202 results about "Basic hydrolysis" patented technology

The invention relates to ultrafine fiber with high color fastness and a manufacturing method thereof. The method comprises the steps of adding 3-40% coloring agent into a polymer powder to make into colored stock particles; adding the colored stock particles into spinning polymer polyester and/or polyamide in a ratio of 0.2-15%, and mixing; melt extruding the spinning polymer with a conjugate spinning machine, and coiling to obtain colored POY composite fiber; stretching and false-twist texturing to obtain colored fiber with high color fastness; and splitting with a basic hydrolysis method to obtain colored ultrafine fiber with high color fastness. The colored ultrafine fiber with high color fastness has excellent handfeel and color fastness to washing and light, and contains mass-colored dyeing components, so as to dispense with dyeing after being made into a textile. The colored ultrafine fiber has the advantages of simple process, low cost, low pollution, small product color difference, good color fastness, low fading liability, wide color spectra, and vivid and bright color.

The present invention relates to process of extracting cholic acid, deoxycholic acid and bilirubin from bile of pig, ox and sheep. Bile of pig, ox and sheep consists of water in about 97 %, bile acid in about 2.5 % and bilirubin in about 0.4 %; and contains also phospholipid, cholesterol, Na, K, Ca, phosphate, carbonate, small amount of protein, and other components. Fresh bile is treated through cooling, filtering to defat, basic hydrolysis, acidification and organic solvent extracting to obtain bilirubin; the rest solution is further treated through deep saponification, acidification and organic solvent precipitation to obtain the mixture of cholic acid and deoxycholic acid; and the mixture is re-crystallization separated to obtain high purity cholic acid and deoxycholic acid.

The invention relates to an energy regeneration method for solid organic waste alkaline thermal hydrolysis supernate. Solid organic waste mainly comprises kitchen waste and sludge. The energy regeneration method for the solid organic waste alkaline thermal hydrolysis supernate comprises the following steps that (1) after the organic waste, water and alkali hydrolysis agents are proportioned and mixed in a proportioning and preheating tank, heating is conducted, so that the temperature of the materials in the tank is increased to 30-99 DEG C; (2) the materials in the proportioning and preheating tank are sent into a reaction kettle through a pump for the temperature rise reaction, and finally the temperature of the materials is controlled between 100 DEG C and 140 DEG C, and the reaction continues to be conducted for 90-120 minutes; (3) the materials after the hydrolysis reaction are conveyed into a flash evaporation tank for pressure relief and cooling, so that the temperature of the materials is decreased to 50-100 DEG C; (4) clarified liquid and solid are obtained after solid-liquid separation; and (5) the liquid obtained after solid-liquid separation is delivered into an anaerobic digestion system for anaerobic digestion treatment, and thus marsh gas is generated. By the adoption of the energy regeneration method for the solid organic waste alkaline thermal hydrolysis supernate, toxin removal, stabilization, minimization and energy regeneration of the organic waste can be achieved at a time.

The invention provides a method for extracting lutein from marigold particles. The method comprises the following preparation steps: (1) grinding marigold dried flower particles sifting out, placing the powder in an extraction device, continuously passing the powder through organic solvent, and collecting and filtering the extracting solution; (2) placing the extracting solution in a distillationstill for distillation and carrying out basic hydrolysis on the concentrated extracting solution with the participation of a phase transfer catalyst; (3) using acid to adjust solution pH value after saponification, and adding distilled water for stirring; (4) extracting the lutein by organic solvent, carrying out reduced pressure distilling and recovery on extract liquor, thus obtaining lutein crude product; and (5) carrying out eluviation and obtaining food or medical grade lutein by vacuum drying. The invention features simple method, low cost, easy post-processing, and achieves content of final product which reaches more than 97%, therefore, the lutein extracted by the method of the invention can be applied as food additive and raw materials of medicines and health products and is applicable to industrial mass product.

