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Preparation method of chlortetracycline sustained-release microspheres

A technology for slow-release microspheres and chlortetracycline, which is applied to non-active ingredients in medical preparations, pharmaceutical formulations, active ingredients of tetracycline, etc. The effect of higher viscosity, shorter drying time and higher utilization rate

Active Publication Date: 2015-06-03
SOUTH CHINA AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The present invention optimizes the mixing conditions of chlortetracycline montmorillonite suspension and sodium alginate solution, adopts high-speed magnetic stirring and mixing to solve the problem of high viscosity of the mixed liquid and difficult stirring, and sufficient stirring can The mixed solution is evenly dispersed, which is beneficial to the stability of aureomycin and the formation of slow-release microspheres; in addition, the present invention also optimizes the drying method, and adopts the ethanol soaking and air-drying method to overcome the shortcomings of other drying methods, and the dried microspheres Regular shape, short drying time, microspheres soaked in ethanol and room temperature environment are conducive to maintaining the stability of aureomycin properties

Method used

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  • Preparation method of chlortetracycline sustained-release microspheres
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  • Preparation method of chlortetracycline sustained-release microspheres

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] A preparation method of aureomycin-montmorillonite slow-release microspheres, comprising the steps of:

[0035] S1. Mix 2.0g chlortetracycline and 11.8g montmorillonite evenly, add 2000 parts of water, stir magnetically, and the speed is 200r min -1 , the stirring time is 120min;

[0036] S2. Add 6.0 g of sodium alginate to 4000 parts of water, and heat to prepare a sodium alginate solution at a heating temperature of 60° C.;

[0037] S3. Add the S1 suspension to the S2 sodium alginate solution, stir evenly with a magnetic force, and the speed is 1200r min -1 , the stirring time is 120min;

[0038] S4. Drop the above mixture into 0.2% calcium chloride solution at a rate of 5ml / min for cross-linking for 30min, wash three times with water, soak in absolute ethanol for 90min, filter, collect gel balls, and dry naturally to obtain aureomycin-mongocytidine Destoned slow-release microsphere finished products;

[0039] The molecular weight of the sodium alginate is 12000. ...

Embodiment 2

[0042] A preparation method of aureomycin-montmorillonite slow-release microspheres, comprising the steps of:

[0043] S1. Mix 2.3g chlortetracycline and 11.0g montmorillonite evenly, add 2000 parts of water, stir magnetically, and the speed is 500r min -1 , the stirring time is 90min;

[0044] S2. Add 6.5g of sodium alginate to 4000 parts of water, and heat to prepare a sodium alginate solution at a heating temperature of 90°C;

[0045] S3. Add the S1 suspension to the S2 sodium alginate solution, stir evenly with a magnetic force, and the rotation speed is 1000r min -1 , the stirring time is 120min;

[0046] S4. Drop the above mixture into 3.0% calcium chloride solution at a rate of 8ml / min for crosslinking for 30min, wash three times with water, soak in absolute ethanol for 30min, filter, collect gel balls, and dry naturally to obtain aureomycin-mongocytidine Destoned slow-release microsphere finished products;

[0047] The molecular weight of the sodium alginate is 8000....

Embodiment 3

[0050] A preparation method of aureomycin-montmorillonite slow-release microspheres, comprising the steps of:

[0051] S1. Mix 2.8g chlortetracycline and 10.3g montmorillonite evenly, add 2000 parts of water, stir magnetically, and the speed is 500r min -1 , the stirring time is 90min;

[0052] S2. Add 6.5g of sodium alginate to 4000 parts of water, and heat to prepare a sodium alginate solution at a heating temperature of 70°C;

[0053] S3. Add the S1 suspension to the S2 sodium alginate solution, stir evenly with a magnetic force, and the rotation speed is 1000r min -1 , the stirring time is 120min;

[0054] S4. Drop the above mixture into 2.0% calcium chloride solution at a rate of 10ml / min for crosslinking for 30min, wash three times with water, soak in absolute ethanol for 45min, filter, collect gel balls, and dry naturally to obtain aureomycin-mongocytidine Destoned slow-release microsphere finished product;

[0055] The molecular weight of the sodium alginate is 500...

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Abstract

The invention discloses a preparation method of chlortetracycline sustained-release microspheres. The method comprises steps as follows: mixing chlortetracycline with montmorillonite, adding the mixture to water to prepare a suspension, adding the suspension to a sodium alginate solution, evenly mixing the mixture, dropping the mixture into a calcium chloride solution for crosslinking, and collecting and air-drying gel spheres to obtain the chlortetracycline sustained-release microspheres. The condition of mixing of the chlortetracycline-montmorillonite suspension with the sodium alginate solution is optimized, the problems that mixtures are higher in viscosity and difficult to stir are well solved by the aid of high-speed magnetic stirring and even mixing, the mixture is evenly dispersed through full stirring, and stabilization of the chlortetracycline and formation of the sustained-release microspheres are facilitated. Besides, the drying method is also optimized, defects of other drying methods are overcome due to adoption of an ethanol soaking and air-drying method, the dried microspheres are regular in form, the drying time is shorter, and soaking of the microspheres with ethanol and the room temperature environment are beneficial to stabilization of properties of the chlortetracycline.

Description

technical field [0001] The invention belongs to the field of feed additives, and in particular relates to a preparation method of aureomycin slow-release microspheres. Background technique [0002] Chlortetracycline (Chlortetracycline), also known as chlortetracycline, is a kind of tetracycline derivatives. It is a kind of high-efficiency broad-spectrum antibiotics. Protozoa etc. all have inhibitory effect, and the mechanism of action is that the drug can specifically bind to the A position of the 30S subunit of the bacterial ribosome, inhibiting the growth of the peptide chain and affecting the synthesis of bacterial proteins. [0003] As a high-efficiency broad-spectrum antibiotic, aureomycin can inhibit or kill some pathogenic microorganisms in the digestive tract of livestock and poultry, promote the growth and reproduction of beneficial bacteria, regulate the intestinal microecology, improve the state of the intestinal tract, increase the utilization rate of nutrients, ...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61K33/06A61K31/65A61K47/36A61P31/04A61P33/02A61P1/12A61J3/00
Inventor 孙永学张一鸣王勉之孙静
Owner SOUTH CHINA AGRI UNIV
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