79results about How to "Stable in nature" patented technology

The invention discloses a synthetic method of a water soluble ultraviolet light absorber BP-9. The method mainly comprises the following process steps: (1) carrying out methylation on the main raw materials of 2, 2', 4, 4'-tetrahydroxyl benzophenone, a transition metal salt catalyst and a mixed solvent which is prepared from dichloroethane and anhydrous ethanol in equal parts by weight to obtain 2, 2'-dihydroxyl-4, 4'-dimethoxyl benzophenone; (2) carrying out sulfonation reaction on the main raw materials of methylate, sulfamic acid and C1-C3 halohydrocarbon to obtain 2, 2'-dihydroxyl-4, 4'-dimethoxyl benzophenone-5, 5'-disulfonic acid; and (3) carrying out neutral reaction on the main raw materials of sulfonated product, inorganic base and ethanol water to finally obtain the BP-9 product. The synthetic method disclosed by the invention is few in reaction step, low in cost, high in product purity and stable in quality, and raw materials are easily available.

This invention belongs to the field of soil conditioner technology, and relates to a method for preparing a soil conditioner, the resulting soil conditioner, and its application method. The preparation method includes the following steps: mixing brewing sludge and biogas residue with sorghum straw particles to obtain a mixture; adjusting the carbon-to-nitrogen ratio to 20:1 to 40:1; adding an organic material composting agent; aerobic fermentation at 55℃ for ≥15 days; turning and cooling the pile at temperatures >65℃; and fermenting for 15-30 days after cooling to below 50℃ to obtain the soil conditioner. By utilizing the nitrogen source of the biogas residue to neutralize the high-carbon characteristics of the straw, and further enhancing the synergistic decomposition of the two by the organic material composting agent, this invention promotes rapid aerobic fermentation and stable high-temperature fermentation for over 15 days. This ensures harmlessness while avoiding the high-temperature burning of beneficial bacteria in the composting agent and the disruption of the synergistic decomposition of the biogas residue and straw, achieving complementary advantages between the biogas residue and straw, and producing a loose, breathable, nutrient-balanced, and safely composted soil conditioner.

This invention belongs to the field of photocrosslinking probe technology, specifically relating to a GUSB photocrosslinking probe, its preparation method, and its application. The GUSB photocrosslinking probe has the general chemical formula C0. 13 H 18 N2O6-R, wherein R is any one of the oxalic group elements or peptide bonds. The R group covalently connects the glucuronic acid recognition core and the photosensitive unit in the GUSB photocrosslinking probe, and the R group contains no more than 4 atoms, resulting in a small size and low steric hindrance. The GUSB photocrosslinking probe provided by this invention uses glucuronic acid as the recognition core, combined with a small-volume diazacyclopropane photosensitive unit and a terminal alkyne group, to achieve µM-level in-situ covalent capture of active GUSB in complex systems such as cells or tissues. The probe of this invention significantly improves positioning accuracy, sensitivity, data availability, quantification, and enrichment, while also possessing advantages such as modular synthesis, mild conditions, and strong system compatibility, effectively addressing the technical shortcomings of existing technologies that struggle to accurately obtain GUSB activity in situ under low-dose conditions.

The application relates to a method for producing jet fuel from oil and fat raw materials, wherein the oil and fat raw materials are reacted with a hydrotreating catalyst in a hydrotreating reaction zone, the obtained liquid hydrocarbons are introduced into a first hydroisomerization reaction zone, an optional second hydroisomerization reaction zone is arranged, the obtained diesel oil fraction is recycled into the first hydroisomerization reaction zone or introduced into the second hydroisomerization reaction zone for reaction, and the reaction effluent is separated to obtain jet fuel. The application can produce high-quality biological jet fuel at a high yield.

The application discloses a preparation method of carbon dot material based on blue bacteria, and the carbon dot material is prepared by taking blue bacteria photosystem pigment as raw material. The semiconductor fluorescent carbon dot prepared by the method has stable properties, has wide spectrum absorption to sunlight, can convert ultraviolet light, visible light and infrared light into red light, and has good photoelectric performance. The application further discloses a preparation method of a blue bacteria-based semiconductor fluorescent carbon dot-blue bacteria hybrid, and application of the carbon dot material based on blue bacteria in crop production.

