lower limbs on two sides through a multi-modal sensing device, performing motion artifact elimination and signal quality screening, and generating preprocessed time sequence data; performing dynamic time warping and feature extraction on the time series data, calculating a bilateral symmetry index and an instantaneous and accumulated time-varying difference degree, and fusing the bilateral symmetry index and the instantaneous and accumulated time-varying difference degree with absolute physiological parameters to form a comprehensive risk assessment vector; establishing a dynamic baseline based on the historical risk vector, calculating a current deviation index, and recognizing an abnormal state in combination with a double-side cooperation mode; and according to the deviation index and the duration, in combination with the abnormality type and the severity, generating a graded early warning signal containing a risk grade and a disposal suggestion through multi-stage judgment, thereby realizing early warning and risk management of thrombus.

The invention discloses a TAVR postoperative blood flow parameter complementing method based on CT-MRI fusion, and belongs to the technical field of crossing of medical image processing and computational fluid mechanics. A CT valve frame registration technology is adopted, an invisible artificial valve leaflet three-dimensional structure is reconstructed through valve frame information in a CT image and is coupled with a dynamic heart model, a complete valve mechanical and functional simulation platform is constructed, the problem of an imaging blind area is solved, hemodynamic parameters of an inlet and an outlet of a postoperative area are further collected in combination with 4D Flow MRI, and the artificial valve leaflet three-dimensional structure is obtained. The blood flow conditions of the upstream and the downstream of the artificial valve area at each stage of contraction and relaxation of the TAVR postoperative part are comprehensively restored, the temporal-spatial resolution and the physical authenticity of the boundary condition in fluid-solid coupling simulation are greatly improved, and the more real passive response of the valve leaflet under the action of the blood flow is obtained; and a reliable basis is provided for quantitative and mechanical risk analysis of postoperative complications such as thrombosis, perivalvular leakage and valve leaflet fatigue.

The invention provides a multifunctional intelligent anti-thrombus PICC (peripherally inserted central catheter) for tumor chemotherapy, which comprises a catheter body, a catheter tip, a main infusion cavity, a first auxiliary cavity and a second auxiliary cavity, and the first auxiliary cavity and the second auxiliary cavity are arranged around the main infusion cavity to form a spiral structure; a micro pressure sensor array is embedded in the pipe wall of the first auxiliary cavity; a biological impedance measuring electrode pair is embedded in the pipe wall of the second auxiliary cavity; and the micro pressure sensor array, the biological impedance measuring electrode pair, the micro ultrasonic transducer and the temperature sensor are connected with a processor. According to the method, active thrombus prevention is achieved, passive treatment is changed into active prevention through a triple mechanism, and the thrombus occurrence rate is greatly reduced; meanwhile, the tube body is formed by mutually winding, fusing and extruding three independent cavities (a main infusion cavity, a first auxiliary cavity and a second auxiliary cavity) like a DNA double helix (triple helix is provided herein); and the mechanical stimulation and damage to the inner wall of the blood vessel are reduced.

The invention provides an application of catalase nanoparticles in preparation of a medicine for preventing or treating thrombus. A method for preparing the catalase nanoparticles comprises the following steps: 1) reacting dopamine with melanin to generate melanin modified by the dopamine; 2) preparing catalase with carboxyl activated by EDC; and 3) in the presence of NHS, mixing the melanin modified by dopamine with the catalase with carboxyl activated by EDC, stirring overnight, then adding amino methoxy polyethylene glycol (mPEG-NH2), and continuing to react for 3 hours to obtain a product, namely the melanin-dopamine-catalase nanoparticles. The catalase nanoparticles provided by the invention can maintain the biological activity of melanin and catalase for a long time, and can avoid the risk of bleeding when preventing or treating thrombus.

