24 results about "Minocycline" patented technology

To provide a novel tetracycline derivative having reduced antimicrobial activity for use in treating disorders of the central nervous system.SOLUTION: Provided are novel molecules comprising a modified tetracycline molecule including Deamino Diacetyl Minocycline, Methyl Ether Minocycline, Ethyl Ether Minocycline, Propyl Ether Minocycline, Butyl Ether Minocycline, Butyl Ether Monoacetyl Minocycline, Butyl Ether Diacetyl Minocycline, Butyl Ether Triacetyl Minocycline, or Butyl Ether Tetra Acetyl Minocycline, pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, and tautomers thereof, and methods for using the same to treat Alcohol Use Disorder (AUD), Substance Use Disorder (SUD), tobacco use, pain, or proinflammatory disorders.SELECTED DRAWING: None

The application belongs to the technical field of medicine, and relates to a use of minocycline in preparation of an antitumor synergist. The minocycline, as the antitumor synergist, has a synergistic effect with 5-fluorouracil and gemcitabine, significantly enhances the curative effect of an antitumor drug, reduces the dosage of the antitumor drug, and reduces side effects of the antitumor drug on the body or damage of the antitumor drug to normal tissue cells.

The present application relates to a method of treating an inflammatory skin condition by administering a pharmaceutical composition comprising a reduced dose of minocycline to a subject in need thereof, wherein said administration provides an effective plasma or interstitial fluid concentration of minocycline for treating the inflammatory skin condition.

Resorbable implants comprising poly(butylene succinate) and copolymers thereof have been developed. The implants implants are preferably sterilized, and contain less than 20 endotoxin units per device as determined by the limulus amebocyte lysate (LAL) assay, and are particularly suitable for use in procedures where prolonged strength retention is necessary, and can include one or more bioactive agents. The implants may be made from fibers and meshes of poly(butylene succinate) and copolymers thereof, or by 3d printing, and the fibers may be oriented. Coverings and receptacles made from forms of poly(butylene succinate) and copolymers thereof have also been developed for use with cardiac rhythm management devices and other implantable devices. These coverings and receptacles may be used to hold, or partially / fully cover, devices such as pacemakers and neurostimulators. The coverings and receptacles are made from meshes, webs, lattices, non-wovens, films, fibers, and foams, and contain antibiotics such as rifampin and minocycline.

The invention belongs to the technical field of biological medicine, and particularly relates to a nano-micelle preparation loaded with minocycline and application of the nano-micelle preparation to treatment of cerebral hemorrhage, the nano-micelle preparation is prepared by taking a polyethylene glycol-polycaprolactone nano material PEG3000-PCL2000 as a carrier, and jointly loading minocycline MINO and a CD147 monoclonal antibody Anti-CD147, so that the nano-micelle preparation is prepared. And the bionic nano-drug MINO (at) PNM (at) CD147 with an active targeting function is constructed. The nano-micelle preparation has a brain targeting property and can be enriched in cerebral hemorrhage tissues, so that the local drug concentration and the treatment efficiency are remarkably improved; the traditional Chinese medicine composition can improve neurological impairment caused by cerebral hemorrhage and significantly reduce the volume of cerebral hematoma, and has an obvious treatment effect on cerebral hemorrhage; the number of inflammatory cells in the peripheral area of hematoma and expression of inflammatory mediators can be remarkably reduced, and therefore the inflammatory response in cerebral hemorrhage tissue is relieved.

The invention discloses injectable hydrogel for treating periodontitis as well as a preparation method and application of the injectable hydrogel. The injectable hydrogel is prepared from the following raw materials: chitosan and derivatives thereof, oxidative modified natural polysaccharide and modified hydroxyapatite, the modified hydroxyapatite comprises hydroxyapatite, and the surface of the hydroxyapatite is modified with a metal polyphenol network. The modified hydroxyapatite has multiple functions of oxidation resistance, immunoregulation, osteogenesis promotion, migration promotion, tube formation promotion, antibiosis and the like, and can be combined with the injectable hydrogel with biological adhesion and self-healing performance to realize better in-vivo tissue healing. The injectable hydrogel of the composite functional hydroxyapatite nanoparticles synthesized by the invention has biocompatibility, oxidation resistance, immunoregulation performance, osteogenesis promotion performance and antibacterial performance, and can realize better alveolar bone regeneration and repair in a rat periodontitis model, and the effect of the injectable hydrogel is superior to that of clinically common minocycline.