This invention relates to the field of medical biopolymer materials technology, specifically to an injectable hydrogel for kidney stone removal, its preparation method, and its application. The preparation materials include at least a precursor solution 1 and a precursor solution 2. Precursor solution 1 contains at least a polyethylene glycol derivative and a thickener, while precursor solution 2 contains at least a polyamino polymer. By optimizing the formulation ratio of the two-component precursor solutions, a hydrogel with strong conformability, good toughness, and viscosity is formed in situ in the kidney stone area. This encapsulates the kidney stone, facilitating its removal from the body and avoiding the safety hazards associated with small kidney stone fragments or conventional drug treatment.

This invention belongs to the field of lithium battery material technology, specifically relating to a metal oxide / mesoporous manganese dioxide / conductive polymer composite material, its preparation method, and its application. The preparation method includes the following steps: 1) ball milling a commercial metal oxide; 2) mixing the metal oxide powder with an organic polymer monomer and a methyl orange solution and ultrasonically dispersing the mixture to obtain a liquid mixture; 3) adding a potassium permanganate solution to the liquid mixture and performing a high-pressure hydrothermal reaction under stirring to obtain the composite material; 4) subjecting the composite material to alkali treatment, filtering, washing with water, and drying to obtain the metal oxide / mesoporous manganese dioxide / conductive polymer composite material. This metal oxide / mesoporous manganese dioxide / conductive polymer composite material can be used to prepare lithium battery cathode materials with high specific capacity, high conductivity, and high stability in a simple, efficient, and low-cost manner. It is easy to industrialize and solves the problems of low conductivity and poor rate discharge performance of traditional metal oxide cathode materials.

The application belongs to the technical field of tunnel and underground engineering disaster prevention and control, and particularly relates to a cement-polyurethane composite grouting material suitable for dense soft rock reinforcement and a preparation method thereof. The composite grouting material is mainly formed by mixing a penetration cross-linking liquid and a grout vein skeleton liquid. The penetration cross-linking liquid is formed by mixing a grouting material A component and a grouting material B component. A semi-prepolymer is obtained by pre-polymerization reaction of a polyisocyanate and a polyether polyol, and then a diluent and a catalyst are added to the semi-prepolymer to obtain the grouting material A component; a surfactant, a retarder and water are mixed to obtain the grouting material B component; and cement and water are uniformly mixed in a certain proportion to obtain the grout vein skeleton liquid. The cement-polyurethane composite grouting material and the preparation method thereof can achieve penetration-splitting composite reinforcement effect when grouting in a dense soft rock poor geological section with strong density and poor permeability, and the grout preparation process and grouting operation steps are more simple and efficient.

The present application relates to a kind of biodegradable dark color mulch and its preparation method, and dark color mulch is made of cellulose, hemicellulose and degradable coating.The manufacturing method includes the preparation of dark color mulch substrate, coating layer coating.It specifically includes slurry compounding, beating, additive addition, is formed by papermaking, dehydration, pre-drying, coating, sizing, drying, calendering, product after drying.The local film has good wet strength, light resistance, weather resistance, heat preservation and entropy increasing effect.The results of farmland degradation experiment show that the mulch can be biodegraded after 50~60 days, and the biodegradation rate is more than 90%.

The application provides a porous spherical high-activity magnesium oxide and a preparation method thereof; the preparation method of the porous spherical high-activity magnesium oxide comprises the following steps: S1, obtaining a magnesium bicarbonate solution; S2, performing spray drying on the magnesium bicarbonate solution to obtain light magnesium carbonate solid powder, wherein the light magnesium carbonate solid powder has a hollow spherical structure; and S3, performing calcination on the light magnesium carbonate solid powder to obtain the porous spherical high-activity magnesium oxide. The high-activity magnesium oxide with a porous hollow spherical structure can be obtained, and the prepared magnesium oxide reaches the product standard of activity-180 in the standard HG / T 3928-2012 Industrial Active Light Magnesium.

