17 results about "Basic hydrolysis" patented technology

The invention provides a method for preparing a flame-retardant hydrophobic aerogel composite material by a co-precursor method. The method comprises the following steps: mixing a water glass solution and phosphoric acid for hydrolysis reaction to obtain an acidic hydrolysate; 3-aminopropyltriethoxysilane, water and absolute ethyl alcohol are mixed for a hydrolysis reaction, and alkaline hydrolysate is obtained; mixing and reacting the acidic hydrolysate and the alkaline hydrolysate to obtain a co-precursor prepolymerization solution, continuously adding a water glass solution, and compounding with a glass fiber mat before gelling to form a silicon dioxide wet gel composite mat; sealing and aging the silicon dioxide wet gel composite felt in a precursor solvent, performing surface modification in a mixed solution of hexamethyldisiloxane, absolute ethyl alcohol and hydrochloric acid, and drying to obtain the flame-retardant hydrophobic aerogel composite material. The aerogel has excellent flame retardance and heat insulation property.

The invention belongs to the technical field of chemical preparation of nano-porous materials, and relates to core-shell type porous silicon dioxide microspheres, a preparation method thereof and application of the core-shell type porous silicon dioxide microspheres in structural color. The preparation method comprises the following steps: (1) mixing absolute ethyl alcohol, ammonia water and deionized water to obtain alkaline hydrolysate; (2) mixing tetraethyl orthosilicate with organosilane to obtain a silane mixed solution; (3) simultaneously and respectively dropwise adding the alkaline hydrolysate and the silane mixed liquid into the silicon dioxide microsphere dispersion liquid under stirring, and reacting to obtain an intermediate; and (4) calcining the obtained intermediate at 550-650 DEG C to obtain the core-shell type porous silicon dioxide microspheres. The preparation method of the core-shell type porous silicon dioxide microspheres is simple, easy to operate and mild in condition. The raw materials are simple, easy to obtain, non-toxic and harmless, a surfactant and a template agent are not needed, and the cost is greatly reduced.

The invention discloses a substituted benzoxazinone-isoxazoline compound as well as a preparation method and application of the substituted benzoxazinone-isoxazoline compound. The preparation method comprises the following steps: by taking DMF (Dimethyl Formamide) as a solvent, reacting ethyl bromoacetate with a compound (II) to generate a compound (III), performing cyclization in the presence of acetic acid and reduced iron powder to obtain a compound (IV), reacting the compound (IV) with hydroxylamine hydrochloride to generate a compound (V), reacting the compound (V) with NCS and MMA (Methyl Methacrylate) in the presence of TEA (Tetraethyl Ammonium) to generate a compound (VI), and reacting the compound (VI) with NCS and MMA to generate a compound (V). Reacting the compound (VI) with propargyl bromide to obtain a substituted benzoxazinone-isoxazoline compound, performing alkaline hydrolysis on the substituted benzoxazinone-isoxazoline compound, and performing condensation reaction on the substituted benzoxazinone-isoxazoline compound and alcohol or amine to obtain a target product. According to the present invention, the weeding activity test results of the obtained product show that the inhibition effects of the compounds I1, I2, I4, I15 and I16 on the rape are good under the concentration of 100 ppm, the excellent weeding activity is provided, and the good prevention and control effect on the invasive organism zinnia elegans is provided.

The invention discloses a preparation method of amorphous arfamarin. The method comprises the following steps: by taking 4-[3-(3-chloro-5-trifluoromethyl-phenyl)-4, 4, 4-trifluoro-1-oxo-2-butene-1-yl]-naphthalene-1-methyl formate and hydroxylamine hydrochloride as initial raw materials, carrying out cyclization reaction under the catalysis of a phase transfer catalyst and an acid-binding agent, then carrying out alkaline hydrolysis reaction, and finally, carrying out reaction with 2-amino-N-(2, 2, 2-triazole-1-yl)-1-methyl-2-oxo-2-butene-1-yl)-1-methyl-2-oxo-2-butene-1-yl)-2-amino-N-(2, 2, 2-triazole-1-yl)-1-methyl-2- 2, 2, 2-trifluoroethyl) acetamide is subjected to a condensation reaction to obtain a crude product of arfola, and the amorphous arfola is obtained through dissolution, decoloration and spray drying. The method is short in synthetic route, mild in reaction condition, simple and convenient to operate, high in conversion rate and suitable for industrial production, the purity can reach 99.5% or above, the single impurity content is smaller than 0.1%, and the finished product crystal form is amorphous.