The invention discloses a preparation method of 1-(4-chlorophenyl)-2-cyclopropyl-1-acetone (I) and an intermediate thereof as well as the preparation method of the intermediate. The preparation method of 1-(4-chlorophenyl)-2-cyclopropyl-1-acetone (I) comprises the following steps of: carrying out Darzen condensation reaction on alpha-halo-p-chlorophenylacetate (II) and acetylcyclopropane (III) as raw materials in the presence of alkaline to prepare glycidic ester (IV); and carrying out basic hydrolysis on the obtained glycidic ester (IV) to be converted to a corresponding glycerate (V), and further carrying out decarboxylation reaction under acidic conditions to prepare 1-(4-chlorophenyl)-2-cyclopropyl-1-acetone (I) as a bactericide cyproconazole intermediate. The preparation method is simple in process, the three-step reaction can be realized through continuous operation or 'one-pot method'; and the product 1-(4-chlorophenyl)-2-cyclopropyl-1-acetone (I) is high in content and suitable for large-scale development.

A method for the chemical depolymerization of waste polyethylene terephthalate by application of microwave radiation and solvolysis in the presence of a catalyst comprising the first stage where the waste polyethylene terephthalate is mixed up with an microwaves absorbing activator, the mixture is melted by its exposing to a microwave radiation on a frequency from 915 to 2450 MHz and with a power output from 0.1 to 0.5 kW per kg of a charge, at a temperature from 230 to 330° C., under atmospheric pressure and the second stage, where the molten mixture is subjected to solvolysis, including acidic or basic hydrolysis, alcoholysis or glycolysis in the presence of a catalyst under continuing microwave radiation and atmospheric pressure yielding terephthalic acid, salts or esters thereof, and ethylene glycol.

The invention discloses a method for preparing modified glass microspheres, which comprises the steps of: firstly, coprecipitating a titanium source and a basic hydrolysis reaction solution in water, reacting to obtain a white titanium hydroxide deposit; obtaining a titanium dioxide sol precursor after carrying out washing, peptizing and aging; then carrying out hydro-thermal treatment to obtain anatase phase titanium dioxide sol; mixing the anatase phase titanium dioxide sol with glass microspheres; mill-grinding, and cooling after thermal treatment to obtain the titanium dioxide modified glass microspheres for light scattering of a dye sensitization solar battery. The finished glass microsphere product prepared by using the method for preparing the modified glass microsphere is wrapped with well-crystallized anatase phase titanium dioxide particles on the surface; and the mill-ground glass microspheres have irregular shapes, and have maximum particle diameter of about 400nm and minimum particle diameter of about 200nm, which ensures the compactness of the glass microspheres subjected to film formation.

The invention discloses a preparation method for a loosened porous cuprous oxide material and an application of cuprous oxide in electrocatalytic reduction of carbon dioxide. The preparation method disclosed by the invention comprises the following steps: mainly taking dilute acid and copper iodide powder after cleaning with ethyl alcohol as raw materials; preparing in a potassium iodide or sodiumiodide solution, thereby acquiring a complexing solution; adding a certain amount of complexing solution into a strong base solution at a ratio, thereby acquiring a sediment product; lastly, using ultrapure water and acetone for repeatedly centrifugal cleaning, and drying by blowing nitrogen, thereby acquiring the loosened porous cuprous oxide material. According to the invention, a simple, quick, safe and controllable basic hydrolysis method is adopted for synthesizing the loosened porous cuprous oxide material with clean surface, increasing specific surface area of the material and promoting catalytic activity; residual oxygen is utilized to reduce activation barrier of coupling reaction of intermediate products, so that reaction activity for high-carbon products is greatly boosted; total Faraday efficiency of the material for electro-catalytically reducing carbon dioxide into high-carbon products, such as ethylene, ethyl alcohol and normal propyl alcohol, is increased to above 80%.

