576results about How to "Avoid splitting" patented technology

The present invention provides processes for measuring DNA or RNA binding proteins, specific nucleic acids, as well as enzyme activities using labeled nucleic acids of labeled protein/peptide molecules.

A moving target detection imaging method of a dual-channel frequency modulation continuous wave SAR system comprises the steps of recording echo data by a radar system, performing residual video phase removing processing on the echo data, performing Doppler frequency shift compensation on the data, performing phase deviation compensation on two-channel conversion data, and performing subtraction processing on the two-channel data; performing migration correction and direction dechirping processing on an image with clutter cancellation to realize the rough imaging of a target, and detecting the moving target and extracting one by one; performing inverse transformation on the extracted targets to an original data domain, estimating motion parameters to construct a precise direction dechirping function of the moving target, performing residual video phase removing processing, precise direction dechirping processing and distance migration correction, constructing a fuzzy function for compensation, and then performing Keystone transformation to finish the precise image of the moving target. The moving target detection imaging method solves the imaging problem of the fast moving target when motion parameters are unknown under the continuous wave system, so the signal-to-noise rate and the target detection probability are greatly improved.

The invention belongs to the technical field of laser radars, and discloses a depth map-based three-dimensional laser radar point cloud target segmentation method, which comprises the following stepsof: converting three-dimensional point cloud data acquired by a three-dimensional laser radar into a two-dimensional depth map; calculating an angle value formed by two adjacent points in each columnin the depth map, and traversing to obtain an angle matrix corresponding to the depth map; traversing the depth map through a breadth-first search algorithm, if the angle difference between two pointson adjacent positions of the depth map is smaller than a specified threshold value, marking the depth map as the same type, thereby finding out the part, belonging to the ground, in the depth map, and removing ground point cloud data according to the mapping relation between the point cloud and the depth map; and carrying out target segmentation on the non-ground point cloud based on an improvedDBSCAN algorithm, and judging whether the point cloud is a core point or not according to an adaptive parameter eps while considering a spatial Euclidean distance and an angle distance. According to the method, the segmentation efficiency on the depth map is improved, the real-time requirement is met, and the problems of under-segmentation and over-segmentation are effectively solved.

A detector (110) for determining a position of at least one object (118) is proposed. The detector (110) comprises: —at least one optical sensor (112), the optical sensor (112) being configured to detect at least one light spot (156) generated by at least one light beam (150) propagating from the object (118) towards the detector (110), the optical sensor (112) having at least one matrix (152) of pixels (154), each pixel (154) being adapted to generate at least one pixel signal s_i,j in response to an illumination of the pixel (154) by the light beam (150); —at least one non-linearization device (123) configured to transform the pixel signals s_i,j of all pixels (154) i, j or of at least one group of pixels (154) into nonlinear pixel signals s′_i,j, the nonlinear pixel signals s′_i,j each being a nonlinear function of the power of the illumination p_i,j of the respective pixel (154); —at least one summing device (125) configured to add up the nonlinearpixel signals s′_i,j of all pixels (154) i, j or of the at least one group of pixels (154) and to generate at least one nonlinearsum signal S′=Σ_ijs′_ij; and —at least one evaluation device (126), the evaluation device (126) being configured to determine at least one longitudinal coordinate z of the object (118) by evaluating the nonlinear sum signal S′.

The invention relates to a catheter insertion system utilizing a catheter introducer device having an introducer sheath, the catheter insertion system comprise a catheter containment unit in which a catheter tube having a catheter hub is held, said catheter containment unit comprises an opening adapted to sealably and reversibly connect to an inserter head, said inserter head is adapted to sealably and reversibly connect, and provide said catheter tube passage, to said catheter introducer device, wherein said catheter containment unit comprises at least one flexible portion and an elastic/resilient portion located near its opening for advancing portions of said catheter tube through said passage, and wherein said inserter head is adapted to sealably receive a portion of said catheter hub in a socket provided therein.

The invention discloses an aramid rubber canvas fabric structure for high-strength conveyor belts and a production process of the aramid rubber canvas fabric structure. The aramid rubber canvas fabric structure comprises warps and wefts, aramid materials are adopted in the warps, at least four warps are paved in the belt length direction, nylon industrial yarns are adopted in the wefts which are crisscrossly paved on upper end faces and lower end faces of the warps, the wefts on upper and lower layers are tightly crisscrossly bonded to the warps by adopting bundling yarns, and a canvas fabric structure is obtained after secondary bath gum dipping; the production process includes single-layer canvas knitting, secondary bath gum dipping and reeling. Single-layer structures of the warps adopting the aramid materials and the weft adopting the nylon materials are knitted through bundling yarns, the high-strength conveyor belts with the strength higher than 2500N/mm are produced after secondary bath gum dipping, mechanical physical properties of the conveyor belts are improved, layer reduction and weight reduction of the conveyor belts are realized during the production process, the conveyor belts are adaptively high strengthened, less layered and lightweight, energy consumption is reduced, the production process is further simplified, and production efficiency is higher.

