79results about How to "Dosage controllable" patented technology

The invention belongs to the field of drug synthesis and relates to an entecavir compound and a synthetic method of an intermediate of the entecavir compound. The novel synthetic method comprises: by taking (S)-3-hydroxyl dimethyl adipate as an initial raw material, preparing an intermediate 9 through hydroxyl TBS protection, Dieckmann condensation reaction, ketone protection to ketal, ester group reduction to hydroxyl, hydroxyl protection, deprotection, ketone to silyl enol ether and Rubottom oxidizing reaction; and preparing entecavir from the intermediate 9 through wittig reaction, Mitsunobu reaction, silicon preventing radical group removal and basic hydrolysis. The novel synthetic method provided by the invention is mild and easily controllable in reaction condition, simple to operate, high in product yield, high in purity and suitable for industrialized mass production.

The invention discloses a method for preparing dapoxetine hydrochloride. The method comprises the following steps: subjecting (s)-3-amino-3-phenylpropionic acid or an ester thereof to a reduction reaction in a reduction system prepared from a hydroborate and a boron trifluoride complex, so as to obtain an intermediate 1, i.e. (s)-3-amino-3-phenylpropanol; subjecting the (s) intermediate 1 to an Eschweiler-Clark reaction with formic acid and formaldehyde, so as to obtain an intermediate 2; subjecting the intermediate 2 to a Williamson ether forming reaction with 1-fluoronaphthalene, so as to obtain a free alkali, i.e. (s)-N,N-dimethyl-3-(1-naphthyloxy)phenyl propyl amine; subjecting the free alkali to a salt forming reaction with alcohol-acyl chloride or a chloride thereof, a hydrochloric acid organic solution or hydrochloric acid gas, thereby obtaining dapoxetine hydrochloride. According to the method, the synthesis route is low in production cost, the reaction conditions are mild, all the materials are readily available, the raw materials are low in toxicity, the reaction is simple in operation and high in safety, and the product is high in purity and yield and is environmentally friendly, so that the method is applicable to industrial large-scale production.

The invention relates to a preparation method of an SAPO-34 molecular sieve. A solid phase is ground and synthetized into the molecular sieve. The preparation method specifically comprises the following steps of (1) pouring a silicon resource, an aluminum source, a template and water into a mortar for grinding and mixing so as to obtain a mixture, and loading the uniformly ground mixture into a reaction kettle for a crystallization reaction; (2) after crystallization is completed, performing cooling, performing washing with ionized water until the washed mixture is neutral, and performing drying so as to obtain molecular sieve raw powder; and (3) roasting the molecular sieve raw powder in the air, so as to obtain products, wherein the silicon resource is white carbon black or silica gel ; the aluminum source is boehmite or aluminum hydroxide, and the template is one or more of tetraethylenepentamine phosphate TEPA.H3PO4. diethylenetriamine phosphate DETA.H3PO4 or diethylamine phosphate DEA.H3PO4.

A near dry machining liquid supplying device in mechanic process field is provided, a micro spraying device is arrange in a nozzle, which is composed of an inner side micro spraying and an outer size micro spraying, and a lubricate entrance is provided on; the outer side micro spraying device is composed of an outer side shaking base plate, an outer side pressure PZT lead wire, an outer side PZT, an outer cavity, an air entrance, an air micro spraying hole and a spraying hole film; the outer side PZT is pasted on the outer side shaking base plate, the outer side PZT lead wire is pasted on the upper and the lower side of the outer side PZT, the outer side shaking base plate is pasted on the spraying hole film the air entrance is provided on the size wall of the spraying hole film, the air micro spraying hole is provided on the spraying hole film; the inner side micro spraying is composed of an inner side shaking base plate, an inner PZT lead wire, an inner PZT, an inner cavity, a lubricate entrance, a lubricate micro spraying hole and a spraying hole film; the inner side PZT is pasted on the inner side shaking base plate, the inner PZT lead wire is pasted at the upper and the lower side of the inner side PZT, the inner shaking base plate is pasted to the spraying hole film, the lubricate micro spraying hole is provided on the spraying hole film.