The invention belongs to the field of drug synthesis and relates to an entecavir compound and a synthetic method of an intermediate of the entecavir compound. The novel synthetic method comprises: by taking (S)-3-hydroxyl dimethyl adipate as an initial raw material, preparing an intermediate 9 through hydroxyl TBS protection, Dieckmann condensation reaction, ketone protection to ketal, ester group reduction to hydroxyl, hydroxyl protection, deprotection, ketone to silyl enol ether and Rubottom oxidizing reaction; and preparing entecavir from the intermediate 9 through wittig reaction, Mitsunobu reaction, silicon preventing radical group removal and basic hydrolysis. The novel synthetic method provided by the invention is mild and easily controllable in reaction condition, simple to operate, high in product yield, high in purity and suitable for industrialized mass production.

The invention discloses a preparation method of polyacrylic acid hollow microgel. According to the preparation method, an oil phase is added into a water phase, triethylamine and tetraethoxysilane are dropwise added under an alkaline condition to carry out in-situ hydrolysis to generate nano-silica particles as a surfactant, and a stable 'oil-in-water' form Pickering emulsion is generated; polyacrylonitrile is incompatible with isooctane, so that raw monomer droplets are subjected to phase separation, and isooctane is extruded to the centers of the droplets of a mini-emulsion to form liquid cores; after monomers are polymerized, polyacrylonitrile hollow microspheres are obtained and are subjected to basic hydrolysis to generate the polyacrylic acid hollow microgel. The preparation method has the advantages that the process is simple, the operation is feasible, reaction conditions are mild and easy to control, the consumption of the surfactant is reduced, and the preparation method is applicable to industrial production and is environment-friendly. The prepared polyacrylic acid hollow microgel is stable in structure and controllable in hollow size and can be applied to the fields of medicine controlled release, chemical separation, biosensing and the like.

The invention discloses a preparation method of cilastatin sodium, comprising the following steps of: taking 7-chloro-oxo-ethyl oenanthate and (S)-(+)-2, 2-dimethyl cyclopropane formamide as raw materials, and carrying out condensation reaction and basic hydrolysis to obtain (Z)-7-chloro-2((S)-2, 2-dimethyl cyclopropane formamido)-2-heptenoic acid; then, adding alkaline compound for reaction, and separating and purifying to obtain (Z)-7-chloro-2((S)-2, 2-dimethyl cyclopropane formamido)-2-heptenoic acid metal salt crystal; leading the metal salt crystal and cysteine hydrochloride for condensation reaction, acidizing the reaction liquid by hydrochloric acid, washing by organic solvent and concentrating, then loading sample into macroporous absorption resin for purifying, directly using sodium hydroxide solution for elution, and obtaining cilastatin sodium solid after the treatment of eluent. The preparation method simplifies the preparation technique, and effectively improves the chrominance, the purity and the yield of the cilastatin sodium.

The invention relates to a simple and convenient preparation method of a key intermediate (2-methyl-4-amino-5-amino methyl pyrimidine) for the vitamin B1. According to the method, lewis acid is used for catalyzing addition condensation reaction of acetamidine and 3-formyl amino ethyl cyanide and then catalyzing reaction of the condensation product and triethyl orthoformate to introduce a formyl chiral auxiliary, an imdo group and the formyl chiral auxiliary are subjected to ring formation to form 2- methyl-4-formyl amino-5- amino methyl pyrimidine, and finally basic hydrolysis is performed, so that 2-methyl-4-amino-5-amino methyl pyrimidine is obtained. The reaction procedures are carried out sequentially by adopting the one-pot method, the products in each step require no separation and purification, and the operation is simple and convenient. According to the method, highly toxic o-chloroaniline and other phenylamine compounds are not used, so that residue of o-chloroaniline compounds in the vitamin B1 product can be completely avoided. Meanwhile, the production wastewater is less and the yield is high.

