61 results about "Poly-L-lactide" patented technology

The invention discloses a nanofiber functional dressing for wound healing of burns and scalds, and belongs to the technical field of wound repairing dressings. The dressing is prepared through double-layer electrostatic spinning and comprises a hydrophilic nanofiber layer and a hydrophobic nanofiber layer. The hydrophobic nanofiber layer is prepared by electrostatic spinning of an antibacterial composite modified material and isocyanate-terminated oligomeric lactic acid, and the antibacterial composite modified material is prepared by acylating chlorination of (9I)-2, 4, 8, 10-tetraoxaspiro [5.5] undecane-3, 9-dipropionic acid, reaction of the acylating chlorination product and N, N-bis (2-benzimidazole methyl) amine, and quaternization of benzyl chloride. The tetrooxaspiro rigid structure improves the thermal stability and inhibits the molecular chain from absorbing water and expanding; the quaternized benzimidazole group destroys cell membranes through positive charges, and can efficiently resist bacteria. An amido bond in the hydrophilic layer and a urea bond formed by the antibacterial material and an isocyanate group remarkably improve the liquid absorption capacity; the hydrophobic layer provides mechanical support and ductility; two layers of interfaces are fused through heat treatment, the overall tearing strength is improved, and the joint movement requirement is met.

The invention relates to the field of cosmetics, and discloses a moisturizing and anti-aging micro-capsule composition for cosmetics and a preparation method thereof.The micro-capsule composition comprises a dispersion matrix and a flexible bead, and the flexible bead comprises an active material and a micro-capsule wall, the active materials comprise a centella asiatica extract, a cynanchum atratum extract, an olive leaf extract, a scutellaria baicalensis extract and glycerol tri (ethylhexanoate) ester, and the microcapsule wall comprises soybean lecithin, modified polylactic acid, chondrus crispus and calcium alginate. The modified polylactic acid is prepared by carrying out graft copolymerization reaction on chitosan and L-lactide in chlorinated 1-butyl-3-methylimidazole and then carrying out graft modification by using L-arginine, the active material is wrapped in the capsule wall of the microcapsule to form the flexible bead, and the flexible bead is uniformly suspended in the dispersion matrix; the cosmetics are endowed with better anti-wrinkle and moisturizing effects.

This disclosure relates to crystalline forms of 3-acyl-buprenorphine derivatives and sustained release injectable pharmaceutical compositions for treatment of opioid dependence, pain or depression, including an aqueous suspension of crystalline 3-acyl-buprenoprhine, or a pharmaceutically acceptable salt thereof, wherein the composition does not include an organic solvent, a polylactide polymer, a polyglycolide polymer, or a copolymer of polylactide and polyglycolide. This disclosure also includes 3-acyl-buprenoprhine or a pharmaceutically acceptable salt thereof prepared in a controlled release matrix, including poly(lactide-co-glycolide), sucrose acetoisobutyrate, lecithin, diolein and a combination of two or more thereof.

The present invention belongs to the technical field of patch materials and relates to a double-layer composite patch with a healing and repairing function and a preparation method thereof. The double-layer composite patch is composed of an oriented fiber layer and a random dense layer composited up and down; the components of the oriented fiber layer are synthetic polymers and natural polymers, the synthetic polymer is polylactic acid, poly (L-lactide-caprolactone) or poly (lactic acid-glycolic acid copolymer), and the natural polymer is insoluble type I collagen; during preparation, the oriented fiber membrane obtained by electrospinning is first cut and pre-tensioned and placed in a bidirectional clamping device, and then the bidirectional clamping device is placed in a vacuum oven for annealing treatment, and finally the random dense membrane obtained by electrospinning and the oriented fiber membrane after annealing treatment are composited by ultrasonic welding to obtain the double-layer composite patch. The double-layer composite patch of the present invention has both anti-inflammatory and repair functions while achieving the synergy of "exogenous efficient barrier" and "endogenous precise guidance" functions; the preparation method is simple.

