The utility model relates to the technical field of product packaging, in particular to a portable sanitary towel packaging box which comprises a box body with an opening in the top, a top cover used for sealing the opening in the top of the box body, a fence fixedly connected with the upper end of the box body and a reinforcing band fixedly connected with the fence. The bottom of the reinforcing band is fixedly connected with the box body, the top of the reinforcing band is rotationally connected with the top cover, and detachable fixing assemblies are arranged on the top cover and the box body; a partition is fixedly arranged at the bottom of the box body, the area, located below the partition, in the box body is a containing cavity used for storing compressed tissues, a side cover is arranged on one side of the containing cavity, and the bottom of the side cover is rotationally connected with the bottom of the box body so that the side cover can face upwards after the containing cavity is opened; according to the scheme, the technical problem that an existing sanitary towel packaging box is poor in durability and practicability can be solved.