11 results about "Basic hydrolysis" patented technology

The invention discloses a substituted benzoxazinone-isoxazoline compound as well as a preparation method and application of the substituted benzoxazinone-isoxazoline compound. The preparation method comprises the following steps: by taking DMF (Dimethyl Formamide) as a solvent, reacting ethyl bromoacetate with a compound (II) to generate a compound (III), performing cyclization in the presence of acetic acid and reduced iron powder to obtain a compound (IV), reacting the compound (IV) with hydroxylamine hydrochloride to generate a compound (V), reacting the compound (V) with NCS and MMA (Methyl Methacrylate) in the presence of TEA (Tetraethyl Ammonium) to generate a compound (VI), and reacting the compound (VI) with NCS and MMA to generate a compound (V). Reacting the compound (VI) with propargyl bromide to obtain a substituted benzoxazinone-isoxazoline compound, performing alkaline hydrolysis on the substituted benzoxazinone-isoxazoline compound, and performing condensation reaction on the substituted benzoxazinone-isoxazoline compound and alcohol or amine to obtain a target product. According to the present invention, the weeding activity test results of the obtained product show that the inhibition effects of the compounds I1, I2, I4, I15 and I16 on the rape are good under the concentration of 100 ppm, the excellent weeding activity is provided, and the good prevention and control effect on the invasive organism zinnia elegans is provided.

The invention discloses a preparation method of amorphous arfamarin. The method comprises the following steps: by taking 4-[3-(3-chloro-5-trifluoromethyl-phenyl)-4, 4, 4-trifluoro-1-oxo-2-butene-1-yl]-naphthalene-1-methyl formate and hydroxylamine hydrochloride as initial raw materials, carrying out cyclization reaction under the catalysis of a phase transfer catalyst and an acid-binding agent, then carrying out alkaline hydrolysis reaction, and finally, carrying out reaction with 2-amino-N-(2, 2, 2-triazole-1-yl)-1-methyl-2-oxo-2-butene-1-yl)-1-methyl-2-oxo-2-butene-1-yl)-2-amino-N-(2, 2, 2-triazole-1-yl)-1-methyl-2- 2, 2, 2-trifluoroethyl) acetamide is subjected to a condensation reaction to obtain a crude product of arfola, and the amorphous arfola is obtained through dissolution, decoloration and spray drying. The method is short in synthetic route, mild in reaction condition, simple and convenient to operate, high in conversion rate and suitable for industrial production, the purity can reach 99.5% or above, the single impurity content is smaller than 0.1%, and the finished product crystal form is amorphous.

The invention provides a method for extracting and detecting organic acid in tea leaves, and belongs to the technical field of food detection. The invention provides a method for extracting organic acid in tea leaves, which comprises the following steps: pretreating the tea leaves to obtain tea leaf freeze-dried powder; performing alkaline hydrolysis extraction on the tea freeze-dried powder to obtain an extracting solution; and adjusting the extracting solution to be acidic, and then carrying out back extraction to obtain the organic acid. The method is simple and convenient to operate and mild in reaction condition, oxidative degradation of the organic acid in the extraction process can be effectively avoided, the detection variety of the organic acid is increased by arranging the reasonable extracting agent and extraction steps, the conversion rate and extraction efficiency of the organic acid are remarkably improved, and the stability and repeatability of a detection result are guaranteed. Liquid chromatography-tandem mass spectrometry detection is utilized, qualitative and quantitative analysis is achieved through an external standard method, 26 organic acids in tea can be detected at the same time, and the method has the advantages of being short in time consumption, multiple in items, high in stability, wide in application range and the like.

The present application relates to a kind of preparation method of triphosphoryl uridine trisodium and its preparation.The present application uses ionic liquid as reaction solvent, 2-chloro-4H-1,3,2-benzene dioxaphosphorin-4-ketone (compound 1) is reacted with tributylammonium pyrophosphate to generate cyclic intermediate 2, then uridine is reacted, and then it is obtained by oxidation, basic hydrolysis ring-opening step triphosphoryl uridine trisodium.The present application uses ionic liquid as solvent to promote the site selectivity of the hydroxyl group in the ribose structure of uridine in the reaction, which can make the reaction intermediate 2 react with the hydroxyl group of the 5' position of uridine with high selectivity, so as to obtain UTP with high yield, and the present application also prepares UTP into the form of trisodium salt to facilitate purification and preservation.The present application solves the problems of long steps and low yield in the prior art when using chemical synthesis method to synthesize UTP.

The present invention relates to a preparation method for pyrrolo[2,3-d]pyrimidine derivative and a novel intermediate. The preparation method comprises the following steps: step 1: performing a substitution reaction between compound VII and compound VIII to obtain compound VI; step 2: under Lewis acid catalysis, subjecting compound VI to a Strecker reaction with an ammonia source and a cyanide and then hydrolyzing a cyano group of a product of the Strecker reaction, and converting the cyano group into a carboxyl group to obtain compound V; step 3: using trifluoroacetyl to protect an amino group of compound V to obtain compound III; step 4: performing a condensation dehydration reaction between intermediate III and compound IV to obtain compound II; and step 5: subjecting compound II to basic hydrolysis to remove the trifluoroacetyl protecting group and obtain AZD5363. The reaction conditions of the preparation method are mild and easy to control, the reaction process is easy to monitor, low cost of starting material is achieved, a work-up method of each step of the reaction is simple, high yield and good purity are achieved, and good application prospects and value are achieved.