This invention relates to the field of lyophilized formulation technology, specifically disclosing an esupagglutide α-nano-lyophilized micelle and its preparation method. The micelles of this invention utilize polylactic-co-hydroxyacetic acid copolymer and sodium phosphatidylglycerol as micelle carriers, with arginine and cysteine ​​providing branching synergistic effects. Homogenization via film formation and low-temperature lyophilization yield lyophilized nano-micelle powder. The nano-micelle powder reduces protein oxidative decomposition during lyophilization, decreases impurity fragments, and reduces various non-fucose glycosylation, basic components (succinimide, methionine oxidation products), N-terminal deletion, Asn deamidation, and Met and Trp residue oxidation impurities that affect product quality. Product quality analysis and animal experiments after reconstitution show good resistance to impurities and degradation risk. The reconstituted esupagglutide α-nano-micelle system exhibits better stability and sustained-release properties, enhancing the hypoglycemic sustained-release effect 72 hours after injection, significantly improving upon conventional non-micelle formulations.

The invention relates to a preparation method of polylactic acid. Lactide is subjected to a polymerization reaction under the action of a catalyst, polylactic acid is prepared, the structural formula of the catalyst is shown in the formula (1), in the formula (1), R1, R2 and R3 are independently selected from-H or C1-C10 alkyl groups, x and y meet the condition that the algebraic sum of positive and negative valences in the structural formula is 0, and M is selected from metal elements of the IA group, the IIA group, the IIIA group, the IVA group, the IB group or the IIB group. According to the invention, by adding the catalyst with the synergistic catalysis effect of ring-opening polymerization and racemization of lactide, the ring-opening polymerization reaction of lactide is effectively promoted, and the racemization reaction of lactide is controlled, so that the ratio of L-lactic acid to D-lactic acid units in a polylactic acid product is controlled, the melting point of polylactic acid is adjusted, the production cost is reduced, and the product quality is improved. The limitation of raw materials is eliminated, so that the prepared polylactic acid product can be suitable for more application fields.

A process of producing polylactic acid is provided. The process comprises separating from the crude lactide composition a meso-lactide enriched composition, containing less than 80 mol % of meso-lactide based on a total content of lactide, and a meso-lactide depleted composition. The process comprises polymerizing a polymerization composition comprising meso-lactide and at least one of L-lactide and D-lactide to form a crude polylactic acid composition and devolatilizing the crude polylactic acid composition to produce a purified polylactic acid composition and a composition containing unreacted lactide. The process comprises subjecting the meso-lactide enriched composition to a first purification to produce a purified meso-lactide enriched composition, and subjecting the meso-lactide depleted composition or to a second purification to produce a purified meso-lactide depleted composition. The first and second purifications comprise at least one crystallization step. The polymerization composition contains at least a portion of the purified meso-lactide enriched composition.

A process for producing polylactic acid comprising the steps of: a) providing a crude lactide composition comprising meso-lactide and at least one of L-lactide and D-lactide, b) isolating a meso-lactide enriched composition and a meso-lactide depleted composition from the crude lactide composition, wherein the meso-lactide-enriched composition comprises less than 80 mol% of meso-lactide, based on the total content of lactide, c) polymerizing a polymeric composition comprising meso-lactide and at least one of L-lactide and D-lactide into a crude polylactic acid composition, and optionally devolatilizing the crude polylactic acid composition, d) subjecting the meso-lactide-enriched composition or a mixture of the meso-lactide-enriched composition and a portion of the composition comprising unreacted lactide to purification comprising at least one crystallization step to produce a purified polylactic acid composition and a composition comprising unreacted lactide, d) subjecting the meso-lactide-enriched composition or a mixture of the meso-lactide-enriched composition and a portion of the composition comprising unreacted lactide, the present invention relates to a method for purifying a meso-lactide-enriched composition, e) subjecting a meso-lactide-depleted composition or a mixture of a meso-lactide-depleted composition and a portion of a composition comprising unreacted lactide to a purification comprising at least one crystallization step to produce a purified meso-lactide-enriched composition, e) subjecting a meso-lactide-depleted composition or a mixture of a meso-lactide-depleted composition and a portion of a composition comprising unreacted lactide, the polymeric composition comprises at least a portion of the purified meso-lactide enriched composition produced in step d) and / or at least a portion of the purified meso-lactide depleted composition produced in step e), to produce a purified meso-lactide depleted composition, where the polymeric composition comprises at least a portion of the purified meso-lactide enriched composition produced in step d) and / or at least a portion of the purified meso-lactide depleted composition produced in step e).

