593 results about "Thrombosis" patented technology

The invention discloses an intelligent training method for preventing lower limb thrombus and a related device, and the method comprises the steps: inputting the physiological parameters of a patient, the initial exercise ability evaluation information and the personalized rehabilitation target information into a DQN multi-mode fusion model, and generating an ankle pump exercise training scheme meeting the rehabilitation demands of the patient; monitoring ankle pump motion execution information of the patient in real time through wearable equipment; according to the ankle pump motion training scheme and the ankle pump motion execution information of the patient, a lower limb thrombus training effect evaluation result of the patient is calculated, and the lower limb thrombus training effect evaluation result comprises the blood circulation improvement degree, the joint motion range and the gait characteristics; according to a lower limb thrombus training effect evaluation result of the patient, predicting lower limb thrombus potential recovery disorder and a falling risk level of the patient, and starting a grading alarm program according to the potential recovery disorder and the falling risk level. The training effect is comprehensively evaluated through the multi-modal data fusion training method, and the lower limb thrombus rehabilitation efficiency is improved.

The invention provides an anticoagulant coating for medical instruments, which can be used in the field of regenerative medical instruments. The prepared anticoagulant coating has short-term and long-term anticoagulant performance, and in addition, the thrombin responsive nanoparticles wrapped in the hydrogel coating can selectively release a factor Xa (FXa) inhibitor apixaban according to needs, so that thrombosis is inhibited in the middle stage of implantation. In-vitro and in-vivo experimental evidences show that after the material is implanted for a long time, an organized endodermis can be seen on the surface of the material, and the material has a special antithrombotic characteristic. The dynamic adjusting system has a multi-layer protection mechanism, and a new thought can be provided for designing the surface of a contact blood material adapting to environmental conditions.

The present invention discloses a prosthetic heart valve comprising at least two valve components, a sealant covering the valve components, and an edge-sealing structure. A space is formed between the valve components covered with the sealant. The edge-sealing structure has a closed end face and connects the ends of the sealant to form a closed space within the space. The prosthetic heart valve provided by the present invention can reduce the risk of thrombosis between the valve components. Because the edge-sealing structure is flexible, it has little effect on the compression and gripping of the prosthetic valve, and the addition of the edge-sealing structure does not affect the normal function of the prosthetic valve.

The invention discloses a femoral artery paracentesis post-operation pressure-controlled hemostasis device and a monitoring intelligent control system thereof, and relates to the technical field of medical apparatuses and instruments, and the femoral artery paracentesis post-operation pressure-controlled hemostasis device comprises an assembly panel; the air bags are arranged at the bottom of the assembly panel; the air pump is arranged at the top of the assembly panel and used for controlling the air bags to contract; the control piece is arranged at the top of the assembly panel and used for controlling the air pump; the Doppler probe is arranged at the bottom of the assembly panel and used for detecting the blood flow speed of the far end of a puncture point, the hemostasis safety and efficiency are remarkably improved through multi-mode intelligent control and a real-time feedback mechanism, the vein area is accurately recognized and avoided in combination with ultrasonic and infrared spectrum analysis of the artery positioning module, the thrombus forming probability is effectively reduced, and the blood flow speed of the far end of the puncture point is detected. The pressure-time optimization model dynamically shortens the compression time (target 3 hours) based on the real-time hemostatic effect, and improves the comfort of the patient while ensuring the hemostatic effect.

The invention discloses a sublingual collateral feature extraction and pathological analysis system and method, and relates to the technical field of traditional Chinese medicine tongue diagnosis. Dynamic pressure is applied to the sublingual through a miniature ultrasonic array arranged in a tongue depressor, and meanwhile, an annular polarization multispectral light source is started; an ultrasonic echo signal, a photoacoustic pressure wave and an anti-reflection multispectral image are collected to generate a time-space synchronous fusion data set, and further through a compressed sensing reconstruction algorithm, a biomechanical feedback engine, an acousto-optic thrombus analysis module and the like, the thrombus is reconstructed. According to the four-dimensional pathological risk assessment map generation method and system, the limitation of traditional static detection is overcome, dynamic coupling assessment of blood vessel biomechanical characteristics and thrombosis is achieved, and the risk assessment map generation method and system have the advantages of being high in accuracy, high in accuracy and high in reliability. And the clinical applicability and the diagnosis efficiency of sublingual vein analysis are remarkably improved.