The invention discloses a synthetic method of pyrroloquinoline quinone. The synthetic method comprises the following steps: carrying out alkali treatment on 2-methoxy-5-nitroaniline hydrochloride as a raw material, so as to obtain a compound 1; carrying out formylation on the compound 1 under a catalysis condition of an ionic liquid, so as to obtain a compound 2; adopting sodium borohydride to reduce the compound 2 to obtain a compound 3; carrying out diazotization on the compound 3, and then enabling action between the diazotized compound 3 and HBF4 to obtain a compound 4; enabling reaction of the compound 4 and 2-methylethyl acetoacetate to obtain a compound 5; treating the compound 5 with formic acid to obtain a compound 6; carrying out amid catalysis and exchange with the ionic liquid on the compound 6 to obtain a compound 7; enabling reaction of the compound 7 and 2-oxodimethyl glutaconate to obtain a compound 8; feeding hydrogen chloride to the compound 8 under the action of Cu(OAc)2*2H2O to obtain a compound 9; carrying out basic hydrolysis on the compound 9 to obtain a compound 10. The synthetic method disclosed by the invention is cheap and accessible in raw materials, stable, high in reaction yield, quick in reaction, and easy for product separation, and is environment-friendly as the catalyst can be recycled.

The invention relates to a method for preparing microprotein, which takes active sludge generated during biochemical treatment of sewage and waste water, particularly remained active sludge from town sewage treatment plants, as raw materials. The method is characterized in that the active sludge is subjected to concentration regulation, hot basic hydrolysis, residue-liquid separation, filtrate condensation and concentrated solution drying to obtain protein products with different concentrations. The method has the advantages of simple technological process and equipment and easy industrialized production, and protein products prepared have the advantages of good foamability and foaming stability, high yield and low cost.

The invention discloses a preparation method for an antibacterial acrylic fiber and especially relates to a method for preparing a new antibacterial fiber by utilizing the process of taking a polyacrylonitrile fiber as a carrier and modifying through chemical etching. The preparation method comprises the following steps: performing basic hydrolysis etching on the polyacrylonitrile fiber, loading a silver antibacterial agent and reducing silver ions; adjusting the concentration and time of an amido solution and the concentration of the silver antibacterial agent by controlling the charge rate and hydrolysis temperature; and selecting a suitable reducing agent so as to prepare the silver antibacterial acrylic fiber with a broad-spectrum antibacterial function. The antibacterial acrylic fiber prepared according to the preparation method feels soft, is wide in antibacterial spectrum, has a long-lasting antibacterial property, is safe and reliable, can be prepared into health-care underwear, insoles, operation uniform, nurse uniform, medical gauze and the like, and is wide in application prospect.

The invention discloses a large-scale blood plasma sphingolipid profile analysis method based on liquid chromatography-mass spectrometry combination, which is characterized in that sphingolipid in blood plasma is extracted by double-phase extraction with methyl tertiary butyl ether/methanol/water (MTBE/MeOH/H2O) combined with mild basic hydrolysis. Then rapid semi-quantitative analysis is realized within 15 min by combination of ultra-high performance liquid chromatography-electro-spray ionization-mass spectrometry. In the invention, the MTBE/MeOH/H2O extraction system is simple, rapid, and easy to operate, has less protein interference in the extract, and has good repeatability; interference of high-abundance phospholipid and glyceride in the lipid group is eliminated by hydrolysis; ion inhibition is reduced; therefore, the purpose of detecting low-abundance sphingolipid with high sensitivity is achieved. With the high resolution separation capability of subsequent ultra-high performance liquid chromatography (UHPLC) and the specificity of MRM, effective distinguishing of isomers is realized, and the introduction of complex isotope correction during quantification is avoided, which makes the method more rapid and accurate.

