The invention discloses a pipe clamp, with a sound-proof soft cushion layer, capable of fixing a pipe in advance. The pipe is provided with two main bodies clamped face to face, a mechanism locking the two main bodies and a mechanism, wherein the pipe clamp is connected on a supporting body through the mechanism. After clamping the pipe and being locked, the two main bodies form a circle or an oval. Soft cushion layers are attached to the inner surfaces of cambered surfaces of the two main bodies, wherein a soft cushion layer is attached to the inner surface of a cambered surface, with the arc length not larger than that of a semi circle arc, of a main body with the arc length larger than that of the semi circle arc; and hard clamping protrusions are installed on the surfaces of the left and right inner sides of a circular arc with the arc length not smaller than that of the semi circle arc or of a plane, and are clamped on the left and right top ends of the soft cushion layer through a U-shaped mode. The pipe clamp, with the sound-proof soft cushion layer, capable of fixing the pipe in advance is simple and reasonable in structure. In the process of actually installing and testing the pipe, through the sound-proof soft cushion layer is attached to the inner surface of a main body (a fixed body) with the arc length larger than that of the circular arc of the semi-circle, the body can independently, temporarily and stably fix the pipe in advance, the pipe can not drop from the main body (the fixed body), and the sound-proof soft cushion layer can not easily drop from the pipe clamp. An installment worker can more conveniently and more effectively work.