The invention relates to a medical instrument, and particularly discloses a thrombus removing device which comprises a sheath tube, a thrombus suction catheter is arranged in the sheath tube, the front end of the thrombus suction catheter is connected with a tip head outside the sheath tube, at least one thrombus suction hole is formed in the tube wall of the front section of the thrombus suction catheter, and the tip head is connected with the thrombus suction catheter. The front section of the thrombus suction catheter is further provided with a thrombus capturing net which can be unfolded or folded into the sheath tube, the thrombus capturing net is located on the periphery of the thrombus suction hole, the rear section of the sheath tube is provided with a flushing opening, and the flushing opening is connected with a flushing pipeline through a valve. The device has the functions of trapping, thrombus breaking and suction, is simpler in structure, easy to produce and manufacture and low in cost, thoroughly solves the blockage problem in the thrombus extraction process, does not need in-vitro maintenance, and can continuously perform thrombus extraction operation.

The invention discloses a deep venous thrombosis early warning method and system based on multi-modal physiological signals, and relates to the technical field of health monitoring. The method is used for realizing thrombus early recognition and graded early warning. The method comprises the following steps: synchronously acquiring physiological signals of lower limbs on two sides through a multi-modal sensing device, performing motion artifact elimination and signal quality screening, and generating preprocessed time sequence data; performing dynamic time warping and feature extraction on the time series data, calculating a bilateral symmetry index and an instantaneous and accumulated time-varying difference degree, and fusing the bilateral symmetry index and the instantaneous and accumulated time-varying difference degree with absolute physiological parameters to form a comprehensive risk assessment vector; establishing a dynamic baseline based on the historical risk vector, calculating a current deviation index, and recognizing an abnormal state in combination with a double-side cooperation mode; and according to the deviation index and the duration, in combination with the abnormality type and the severity, generating a graded early warning signal containing a risk grade and a disposal suggestion through multi-stage judgment, thereby realizing early warning and risk management of thrombus.

The invention discloses a TAVR postoperative blood flow parameter complementing method based on CT-MRI fusion, and belongs to the technical field of crossing of medical image processing and computational fluid mechanics. A CT valve frame registration technology is adopted, an invisible artificial valve leaflet three-dimensional structure is reconstructed through valve frame information in a CT image and is coupled with a dynamic heart model, a complete valve mechanical and functional simulation platform is constructed, the problem of an imaging blind area is solved, hemodynamic parameters of an inlet and an outlet of a postoperative area are further collected in combination with 4D Flow MRI, and the artificial valve leaflet three-dimensional structure is obtained. The blood flow conditions of the upstream and the downstream of the artificial valve area at each stage of contraction and relaxation of the TAVR postoperative part are comprehensively restored, the temporal-spatial resolution and the physical authenticity of the boundary condition in fluid-solid coupling simulation are greatly improved, and the more real passive response of the valve leaflet under the action of the blood flow is obtained; and a reliable basis is provided for quantitative and mechanical risk analysis of postoperative complications such as thrombosis, perivalvular leakage and valve leaflet fatigue.