An inner spacer is formed in a sidewall of a gate in contact with a first active region that is electrically connected to an upper capacitor, thereby reducing a gate induced drain leakage (GIDL). A structure of a recess gate transistor includes a gate insulation layer, a gate electrode, a first gate spacer, a second gate spacer and source/drain regions. The gate insulation layer is formed within a recess. The gate electrode is surrounded by the gate insulation layer and is extended from within the recess. The first gate spacer is spaced with a predetermined distance horizontally with a portion of the gate insulation layer, being formed in a sidewall of the gate electrode. The second gate spacer is formed in another part of the sidewall of the gate electrode. The source/drain regions are formed mutually oppositely on first and second active regions with the gate electrode therebetween.

The present invention provides modulators of complement activity. Also provided are methods of utilizing such modulators as therapeutics.

The invention relates to the technical field of geotechnical engineering and road engineering, and particularly discloses a load-shedding type rigid culvert structure, which comprises a foundation, culvert side walls, a culvert top plate, load-shedding blocks and load-shedding holes, wherein the load-shedding blocks are positioned just above the culvert side walls, and form an integral structure together with the culvert side walls, the load-shedding holes are positioned between the two load-shedding blocks just above a culvert, and the interior of each load-shedding hole is filled with light-weight flexible material. The culvert structure has the advantages that after the structure is adopted, the construction and operation are easy and convenient, and the implementation is easy; the pressure of soil at the top of the culvert is obviously reduced, and the problem of cracking of the culvert is effectively solved; one part of load at the top of the culvert is transferred into the surrounding soil through the soil arch effect at the top of the culvert, the other part of load is transferred to the foundation through the culvert side walls, and then the vertical compressive capability of the culvert side walls is fully realized; the maximum bending moment of the culvert side walls is effectively reduced, and the stress distribution of the culvert is more reasonable; the stress asymmetry of the culvert is effectively reduced, and the separation and cracking of the connecting part of the top of the culvert and the side wall are avoided; the load-shedding effect is obviously improved.

The invention relates to a preparation method of Apremilast, comprising the following steps: by taking 3-hydroxy-4-methoxybenzaldehyde as a staring material, reacting with hydroxylamine hydrochloride to obtain 3-hydroxy-4-methoxy cyanobenzene, reacting with bromoethane to obtain 3-ethyoxyl-4-methoxy cyanobenzene, and then reacting with dimethyl sulfone under the action of n-butyllithium, and hydrolyzing in aqueous hydrochloric acid solution to obtain 1-(3-ethyoxyl-4-methoxyphenyl)-2-(mesyl)ketol); finally by taking S-(-)-alpha, alpha-diphenyl-2-pyrrolidine methanol as a chiral catalyst and taking borane dimethyl sulfide complex solution as a reductant, obtaining chirality S-3-ethyoxyl-4-methoxy group-alpha[(mesyl)benzyl alcohol], and then reacting with 3-acetamido-phthalimide under the action of triphenylphosphine and diethyl azodicarboxylate, thus obtaining the Apremilast. According to the preparation method, the process is effectively simplified, the reaction conditions are mild, the product yield and purity are relatively high, and large-scale industrial production is benefited.

The invention discloses a method for machining slotted holes on carbon fiber laminated boards, which belongs to a machining method for nonmetallic materials, solves the problem that by the existing milling and drilling methods, carbon fiber laminated boards are easy to laminate, split and burn, and aims at improving the machining precision of carbon fiber composite products and reducing the surface roughness of carbon fiber composite products. The method disclosed by the invention comprises a clamping step, a machining step and a post-processing step, wherein the machining step is one or two of a milling machining step and a drilling machining step. According to the invention, in the machining process, a non-deformed clamping mode is used, and through selecting reasonable cutting tool materials, geometric parameters of cutting tools, and milling and drilling machining parameters, the appearance allowances in machining are reasonably arranged, thereby solving the quality problems of laminating, splitting and burning and the like existing in the process of opening or drilling carbon fiber thin-wall revolution bodies and carbon fiber laminated boards by using the traditional methods, so that the qualified rate of carbon fiber parts is increased from 50% to more than 99%.

Disclosed are compounds of the formula:

where variables Q, Z, X, R₁₅, R₂, R₃, and R_c are defined herein. Compounds disclosed herein are inhibitors of the beta-secretase enzyme and are therefore useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal.

The invention discloses a data transmission method, a data receiving method and a system based on a virtual machine. The data transmission method is applied to a virtual machine framework provided with a host and a client. The method includes the steps that a back end virtual network device of the host acquires data of a socket buffer area; data slots of the data of the socket buffer area are stored in the form of a chain table, wherein the size of the data slots is equal to that of a data package sent by a physical network card of the host; and the data slots are mapped to a shared memory area so that the client can read the data slots from the shared memory area conveniently. According to method or the system, separation of big data packages can be avoided, and system overhead of the Host can be reduced.