Optical article incorporating a functionalized substrate, functionalizing and manufacturing methods thereof. The invention relates to an optical article comprising a surface-functionalized optical substrate and an optical element deposited on the same, an eyewear comprising this article, a method for functionalizing the substrate and a method of manufacturing this article. The optical substrate (5) is based on a first thermoset polymer and has a first outer surface, and the optical element (10) is based on a second thermoset polymer selected from (meth)acrylate based resins, has a second inner surface and is deposited on the optical substrate (5), the second inner surface being bonded to the first outer surface by covalent bonds at an interface thereof. According to the invention, the first outer surface is functionalized by functional groups comprising a product of a radical crosslinking reaction between the second thermoset polymer and a derivative of an organosilane compound which contains a vinyl or (meth)acrylate end group, and the derivative of the organosilane compound is a basic hydrolyzate thereof, the basic hydrolysate being grafted on the first outer surface to at least partially form said interface.

The present invention relates to a process for treating a polymeric material (PM) comprising a polyamide (PA66) based polymer and at least one filler (F1), the process comprising providing a polymeric material (PM) comprising a polyamide (PA66) based polymer and at least one filler (F1) and a solvent composition (SC) comprising water and optionally a polar solvent; preparing a mixture (M-0) from the polymeric material (PM) and the solvent composition (SC); subjecting mixture (M-0) to depolymerization conditions (D1) comprising a depolymerization temperature T(D1) in the range of from 150 to 300°C and a depolymerization time t(D1) of at least 5 minutes, preferably in the range of from 5 to 120 minutes, in particular in the range of from 5 to 30 minutes, in the presence of a base, wherein the factor F(D1)=T(D1) x t(D 1 ) is in the range of from 40 to 2200 K*h, obtaining a mixture (M-1) comprising the solvent composition (SC), soluble monomers and / or oligomers of the polyamide (PA66) based polymer, filler (F1), insoluble monomers and insoluble residues; separating the filler (F1), insoluble monomers and insoluble residues from mixture (M-1) obtaining mixture (M-2) comprising the filler (F1), insoluble monomers and insoluble residues, and mixture (M-3) comprising the solvent composition (SC), and soluble monomers and / or oligomers of the polyamide (PA66) based polymer; and optionally separating the filler (F1) from further components of mixture (M-2).

To produce a highly pure terephthalic acid by using polyester depolymerization.SOLUTION: A method for producing highly pure terephthalic acid comprises: preparing a solvent by mixing an alkaline catalyst with a basic hydrolysis solvent consisting of an alkylated aromatic compound and a polarity adjusting compound; obtaining a polyester depolymerization product by treating waste polyester with the solvent; preparing a sludge cake aqueous solution containing a terephthalate metal salt by filtering the polyester depolymerization product to obtain a sludge cake and adding purified water to the filtered sludge cake; obtaining an aqueous solution containing a terephthalate metal salt by treating the sludge cake aqueous solution with an organic solvent; purifying the terephthalate metal salt aqueous solution by treating the aqueous solution with an adsorbent; and precipitating solid terephthalic acid by treating the purified terephthalate metal salt aqueous solution with an acidic solution.SELECTED DRAWING: Figure 1

The invention relates to the technical field of sludge treatment and resource utilization, in particular to a method for preparing an amino acid compound fertilizer by basic hydrolysis of excess sludge. According to the invention, the waste residual sludge is taken as a raw material, a low-cost residual sludge hydrolysis process is developed, and protein in the residual sludge is efficiently converted into amino acid, so that the amino acid compound fertilizer capable of being applied to crops is prepared, reduction, harmlessness and recycling of the residual sludge are realized, and the high-quality amino acid compound fertilizer is produced; the problems that the existing residual sludge treatment cost is high, the environmental risk is large, the amino acid fertilizer production raw materials are expensive, the resource consumption is serious and the like can be solved, and remarkable economic and environmental benefits are achieved.

The present application relates to the technical field of resin organic synthesis. The method for preparing small molecule substance adsorption resin by post-crosslinking gel resin comprises the following steps: (1) oil phase preparation (2) water phase preparation (3) polymerization (4) chloromethylation: adding white ball resin into a reaction container, swelling by adding chloromethyl ether, stirring to mix uniformly by adding anhydrous zinc chloride, and adding concentrated sulfuric acid drop by drop to react to obtain chloro ball resin; (5) post-crosslinking reaction: adding chloro ball into a container, swelling by adding dichloroethane, stirring to dissolve by adding anhydrous ferric chloride, and heating to react to obtain post-crosslinked resin (6) hydrolysis reaction: adding the post-crosslinked resin into sodium hydroxide solution to perform alkaline hydrolysis. The resin of the present application is prepared into gel resin without using a pore former, then the gel resin is post-crosslinked, the obtained resin has a narrower pore size, a uniform pore structure distribution, more effective pore structures capable of adsorbing small molecules, and greatly improved adsorption capacity for small molecule substances.

A method for breaking down a halogenated hydrocarbon (HHC) compound that exists in the gaseous state at atmospheric conditions, includes the following: a) adding the HHC compound to an alkaline solution having a pH greater than 7 to generate a mixture of reagents; b) pressurizing the mixture of reagents to keep the alkaline solution in the liquid state and promote increased solubilization of the HHC compound in the alkaline solution; c) heating the mixture of reagents to a temperature within the range of 20° Celsius to 400° Celsius; and d) holding the mixture of reagents at the temperature in a reactor vessel for a period of time to separate a halogen atom from the HHC compound via alkaline hydrolysis.