The invention discloses siraitia grosvenorii and honeysuckle solid tea with a health-care function. The solid tea is prepared by the following steps: firstly, crushing fresh siraitia grosvenorii and adding water to extract for three times; concentrating and drying a fresh siraitia grosvenorii extraction solution to obtain siraitia grosvenorii powder; immersing honeysuckles into water to be extracted for one time; concentrating and drying an extraction solution to obtain honeysuckle powder; uniformly mixing the siraitia grosvenorii powder, the honeysuckle powder and starch; adding water and tabletting to form a siraitia grosvenorii and honeysuckle solid tea sheet. According to the siraitia grosvenorii and honeysuckle solid tea, the siraitia grosvenorii powder in the raw materials has the effect of moistening the lung to arrest cough and the honeysuckles have the effects of detoxifying, diminishing inflammation, sterilizing, disinfecting, realizing diuresis and relieving itching; the two raw materials are subjected to scientific medicine compatibility to overlap the effects, so that the health-care effect is better; the tea is convenient to drink and the tea sheet is put into drinking water to make the tea; the tea can be drunk at any time and any place; the dosage is easy to control; the tea flavor is sweet and fragrant; the siraitia grosvenorii and honeysuckle solid tea with the health-care function is suitable for wider population to drink.

The invention relates to the technical field of food additives, and concretely discloses a natural brown food coloring and a preparation method thereof. The natural brown food coloring is produced from, by weight, 0.5-3% of cochineal red, 1-5% of monascus yellow, 0.5-3% of gardenia yellow, 1-5% of gardenia blue and 0.1-1% of fatty acid monoglyceride and fatty acid diglyceride The coloring has good water solubility, can be uniformly colored on foods in use, and solves the disadvantages of poor solubility and non-uniform coloring in foods due to only dispersion coloring of present natural brown food colorings.

The invention provides a composition with an antioxidant function. The composition is prepared from the following raw materials: 1-9 parts of roxburgh rose powder, 0.1-0.5 part of a haematococcus pluvialis extract, 0.2-1 part of fructus hippophae powder and 1-10 parts of an Angelica Keiskei extract. The composition can be prepared into drugs, health care products or foods. According to reasonable combined compatibility, the defects of the related components are changed, so that the effects are perfect, the various components achieve a synergistic effect and promote one another, the composition has the primary antioxidant scavenging activity and also has secondary antioxidant repair capacity and blood purification capacity, and multiple active substances and traced elements contained in the composition provide a support basis for the antioxidant effect, so that a powerful and complete antioxidant system is constructed. The composition has an obvious antioxidant effect, can be used for effectively preventing and treating cardiovascular and cerebrovascular diseases and well maintaining and promoting the health of the cardiovascular and cerebrovascular system and has the effects of inhibiting tumors, delaying senescence, enhancing the immunity and the like.

The invention relates to a laundry tablet and a cleaning method thereof. The laundry tablet comprises a base fabric, and also comprises the following raw materials in parts by weight: 10-15 parts of coconut oil, 15-20 parts of amino acid, 5-10 parts of alkyl glucoside, 5-10 parts of fatty acid ester, 8-15 parts of betaine laurate, 1-5 parts of cocamidopropyl betaine, 5-10 parts of pomelo peel and 5-30 parts of lauryl alcohol sodium sulfate. The laundry tablet is free of any additive, can not hurt the skin, is mild without hurting hands, is convenient to carry, and has the advantages of controllable consumption, simple structure, environment friendliness, no pollution and high cleaning capacity.