A nested valved pipeline comprises an outer pipeline, a pipeline support on the inner wall of the outer pipeline and valve leaflets arranged on the pipeline support, 3-5 main ribs extend from the center of the root of each valve leaflet to the edge of each valve leaflet, secondary branch ribs are distributed among the main ribs, and the main ribs and the secondary branch ribs form reinforcing ribs for net-shaped supporting; the reinforcing ribs are embedded into the valve leaflets and are integrally formed with the valve leaflets; the root of the reinforcing rib extends to the attachment area of the valve leaflet and the pipeline support to form a T-shaped anchoring structure, an annular groove is designed in the edge, close to the root of the valve leaflet, of the pipeline support, the T-shaped anchoring structure of the reinforcing rib is embedded into the groove of the pipeline support, and a gap between the valve leaflet and the pipeline support is filled with biological glue; the pipeline support and the outer pipeline are combined and fixed in a physical and chemical mode. The valve leaflet falling risk is reduced, the fatigue life is prolonged, and the reflux and thrombus risks are reduced; due to the nested design of the outer pipeline and the pipeline support, the connecting difficulty between the valve leaflet and the outer pipeline is reduced, and 3D complex design and batch production of the valve leaflet are conveniently achieved.

An implantable pump system is provided, including an implantable blood pump suitable for use as a partial support assist device, the system further including an extracorporeal battery and a controller coupled to the implantable pump, and a programmer selectively periodically coupled to the controller to configure and adjust operating parameters of the implantable pump. The implantable pump includes a flexible membrane coupled to an electromagnetic actuator including a magnetic assembly and electromagnetic assembly, so that when the electromagnetic assembly is energized, the electromagnetic assembly causes wavelike undulations to propagate along the flexible membrane to propel blood through the implantable pump. The controller may be programmed by a programmer to operate at frequencies and duty cycles that mimic physiologic flow rates and pulsatility while operating in an efficient manner that avoids thrombus formation, hemolysis and / or platelet activation.

A prosthetic heart valve for the treatment of structural heart disease wherein the prosthetic heart valve includes an expandable frame that a) has an open cell geometry in the frame of the prosthetic heart valve that can be used to reduce delivery system size, b) has high radial strength, c) has improved restoration of the physiologic EOA, d) has lower recoil, e) has little or no longitudinal foreshortening, f) allows for proper placement of the bioprosthetic valve in relation to the native commissures of the valve, h) has symmetrical and cylindrical expansion of the prosthetic valve resulting in lower rates of leaflet thrombosis and structural valve deterioration, and / or i) prevents allergic response and restenosis associated with nickel content.

The invention belongs to the technical field of microorganisms and biological medicines, and particularly relates to a postbiotic preparation for improving vascular elasticity and relieving hypertension and thrombus as well as a preparation method and application of the postbiotic preparation. Specifically, a strain of lactobacillus rhamnosus is obtained through screening, a postbiotic preparation is successfully developed based on the strain, and tests prove that the lactobacillus rhamnosus has the effects of reducing inflammatory response of vascular endothelium and reducing oxidative stress level so as to promote repair and regeneration of vascular endothelial cells, improve vascular elasticity and quickly improve hypertension; the anti-thrombus effect can be realized. Meanwhile, by optimizing the condition parameters of the preparation process of the metabolite preparation and combining anaerobic fermentation and aerobic fermentation on the lactobacillus rhamnosus, the advantage that metabolites are comprehensive and rich is achieved, and the metabolite preparation has good practical application value.

The invention relates to an extracorporeal circulation control method based on membrane lung resistance and an extracorporeal membrane lung oxygenation system thereof, and aims to solve the core technical bottlenecks of membrane lung blockage, efficiency reduction, embolism risk increase and operation time limitation caused by coagulation activation and thrombosis due to the fact that blood is in contact with non-biological materials in an ECMO system. The core is that pressure sensors at three key positions are used for monitoring an outlet and an inlet of the magnetic suspension blood pump and a membrane lung outlet in real time. And calculating membrane lung resistance pressure difference and scouring resistance pressure difference on the basis. And the system continuously judges whether the pressure difference is abnormal or not. When the pressure difference is normal, the constant flow mode of the blood pump is maintained, and the operation efficiency and stability are guaranteed. And once it is detected that the membrane lung resistance pressure difference and / or the flushing resistance pressure difference are / is abnormal, the blood pump is immediately switched to the pulsation mode. On one hand, thrombus which is deposited or loosened on membrane lung fibers can be physically scoured and scattered, and the blocking process is delayed; on the other hand, the risk that large free thrombus forms embolism can be remarkably reduced.