The application discloses a method for digesting and separating fluorinated aluminum by program, which comprises the following steps: placing a catalyst with metal elements supported on alumina as a carrier into a reaction container of a cluster digestion device, adding hydrochloric acid and / or nitric acid, setting a digestion program, introducing inert gas for pre-pressurization, performing primary digestion, and simultaneously starting a condensation reflux atomizer; after the program is completed, adding hydrofluoric acid, setting a digestion program, and performing secondary digestion; after the digestion is completed, entering a cooling and crystallization program, performing cooling and crystallization, and separating to obtain a sample solution to be detected and a solid; the solid is dried and calcined to obtain fluorinated aluminum crystals, and the liquid is used for detecting the content of metal elements. The method is applied to the digestion treatment of the alumina sample with metal elements supported thereon, has a large sample treatment range, complete digestion, no volatile loss of elements, and can separate AlF3 in an alpha crystal form through the program digestion of the digestion device.

The application relates to the field of wind power blades, and discloses a wind power blade manhole plate and manhole cover plate as well as a preparation method and application thereof. The method comprises the following steps: (1) mixing unsaturated polyester resin, a thickening agent, an initiator, a crosslinking agent, a low shrinkage agent, a release agent, a polymerization inhibitor, an inorganic filler and waste glass fibers, and then filling the mixture into a mold for preheating; (2) performing mold pressing on the preheated material to obtain a preformed material; and (3) performing heat treatment on the preformed material, and then performing demolding to obtain the wind power blade manhole plate and manhole cover plate. The method is prepared by creatively adopting a mold pressing forming method, and waste glass fibers are used as raw materials for preparation, so that the preparation cost is saved, and the preparation efficiency is improved.

The invention relates to a liquid decolorizing agent for decolorizing crude styrene and a decolorizing method of crude styrene. The liquid decolorizing agent contains 70-90 wt% of a decolorizing component and the balance of a polymerization inhibitor. Wherein the decolorizing component contains a first decolorizing component and optionally a second decolorizing component, and the first decolorizing component contains citraconic anhydride. The decolorizing agent disclosed by the invention is liquid at normal temperature, stable in property and good in decolorizing effect.

The invention provides a carbon fiber reinforced polyether-ether-ketone self-lubricating composite material and a preparation method and application thereof.The preparation method comprises the steps that carbon fiber serves as an anode, voltage is applied to an electrolyte solution, electrochemical oxidation treatment is conducted, hydroxylated carbon fiber is obtained, the hydroxylated carbon fiber and 2-amino-5-nitrobenzothiazole are mixed, and the carbon fiber reinforced polyether-ether-ketone self-lubricating composite material is obtained. Adding an anhydrous modified reaction solvent, and reacting at 25-40 DEG C for 4-10 hours to obtain modified carbon fibers; and melting and granulating the self-lubricating composite material: mixing the modified carbon fiber, polyether-ether-ketone, a lubricant and an auxiliary agent in a high-speed mixer for 10-20 minutes, extruding by using a double-screw extruder, cooling, and granulating to obtain the carbon fiber reinforced polyether-ether-ketone self-lubricating composite material. The carbon fiber reinforced polyether-ether-ketone self-lubricating composite material is applied to self-lubricating mechanical parts. According to the self-lubricating composite material, the self-lubricating performance is improved, the interface bonding energy between the carbon fibers and the polyether-ether-ketone is enhanced, and the self-lubricating composite material has good mechanical performance.

The present application relates to a kind of probiotic oil agent for improving non-alcoholic fatty liver disease, preparation method and application, the probiotic oil agent includes active ingredient A and active ingredient B, the active ingredient A is mucinophilic Akkermansia Akk11, and the preservation number is CCTCC NO:M2024119;The active ingredient B is Omega-3 fatty acid.The present application is combined with mucinophilic Akkermansia Akk11 and Omega-3 fatty acid, and is prepared into oil agent, and the improvement of NAFLD symptom can play the coordinated synergistic effect, can be used for the prevention and treatment of NAFLD.

This invention provides a recombinant Staphylococcus aureus enterotoxin B nanoparticle protein vaccine, mSEB-mi3, its preparation method, and its applications. This invention utilizes a SpyTag / SpyCather protein linker system to connect the recombinant protein to the nanoparticle protein, allowing mSEB to be displayed on the surface of self-contained nanoparticles, thus obtaining the recombinant Staphylococcus aureus enterotoxin B nanoparticle protein mSEB-mi3. Both mSEB-SpyTag and SpyCather-mi3 proteins in this invention are induced to be expressed in soluble form in Escherichia coli. The mSEB-SpyTag and SpyCather-mi3 of this invention can be covalently bound via isopeptide bonds to form the mSEB-mi3 nanoparticle protein vaccine. The binding conditions are simple, and when combined with the adjuvant MF59, it can induce rapid antibody production in mice, generating a high-level immune response and exerting a protective effect. Furthermore, its antibody response rate and protective efficiency are superior to those of the monomeric protein mSEB.