The invention provides a spray washing device which comprises a base plate, supporting legs and a washing unit. The supporting legs are fixed to the lower portion of the base plate, the washing unit is fixed to the base plate, the washing unit comprises a cover, spraying modules and guide rails, the bottom of the cover is connected with the edge of the base plate, the guide rails are arranged on the base plate, the mounting direction of the guide rails is identical to the length direction of the base plate, and the spraying modules are arranged on the two sides of the guide rails in a staggered mode. A guide module is arranged on the guide rails, and used for keeping washed objects vertical. An inlet and an outlet are formed in the positions, corresponding to the two ends of the guide rails, on the cover respectively. The spray washing device has the advantages that the spraying modules are arranged on the two sides of the guide rails respectively, bidirectional washing is achieved, and therefore the washing effect is good; the washing process is carried out in the cover, the splashing phenomenon is avoided, and the environment of the site cannot be influenced; the inlet and the outlet are formed in the two ends of the cover, a plurality of baking trays can be continuously washed, washing speed is high, and washing efficiency is high; the amount of cleanout fluid is easy to control.

The invention discloses a corrosion liquid and a corrosion method for an original austenite grain boundary of medium carbon steel. The corrosion liquid comprises water, hydrochloric acid, picric acid,carbon tetrachloride, ethanol and LaFang shampoo in the ratio being (38-42 mL):(2-3 mL):(4-5 g):( 4-5 mL) (9-11 mL) (5-6 mL), wherein the concentration of hydrochloric acid is 36%-38% (by mass). Firstly, distilled water is put in a beaker, ethanol is added, hydrochloric acid, picric acid, carbon tetrachloride and LaFang shampoo are sequentially and slowly added randomly, and finally, the mixtureis stirred and mixed uniformly. The preparation method of the corrosion liquid is simple and the corrosion liquid can be stored for a long time.

The invention discloses a traditional Chinese medicine mask for surface anesthesia. A main material of the traditional Chinese medicine mask is mask paper or mask fabric. The traditional Chinese medicine mask is characterized in that traditional Chinese medicine anesthesia ingredients are soaked in the main material and are obtained by extracting toad venom, raw pinellia, pedate pinallia jackinthepulpit rhizome, raw pepper, borneol, camphor and mint. A traditional Chinese medicine extract anesthesia mask can achieve local skin anesthesia within a short time, and has the characteristics of quick effectiveness, strong and durable action, higher penetrability and the like.

The invention discloses water-permeable bonding screeding mortar for water-permeable brick pavement, and belongs to the technical field of construction materials. The water-permeable bonding screeding mortar is prepared from the following components in percentage by mass: 10-20 percent of P.O42.5 ordinary Portland cement, 75-88.7 percent of machine-made sand, 1-2 percent of highly active mineral admixture, 0.05-0.15 percent of polycarboxylate superplasticizer, 0.05-0.15 percent of cellulose ether and 0.2-0.4 percent of redispersible latex powder. By using the water-permeable bonding screeding mortar for water-permeable brick pavement, the water-permeating and water storing capability of the water-permeable bricks can be remarkably improved. The water-permeable bonding screeding mortar has the advantages of high bearing capacity, strong bonding force, convenience in construction, reasonable cost and the like, and has the effects of reducing labor intensity, improving operation environment, remarkably reducing waste and facilitating energy conservation and emission reduction.

The invention discloses a glucosamine hydrochloride capsule preparation and a preparation method thereof. The glucosamine hydrochloride capsule preparation consists of a capsule shell and contents, wherein the contents are glucosamine hydrochloride and magnesium stearate; and the ratio of the using amount of the glucosamine hydrochloride to the using amount of the magnesium stearate is 100:0.5-2. Compared with products sold in the market, the contents of the capsules of the invention reduce the sorts of auxiliary materials, control the using amounts of the auxiliary materials, reduce the total amount of the auxiliary materials for absorption and metabolism after a patient takes the capsules, avoid the occurrence of uncertain hazards and lighten the burden of keeping a pleasant ecological environment in the patient. Compared with processes for performing tabletting to form large tablets, crushing the large tablets, adding the magnesium stearate for uniform mixing and filling the mixture to form the capsule products sold in the market, the preparation process for the capsule preparation remarkably reduces loss in the production process as the steps of performing tabletting to form large tablets and crushing the large tablets are saved, is favorable for industrial production and reduces the cost.

