The invention discloses a manufacturing method of a flexible-rigid circuit board. The manufacturing method comprises the steps of manufacturing a flexible board image, attaching a protective film, punching an OPE hole in the flexible board, attaching a protective adhesive tape, conducting surface treatment on the flexible board, arranging plates, pressing the flexible board and a rigid board, punching a registration hole, manufacturing an outer-layer image and uncovering, and simultaneously tearing off the protective adhesive tape. According to the manufacturing method, in the flexible board manufacturing process, the protective adhesive tape is additionally attached after the protective film is attached and the OPE hole is punched, the protective adhesive tape is torn off in the subsequent uncovering procedure, the problem that the flexible board is stained and broken caused by liquid medicine leakage due to broken copper in the production process of the existing method can be solved, meanwhile, the windowing copper surface of the flexible board area can be protected, the rejection rate is lowered, the normal operation of the work procedures can be ensured, and the thickness of the plate can not be affected.