The application provides a polylactic acid graft copolymer and a preparation method and application thereof, the copolymer has a compound or mixture with a general formula I structure, L-lactide, maleic anhydride and an initiator are mixed and reacted, maleic anhydride grafted L-lactide is obtained first, then the maleic anhydride grafted L-lactide is mixed with a catalyst and an initiator, low-temperature prepolymerization is carried out to obtain a MA-LLA oligomer; the MA-LLA oligomer is mixed with an antioxidant, high-temperature polymerization is carried out, and a maleic anhydride grafted polylactic acid copolymer material is obtained. The application provides a brand-new route for synthesizing the polylactic acid graft copolymer, the grafting efficiency is greatly improved, the polymer molecular weight is increased, more maleic anhydride polar groups are successfully introduced on the side chain of the polylactic acid through the grafting reaction, the toughness and elongation at break of the polylactic acid material are improved, the glass transition temperature is improved, and the prepared graft modified polylactic acid copolymer material is green and fully biodegradable.

The invention provides an unsaturated aliphatic ester grafted polylactic acid copolymer, which has a structure shown in the following general formula, R1, R2,... and Rn are respectively and independently selected from H or # imgabs 0 #, R is a C1-C6 substituted or unsubstituted alkyl group, and the number of R1, R2,... and Rn which is a # imgabs 1 # group accounts for not less than 25 mol% of the total amount of R1, R2,... and Rn. The preparation method comprises the following steps: firstly copolymerizing unsaturated aliphatic ester and L-lactide, then pre-polymerizing at low temperature to obtain HEM-LLA oligomer, and finally polymerizing at high temperature to obtain the copolymer with high molecular weight. More unsaturated aliphatic ester polar groups are successfully introduced on a side chain of polylactic acid through grafting reaction, so that the toughness, elongation at break and glass transition temperature of the polylactic acid material are improved, and the product is green and can be fully biodegraded. # imgabs2 #

Polylactide resin compositions that exhibit rapid hydrolysis rates and leave small amounts of residuals include a poly(meso-lactide) and a second polylactide. The polylactide resin compositions are useful in applications in which rapid hydrolysis is wanted under mildly to moderately elevated temperatures, such as in certain oil & gas well treatment applications.

The present invention discloses a continuous polymerization process for producing polylactic acid chips from lactide, comprising the following steps: lactide in a lactide workshop and a devolatilization reactor enters a lactide buffer tank through a lactide pipeline; a portion of the lactide is circulated to the lactide buffer tank, and another portion of the lactide enters a lactide preheater; lactide and three catalysts enter a static mixer for full mixing; after mixing, the mixture enters a lactide prepolymerization reactor for ring-opening polymerization; the mixture is transported to a lactide polymerization system for polymerization reaction to generate a melt; a portion of the melt output from the polymerization system is circulated to a tubular reactor, and another portion is transported to a devolatilization reactor for devolatilization; after devolatilization, the melt is mixed with a modified additive and then transported to a granulation system by a devolatilization discharge pump, and the polymerization process is completed. The present invention has multiple devices in a closed system and is protected by high-purity nitrogen, so that the entire production process will not come into contact with air, and polylactic acid will not be oxidized or degraded.

The application relates to an electrostatic spinning anti-adhesion membrane and a preparation method and application thereof. The electrostatic spinning anti-adhesion membrane comprises an inner layer, an intermediate layer and an outer layer which are sequentially stacked; the inner layer comprises polyglycolide-lactide-polyethylene glycol, the intermediate layer comprises polyglycolide-lactide, and the outer layer comprises polylactic acid-caprolactone. The electrostatic spinning anti-adhesion membrane has a three-dimensional nanofiber network structure of a biomimetic extracellular matrix, excellent mechanical properties, body temperature response softening and gradient degradation characteristics, can balance the degradation speed and the mechanical properties, reduce the mechanical damage of the material to the surrounding tissues, and can effectively prevent postoperative tissue adhesion.

The invention relates to piezoelectric hydrogel, a preparation method thereof and an ultrasonic treatment device. The piezoelectric hydrogel comprises methacrylated gelatin, potassium sodium niobate, polydopamine, polylactic acid, carboxymethyl chitosan, epidermal growth factors and glycerin, the surface of the potassium sodium niobate is modified with the polydopamine, and the potassium sodium niobate, the polydopamine, the polylactic acid, the carboxymethyl chitosan, the epidermal growth factors and the glycerin are dispersed in the methacrylated gelatin. According to the invention, a biodegradable piezoelectric material is combined with an ultrasonic technology, when the piezoelectric hydrogel is used as a wound dressing and is attached to an epidermis wound, the piezoelectric material is induced by ultrasound to generate a large amount of active oxygen, and the active oxygen can quickly kill bacteria from the wound, so that the epidermis wound is repaired.