A pharmaceutical composition for treating moderate or severe rosacea comprises a formulated, body weight-independent low dose of minocycline that reduces the severity of rosacea in at least 2 weeks with a decrease in lesion count, Investigator's Global Assessment (IGA) score, and Clinician's Erythema Assessment (CEA) score with a measured improvement in quality of life.

A pharmaceutical composition for treating moderate or severe rosacea comprises a formulated, body weight-independent low dose of minocycline that reduces the severity of rosacea in at least 2 weeks with a decrease in lesion count, Investigator's Global Assessment (IGA) score, and Clinician's Erythema Assessment (CEA) score with a measured improvement in quality of life.

Methods and compositions for treating bacterial infections using tetracycline compounds are described. For example, in one embodiment, the invention provides a method for treating an infected subject, comprising administering an effective amount of 9-[(2,2-dimethylpropylamino)-methyl]-minocycline or a salt thereof to said subject to treat said subject, wherein 9-[(2,2-dimethylpropylamino)-methyl]-minocycline is orally administered for two consecutive days at a dose of about 450 mg / day, followed by administration for five or more days at a dose of about 300 mg / day.

The present invention relates to a composition for preventing or treating periodontal disease and a dental composite antibiotic ointment composition. The composition for preventing or treating periodontal disease according to the present invention comprises minocycline and metronidazole as effective ingredients.

The application is suitable for the technical field of drug synthesis, and provides a continuous flow preparation method and system of a secondary amine derivative of C9 position of omadacycline, the method is that minocycline C9-amino methylate, alkyl aldehyde compound and tertiary amine acid acceptor are dissolved in an organic solvent to form a raw material liquid, hydrogen is continuously introduced into a microreactor filled with a solid palladium carbon catalyst, and a reductive amination reaction is carried out under the condition of 50-70 DEG C and 1.0-2.5 MPa, the residence time of the material is 10-30 minutes, and high-purity product is obtained after post-treatment. The special system includes a feeding module, a mixing and preheating module, a microreaction module, a detection and control module and a product collection module, and each module cooperates to realize continuous and high-precision reaction. The application solves the defects of low efficiency, high safety risk and unstable product quality of the traditional kettle process, the product yield is more than 95%, the HPLC purity is higher than 98.5%, and the application is intrinsically safe, easy to industrialize, and environmentally friendly.

The invention provides nitrate reducing bacteria C381 as well as a method and application thereof. The nitrate reducing bacteria C381 is preserved in China General Microbiological Culture Collection Center (CGMCC), and the preservation number is CGMCC No.36842; the invention provides a novel oral cavity probiotic nitrate reducing bacteria C381, the nitrate reducing bacteria C381 has an inhibition effect on periodontal disease bacteria, and the nitrate reducing bacteria C381 is sensitive to antibiotics such as erythromycin, piperacillin, minocycline, doxycycline, cefazolin, tetracycline, amikacin, gentamicin, vancomycin and cefoperazone, and can be used for preparing oral cavity probiotics for treating periodontal disease bacteria. And the product has good survival ability in the oral cavity.

The invention provides bacillus C367 as well as a method and application thereof. The bacillus C367 is preserved in the China General Microbiological Culture Collection Center (CGMCC), and the preservation number is CGMCC No.36841; the bacillus C367 is separated from the Inner Mongolia cheese; the bacillus C367 can be used for preparing medicines for treating or preventing periodontal diseases; the invention provides a novel oral cavity probiotic bacillus C367, the bacillus C367 has an inhibition effect on periodontal disease bacteria, and the bacillus C367 is sensitive to antibiotics such as minocycline, amikacin, tetracycline, erythromycin, cefoperazone, streptomycin, kanamycin, gentamicin, vancomycin and ceftriaxone, and has good survival ability in an oral cavity.