The invention belongs to the technical field of medicines and health-care products, and discloses an earthworm protein peptide polypeptide tablet with functions of dissolving thrombus and protecting blood vessels. Comprising the following components in parts by mass: 20 to 50 parts of earthworm protein peptide, 30 to 40 parts of sorbitol, 2 to 5 parts of lactose, 2 to 10 parts of freeze-dried natto powder, 2 to 10 parts of rice bran fatty alkanol, 1 to 5 parts of dunaliella salina powder, 1 to 5 parts of bovine myocardial peptide powder, 0.01 to 0.05 part of collagen peptide, 0.01 to 0.05 part of soybean peptide powder, 0.01 to 0.05 part of vitamin B6, 0.04 to 0.12 part of a compound nutrition enhancer, 1 to 5 parts of fructo-oligosaccharide, 0.01 to 0.05 part of magnesium stearate and 0.04 to 0.012 part of a compound coating agent. The earthworm protein peptide polypeptide tablet has the effects of thrombolysis and blood fat reduction, can assist in preventing thrombosis, regulating blood fat metabolism and assisting in reducing cholesterol, and has an antioxidant function.

Methods for determining likelihood of thrombosis based on patient-specific anatomic, valve, and flow parameters are disclosed herein. Such methods are used to select a transcatheter aortic valve that decreases likelihood of thrombosis after TAVR procedures. The methods correlate a number of fluid flow and geometric parameters such as stasis volume, neo-sinus volume, kinematic viscosity, dynamic viscosity, heart rate, the circulation, ejection time, velocity of the main jet, wall shear stress, total kinetic energy in the neo sinus volume, width of the neo-sinus, height or depth of the neo-sinus, the angle between the velocity direction and the stent of the transcatheter valve, the distance from the tip of the leaflet perpendicular to the leaflet edge and intersecting the sinotubular junction, and the cross-sectional area of the neo-sinus taken from a longitudinal or axial perspective. Such parameters are used to derive empirical or semi-empirical mathematical models to determine the likelihood of thrombosis.

The invention provides a multifunctional intelligent anti-thrombus PICC (peripherally inserted central catheter) for tumor chemotherapy, which comprises a catheter body, a catheter tip, a main infusion cavity, a first auxiliary cavity and a second auxiliary cavity, and the first auxiliary cavity and the second auxiliary cavity are arranged around the main infusion cavity to form a spiral structure; a micro pressure sensor array is embedded in the pipe wall of the first auxiliary cavity; a biological impedance measuring electrode pair is embedded in the pipe wall of the second auxiliary cavity; and the micro pressure sensor array, the biological impedance measuring electrode pair, the micro ultrasonic transducer and the temperature sensor are connected with a processor. According to the method, active thrombus prevention is achieved, passive treatment is changed into active prevention through a triple mechanism, and the thrombus occurrence rate is greatly reduced; meanwhile, the tube body is formed by mutually winding, fusing and extruding three independent cavities (a main infusion cavity, a first auxiliary cavity and a second auxiliary cavity) like a DNA double helix (triple helix is provided herein); and the mechanical stimulation and damage to the inner wall of the blood vessel are reduced.

The utility model discloses automatic movement auxiliary equipment for preventing thrombus of lower limbs, and relates to the technical field of physiotherapy devices. The device comprises a bottom plate, the right side of the top face of the bottom plate is fixedly connected with a shank bearing assembly, the front face of the bottom plate is fixedly connected with a first supporting plate, the back face of the bottom plate is fixedly connected with a second supporting plate, and a fixing plate is arranged between the first supporting plate and the second supporting plate; binding assemblies used for limiting the feet of the patient are arranged on the surface of the fixing plate, control assemblies used for controlling the fixing plate to rotate and move are installed on the surfaces of the first supporting plate and the second supporting plate, the effect that the ankles of the patient can be conveniently assisted in exercising in the using process is achieved, the patient does not depend on completely independent force generation, and the use is convenient. The exercise process can be more easily insisted, the amplitude of ankle movement can be controlled, and adverse effects on rehabilitation due to the fact that the amplitude is too large are avoided.

