The invention discloses a composition containing HFC-161 and a stabilizer, wherein the stabilizer is selected from one or more of epoxy compound, nitro-compound, hindered amines, hindered phenols, secondary arylamines, beta-diketones, phosphite esters, salicylic acid esters, cinnamic acid esters, hydroxybenzophenones, hydroxybenzoic acids, hydroxylphenyl benzotriazoles, hydroxylphenyl triazines, oxanilides, formamidines, polyhydric alcohols, ortho-formates, organosulfur compounds, olefins, ethanol amines and fatty amines. The composition provided by the invention is capable of keeping a stable state in a long time under the coexistence of air or oxygen, and capable of being used as a heat transfer composition in the form of a liquid or a gas, a refrigerant, an aerosol propellant and the like.