A drug-eluting stent for insertion in a blood vessel includes a tubular mesh structure composed of a magnesium alloy and a poly-L-lactide layer that is micro arc oxidized disposed over the tubular mesh structure. The biodegradable drug-eluting stent further includes Zotarolimus and Rosuvastatin integrated into the poly-L-lactide layer to provide controlled and sustained drug release. Advantageously, wherein the drug-eluting stent is configured to be deployed in the blood vessel to provide drug delivery to a target site.

The application discloses a preparation method of an anti-adhesion, repair-promoting and antibacterial composite patch. L-lactide and glycolide are used as monomers to synthesize four-arm polylactic acid-glycolic acid 4arm-PLGA through ring-opening polymerization; then, L-lysine and 1,2-propylene glycol are used to prepare hydrophilic BLPD through esterification reaction, and the 4arm-PLGA is copolymerized with the 4arm-PLGA to obtain a block copolymer 4arm-PLGA-BLPD; subsequently, the proportion of PCL, the 4arm-PLGA-BLPD, the 4arm-PLGA and an antibacterial drug is regulated, and the composite patch is prepared through continuous electrospinning technology. The composite patch has good biosafety, antibacterial property, anti-adhesion between the patch and human organs and repair-promoting property, and has a wide application prospect in surgical operations, especially in hernia repair.

To provide a tissue replacement implant that is clinically effective for treatment of a variety of retinal diseases and retinal dysfunction, and can be produced using Good Manufacturing Practice (GMP) / clinical-grade manufacturing, and a method of treating a subject.SOLUTION: Tissue replacement implants are provided that include polarized retinal pigment epithelial cells on a poly(lactic-co-glycolic acid) (PLGA) scaffold. The PLGA scaffold is 20-30 microns in thickness, and has a DL-lactide / glycotide ratio of about 1:1, an average pore size of less than about 1 micron, and a fiber diameter of about 150 to about 650 nm.SELECTED DRAWING: None

The present invention provides compositions comprising peptide-coupled biodegradable poly(lactide-co-glycolide) (PLG) particles. In particular, PLG particles are surface-functionalized to allow for coupling of peptide molecules to the surface of the particles (e.g., for use in eliciting induction of immunological tolerance).

Prostamide-containing intraocular implants that biodegrade in the eye and that are effective for reducing intraocular pressure in an eye for a sustained period. The implants generally contain a prostamide, such as bimatoprost, and at least three distinct biodegradable polymers selected from polylactide and poly(lactide-co-glycolide) polymers and are optimized for placement in and compatibility with the anterior chamber of the eye, particularly the anterior chamber angle. Methods for making and using the implants to reduce ocular hypertension and intraocular pressure in a patient are described.

The invention belongs to the technical field of patch materials, and relates to a double-layer composite patch with healing promoting and repairing functions and a preparation method thereof. The double-layer composite patch is formed by vertically compounding an oriented fiber layer and a random compact layer; the components of the oriented fiber layer are a synthetic polymer and a natural polymer, the synthetic polymer is polylactic acid, poly L-lactide-caprolactone or a polylactic acid-glycolic acid copolymer, and the natural polymer is insoluble I-type collagen; the preparation method comprises the following steps: cutting an oriented fiber membrane obtained by electrostatic spinning, pre-applying tension, putting the cut oriented fiber membrane into a two-way clamping device, putting the two-way clamping device into a vacuum oven for annealing treatment, and finally compounding a random dense membrane obtained by electrostatic spinning and the annealed oriented fiber membrane through ultrasonic welding. And preparing the double-layer composite patch. The double-layer composite patch disclosed by the invention has anti-inflammatory and repairing functions, and meanwhile, the cooperation of an exogenous efficient blocking function and an endogenous precise guiding function is realized; the preparation method is simple.