The virtual Server (vServer) of an intermediary device deployed between a plurality of clients and services supports parameters for setting maximum segment size (MSS) on a per vServer/service basis and for automatically learning the MSS among the back-end services. In case of vServer/service setting, all vServers will use the MSS value set through the parameter for the MSS value set in TCP SYN+ACK to clients. In the case of learning mode, the backend service MSS will be learnt through monitor probing. The vServer will monitor and learn the MSS that is being frequently used by the services. When the learning is active, the intermediary device may keep statistics of the MSS of backend services picked up during load balancing decisions and once an interval timer expires, the MSS value may be picked by a majority and set on the vServer. If there is no majority, then the highest MSS is picked up to be set on the vServer.

The invention discloses a method for synthesizing silodosin. The method comprises the following steps: by taking 7-cyanoindoline as an initial raw material, synthesizing a 1-(benzoyloxypropyl)-7-cyanoindoline compound (I); reacting with a compound (II) to synthesize a key chiral intermediate 5-[(2R)-2-(benzylamino)-1-acetone]-1-{3-(benzoyloxy)propyl]-7-cyanoindoline compound (III), and reducing through triethyl silicane to obtain a compound (IV); performing catalytic hydrogenation to obtain a compound (V), carrying out a condensation reaction with a compound (VI) under alkaline conditions to obtain a compound (VII), and finally, hydrolyzing under alkaline and H2O2 conditions to obtain silodosin. The compound (I) and the compound (II) are subjected to chiral synthesis to obtain the key chiral compound (III), resolution is avoided, and the optical purity is controllable, so that the reaction yield is greatly improved, the reaction conditions are mild, generation of byproducts in a conventional process is avoided, the production cost is reduced, and the purity is high. The labor intensity is alleviated, the method is environment-friendly and easy for industrial production, and the total yield is high and is improved from 20 percent in a literature report to be about 43 percent.

The invention provides a fast frame-climbing method of shed frame pear tree boughs. The frame-climbing method is carried out on a shed frame of a three-line one plane or two-line one plane mode, and frame climbing is carried out by three steps of strengthening, pulling in an inclined mode, and pulling in a level mode. The first step of strengthening is that young shoots are guided onto an elevation guide line in a vertical mode during a growing season so that the young shoots can keep a vertical growing state. The second step of pulling in an inclined mode is that base parts of the shoots growing vertically are pulled in a level mode and fixed behind the shed frame face during autumn of the same year, and then are guided onto the elevation guide line according to a 45-degree angle, namely, the base parts of the shoots are firstly pulled in a level mode and fixed and then pulled in an inclined mode. The third step of pulling in a level mode is that the shoots are pulled in a level mode and fixed on the shed frame face during autumn of the next year. The fast frame-climbing method has the advantages of being fast in frame-climbing, few in water shoots, small in trimming quantity, large in frame face fruit area, high in output and the like.

The invention relates to automatic hole forming equipment for composite airfoil components. The automatic hole forming equipment is five-axis linkage numerically controlled equipment, and comprises a main rack, a B-axis support, an A-axis rotary table, a Z-axis subassembly, a Y-axis drag chain, a Z-axis drag chain, a scrap suction device, a knife lubricating system and an oil pump of the lubricating system, wherein a spindle is arranged on the Z-axis subassembly; a component knife which can be used for drilling holes, reaming holes and reaming pits is hydraulically clamped on the spindle; four laser distance measuring sensors are symmetrically arranged at ends of the Z-axis subassembly and are distributed on four quadrants; a pressure foot support is arranged below the Z-axis subassembly; and pressure feet are arranged on the periphery of a center hole of the pressure foot support, and are provided with pressure foot sensors. By using the automatic hole forming equipment and the hole forming method, the clamping and positioning precision is high, the accuracy of formed holes is high, and damage to composites in a hole forming process is reduced, so that the quality of a product is improved while the work efficiency is improved.

The invention provides a text detection and recognition method based on a convolutional neural network and in a natural scene. The method includes: training a quick area convolutional neural network to acquire a network for text detection in the natural scene to perform text detection in the natural scene; collecting vocabularies to acquire a dictionary; learning features of text vocabularies to train a convolutional neural network classifier, and classifying input areas to realize text recognition. By utilizing the method, good text detection and recognition results can be acquired under the background of different complex degrees and different text fonts and colors.

The invention discloses a drilling and grouting combined device for grouting reinforcement of a water-rich sand stratum and a construction technique. The drilling and grouting combined device for grouting reinforcement of the water-rich sand stratum comprises a grouting pipe body. The grouting pipe body is formed by sequentially connecting a plurality of grouting pipes. The outer side of the pipe wall of each grouting pipe is sleeved with an expandable grout container. A plurality of grout outlets are formed in the portions, matched with the grout containers, of the pipe walls of the grouting pipes. Grout enters the grout containers from the grout outlets of the grouting pipes to make the grout containers expand, and thus the grout containers and the sand stratum around the grout containers are compacted. Integrated operation of drilling and grouting reinforcement in the sand stratum can be achieved through the drilling and grouting combined device. According to the drilling and grouting combined device for grouting reinforcement of the water-rich sand stratum and the construction technique, since the grout containers can contain the grout and can expand, the splitting effect of grout on the sand stratum and linear extension of grout veins during grouting in the prior art are eliminated; and the purpose of reserving the grout around drilled holes is achieved, and the effect of compacting the loose sand stratum around the drilled holes is achieved through expansion of the grout containers.