The present application relates to the technical field of Dendrobium officinale, and particularly relates to Dendrobium officinale coated microparticles and a preparation method thereof. The present application separates the contact of Dendrobium officinale superfine powder with moisture and oxygen in the air through an outer coating film, reduces moisture absorption and oxidation, makes the property stable, and prevents caking, thereby solving the stability problem of Dendrobium officinale superfine powder, which is easy to absorb moisture and caking, and is easy to oxidize and reduce effectiveness. The Dendrobium officinale coated microparticles have small particle size, no grit feeling in oral administration, ensure the drug administration effect, and have good taking experience. The present application prepares Dendrobium officinale superfine powder into D 50 The present application separates the contact of Dendrobium officinale superfine powder with moisture and oxygen in the air through an outer coating film, reduces moisture absorption and oxidation, makes the property stable, and prevents caking, thereby solving the stability problem of Dendrobium officinale superfine powder, which is easy to absorb moisture and caking, and is easy to oxidize and reduce effectiveness. The Dendrobium officinale coated microparticles have small particle size, no grit feeling in oral administration, ensure the drug administration effect, and have good taking experience. The present application prepares Dendrobium officinale superfine powder into D

The application discloses taraxacum-derived carbon dots with tunable fluorescence and application thereof, and two kinds of carbon dots R-CDs and B-CDs with fluorescent colors can be obtained by high-temperature tuning with taraxacum as a carbon source, thereby creating conditions for double-channel fluorescence detection. The R-CDs can detect the percentage content of water in various organic solvents, and the test paper prepared can be repeatedly used for multiple times. The B-CDs are a multi-mode probe with fluorescence / colorimetric / absorption / RGB identification, and can simultaneously analyze and detect DNP in multiple ways. When a certain concentration of DNP is added into the B-CDs probe solution, a relatively significant fluorescence quenching phenomenon occurs, and the color of the solution becomes yellow. The specific detection of DNP is distinguished from other interfering components (metal ions, biological molecules and aromatic nitro compounds), and the detection method can be verified with each other, thereby improving the accuracy of detection. Meanwhile, the double-channel and multi-modal target detection is realized.

The invention discloses a method for preparing a polyfluoroalkyl coumarin derivative, and belongs to the field of organic synthesis. According to the method, cheap and easily available polyfluorocarboxylic acid anhydride is used as a polyfluoroalkylating reagent, and in-situ activation of NHPI is combined to prepare the C3-site polyfluoroalkyl substituted coumarin derivative. Under the condition of visible light catalysis, polyfluoroalkyl carboxylic acid anhydride is used as a polyfluoroalkylating reagent, polyfluoroalkyl free radicals are generated through in-situ activation of NHPI, the free radicals and aromatic propiolate are subjected to a free radical cyclization rearrangement reaction, and finally preparation of the C3-site polyfluoroalkyl substituted coumarin derivative is achieved. The polyfluoroalkyl carboxylic acid anhydride used in the method is stable in property, low in price and easy to obtain, and the synthesis cost is reduced. The method is wide in applicable substrate range and applicable to various polyfluoroalkyl carboxylic acid anhydrides, and the tolerance of reaction functional groups is good.

According to the preparation method, indene amine and dicyandiamide are used as reactants, magnesium-aluminum hydrotalcite is used as a catalyst, a biguanide intermediate is obtained through a reaction in an organic solvent, the Mg / Al molar ratio of the magnesium-aluminum hydrotalcite is 3: 1-4: 1, and the magnesium-aluminum hydrotalcite is roasted and activated at the temperature of 400-500 DEG C; and reacting the biguanide intermediate with R-2-methyl fluoropropionate, so as to generate the indaziflam. According to the present invention, the activated magnesium-aluminum hydrotalcite is adopted as the catalyst to prepare the indaziflam, such that the aluminum-containing wastewater can be avoided, the property of the biguanide intermediate generated through the reaction is stable, and the purity and the yield of the prepared indaziflam are high.