The present application relates to a kind of isoprenyl-alpha-pyrone dimer Hypericumonates D-F and its preparation method and application, belong to the field of medicinal chemistry, the isoprenyl-alpha-pyrone dimer Hypericumonates D-F is first extracted from the leaves and branches of Hypericum monogynum Isolation, its structural formula is D-F formula.Compounds D-E has significant inhibitory effect on the NO production in mouse microglial cells (BV-2 cells) induced by lipopolysaccharide (LPS), and its activity is stronger than that of positive drug minocycline, with the potential application in the field of neuroinflammatory drugs, the present application simultaneously relates to a kind of pharmaceutical composition, it includes above-mentioned isoprenyl-alpha-pyrone dimer Hypericumonates D-F, and pharmaceutically acceptable adjuvant, it has the efficacy of anti-neuroinflammation.

The application discloses application of total flavones of radix scutellariae combined with tetracycline antibiotics in preparation of products against staphylococcus aureus, and belongs to the technical field of medicines. The application provides an antibacterial composition containing total flavones of radix scutellariae and tetracycline antibiotics, aiming at the problems of high drug resistance rate and great toxic side effects of tetracycline antibiotics in the treatment of staphylococcus aureus and methicillin-resistant staphylococcus aureus infection. The total flavones of radix scutellariae contain more than 89% of flavones, and contain various active ingredients such as baicalin and baicalein. The tetracycline antibiotics are selected from doxycycline or minocycline. In vitro experiments prove that the combination of the two has a significant synergistic antibacterial effect on staphylococcus aureus and drug-resistant staphylococcus aureus, and the dosage of doxycycline or minocycline can be reduced by 75%, thereby effectively reducing the toxic side effects.

The invention provides application of minocycline in preparation of a medicine for treating benign prostatic hyperplasia, and belongs to the technical field of biological medicine. The invention provides application of minocycline in preparation of a medicine for treating benign prostatic hyperplasia, and provides a safe, convenient and efficient oral medicine treatment scheme for clinically treating benign prostatic hyperplasia, especially fibrosis pathological changes accompanied by benign prostatic hyperplasia. According to the scheme, improvement and volume retraction of a gland tissue structure can be realized directly aiming at a core pathological link of a disease, so that the urination obstruction symptom of a patient is effectively relieved, wounds and risks caused by surgical treatment are avoided, the accessibility of treatment and the compliance of the patient are greatly improved, and remarkable clinical application value and market prospect are achieved.

To provide minocycline for treating inflammatory skin conditions.SOLUTION: The present application relates to a method of treating an inflammatory skin condition by administering to a subject in need thereof a pharmaceutical composition comprising a reduced dose of minocycline, wherein said administration results in an effective plasma or interstitial fluid concentration of minocycline to treat the inflammatory skin condition. The present application provides a method of treating an inflammatory skin condition, such as rosacea, by administering a pharmaceutical composition comprising a reduced dose of minocycline to provide an effective treatment for said inflammatory skin condition.SELECTED DRAWING: None

The invention provides preparation of an iron-copper bimetallic nano-enzyme and application of the iron-copper bimetallic nano-enzyme in detection of tetracycline antibiotics in food. The nano enzyme is synthesized by a simple coordination-assisted polymerization assembly method, and has excellent colorimetric performance (peroxidase-like and laccase-like activity) and fluorescence performance. The three-channel colorimetric fluorescent sensing array constructed on the basis of the performance can realize accurate recognition of five tetracycline antibiotics (tetracycline, oxytetracycline, doxycycline, minocycline and metacycline), and can efficiently distinguish binary and ternary mixed tetracycline antibiotics in different proportions at the same time. In order to break through equipment and cost limitations of a traditional detection method, the invention also develops a portable detection device with a built-in test paper sheet, and realizes rapid and field detection of tetracycline antibiotics in actual samples such as milk, chicken farm sewage and the like in combination with smartphone photographing and Image J software analysis, and has a good actual application prospect.