The invention discloses a cleaning solution for cleaning the surface of printing and dyeing equipment. The cleaning solution comprises, by weight, 4-16 parts of inorganic acid, 0.2-0.7 part of potassium thiocyanate, 2-4 parts of hydrochloric acid, 2-4 parts of nitric acid, 2-4 parts of hydrogen fluorideammonia, 0.1-0.9 part of penetrant, 0.2-1 part of corrosion inhibitor, 0.1-0.4 part of aniline, 0.1-0.8 part of emulgator, and 100-150 parts of water. According to the cleaning solution for cleaning the surface of the printing and dyeing equipment, multiple kinds of the inorganic acid cooperate with the corrosion inhibitor and the penetrant; special effects such as permeating, stripping, decomposing and diffusing are performed; different chemical reactions such as decomposing and combining are conducted among the inorganic acid, the corrosion inhibitor, the penetrant and dirt; and the purposes that the dirt is cleaned and the surface of the equipment is not damaged are finally achieved.

The invention belongs to the technical field of asphalt recycling agents and in particular discloses a structure of a warm mixing recycling agent. The structure comprises a capsule shell, and a recycling agent composed of used oil, graphene, light oil and desulfurized rubber powder, wherein the recycling agent is liquid and is filled in the capsule shell; the capsule shell comprises a shell cap, ashell and an encapsulation ring; the shell is matched with the shell cap; the encapsulation ring is used for sealing the joint of the shell cap and the shell; an insertion groove through which the shell is inserted is formed in the end of an opening in the shell cap; the insertion groove is in interference fit with the shell; a rubber is arranged at the end, which is far away from the shell, of the insertion groove; the runner is communicated with the interior of the shell cap; a filling port is formed in the shell cap and communicated with the insertion groove; a drainage groove is formed inthe end, which is close to the shell cap, of the shell; the drainage groove is communicated with the insertion groove; the material of the encapsulation ring is the same as that of the shell cap andthe shell. The invention aims to solve the problems that the recycling agent is difficult to transport and the usage amount is difficultly controlled during use.

The invention discloses a method for instantaneous high-temperature synthesis of a transition metal carbide nano array by using an oxide as a template, which comprises the following steps: (1) growing a transition metal oxide with a nano array structure on a substrate to obtain a transition metal oxide nano array; (2) taking the transition metal oxide nano array as a substrate, and depositing a graphene nanosheet on the surface of the transition metal oxide nano array; and (3) treating the graphene nanosheets loaded on the metal oxide template under the conditions that the current is 0-20 A and the voltage is 40-80 V, so that the graphene reacts with the metal oxide, the treatment time is 20-100 ms, and the metal carbide with the array morphology is obtained. By reasonably constructing the structure of the transition metal carbide catalyst and designing the specific morphology of the nano material, the number of active sites on a given electrode is increased, so that the activity of an electrocatalyst system is improved.

The invention relates to the technical field of medicine, and discloses a traditional Chinese medicine composition for preparing an antidiabetic nephropathy product kidney-milkvetch root No.1 and a preparation method and application of the traditional Chinese medicine composition. The kidney-milkvetch root No.1 is prepared from milkvetch roots, prepared rehmannia roots, fructus corni, semen cuscutae, pollen typhae, radix salviae miltiorrhizae, ramuli euonymi, rhizoma coptidis, corn stigmas and radix achyranthis bidentatae; the effect of treating qi-yin deficiency blood stasis type diabetic nephropathy is significant, and the proteinuria content of an early-middle-stage diabetic nephropathy patient can be decreased; in the aspect of protecting the residual renal function, clinical random control study shows that the marked effective rate is 62.1%, the effective rate is 24.1%, and the total effective rate is 86.2%. The traditional Chinese medicine composition is wide in raw material source, low in cost, simple in preparation technology, high in yield and stable in property; a preparation prepared from the traditional Chinese medicine composition is stable in quality, capable of achieving easy and convenient quality control, low in production cost, capable of conveniently achieving industrialized production, safe, low in toxicity and convenient to use and provides a new medicine source and safe raw material for prevention, treatment and research of antidiabetic nephropathy and direct related diseases thereof.