The invention discloses a method for preparing polylactic acid by separating and purifying L-lactide, which is characterized by comprising the following steps: (1) mixing oligomeric lactic acid and a catalyst, feeding the mixture into a depolymerization reaction system, separating out a stream 12, feeding the stream 12 into a suspension crystallization system, and feeding a stream 15 into a third rectifying tower for purification; (2) feeding a stream 13 purified by the suspension crystallization system into a polymerization unit, and feeding crystallization mother liquor into a first rectifying tower through a stream 17; a stream 19 purified by the first rectifying tower enters a third rectifying tower, and a stream 20 separated by the first rectifying tower enters a second rectifying tower; (3) feeding a stream 22 extracted from the top of the second rectifying tower into a suspension crystallization system, and returning a stream 23 separated from the second rectifying tower to the first rectifying tower; (4) feeding a stream 25 extracted from the third rectifying tower into an m-lactide collecting tank; and (5) extracting polylactic acid from the polymerization unit. The method is high in product yield, high in efficiency, high in byproduct utilization rate and capable of effectively reducing energy consumption.

A process for the decomposition of a polyester (e.g., an aliphatic polyester such as polyflactic acid)) to the cyclic ester monomer from which it is produced, (e.g., a lactide), which employs an organometallic complex of an amine tris(phenolate) ligand is provided. Also provided is a cyclic ester formed by the process, a (e.g., recycled) polyester formed of such a cyclic ester, processes of preparing self-decomposing / recyclable polyesters, and processes of recycling polyesters.

In the existing polylactic acid production, lactide is firstly prepared from lactic acid or purchased, and then lactide is subjected to ring-opening polymerization by using a relatively expensive catalyst such as metal zinc elementary substance, so that polylactic acid is prepared in two steps. According to the scheme, food-grade zinc acetate dihydrate is used as a catalyst for catalyzing lactic acid to accelerate dehydration condensation reaction, and lactic acid obtained by fermenting lactic acid bacteria after saccharification of starch is subjected to one-step catalysis is heated, stirred and polycondensed at a proper temperature to prepare polylactic acid. The whole process is free of disordered interference reaction, and all reactant products belong to food grade, are non-toxic and harmless, and are ecological and environment-friendly. Complex and expensive instruments, equipment and reagents are not needed. Zinc acetate dihydrate is easily dissolved in a lactic acid aqueous solution, ionized zinc ions have two valence states of + 1 valence and + 2 valence, an empty electron orbital and a unique Ar 3d10 electronic structure and have strong electronegativity, the + 1 valence zinc ions lose or obtain one electron, the surfaces of the zinc ions have rich catalytic active sites, and the catalytic activity of the zinc ions is improved. In an acid environment of a lactic acid solution, zinc ions catalyze hydroxyl carboxyl contained in lactic acid molecules to accelerate transition loss of electrons with different probabilities and probabilities or shift deflection of direction, angle and the like of shared electrons, so that water molecules are formed and removed, and dehydration condensation of hydroxyl carboxyl in lactic acid molecules and between lactic acid molecules is continuously catalyzed; and carrying out polycondensation on the oligomeric lactic acid to obtain polylactic acid. Meanwhile, a small amount of intermediate lactide formed by heating and catalyzing is also subjected to ring-opening polymerization reaction to form a linear polylactic acid chain.

The invention belongs to the technical field of crossing of biological medicine and advanced manufacturing, and particularly relates to a 4D printing gastric retention preparation for drug sustained release. The 4D printing gastric retention preparation is prepared by performing 4D printing on a composite material containing a medicine and a shape memory polymer, the shape memory polymer is a blend of polylactic acid (PLA) and polyvinyl alcohol (PVA), and the proportion of the PLA to the PVA is configured to regulate and control the drug release behavior and the physical retention performance of the preparation in the stomach environment; the gastric retention preparation is provided with a first permanent shape and a second temporary shape, the first permanent shape can be obtained by triggering the second temporary shape at a triggering temperature, and the triggering temperature is 35-40 DEG C. The device can be triggered under the human body stomach temperature (37 DEG C) and body fluid environment, changes from a compact temporary shape to an expanded permanent shape, can be retained in the stomach for 8 hours and can be safely discharged after medicine release, and long-acting retention in the stomach and medicine controlled release are achieved.

The application discloses a method for preparing lactide by cracking polylactic acid with lithium amine imine catalyst, and belongs to the technical field of chemical recycling of polylactic acid. The method comprises the following steps: dissolving polylactic acid in a solvent, adding methanol and a lithium amine imine catalyst to perform a pre-depolymerization reaction; removing the solvent by evaporation, then increasing the temperature to perform depolymerization, and recovering lactide monomers under reduced pressure. The method generates oligomers by pre-depolymerization to serve as endogenous reaction media, thereby reducing the depolymerization temperature and improving the depolymerization efficiency. The method has the advantages of small catalyst dosage, no heavy metal residue, simple post-treatment, high lactide yield, good selectivity and the like, and can be used for high-value recycling of polylactic acid waste and substandard products.