The invention discloses a fusion protein rHTA and application thereof, the fusion protein rHTA is sequentially composed of a Hirudin protein, a thrombin cleavage site and an AnxV protein from the N terminal to the C terminal, and the amino acid sequence is as shown in SEQ ID NO: 4 from the 1st site to the 393th site from the N terminal. Experiments prove that the fusion protein rHTA is specifically activated by thrombin at the local part of thrombus and releases AnxV protein and Hirudin protein, and the AnxV protein can specifically recognize and combine with PS, so that the fusion protein rHTA is enriched at the thrombosis part containing platelets in a targeted manner, the Hirudin protein is locally released under the action of thrombin, local precise anticoagulation is realized, and the anticoagulation efficiency is further enhanced. Therefore, the fusion protein rHTA provided by the invention not only has high anticoagulant activity, but also realizes enrichment and release at the thrombus formation part, and reduces the bleeding risk. The method has an important application value.

An antithrombotic surface-modified biomaterial is provided comprising a biomaterial substrate coated with a polymerizable dopamine-containing bioadhesive to which is attached one or more antithrombotic agents. A method of preparing the surface-modified biomaterial is also provided. The surface-modified biomaterial is beneficial for use in blood-contacting medical devices such as catheters, dialyzers and blood oxygenators to prevent or minimize the occurrence of thrombosis on the surface thereof.

The application provides an absorbable vascular stent covering facilitating endothelialization and a preparation method thereof, and belongs to the technical fields of biomedical materials and vascular stent covering preparation. The absorbable vascular stent covering facilitating endothelialization is prepared based on modified silk fibroin and domestic silkworm silk. The inner surface of the absorbable vascular stent covering facilitating endothelialization has a nano topological structure and a matrix-like component simulating a vascular basement membrane, and the outer surface has a micro topological structure. The absorbable vascular stent covering facilitating endothelialization has good mechanical properties and excellent endothelial cell activity, and can be used for producing a vascular stent capable of rapidly forming a new endothelial layer, maintaining stable blood flow, and inhibiting thrombosis and inflammation.

The present disclosure relates to methods of reducing the risk of thrombosis with thrombocytopenia syndrome (TTS) associated with adenoviral vector therapy.

The invention discloses application of polyol nitrate in frostbite resistance, and belongs to the technical field of skin protection articles. The polyol nitrate is used as an active component of the ointment, and by slowly releasing nitric oxide and activating vascular endothelial nitric oxide synthase, spasm capillaries in the early stage of frostbite are effectively relaxed, platelet aggregation and thrombosis are inhibited, so that the pathological cascade reaction of frostbite is blocked, and the prevention and treatment effects on frostbite are remarkably improved. Compared with the prior art, the polyol nitrate and the ointment are scientific and reasonable in preparation method and safe and convenient to use, and a brand-new and effective solution is provided for prevention and treatment of skin frostbite in a cold environment.

The invention relates to the technical field of medical instruments, and discloses an intervention pump conveying device which comprises an expansion assembly, a conveying assembly and a pushing assembly, and the conveying assembly comprises a front end assembly and a rear end assembly which are detachably and fixedly connected; the expansion assembly is detachably and fixedly connected with the front end assembly, the front end assembly and the rear end assembly are connected to form an intervention channel allowing the pushing assembly to carry the intervention pump to penetrate through, and the pushing assembly is provided with a pushing channel allowing a pump line of the intervention pump to penetrate through in the axial direction. The pushing assembly can fix or loosen a pump line of the intervention pump so as to achieve pushing and releasing of the intervention pump. The invention further discloses another conveying method of the interventional pump. By constructing a split type collaborative structure, accurate pushing and stable releasing of the interventional pump are achieved, mechanical invasion and occupation to punctured blood vessels are reduced, the risk of complications such as thrombosis and bleeding is reduced, the surgical operation process is simplified, and the minimally invasive property and safety of interventional therapy are improved.

The thrombus aspiration catheter comprises a catheter body and a deformation structure, and the deformation structure comprises a plurality of supporting rings and deformation assemblies arranged between every two adjacent supporting rings; when the axial distance between every two adjacent supporting rings is reduced, the deformation assembly deforms inwards in the radial direction, and the deformation assembly and the two adjacent supporting rings jointly form a variable-diameter channel with the inner diameter firstly decreasing and then increasing from far to near. When the axial distance between every two adjacent supporting rings is increased, the deformation assemblies deform and recover in the radial direction, and the minimum inner diameter of a channel formed by the deformation assemblies and the two adjacent supporting rings is correspondingly increased. The variable-diameter channel can form mechanical wrapping and clamping on the thrombus at the position with the minimum inner diameter, and thrombus escape or far-end embolism in the suction process is effectively prevented; meanwhile, the structure is beneficial for forming a negative pressure enhancing cavity at the far end of the catheter body, and stable grasping and concentrated efficient suction of the thrombus are achieved.