The invention provides a method for extracting and detecting organic acid in tea leaves, and belongs to the technical field of food detection. The invention provides a method for extracting organic acid in tea leaves, which comprises the following steps: pretreating the tea leaves to obtain tea leaf freeze-dried powder; performing alkaline hydrolysis extraction on the tea freeze-dried powder to obtain an extracting solution; and adjusting the extracting solution to be acidic, and then carrying out back extraction to obtain the organic acid. The method is simple and convenient to operate and mild in reaction condition, oxidative degradation of the organic acid in the extraction process can be effectively avoided, the detection variety of the organic acid is increased by arranging the reasonable extracting agent and extraction steps, the conversion rate and extraction efficiency of the organic acid are remarkably improved, and the stability and repeatability of a detection result are guaranteed. Liquid chromatography-tandem mass spectrometry detection is utilized, qualitative and quantitative analysis is achieved through an external standard method, 26 organic acids in tea can be detected at the same time, and the method has the advantages of being short in time consumption, multiple in items, high in stability, wide in application range and the like.

The present application relates to a kind of preparation method of triphosphoryl uridine trisodium and its preparation.The present application uses ionic liquid as reaction solvent, 2-chloro-4H-1,3,2-benzene dioxaphosphorin-4-ketone (compound 1) is reacted with tributylammonium pyrophosphate to generate cyclic intermediate 2, then uridine is reacted, and then it is obtained by oxidation, basic hydrolysis ring-opening step triphosphoryl uridine trisodium.The present application uses ionic liquid as solvent to promote the site selectivity of the hydroxyl group in the ribose structure of uridine in the reaction, which can make the reaction intermediate 2 react with the hydroxyl group of the 5' position of uridine with high selectivity, so as to obtain UTP with high yield, and the present application also prepares UTP into the form of trisodium salt to facilitate purification and preservation.The present application solves the problems of long steps and low yield in the prior art when using chemical synthesis method to synthesize UTP.

The present invention relates to a hydrolysed extract of de-oiled hemp seed cake obtained by alkaline hydrolysis at a pH of greater than or equal to 11, the peptide fractions thereof, the combination of this extract or the peptide fractions thereof with an ethanolic extract of hemp seed cake, and a pharmaceutical composition comprising same. The invention further relates to a method for producing the hydrolysed extract according to the invention. Finally, the invention relates to the hydrolysed extract according to the invention or a peptide fraction thereof or the combination or composition comprising same, for use as a drug.

The present invention relates to a preparation method for pyrrolo[2,3-d]pyrimidine derivative and a novel intermediate. The preparation method comprises the following steps: step 1: performing a substitution reaction between compound VII and compound VIII to obtain compound VI; step 2: under Lewis acid catalysis, subjecting compound VI to a Strecker reaction with an ammonia source and a cyanide and then hydrolyzing a cyano group of a product of the Strecker reaction, and converting the cyano group into a carboxyl group to obtain compound V; step 3: using trifluoroacetyl to protect an amino group of compound V to obtain compound III; step 4: performing a condensation dehydration reaction between intermediate III and compound IV to obtain compound II; and step 5: subjecting compound II to basic hydrolysis to remove the trifluoroacetyl protecting group and obtain AZD5363. The reaction conditions of the preparation method are mild and easy to control, the reaction process is easy to monitor, low cost of starting material is achieved, a work-up method of each step of the reaction is simple, high yield and good purity are achieved, and good application prospects and value are achieved.

