4 results about "Minocycline" patented technology

The present invention relates to a composition for preventing or treating periodontal disease and a dental composite antibiotic ointment composition. The composition for preventing or treating periodontal disease according to the present invention comprises minocycline and metronidazole as effective ingredients.

The application is suitable for the technical field of drug synthesis, and provides a continuous flow preparation method and system of a secondary amine derivative of C9 position of omadacycline, the method is that minocycline C9-amino methylate, alkyl aldehyde compound and tertiary amine acid acceptor are dissolved in an organic solvent to form a raw material liquid, hydrogen is continuously introduced into a microreactor filled with a solid palladium carbon catalyst, and a reductive amination reaction is carried out under the condition of 50-70 DEG C and 1.0-2.5 MPa, the residence time of the material is 10-30 minutes, and high-purity product is obtained after post-treatment. The special system includes a feeding module, a mixing and preheating module, a microreaction module, a detection and control module and a product collection module, and each module cooperates to realize continuous and high-precision reaction. The application solves the defects of low efficiency, high safety risk and unstable product quality of the traditional kettle process, the product yield is more than 95%, the HPLC purity is higher than 98.5%, and the application is intrinsically safe, easy to industrialize, and environmentally friendly.

The application discloses application of total flavones of radix scutellariae combined with tetracycline antibiotics in preparation of products against staphylococcus aureus, and belongs to the technical field of medicines. The application provides an antibacterial composition containing total flavones of radix scutellariae and tetracycline antibiotics, aiming at the problems of high drug resistance rate and great toxic side effects of tetracycline antibiotics in the treatment of staphylococcus aureus and methicillin-resistant staphylococcus aureus infection. The total flavones of radix scutellariae contain more than 89% of flavones, and contain various active ingredients such as baicalin and baicalein. The tetracycline antibiotics are selected from doxycycline or minocycline. In vitro experiments prove that the combination of the two has a significant synergistic antibacterial effect on staphylococcus aureus and drug-resistant staphylococcus aureus, and the dosage of doxycycline or minocycline can be reduced by 75%, thereby effectively reducing the toxic side effects.

The application belongs to the technical field of biological medicine, and provides application of ferulic acid in preparation of a photolysis inhibitor of tigecycline and minocycline. The ferulic acid can significantly inhibit degradation of tigecycline or minocycline under light conditions, and further enhance the antibacterial activity of tigecycline or minocycline under light conditions. Compared with the treatment of tigecycline alone, the addition of ferulic acid can significantly enhance the treatment effect of tigecycline or minocycline as an external medicine on skin or soft tissue infection, effectively expand the drug dosage form of tigecycline or minocycline, and provide a safer and more reliable drug preparation for the treatment of complex drug-resistant pathogenic bacterial skin or soft tissue infection.