The invention relates to a crystal form of a compound shown as a formula I or a pharmaceutically acceptable salt thereof and a preparation method of the crystal form of the compound shown as the formula I or the pharmaceutically acceptable salt thereof. The compound of the formula I or the pharmaceutically acceptable salt thereof is used for treating cardiovascular diseases, endothelial dysfunction, diastolic dysfunction, atherosclerosis, hypertension, heart failure, pulmonary arterial hypertension (WHO levels I, II, III, IV), angina pectoris, thrombus, restenosis, myocardial infarction, stroke, cardiac insufficiency, fibrosis, pulmonary hyperplasia, erectile dysfunction, asthma, chronic kidney disease, diabetes, and the like. The composition can be used for treating liver cirrhosis, chronic obstructive pulmonary disease (COPD), acute respiratory distress syndrome, acute lung injury, pulmonary fibrosis, cystic fibrosis or interstitial lung disease.

The invention relates to the field of medical auxiliary instruments, in particular to an auxiliary device for preventing lower limb thrombus and foot drop. The problems of lower limb blood circulation disorder, foot drop and heel pressure sores of long-term bedridden patients are solved. The device comprises a foot moving mechanism, a bearing part and a massage part, the foot moving mechanism drives a foot sole to rotate through a motor, and passive bending and stretching of the foot sole are achieved through the magnetic interaction of a movable magnet and a fixed magnet set; the bearing part is provided with a heel accommodating groove and a heel tendon supporting ridge structure, so that the heel pressure is effectively dispersed; the massage part automatically triggers alternate work of a lifting air bag and a massage air bag through movement of the shank through a pneumatic transmission mechanism, and intermittent lifting of the heel and cyclic massage of the shank are achieved. The device can synchronously maintain the motion range of ankle joints, promote blood circulation of lower limbs and relieve heel pressure, and has the advantages of being high in automation degree, high in adaptability, safe and comfortable.

The disclosure provides a subclinical valve leaflet thrombosis auxiliary identification method, system and signal acquisition device after transcatheter aortic valve replacement, belonging to the technical field of heart information acquisition and identification. The subclinical valve leaflet thrombosis auxiliary identification method is used for auxiliary diagnosis of subclinical valve leaflet thrombosis after transcatheter aortic valve replacement, comprising: collecting a heart sound signal, processing the heart sound signal, obtaining preset parameters of the heart sound signal, and the preset parameters at least including time, frequency and energy; determining a systolic period according to the heart sound signal; identifying the highest energy point in the characteristic interval of the systolic period; obtaining the characteristic frequency corresponding to the highest energy point, and judging whether the characteristic frequency is greater than the threshold frequency, if yes, marking the heart sound signal as an abnormal heart sound signal caused by subclinical valve leaflet thrombosis; if not, marking the heart sound signal as a normal heart sound signal. The method solves the problem that the subclinical valve leaflet thrombosis detection mainly uses multi-dimensional computed tomography, which leads to limited scope of application.

A system for preventing or treating thrombosis associated with a vascular access device (VAD) may include an ultrasound transducer configured to emit thrombus-disrupting ultrasound waves into a patient's body around the VAD. The ultrasound transducer may include a fixation means for fixing the ultrasound transducer to the patient on the VAD. A method of such a system may include an ultrasound-emitting step. The ultrasound-emitting step may include emitting the thrombus-disrupting ultrasound waves from the ultrasound transducer into the patient's body around the VAD.

Therapeutic agents such as Prasugrel, a thienopyridine ADP receptor inhibitor, which inhibit ADP mediated signaling through the P2Y12 receptor, done or in combination with an angiotensin II receptor blocker (ARB) such as Losartan that specifically blocks the angiotensin II type 1 (AT1) receptors, have been shown to be effective in reducing thrombosis and stenosis of grafts, including vascular grafts and tissue engineered vascular grafts ("TEVGs") in multiple in vivo, and that the combination of a inhibitor of the purinergic receptors P2Y12 such as Prasugrel, with losartan, an angiotensin II type 1 receptor inhibitor, more than additively reduced the incidence of TEVG stenosis. In a preferred embodiment, a multi-dosing unit for treatment to reduce stenosis delivers a 2-week course of losartan and Prasugrel.