Optical article incorporating a functionalized substrate, functionalizing and manufacturing methods thereof. The invention relates to an optical article comprising a surface-functionalized optical substrate and an optical element deposited on the same, an eyewear comprising this article, a method for functionalizing the substrate and a method of manufacturing this article. The optical substrate (5) is based on a first thermoset polymer and has a first outer surface, and the optical element (10) is based on a second thermoset polymer selected from (meth)acrylate based resins, has a second inner surface and is deposited on the optical substrate (5), the second inner surface being bonded to the first outer surface by covalent bonds at an interface thereof. According to the invention, the first outer surface is functionalized by functional groups comprising a product of a radical crosslinking reaction between the second thermoset polymer and a derivative of an organosilane compound which contains a vinyl or (meth)acrylate end group, and the derivative of the organosilane compound is a basic hydrolyzate thereof, the basic hydrolysate being grafted on the first outer surface to at least partially form said interface.

The invention discloses a preparation method of high-purity N-methyl halogenated benzamide, which comprises the following steps: by taking halogenated benzoic acid as a raw material, in a high-pressure reaction kettle, only adding methanol and ammonia gas, and realizing amidation and N-methylation of the halogenated benzoic acid by utilizing a one-pot reaction to prepare the N-methyl halogenated benzamide, it can be purified by a basic hydrolysis reaction. According to the invention, methanol is successfully used as a methyl source to realize N-methylation of amide, the use of an acyl halide reagent in the traditional preparation process of N-methyl halogenated benzamide is avoided, the N-methyl halogenated benzamide product is directly prepared through a one-pot reaction under the condition of no additional catalyst, and the purity of the N-methyl halogenated benzamide product is enabled to be gt through simple purification; the method can be used for recycling byproducts and unreacted halogenated benzoic acid, and the byproduct and unreacted halogenated benzoic acid can be recycled. Compared with the traditional process, the method has the advantages that the raw materials are cheap and easy to obtain, the reaction system is green and environment-friendly, the operation steps are simple, and the method is a novel method for effectively producing the N-methyl halogenated benzamide.

The invention discloses composite printing and dyeing slurry and application thereof in polyester, and belongs to the technical field of polyester printing and dyeing, the composite printing and dyeing slurry comprises, by mass, 2-3% of a disperse dye, 1.5-3% of a thickener, 1.0-1.5% of a dispersant, 2-3% of a dyeing assistant, and the balance of water; the composite printing and dyeing slurry provided by the invention has relatively good printing and dyeing performance on polyester fabrics, and is good in dyeing permeability, high in color fastness and comfortable in hand feeling. The added dyeing assistant can enable the fibers to swell in the baking process during printing and dyeing, so that the permeability of the dye is improved, a polymer structure is washed off after alkaline hydrolysis, small molecule groups containing amino structures are left, amino reacts with the epoxy color fixing agent to form a film during color fixing, and the color fastness is improved through chemical bonding.

The present invention relates to a process for treating a polymeric material (PM) comprising a polyamide (PA66) based polymer and at least one filler (F1), the process comprising providing a polymeric material (PM) comprising a polyamide (PA66) based polymer and at least one filler (F1) and a solvent composition (SC) comprising water and optionally a polar solvent; preparing a mixture (M-0) from the polymeric material (PM) and the solvent composition (SC); subjecting mixture (M-0) to depolymerization conditions (D1) comprising a depolymerization temperature T(D1) in the range of from 150 to 300°C and a depolymerization time t(D1) of at least 5 minutes, preferably in the range of from 5 to 120 minutes, in particular in the range of from 5 to 30 minutes, in the presence of a base, wherein the factor F(D1)=T(D1) x t(D 1 ) is in the range of from 40 to 2200 K*h, obtaining a mixture (M-1) comprising the solvent composition (SC), soluble monomers and / or oligomers of the polyamide (PA66) based polymer, filler (F1), insoluble monomers and insoluble residues; separating the filler (F1), insoluble monomers and insoluble residues from mixture (M-1) obtaining mixture (M-2) comprising the filler (F1), insoluble monomers and insoluble residues, and mixture (M-3) comprising the solvent composition (SC), and soluble monomers and / or oligomers of the polyamide (PA66) based polymer; and optionally separating the filler (F1) from further components of mixture (M-2).