The present invention includes novel molecules and methods for using the same to treat Alcohol Use Disorder (AUD), Substance Use Disorder (SUD), tobacco use, pain, or proinflammatory disorders comprising: identifying a subject in need of treatment for at least one of AUD, SUD, pain, or a proinflammatory disorder; and providing the subject with an effective amount of a modified minocycline to ameliorate or eliminate the AUD, SUD, pain, or proinflammatory disorder and that has reduced, or no, antimicrobial activity, wherein the modified tetracycline has a formula, e.g., or the modified doxycycline, minocycline, and tigecycline and their tautomerized structures, where the R-groups shown in the minocycline example above could be different combination of halogen, acetyl ester, methyl ester, and diacetal.

The invention discloses a preparation method of a degradable antibacterial material with slow release performance. The preparation method comprises the following steps: step 1, blending antibiotics and a mixed solvent to obtain an antibiotic solution; the antibiotic is selected from rifampicin and minocycline; the mixed solvent is selected from hexafluoroisopropanol and acetonitrile, and the volume ratio of the hexafluoroisopropanol in the mixed solvent is not less than 25%; step 2, uniformly spraying the antibiotic solution on the surface of a degradable base material through ultrasonic spraying, and then drying to obtain the degradable antibacterial material with the slow release performance. According to the preparation method disclosed by the invention, by regulating and controlling the composition of the mixed solvent and ultrasonic spraying parameters and utilizing the controllable swelling effect of the mixed solvent on the degradable base material, antibiotic molecules are embedded into the surface layer of the material in the atomization spraying process, so that the interface bonding force between the medicine and the degradable base material is remarkably enhanced, and the burst release behavior is effectively inhibited; the continuous and stable in-vitro release performance is realized.

The application belongs to the technical field of biological medicine, and provides application of ferulic acid in preparation of a photolysis inhibitor of tigecycline and minocycline. The ferulic acid can significantly inhibit degradation of tigecycline or minocycline under light conditions, and further enhance the antibacterial activity of tigecycline or minocycline under light conditions. Compared with the treatment of tigecycline alone, the addition of ferulic acid can significantly enhance the treatment effect of tigecycline or minocycline as an external medicine on skin or soft tissue infection, effectively expand the drug dosage form of tigecycline or minocycline, and provide a safer and more reliable drug preparation for the treatment of complex drug-resistant pathogenic bacterial skin or soft tissue infection.

Antimicrobial polycarbonate coatings are provided that may be included on the surface of a medical device such as, e.g., a needleless connector. The antimicrobial polycarbonate coatings may comprise minocycline, rifampin, and / or chlorhexidine. Methods of applying the antimicrobial polycarbonate coating to a medical device (e.g., a polycarbonate connector) are also provided.

The invention discloses a tetracycline hapten, a tetracycline antigen, a tetracycline antibody, a tetracycline detection device, preparation, application and used equipment, and relates to a tetracycline hapten, a tetracycline antigen, a tetracycline antibody, a tetracycline colloidal gold test strip, preparation of the tetracycline hapten, the tetracycline antigen, the tetracycline antibody and the tetracycline colloidal gold test strip, application of the tetracycline colloidal gold test strip in detection of tetracycline drug residues in a water sample and used equipment in preparation The invention provides a tetracycline hapten, the tetracycline hapten is a universal hapten designed and synthesized aiming at a general structure of a tetracycline drug, the hapten is applied to prepare an artificial antigen and an antibody for detecting the tetracycline drug, and the antibody has the characteristics of strong specificity and high sensitivity on the tetracycline drug. The tetracycline antibiotics in the water sample can be accurately detected, and the rapid detection of oxytetracycline, aureomycin and tetracycline as low as 5 [mu] g / L and the rapid detection of doxycycline and minocycline as low as 10 [mu] g / L in the water sample can be realized.