The invention discloses an assessment system for a patient with exercise fear, and relates to the technical field of medical health information. In order to solve the problems that postoperative exercise fears of some patients cannot be recognized in time, and the patients have different degrees of exercise fears after operation, so that thrombosis is easily induced, and quantification cannot be realized. Through triangular verification of physiological stress, behavior avoidance and psychological anxiety, the problem that a traditional scale is too high in subjectivity or insufficient in physiological monitoring specificity is solved, the evaluation accuracy is greatly improved, different rehabilitation stages can be automatically adapted based on a threshold adjustment mechanism of postoperative time and individual differences, misjudgment caused by unified evaluation is avoided, and the evaluation accuracy is improved. The method is suitable for personalized management of old people and patients with complex surgeries, personalized evaluation for the patients is carried out, intervention deviation caused by clinical misjudgment is reduced through multi-modal correlation analysis, passive diagnosis is turned into active prevention, and the postoperative thrombus incidence rate is greatly reduced through early recognition of the patients with movement fear.

The invention provides an application of catalase nanoparticles in preparation of a medicine for preventing or treating thrombus. A method for preparing the catalase nanoparticles comprises the following steps: 1) reacting dopamine with melanin to generate melanin modified by the dopamine; 2) preparing catalase with carboxyl activated by EDC; and 3) in the presence of NHS, mixing the melanin modified by dopamine with the catalase with carboxyl activated by EDC, stirring overnight, then adding amino methoxy polyethylene glycol (mPEG-NH2), and continuing to react for 3 hours to obtain a product, namely the melanin-dopamine-catalase nanoparticles. The catalase nanoparticles provided by the invention can maintain the biological activity of melanin and catalase for a long time, and can avoid the risk of bleeding when preventing or treating thrombus.

The invention discloses an application of an ester compound in preparation of an antithrombotic drug. The structural formula of the ester compound is as shown in the following formula: # imgabs0 #. The ester compound can reduce blood clot formation in thrombus tissues by inhibiting TF expression and improve thrombus-related pathological processes by regulating the level of inflammatory factors (such as TXB2 and 6-keto-PGF1 alpha), and is used for preparing antithrombotic drugs.

The invention can provide compounds, analogs of blebbistatin, effective and selective inhibitors of nonmuscle myosin II relative to cardiac myosin II. Compounds can be used in the method of treating a disease, disorder, or medical condition in a patient, comprising modulating myosin II ATPase, such as treatment of substance abuse relapse disorder, or of renal disease, cancer and metastasis, benign prostate hyperplasia, hemostasis or thrombosis, nerve injury including retinal damage, lung fibrosis, liver fibrosis, arthrofibrosis, wound healing, spinal cord injury, periodontitis, glaucoma and immune-related diseases including multiple sclerosis; or wherein the disease, disorder, or medical condition comprises addiction including abuse of or addiction to anything classified as a Substance-Related or Addictive Disorder in the Diagnostic and Statistical Manual of Mental Disorders (DSM), such as, but not limited to, cocaine, opioids, amphetamines, ethanol, cannabis / marijuana, nicotine, and activities including gambling.Compounds are of general formulawith substituents as defined herein.

The utility model relates to a blood pumping catheter and a ventricular assist system.The blood pumping catheter comprises a perfusion cavity, a perfusion pipeline, an elastic element and a first flow adjusting component, the far end of the perfusion pipeline is connected to the perfusion cavity, the elastic element and the first flow adjusting component are both installed on the perfusion pipeline, and the first flow adjusting component is located between the elastic element and the perfusion cavity; the first preset value is larger than or equal to zero, and the first flow adjusting component is in a cut-off state under the condition that the difference value between the near-end-side pressure of the first flow adjusting component and the far-end-side pressure of the first flow adjusting component is smaller than the first preset value. According to the embodiment of the invention, the blood loss of a patient can be reduced, and the risk of thrombus formation and blockage in the perfusion device and the blood pumping catheter is reduced, so that the operation stability and the operation life of the perfusion pipeline on the near end side of the perfusion device and the blood pumping catheter can be relatively improved.