An absorbable implantable device, including an iron-based substrate, and a zinc-containing protective layer and a corrosion promoting layer provided on the iron-based substrate. The iron-based substrate has an outer wall and an inner wall. The zinc-containing protective layer covers the outer wall and the inner wall of the iron-based substrate. The corrosion promoting layer covers the zinc-containing protective layer. The thickness ratio of the zinc-containing protective layer located on the outer wall to the corrosion promoting layer located on the outer wall is less than the thickness ratio of the zinc-containing protective layer located on the inner wall to the corrosion promoting layer located on the inner wall. The absorbable implantable device has a low risk of thrombosis and can meet the requirements of early support and later rapid corrosion.

The present disclosure describes cyclic peptide inhibitors of Factor XI (FXI), preferably FXIa. Also described are pharmaceutical compositions comprising the cyclic peptides and their use in treating conditions, diseases and / or disorders responsive to FXI, preferably FXIa inhibition, including thrombosis or thrombo-inflammatory conditions.

The utility model relates to the technical field of ventricular septum perforation plugging devices, and discloses a novel ventricular septum perforation plugging device which comprises a fixing column and a first disc-shaped net arranged on the outer side of the fixing column, a connecting waist part is further arranged on the outer side of the fixing column, and the connecting waist part is connected with the first disc-shaped net. A second disc-shaped net is arranged on the side, away from the first disc-shaped net, of the connecting waist part, an end is arranged on one side of the second disc-shaped net, and before use, a small screw at the front end of a transmission steel cable is used for being connected with the end, so that the whole compressed plugging device can be transmitted to a heart defect part through a pipeline; the first disc-shaped net and the second disc-shaped net are used for blocking, the defect part can be blocked, the biological membrane can make contact with the heart defect part, the sealing performance is further improved, meanwhile, the polyurethane coating has certain flexibility, friction between the polyurethane coating and the heart defect part is effectively reduced, and the service life of the heart defect part is prolonged. The heparin coating can reduce the risk of thrombus formation, so that the use risk is reduced.

Synthetic hemocompatible vascular grafts manufactured from polyvinyl alcohol-based biomaterials containing crystalline segments of polyvinyl alcohol, which are long-term fully functioning vascular grafts that provide no activity towards immune systems in recognizing surfaces as foreign bodies that would normally lead to fibrosis, platelet activation and subsequent thrombi formation, and thus occlusion of the grafts.

This application relates to a thrombus removal device. An outer sheath has an axially penetrating sheath lumen. An inner catheter is movably mounted within the sheath lumen of the outer sheath and also has an axially penetrating catheter lumen. A support assembly is located at the distal end of the inner catheter, and this support assembly has both a contracted and an expanded state. A cutting component is located at the distal end of a transmission tube, which is movably mounted within the catheter lumen of the inner catheter. This transmission tube can insert the cutting component into the support assembly. The transmission tube has a suction channel that communicates with the interior of the support assembly. When the cutting component cuts the target object, the external support assembly provides protection, preventing damage to the target blood vessel. After the target object is fragmented by the cutting component, it can be immediately removed from the body through the suction channel. The cutting space of the cutting component coincides with the suction space of the suction channel, thus effectively capturing the fragmented target object. This effectively improves the removal efficiency and prevents the fragmented target object from escaping.

The application discloses an auxiliary exercise device for preventing lower limb thrombus, which comprises a base, an elbow mechanism arranged on the base, a sliding block, a first fixed plate fixed to one end of the base, a second fixed plate fixed to the other end of the base, a first elbow part rotatably arranged on the first fixed plate, a second elbow part arranged on the other end of the first elbow part and connected with the sliding block through a shaft pin, and a supporting pad arranged on the connection between the first elbow part and the second elbow part, and a screw rod arranged on the second fixed plate. The sliding block is driven to slide in the sliding groove on the base through the screw rod, so that the two elbow parts make upward arching and downward flattening movements on the base. When the knee joint of a user is buckled on the supporting pad, the elbow mechanism drives the leg of the user to arch and flatten, so as to facilitate the leg movement of the user and reduce the formation of leg thrombus of the user.