The application discloses an antibacterial peptide derived from the skin of bullfrog and application thereof, and the amino acid sequence of the antibacterial peptide is GSVGPVGPR (as shown in SEQ ID NO:1), and the molecular weight is 824.4504 g / mol. The antibacterial peptide has obvious inhibiting effect on Staphylococcus aureus, and can be used for preparing a medicine for preventing or inhibiting Staphylococcus aureus infection. Meanwhile, the antibacterial peptide and vitamin A have a significant synergistic bactericidal effect on Staphylococcus aureus. The antibacterial peptide and vitamin A can significantly reduce the use concentration of single component, improve the antibacterial efficiency, overcome the bacterial drug resistance problem, and can be used for preparing antibacterial medicines, skin external preparation, medical dressings, feed additives and food preservatives.

This invention provides a pharmaceutical composition containing hezemibrate and an HMG-CoA reductase inhibitor, and may further include one or more excipients selected from calcium carbonate, butylated hydroxyanisole, butylated hydroxytoluene, citric acid, sodium lauryl sulfate, polysorbate, croscarmellose sodium, crospovidone, microcrystalline cellulose, povidone, hydroxypropyl cellulose, lactose, pregelatinized starch, magnesium stearate, and talc. This composition can be formulated into various dosage forms, exhibiting good formulation stability and controllable quality.

The invention relates to the technical field of ceramics, and discloses a method for producing a ceramic product with an anti-counterfeiting function by using a high-temperature-resistant upconversion material, the high-temperature-resistant upconversion material is added into an underglaze color material, and the addition amount is 3-5wt% of the total weight of the underglaze color material; drawing a pattern on a ceramic body by adopting the underglaze color material; applying transparent glaze; sintering at the temperature of 1100 to 1320 DEG C; or coating the slurry A on the surface of the ceramic body; locally covering the slurry B; sintering at the temperature of 690 to 820 DEG C; the slurry A comprises lead-free glass powder and a blender; the slurry B comprises a decorative pigment, a blender and a high-temperature-resistant upconversion material; the addition amount of the high-temperature-resistant upconversion material is 1-5wt% of the total weight of the slurry B; wherein the high-temperature-resistant up-conversion material is YSZ: x mol% of Er < 3 + > and y mol% of Yb < 3 + >; 0 < x < = 6, and 0 < y < = 20. The high-temperature-resistant up-conversion material disclosed by the invention still has efficient luminescence performance after being subjected to secondary high-temperature sintering, and has a wide application prospect in the technical field of ceramic tracing and authentic identification.

The application discloses a method for preparing fluorine-containing diphenylmethane compounds by using sulfur hexafluoride as a fluorination reagent, and belongs to the technical field of organic chemical synthesis. The preparation method comprises the following steps: (1) mixing a photocatalyst, a solvent and a reducing agent, and performing ultrasonic treatment to obtain solution A; mixing a reaction substrate and the solvent to obtain solution B; the photocatalyst is one or more of 4CzIPN, Ir[dF(CF3)ppy]2(dtbpy))PF6, 9-thioxanthone and 10-phenylphenothiazine; the reaction substrate is a compound with a structural formula of R1 and R2 are both H, alkoxy or halogen; (2) mixing the obtained solution A and solution B in a sulfur hexafluoride gas atmosphere, and performing reaction under blue light illumination, and the fluorine-containing diphenylmethane compounds are obtained. The method has the beneficial effects that the fluorine-containing diphenylmethane compounds are efficiently prepared by using sulfur hexafluoride as the fluorination reagent, and by selecting raw materials and catalysts with certain proportions; the reaction raw materials are cheap; the preparation process is safe, mild, has good substrate compatibility and high preparation efficiency.

This invention discloses a supported composite metal-oxide catalyst, its preparation, and its application in the direct synthesis of high-carbon isoolefins from methanol and ethanol. The catalyst consists of a silicon-based support, metal Cu, and oxides. Based on the total mass of the catalyst, the loading of metal Cu is 0.1–30 wt.%, and the loading of oxides is 0–30 wt.%. The oxides are oxides of elements from Groups IIIB, IVB, and / or IIIA of the periodic table. The catalytic system of this invention is stable under high-temperature reaction conditions. Furthermore, when isobutene is the target product, the conversion rate of ethanol can reach 100%, the yield of isobutene is 41.5%, and the total yield of high-carbon isoolefins reaches 41.5%. When isoprene is the target product, the conversion rate of ethanol can reach 98.2%, the yield of isoprene is 17.9%, and the total yield of high-carbon isoolefins reaches 23.9%.