The invention discloses an SIS-loaded polymer tubular structure artificial blood vessel, and relates to the technical field of biomedical treatment, and the SIS-loaded polymer tubular structure artificial blood vessel comprises a polymer tubular structure which is prepared from a high polymer material through an electrostatic spinning or 3D printing process, the high polymer material is selected from at least one of polycaprolactone, polylactic acid, polyurethane, a polylactic acid-glycolic acid copolymer, poly (L-lactide-caprolactone) or poly (p-dioxanone); and the SIS layer is prepared by dissolving SIS powder in 0.1-1M acetic acid solution to prepare a 1%-10% solution. The invention relates to a preparation method of an SIS-loaded polymer tubular structure artificial blood vessel. The preparation method comprises the following steps: preparing SIS: cleaning and segmenting fresh small intestine and jejunum, and scraping an outer membrane, a muscular layer and an inner mucosa; according to the invention, a physical perfusion-freeze drying method is innovatively adopted to realize efficient loading of SIS; and more than 95% of active factors in the SIS are reserved through a gradient decellularization process.

The invention relates to the field of biomedical materials, in particular to cyanoacrylate medical blood vessel blocking glue and a preparation method thereof.The cyanoacrylate medical blood vessel blocking glue is prepared from, by mass, 30-35 parts of 2-octyl cyanoacrylate, 7-8 parts of lactide modified hydroxyethyl methylacrylate, 0.02-0.03 part of polymerization inhibitor propyl gallate, 0.02-0.03 part of initiator, 0.02-0.03 part of initiator, 0.02-0.03 part of initiator, 0.02-0.03 part of initiator and the balance water. By innovatively adopting various functional components and carrying out synergistic compatibility and precise preparation, compared with the prior art, the comprehensive performance of the product is remarkably improved, and the plugging agent has the advantages of rapid and reliable plugging effect, good plugging effect, good plugging effect, good plugging effect, good plugging effect, good plugging effect, good plugging effect, good plugging effect, good plugging effect and the like. Meanwhile, good biocompatibility, intraoperative developing capacity and a potential drug sustained release function are achieved, operation is easy and convenient, performance is stable, a safer and more efficient choice is provided for clinical vascular interventional therapy, and wide application prospects are achieved in the fields of cardiovascular and neurological intervention, peripheral vascular embolism and the like.

This application discloses a sustained-release formulation composition of lumateperone, comprising lumateperone or a salt thereof and a polymer material. The mass ratio of lumateperone to the polymer material is 0.5:9.5 to 5:5, and the polymer material comprises a main material, polylactide, and a selectively present release modifier, the mass of which is 0% to 95% of the main material, polylactide, and the release modifier is a mixture of one or more selected from polylactide or poly(lactide-co-glycolide). The sustained-release formulation of the present invention can achieve a sustained-release effect from one week to three months, can improve patient compliance, and does not have a clear burst release in the early stages, does not have a release delay period, the release of the formulation is stable, and the safety and efficacy of drug release are ensured.

The present invention discloses monomeric THF coordinated Group 13 metal alkoxides, synthesis and catalytic activity thereof The method of synthesis of monomeric THF coordinated Group 13 metal alkoxides (formula I) described in the present invention yields alkyl alcohol adducts of Group 13 metal (Aluminum, Gallium, and Indium) alkoxides have their fourth coordination satisfied. The catalytic activity of the Group 13 metal alkoxide adduct compounds is useful for the ring opening polymerization (ROP) of compounds such as racemic lactide to yield PLA. These Group 13 metal alkoxide adducts initiate polymerization under milder reaction conditions as compared to tin octanoate and thus can serve as catalyst for synthesis of polymers like PLA,Polycaprolactone with 10 high molecular weight.

This invention relates to a lactide composition comprising: lactide and an anti-hydrolysis aid, wherein the anti-hydrolysis aid comprises a molecular sieve and / or an inorganic filler, the molecular sieve having a pore size of 0.1 to 1 nm and the inorganic filler having a particle size of 800 to 3000 mesh; wherein, based on the weight of lactide: the amount of the molecular sieve is 0.01 to 5% by weight; and / or the amount of the inorganic filler is 0.01 to 5% by weight.