To produce a highly pure terephthalic acid by using polyester depolymerization.SOLUTION: A method for producing highly pure terephthalic acid comprises: preparing a solvent by mixing an alkaline catalyst with a basic hydrolysis solvent consisting of an alkylated aromatic compound and a polarity adjusting compound; obtaining a polyester depolymerization product by treating waste polyester with the solvent; preparing a sludge cake aqueous solution containing a terephthalate metal salt by filtering the polyester depolymerization product to obtain a sludge cake and adding purified water to the filtered sludge cake; obtaining an aqueous solution containing a terephthalate metal salt by treating the sludge cake aqueous solution with an organic solvent; purifying the terephthalate metal salt aqueous solution by treating the aqueous solution with an adsorbent; and precipitating solid terephthalic acid by treating the purified terephthalate metal salt aqueous solution with an acidic solution.SELECTED DRAWING: Figure 1

The invention relates to the technical field of sludge treatment and resource utilization, in particular to a method for preparing an amino acid compound fertilizer by basic hydrolysis of excess sludge. According to the invention, the waste residual sludge is taken as a raw material, a low-cost residual sludge hydrolysis process is developed, and protein in the residual sludge is efficiently converted into amino acid, so that the amino acid compound fertilizer capable of being applied to crops is prepared, reduction, harmlessness and recycling of the residual sludge are realized, and the high-quality amino acid compound fertilizer is produced; the problems that the existing residual sludge treatment cost is high, the environmental risk is large, the amino acid fertilizer production raw materials are expensive, the resource consumption is serious and the like can be solved, and remarkable economic and environmental benefits are achieved.

The present application relates to the technical field of resin organic synthesis. The method for preparing small molecule substance adsorption resin by post-crosslinking gel resin comprises the following steps: (1) oil phase preparation (2) water phase preparation (3) polymerization (4) chloromethylation: adding white ball resin into a reaction container, swelling by adding chloromethyl ether, stirring to mix uniformly by adding anhydrous zinc chloride, and adding concentrated sulfuric acid drop by drop to react to obtain chloro ball resin; (5) post-crosslinking reaction: adding chloro ball into a container, swelling by adding dichloroethane, stirring to dissolve by adding anhydrous ferric chloride, and heating to react to obtain post-crosslinked resin (6) hydrolysis reaction: adding the post-crosslinked resin into sodium hydroxide solution to perform alkaline hydrolysis. The resin of the present application is prepared into gel resin without using a pore former, then the gel resin is post-crosslinked, the obtained resin has a narrower pore size, a uniform pore structure distribution, more effective pore structures capable of adsorbing small molecules, and greatly improved adsorption capacity for small molecule substances.

A method for breaking down a halogenated hydrocarbon (HHC) compound that exists in the gaseous state at atmospheric conditions, includes the following: a) adding the HHC compound to an alkaline solution having a pH greater than 7 to generate a mixture of reagents; b) pressurizing the mixture of reagents to keep the alkaline solution in the liquid state and promote increased solubilization of the HHC compound in the alkaline solution; c) heating the mixture of reagents to a temperature within the range of 20° Celsius to 400° Celsius; and d) holding the mixture of reagents at the temperature in a reactor vessel for a period of time to separate a halogen atom from the HHC compound via alkaline hydrolysis.

The invention relates to a process for recovering monomers from a polyamide (PA) of the AABB type, comprising the following steps: a) contacting a product (P) comprising a polymer component comprising the polyamide (PA) with a compound (A *) in order to reduce the molecular weight of the polyamide (PA), the polymer component being in molten form and the compound (A *) being selected from the group of C2-C18 carboxylic acids; b) optionally treating the mixture obtained at the end of step a) in order to remove at least one solid material from the molten mixture; c) the hydrolysis of one or more polyamide molecules present in the mixture obtained at the end of step a) or optionally step b) is carried out in an aqueous medium (i) by acidic or basic hydrolysis involving an acid (Ac) or a base (Ba) and carried out at a pH of less than 6.0 or higher, respectively, or (ii) by enzymatic hydrolysis; d) recovering a stream (S) comprising the diacid (A), the diamine (B) and the compound (A *) at the end of step c), each of the three compounds being in its free form or in the form of a salt, and further processing this stream in order to separate and recover the diacid (A), the diamine (B) and the compound (A *).