The manufacturing method of the light-transmitting waterproof glue of the present invention includes: providing raw materials: acrylate, methyl carbamate, crosslinking agent, ultraviolet absorber, antioxidant and plasticizer; mixing the above raw materials evenly in proportion to form a viscous solution; and stirring, adjusting, extruding and roll-pressing the viscous solution to form the light-transmitting waterproof glue. This method is simple and low-cost, and the prepared glue has improved high light transmittance, excellent waterproof performance and strong adhesive force.

The invention provides a preparation method and application of a ternary rare earth metal alloy particle (at) porphyrin COF mimic enzyme. The preparation method comprises the following steps: suspending porphyrin COF in an ethanol solution containing ternary rare earth metal ions M13 < + >, M23 < 3 + > and M33 < 3 + >, and carrying out a stirring reaction in an N2 atmosphere; after stirring is completed, suction filtration and ethanol washing are conducted, and porphyrin COF solids adsorbed with ternary rare earth metal ions are obtained. And suspending in absolute ethyl alcohol, dropwise adding a NaBH4 ethanol solution while stirring, carrying out stirring reaction in a dark place, centrifuging the suspension, washing with ethanol and deionized water, and carrying out vacuum drying to obtain the mimic enzyme. The invention also provides application of the mimic enzyme in visible light driven CO2 reduction preparation of ethylene. The method adopts room-temperature reaction, takes visible light as an energy source and water as a solvent and a hydrogen source, is green and environment-friendly, high in reduction product generation efficiency and high in ethylene selectivity, and is a green, efficient and practical method for preparing ethylene through CO2 reduction.

The application discloses a kind of SERS substrates based on double enhancement of graphite carbon material, preparation steps include: step S1, polymer array preparation;Step S2, polymer rapid method preparation substrate array;Step S3, femtosecond laser ablation PDMS substrate;It also includes step S4, electron beam evaporation;The application proposes a new double enhanced SERS substrate, utilizes the processing method of femtosecond laser combined with chemical wet etching to prepare pyramid array structure, and efficiently obtains the inverted pyramid template with uniform structure and high specific surface area, and the PDMS substrate prepared by polymer forming method has the advantages of repeatability;The surface of PDMS polymer is laser-induced modified by femtosecond laser pulse processing, and the stacked GCs structure is generated on the surface of material, so that the substrate has the advantages of good enhancement effect, stable properties, many 'hot spots' and the like, and overcomes the limitations of traditional state substrate.

The application discloses a multi-target synergistic composite essential oil composition, a nose inhalation stick and a preparation method thereof, relates to the technical field of aromatherapy and neuropharmacology, and the multi-target synergistic composite essential oil composition is composed of the following natural plant essential oils in percentage by weight, and the sum of the content of each component is 100%: 25-35% of true lavender essential oil; 15-25% of sweet orange essential oil; 10-18% of Roman chamomile essential oil; 8-15% of lemon verbena essential oil; 6-12% of bergamot essential oil; 5-10% of lemon essential oil; 3-8% of ylang ylang essential oil; 2-6% of clary sage essential oil; 1-3% of black pepper essential oil; 1-3% of sandalwood essential oil; and 0.5-2% of patchouli essential oil. The application is based on a clear neuropharmacological mechanism, and eleven kinds of essential oils are scientifically matched without dilution of base oil; a significant emotional relaxation effect is generated within 5-10 minutes of active sniffing; and the application has the auxiliary function of improving sleep difficulty.

This invention relates to a composite adjuvant, its preparation method, and its application. The composite adjuvant comprises a first component and a second component. The first component is an aluminum adjuvant that adsorbs a cyclic dinucleotide, and the second component is an aluminum adjuvant that adsorbs monophospholipid A. The mass ratio of the cyclic dinucleotide to the aluminum adjuvant in the first component is 1:(2-20), and the mass ratio of monophospholipid A to the aluminum adjuvant in the second component is also 1:(2-20). When used in combination with various antigens, the composite adjuvant of this invention can effectively enhance the immune response induced by vaccines, with a significantly better enhancement effect than that of a single adjuvant. The composite adjuvant of this invention is low in cost and has good safety, and can be used as a candidate adjuvant for various vaccines, providing new ideas for the development and application of novel vaccine adjuvants.