The invention relates to a co-production method for preparing corresponding alcohol, ester, aldehyde and acid by oxidizing p-methoxyl methylbenzene by oxygen. The method comprises the following steps: adding p-methoxyl methylbenzene, a catalyst I and a solvent into an oxidizing reaction kettle, and introducing oxygen to react; after oxidizing reaction, recovering the solvent and optionally selecting to apply mechanically, and then adding water to wash the catalyst I to obtain an organic phase I and an aqueous phase I; adding alkali into the organic phase I, decompressing and evaporating an organic phase II, after adding water to the bottom, adjusting the pH value by an acid, and filtering to obtain p-methoxybenzoic acid; distilling the water phase I to recover water, optionally selecting to apply mechanically, further adding the catalyst I and the solvent at the bottom, and optionally selecting to apply mechanically in oxidizing reaction; rectifying the organic phase II to obtain a product p-methoxybenzaldehyde and anisyl acetate; carrying out basic hydrolysis on anisyl acetate to obtain an anisic alcohol crude product; and rectifying to obtain an anisic alcohol pure product. The co-production method provided by the invention has the advantages of greenness and environment protection, mild reaction condition, low cost and less three waste, and is easy to industrially produce, and the obtained product is widely applied to the fields of foods, medicines and daily chemicals.

The invention discloses a preparation method of malonate, which uses chloroacetic acid as a raw material to carry out neutralization reaction, cyanation reaction, alkali hydrolysis reaction, dehydration, acidification reaction, re-dehydration and esterification reaction, and is characterized in that: acidification reaction, further Dehydration and esterification reaction process. The acidification reaction refers to the reaction of sodium malonate and acid in the alkali hydrolysis reaction solution to generate malonate and sodium salt, after the reaction is completed, the undissolved inorganic salt is filtered and separated, and the filtrate is vacuum concentrated and dehydrated to obtain a malonate mixed salt; Esterification refers to the esterification of malonic acid mixed salt with alcohol, water-carrying agent and sulfuric acid to prepare malonate. The preparation method of malonate provided by the invention can make the conversion rate of esterification reaction up to more than 92%, and the product yield can reach more than 85%. The reaction conditions are mild, the process flow is short, the operation is simple, safe, environmentally friendly, easy to implement, and low Low, easy to industrial production, has high application value.

The invention discloses a preparing method of o-chlorobenzene glycine as chloropygray intermediate, which comprises the following steps: A. cyaniding; B. proceeding basic hydrolysis; decoloring; C. neutralizing; crystallizing; D. sucking; drying. The invention is fit for large scale of industrial manufacturing, which avoids toxic hydrocyanic acid from producing.

The present invention relates to a production method of super fine fibre, in particular it relates to a production method of colored functional super fine fibre. Said production method includes the following several steps: directly mixing super fine fibre raw material with coloring material, adjuvant and functional additive according to a certain mixing ratio to obtain colored anti-bacterial mother materi, melting said mother material at high temperature, extruding said molten mother material by using twin-screw extruder and making basic hydrolysis so as to obtain the invented product.

The invention provides a method for preparing protopanoxadiol derivatives of a formula below, namely 20(R)-25-hydroxy-dammarane type-3beta,12beta,20-triols[abbreviated as 20(R)-25-OH-PPD]. The protopanoxadiol derivatives are obtained by hydrolyzing total ginsenoside, wherein the method for hydrolyzing the total ginsenoside comprises a basic hydrolysis process, an acid hydrolysis process I and an acid hydrolysis process II. The structure of the 20(R)-25-hydroxy-dammarane type-3beta,12beta,20-triols is determined by nuclear magnetic resonance spectrum. The method is high in yield and purity, ensures stable product quality and can realize industrial production and can meet the needs for development of new antitumor medicines.

The invention provides a method for detecting doping of other collagen-containing substances in edible bird's nest. The method comprises the following steps: 1) pre-treatment of a sample of edible bird's nest: dividing the sample of the edible bird's nest into two parts, wherein one part employs acid for hydrolysis treatment and fixes the volume to be taken as an acid hydrolysis sample, the other part employs basic for hydrolysis treatment and fixes the volume to be taken as a basic hydrolysis sample, mixing the acid hydrolysis sample and the basic hydrolysis sample, fixing the volume, and taking a mixture as the pre-treatment sample; 2) pre-column derivatization treatment: respectively performing pre-column derivatization on primary amino acid and secondary amino acid of the pre-treated sample by OPA and FMOC to obtain a to-be-measured sample; and 3) respectively performing high performance liquid chromatography detection and analysis on the to-be-measured sample and a standard sample, by comparing the detection spectrums, determining whether the to-be-measured sample contains hydroxyproline and/or sarcosine or not, and whether the standard sample contains the standard object of hydroxyproline and/or sarcosine or not. The method is helpful for determination of quality of the edible bird's nest, and has the advantages of rapid analysis process and sensitive detection.