A nested valved pipeline comprises an outer pipeline, a pipeline support on the inner wall of the outer pipeline and valve leaflets arranged on the pipeline support, 3-5 main ribs extend from the center of the root of each valve leaflet to the edge of each valve leaflet, secondary branch ribs are distributed among the main ribs, and the main ribs and the secondary branch ribs form reinforcing ribs for net-shaped supporting; the reinforcing ribs are embedded into the valve leaflets and are integrally formed with the valve leaflets; the root of the reinforcing rib extends to the attachment area of the valve leaflet and the pipeline support to form a T-shaped anchoring structure, an annular groove is designed in the edge, close to the root of the valve leaflet, of the pipeline support, the T-shaped anchoring structure of the reinforcing rib is embedded into the groove of the pipeline support, and a gap between the valve leaflet and the pipeline support is filled with biological glue; the pipeline support and the outer pipeline are combined and fixed in a physical and chemical mode. The valve leaflet falling risk is reduced, the fatigue life is prolonged, and the reflux and thrombus risks are reduced; due to the nested design of the outer pipeline and the pipeline support, the connecting difficulty between the valve leaflet and the outer pipeline is reduced, and 3D complex design and batch production of the valve leaflet are conveniently achieved.

The invention discloses an aneurysm plugging device and a system for plugging aneurys.The plugging device is constructed to be provided with a slender configuration and an expansion configuration which is elastically converted from the slender configuration to radial expansion, and the expansion configuration comprises a gathering part, an extension section and an expansion section connected with the tail end of the extension section which are sequentially connected; an inner cavity is defined by the extension section in the circumferential direction, the extension section comprises at least one inflection unit, the inflection unit comprises a first section extending in the direction away from the axis and a second section inflecting and extending from the far end of the first section to the axis, the expansion section extends in the direction away from the axis from the tail end of the second section, and the second section and the axis are arranged at an interval; the turning part, connected with the second section, on the expansion section is peripherally enclosed to form an annular opening, and the annular opening is communicated with the inner cavity. The extension section can block a tumor neck opening and is tightly attached to a tumor wall, the expansion section fills a tumor cavity, blood flow from a carrier flow pulse to a tumor top is reduced, thrombosis and aneurysm healing are facilitated, and the blocking device can be prevented from falling off from the tumor neck opening.

An implantable pump system is provided, including an implantable blood pump suitable for use as a partial support assist device, the system further including an extracorporeal battery and a controller coupled to the implantable pump, and a programmer selectively periodically coupled to the controller to configure and adjust operating parameters of the implantable pump. The implantable pump includes a flexible membrane coupled to an electromagnetic actuator including a magnetic assembly and electromagnetic assembly, so that when the electromagnetic assembly is energized, the electromagnetic assembly causes wavelike undulations to propagate along the flexible membrane to propel blood through the implantable pump. The controller may be programmed by a programmer to operate at frequencies and duty cycles that mimic physiologic flow rates and pulsatility while operating in an efficient manner that avoids thrombus formation, hemolysis and / or platelet activation.

A prosthetic heart valve for the treatment of structural heart disease wherein the prosthetic heart valve includes an expandable frame that a) has an open cell geometry in the frame of the prosthetic heart valve that can be used to reduce delivery system size, b) has high radial strength, c) has improved restoration of the physiologic EOA, d) has lower recoil, e) has little or no longitudinal foreshortening, f) allows for proper placement of the bioprosthetic valve in relation to the native commissures of the valve, h) has symmetrical and cylindrical expansion of the prosthetic valve resulting in lower rates of leaflet thrombosis and structural valve deterioration, and / or i) prevents allergic response and restenosis associated with nickel content.

The invention provides a spinal operation bracket, and belongs to the technical field of medical instruments, the spinal operation bracket comprises a frame main body, a head supporting part, a thoracic and abdominal supporting part and a leg supporting part are sequentially arranged from the head end to the tail end of the frame main body, and the spinal operation bracket further comprises a heat preservation device rotationally arranged on the side of the leg supporting part; the heat preservation device can be rotationally arranged on the top side of the leg supporting part in a covering mode so as to preserve heat of the legs of the patient, the probability of thrombus occurrence of the patient is reduced, and the defect that original thrombus falls off due to the fact that the legs of the patient are stimulated can be overcome. Meanwhile, the parts for supporting the chest, the abdomen, the thighs and the shanks can be adjusted according to the physical condition of the patient, so that the operation bracket is more suitable for the patient, the patient feels more comfortable, and meanwhile the stability of the patient on the operation bracket can be guaranteed.

