7 results about "Chlortetracycline" patented technology

The invention relates to an application of an aureomycin A derivative in preparation of an anti-tumor drug, the anti-tumor drug is a drug for preventing or treating liver cancer, and the aureomycin A derivative is selected from a compound shown as a formula (I), or a stereoisomer, a prodrug, a crystal form, a pharmaceutically acceptable salt, a pharmaceutically acceptable ester or a pharmaceutically acceptable solvate of the compound. The aureomycin A derivative disclosed by the invention can be used for remarkably inhibiting the proliferation of liver cancer cells Hepa1-6, and the half inhibitory concentration (IC50 value) is 0.4821 mu g / mL and 0.1701 mu g / mL respectively; 11 days after administration, the tumor volume of a Hepa1-6 ectopic transplantation C57BL / 6 mouse is reduced, and the tumor weight of a Hepa1-6 tumor ectopic transplantation tumor is reduced; the aureomycin A derivative has the effects of remarkably inhibiting proliferation of liver cancer cells at the cellular level and remarkably reducing tumor growth of the liver cancer cells at the animal level, and a research direction is provided for development of new drugs.

This invention discloses a dual-emission molecularly imprinted ratiometric fluorescence sensor, its preparation method, and its application in the detection of chlortetracycline, belonging to the field of chemical sensor technology. The preparation method of this sensor includes the following steps: preparing silica-quantum dot composite nanoparticles; preparing a molecularly imprinted polymer using salicylamide as a template molecule; and using a post-mixing strategy to mix the molecularly imprinted polymer and silica-quantum dot composite nanoparticles in HEPES buffer to construct the dual-emission molecularly imprinted ratiometric fluorescence sensor. The advantages of this invention are: the dual-emission molecularly imprinted ratiometric fluorescence sensor provided by this invention exhibits rich fluorescence color changes, enabling rapid, highly sensitive, and visual detection of chlortetracycline; and the entire detection process is simple, convenient, and fast, making it suitable for widespread application in practical applications.

The invention belongs to the technical field of feed additives, and particularly relates to a preparation method of sheep Zhuang powder, which comprises the following specific steps: preparing an astragalus extract, preparing berberine hydrochloride, and mixing for preparation. In the preparation process of the sheep strengthening powder, the feed additive is added, the feed additive effectively replaces the previous aureomycin, the antibacterial effect (MIC) of the feed additive on escherichia coli AZ1, escherichia coli 8-1 and salmonella sk77 is obviously better than that of the aureomycin, the dosage every time is smaller, animals are healthier, both pathogenic bacteria are killed, the immunity is improved, and the sheep strengthening powder is suitable for being used for preparing sheep strengthening powder. The feed is safe and compliant, has no residue and no withdrawal period, and has the effects of fattening and weight gaining and fierce eating and fierce growth.

The present invention relates to a magnetized modified polypropylene meltblown cloth activation material and a preparation method thereof. The prepared magnetized modified polypropylene meltblown cloth can effectively solve the agglomeration problem of magnetic ferrites in Fenton reactions such as sulfate radical advanced oxidation processes (SR-AOPs), and can activate persulfate in the catalytic system. Degradation and removal experiments have shown that the material has a good removal effect on the antibiotic chlortetracycline. Moreover, the material can relatively easily perform solid-liquid separation from contaminated water bodies under the action of an external magnetic field. The polypropylene meltblown cloth material used is extracted from discarded protective masks, which not only realizes the reuse of waste but also achieves the purpose of using waste to treat pollution.

The invention belongs to the technical field of aureomycin detection, and particularly relates to a preparation method of a carbon quantum dot ratiometric fluorescent probe and a method for detecting aureomycin. The method is based on the characteristic that aureomycin can enable a carbon quantum dot ratio fluorescent probe to correspondingly detect that the color of a system gradually changes from yellow to yellow green to dark blue to light purple to final dark purple under an ultraviolet lamp, and obvious changes occur. Detecting the fluorescence intensity change R425 / R515 of a mixed solution of a to-be-detected sample and D-CDs, and comparing with the standard curve to obtain the aureomycin content in the to-be-detected sample. Besides, a paper-based sensor containing the carbon quantum dot ratio fluorescent probe is prepared, a smart phone is used as a signal reader, carrying is convenient, on-site detection of aureomycin in a limited-resource environment can be achieved, and the detection method is simple, sensitive and efficient.

The present invention provides a method and application for preparing a Co3O4 / CuCo2O4 composite material based on Co-MOF materials, belonging to the technical field of material synthesis and analytical detection. The method comprises the following steps: S1, preparing a Co-MOF material; S2, preparing a Co3O4 / CuCo2O4 material precursor; S3, preparing a Co3O4 / CuCo2O4 composite material; the composite material is obtained by combining a novel Co-MOF material having a two-dimensional wavy layered structure with a copper salt and then calcining it to obtain a novel Co3O4 / CuCo2O4 composite material; the Co3O4 / CuCo2O4 composite material prepared by the present invention has bimetallic properties, can degrade tetracycline antibiotics and some dyes, has stable chemical properties, excellent performance in catalytic degradation of chlortetracycline, and has anti-interference ability.

This invention discloses a hindered Lewis acid-base pair type copper pyrovanadate catalyst, its preparation method, and its application. The preparation method of the catalyst includes the following steps: adding a metavanadate solution to a copper salt solution under stirring conditions, continuing stirring after complete addition to ensure sufficient reaction, then transferring the resulting mixture to a reaction vessel for hydrothermal reaction, and after the reaction is completed, centrifuging to separate the solid, washing, and drying to obtain the hindered Lewis acid-base pair type copper pyrovanadate catalyst. This catalyst can promote singlet oxygen (… 1 The generation of O2 can be used to activate oxidants such as persulfate (PMS) to degrade organic pollutants in water. These organic pollutants include antibiotics, specifically at least one of tetracycline (TC), oxytetracycline (OTC), chlortetracycline (CTC), doxycycline (DOX), and their derivatives. The preparation method of this invention is simple, can be mass-produced, and is inexpensive, thus possessing broad application prospects.