The invention discloses a preparation method of Ozagrel sodium. The method comprises the following steps: performing a bromination reaction on ethyl 4-methylcinnamate and N-bromo-succinimide by takingacetonitrile as a solvent under the triggering of azodiisobutyronitrile, so as to obtain ethyl 4-bromomethylcinnamate; performing a condensation cyclization reaction on the ethyl 4-bromomethylcinnamate and imidazole by taking sodium hydroxide as an acid-binding agent and taking tetrahydrofuran as a solvent, so as to obtain imidazole ethyl 4-methylcinnamate; performing alkali hydrolysis on the imidazole ethyl 4-methylcinnamate, so as to obtain the Ozagrel sodium. According to the preparation method, the condensation cyclization reaction is performed by taking the sodium hydroxide as the acid-binding agent and taking the tetrahydrofuran as the solvent, so that the finally obtained product does not contain toxic components, the yield and the purity of the product can be effectively improved,and the content of genotoxic impurities (the ethyl 4-bromomethylcinnamate and ethyl 4-dibromomethylcinnamate) in the product is zero.

The invention discloses a method for preparing asiatic acid by basic hydrolysis of asiaticoside, which comprises the following steps: 1) adding a raw material of astiaticoside into a water solution of inorganic base in batches, and hydrolyzing the raw material at a temperature of between 45 and 90 DEG C for 1-24 hours; 2) adding acid into the hydrolysate solution, adjusting the pH value to between 2 and 4, depositing the solution, and filtrating the solution to obtain precipitate; and 3) adding the precipitate into organic solvent after drying of the precipitate, dissolving the precipitate and filtering the solvent, adding water into filtrate for crystallization, obtaining a crystal after filtration of the filtrate, and drying the crystal through vacuum so as to obtain asiatic acid products. The asiatic acid products have high yield and purity and can be used for preparing raw materials medicine or astiatic acid derivant; in addition, the method has a simple technical process and low investment, and is easy to realize industrialization.

The invention provides a non-ferrous metal oxide ore chelate collector and a preparation method thereof. The invention is characterized in that the chelate collector is alkyl malonic acid; and the preparation method of the chelate collector is completed in three steps of reaction: 1, solid-liquid phase transfer catalytic hydrocarbylation: directly performing a solid-liquid phase reaction for 0.5 to 4.0 hours at the temperature of 60-200 DEG C by using a phase transfer catalyst, anhydrous carbonate, halogenated hydrocarbon and diethyl malonate as raw materials to prepare alkyl diethyl malonate; 2, basic hydrolysis: hydrolyzing the alkyl diethyl malonate into alkyl sodium malonate by adopting a NaOH solution condition; and 3, acidification: transforming the alkyl sodium malonate into alkyl malonic acid in the acidic condition with the pH of 0.5-6.5, cooling, crystallizing and separating a product, and filtering to obtain the product. The chelate collector has the characteristics of wide raw material sources, low production cost, simple preparation process, stable property and high collection capability and selectivity.

The present invention provides optically active compound 2-methylol-3-(3, 4- methylene dioxy) phenyl propionic acid and the resolution process for preparing the compound. By using substituted benzyl diethyl malonate as initial material and through basic hydrolysis, reduction and acidification, 2-methylol-3-substituted phenyl propionic acid is prepared, which is further resolved to obtain its optical isomer. The present invention has cheap material and other reagent, less wastes produced, simple operation, high yield and low cost, and is suitable for industrial production.