The invention belongs to the technical field of microorganisms and biological medicines, and particularly relates to a postbiotic preparation for improving vascular elasticity and relieving hypertension and thrombus as well as a preparation method and application of the postbiotic preparation. Specifically, a strain of lactobacillus rhamnosus is obtained through screening, a postbiotic preparation is successfully developed based on the strain, and tests prove that the lactobacillus rhamnosus has the effects of reducing inflammatory response of vascular endothelium and reducing oxidative stress level so as to promote repair and regeneration of vascular endothelial cells, improve vascular elasticity and quickly improve hypertension; the anti-thrombus effect can be realized. Meanwhile, by optimizing the condition parameters of the preparation process of the metabolite preparation and combining anaerobic fermentation and aerobic fermentation on the lactobacillus rhamnosus, the advantage that metabolites are comprehensive and rich is achieved, and the metabolite preparation has good practical application value.

The invention discloses a stent with a super-lubricating coating as well as a preparation method and application of the stent, and belongs to the technical field of medical materials. The stent provided by the invention is composed of a stent base material and a super-lubricating coating, wherein the super-lubricating coating is composed of a base material pretreatment layer, a super-hydrophobic layer and a lubricating layer. The porous microstructure constructed on the surface of the stent base material is adjusted, and the compactness of the super-hydrophobic layer and the lubricating layer on the surface of the stent is controlled, so that the long-term and dynamic anti-fouling performance is realized, and the risk of adverse reactions such as infection, thrombosis and restenosis after the stent is implanted is reduced. The coating technology provided by the invention can be applied to various clinically common metal and plastic brackets, and has high clinical value.

The invention relates to an extracorporeal circulation control method based on membrane lung resistance and an extracorporeal membrane lung oxygenation system thereof, and aims to solve the core technical bottlenecks of membrane lung blockage, efficiency reduction, embolism risk increase and operation time limitation caused by coagulation activation and thrombosis due to the fact that blood is in contact with non-biological materials in an ECMO system. The core is that pressure sensors at three key positions are used for monitoring an outlet and an inlet of the magnetic suspension blood pump and a membrane lung outlet in real time. And calculating membrane lung resistance pressure difference and scouring resistance pressure difference on the basis. And the system continuously judges whether the pressure difference is abnormal or not. When the pressure difference is normal, the constant flow mode of the blood pump is maintained, and the operation efficiency and stability are guaranteed. And once it is detected that the membrane lung resistance pressure difference and / or the flushing resistance pressure difference are / is abnormal, the blood pump is immediately switched to the pulsation mode. On one hand, thrombus which is deposited or loosened on membrane lung fibers can be physically scoured and scattered, and the blocking process is delayed; on the other hand, the risk that large free thrombus forms embolism can be remarkably reduced.

The invention discloses an anticoagulation endothelium slow release promoting coating and a preparation method thereof, and relates to the technical field of biomedical materials, the method comprises the following steps: soaking a substrate material in a guide layer solution prepared from dopamine, a silane coupling agent containing double bonds and an amino compound; immersing in an assembly layer solution prepared from a double-bond functionalized high-molecular compound and an endothelial active promoting substance, taking out, and carrying out photo-crosslinking curing; and immersing in a regulation and control layer solution prepared from a double-bond functionalized high-molecular compound and a zwitterionic monomer, and finally taking out for photo-crosslinking and curing to obtain the anti-coagulation endothelial sustained-release promoting coating. According to the method, efficient packaging and slow release of anticoagulation and endothelialization promoting active substances are achieved, and the prepared coating remarkably improves the performance of a blood contact instrument in the aspects of acute-stage thrombus formation resistance and long-acting endothelialization promotion after implantation.

