The invention provides a preparation method of a
sodium hyaluronate composite solution for injection, and the
sodium hyaluronate composite solution for injection is prepared from the following raw materials in parts by weight: 10 to 20 parts of
sodium hyaluronate, 3 to 5 parts of
polylactic acid microspheres, 0.2 to 2.0 parts of
amino acid, 0.3 to 1.5 parts of sodium
chloride, 0.01 to 0.06 part of
sodium dihydrogen phosphate, 0.01 to 0.25 part of
disodium hydrogen phosphate and 80 to 90 parts of water for injection. According to the preparation method, stirring and vacuumizing are conducted twice, bubbles are eliminated, a condensation baffle is additionally arranged at the top of a filling tank, transverse and longitudinal stirring is conducted, materials are conveyed through a
polymer pipeline for filling, bubbles generated in filling are avoided,
PLGA,
PLGA-PEG and PLLG-PEG
polylactic acid microspheres with the molecular weight being 1-30 thousand are increased, and the use effectiveness and durability of the product are improved. The operation method that
sodium hyaluronate and microspheres are soaked, then a
sodium hydroxide solution is added, stirring is conducted, and 1, 4-
butanediol diglycidyl ether is added is adopted, so that the problem of storage layering of the
polylactic acid microspheres is solved. The
sodium hyaluronate composite solution prepared by the method disclosed by the invention is free of bubbles, and the product is safe to use.