In one aspect, the invention provides methods for treating, inhibiting, alleviating, or preventing acute respiratory distress syndrome, pneumonia, or some other pulmonary or other manifestation of coronavirus infection, such as thrombosis, in a mammalian subject infected with coronavirus, such as SARS-CoV-2. The methods comprise the step of administering to a subject infected with coronavirus an amount of a MASP-2 inhibitory agent effective to inhibit MASP-2-dependent complement activation. In one embodiment, the MASP-2 inhibitory agent is a MASP-2 monoclonal antibody, or fragment thereof that specifically binds to a portion of SEQ ID NO:6. In one embodiment, the MASP-2 inhibitory agent is a small molecule MASP-2 inhibitory compound. In one embodiment, the subject is a human subject suffering from COVID-19-induced acute respiratory distress syndrome (ARDS) and requires supplemental oxygen prior to treatment and the MASP-2 inhibitory agent is administered in an amount sufficient to discontinue the need for supplemental oxygen.

The invention discloses a central venous catheter with the adjustable inner diameter. The central venous catheter comprises a catheter body, an adjusting assembly and a limiting assembly. The guide pipe body comprises a plurality of arc-shaped plates and a plurality of corrugated plates, the arc-shaped plates and the corrugated plates are sequentially arranged at intervals, and mounting grooves which communicate with one another are formed in the radial directions of the arc-shaped plates and the radial directions of the corrugated plates; the adjusting assemblies are arranged in the mounting grooves, the multiple adjusting assemblies are sequentially connected to form a circular ring structure, the first end of the first folding plate and the first end of the second folding plate are connected with the top and the bottom of the first end of the adjusting part correspondingly, and the second end of the adjusting part is connected with the first end of the arc-shaped block; the second end of the arc-shaped block is connected with the first folding plate and the second folding plate of the other adjusting assembly; the limiting assembly is arranged on the adjusting part. The inner diameter of the catheter body is adjusted, blood vessels of different inner diameters of a patient can be matched, practicability, convenience and protection to the patient are improved, and the thrombus forming probability and nursing difficulty are reduced.

An implantable medical product and method of use for substantially reducing or eliminating harsh biological responses associated with conventionally implanted medical devices, including inflammation, infection and thrombogenesis, when implanted in in a body of a warm blooded mammal. The bioremodelable pouch structure is configured and sized to receive, encase and retain an electrical medical device therein and to allow such device to be inserted into the internal region or cavity of the pouch structure; with the pouch structure formed from either: (a) first and second sheets, or (b) a single sheet having first and second sheet portions. After receiving the electrical device, the edges around the opening are closed by suturing or stapling. The medical device encased by the bioremodelable pouch structure effectively improves biological functions by promoting tissue regeneration, modulated healing of adjacent tissue or growth of new tissue when implanted in the body of the mammal.

The invention relates to the technical field of probiotic beverages, in particular to a hirudin peptide probiotic beverage with a vascular scavenger function, which is prepared from the following components in percentage by mass: 1 to 10 percent of hirudin peptide, 0.1 to 5 percent of probiotics, 2 to 5 percent of prebiotics, 1 to 5 percent of fruit juice, 0.1 to 2 percent of vitamin, 0.1 to 1 percent of mineral substance, 0.5 to 2 percent of dietary fiber, 0.1 to 1 percent of natural extract, 0.1 to 1 percent of sweetening agent, 0.01 to 0.1 percent of preservative and 70 to 90 percent of water, the hirudin peptide in the beverage serves as a core component of the beverage, has remarkable anticoagulation and thrombolysis effects and can activate a fibrin dissolution system in blood and inhibit the activity of thrombin, so that thrombosis is effectively prevented and treated, the occurrence risk of cardiovascular and cerebrovascular events is reduced, and the hirudin peptide can also expand blood vessels, increase blood flow and promote blood circulation. Microcirculation is improved, the symptoms of palpitation, chest distress, paralysis of hands and feet, dizziness and headache can be relieved, and blood circulation and thrombosis resistance are improved.