579 results about "Vial" patented technology

An apparatus and method for determining the presence of a disease by analyzing a specimen by providing a vial partially containing the specimen and partially containing a headspace above the specimen, injecting an inert gas into the specimen in the vial to cause bubbling of the gas throughout at least a portion of the specimen such that the gas mixes with volatile organic compounds (VOCs) present in the specimen to create a VOC / gas mixture that is released into the headspace, collecting the VOC / gas mixture from the headspace in the vial, supplying the VOC / gas mixture to a chamber within the apparatus, causing the VOC / gas mixture to pass over a sensor array in proximity to the chamber, the sensor array generating an electrical signal as a function of VOCs detected in the VOC / gas mixture, and processing the electrical signal to determine the presence of a disease in the specimen.

The present disclosure provides a method of preparing a lyophilized bispecific molecule composition comprising (a) inducing ice nucleation in a liquid protein composition having a bispecific molecule concentration of at least about 10 mg / ml in a vial exposed to a first temperature of about-18 DEG C to about-10 DEG C for about 60 minutes to about 270 minutes; (b) exposing the vial of (a) to a second temperature of about-25 DEG C to-50 DEG C for about 1 hour to about 5 hours; and (c) drying the composition of (b) at a third temperature of about-5 DEG C to about-25 DEG C for about 25 hours to about 70 hours, and (d) further drying the composition of (c) at a fourth temperature of about 25 DEG C to about 50 DEG C for about 4 hours to about 12 hours to obtain a vial comprising a lyophilized bispecific molecular composition, the composition has a percentage content of high molecular weight material (HMWS) of less than or equal to about 1.5% (mA / ). The disclosure further provides lyophilized bispecific molecule compositions prepared via the methods described herein.

A geological analysis system, device, and method using x-ray fluorescence and spectroscopy are provided. The geological analysis system includes a sample tray which holds the geological sample materials, and sensors including an X-ray fluorescence (XRF) unit and spectrometer. The sample tray includes chambers formed in an upper surface, ports, and passages, each providing communication between an interior of a chamber and an interior of a port. The ports are configured to be attachable to vials. The system positions the sample tray with respect to the sensors for sensing one or more properties of geological sample materials in the sample tray.

In certain embodiments, a vial adaptor comprises a housing configured to couple the adaptor with a vial, an access channel, a regulator channel, and a regulator assembly. The access channel is configured to facilitate withdrawal of fluid from the vial when the adaptor is coupled to the vial. The regulator channel is configured to facilitate a flow of a regulating fluid from the regulator assembly to compensate for changes in volume of a medical fluid in the vial. The regulator assembly can include a valve configured to transition between a closed configuration and an opened configuration.

The invention provides a radiation shielding assembly, a drug vial assembly system, a method of dispensing a drug vial assembly system, and a radiopharmaceutical infusion device. The radiation shielding assembly is used for shielding a medicine bottle assembly containing radiopharmaceuticals, and the medicine bottle assembly is provided with a puncture communication piece capable of transversely moving. The shielding body is provided with a top opening, a small bottle containing cavity and a combination port, and the medicine bottle assembly is contained in the containing cavity through the top opening. The containing cavity is provided with a circumferential matching wall, the distance between the matching wall and the vertical center line is gradually decreased from the starting end to the tail end, and a moving path is provided for assembly. The medicine bottle is guided to move along the wall, and the bottom puncture communicating piece is guided to transversely move inwards and is in butt joint with the combination port when reaching the assembly completion position. After assembly is completed, the puncture communicating piece is in butt joint with the combination port. According to the invention, only one needle puncturing the top of the medicine bottle is used as an inflow channel. Needle adjustment is not needed when medicine is nearly empty, operation is simplified, and the error rate is reduced.

To provide a method for transporting thermoplastic resin vials under sterile conditions and in an exogenous pyrogen-free state, introducing the vials into a filling assembly line, and thereafter allowing the vials to stand without tipping or dropping them, the method is a method for packing vials for filling with contents such as medicaments or cells by vacuum-packing the vials, and includes the following steps:(I) inserting a plurality of vials in a tray with opening portion sides of the vials facing a bottom of the tray,(II) installing a soft film on bottom portions of the vials,(III) introducing the tray having the vials installed therein and the soft film into a gas-impermeable flexible film bag,(IV) depressurizing the inside of the flexible film bag to a prescribed vacuum pressure, and(V) sealing an opening of the flexible film bag.

A pre-filled dual-chamber medical agent delivery system assembled and configured to allow delivery of a single dose of a combined therapeutic agent (e.g., vaccine, drug, medicament, etc.) from a Blow-Fill-Seal (BFS) vial to a patient. The delivery assembly generally includes a modular design consisting of separately constructed components cooperatively arranged and coupled to one another, such as to facilitate delivery of a reconstituted lyophilized agent to a patient.

In certain embodiments, a vial adaptor comprises a housing configured to couple the adaptor with a vial, an access channel, a regulator channel, and a regulator assembly. The access channel is configured to facilitate withdrawal of fluid from the vial when the adaptor is coupled to the vial. The regulator channel is configured to facilitate a flow of a regulating fluid from the regulator assembly to compensate for changes in volume of a medical fluid in the vial. In some embodiments, the regulator assembly includes a flexible member configured to expand and contract in accordance with changes in the volume of the medical fluid in the vial. In some embodiments, the flexible member is substantially free to expand and contract. In some embodiments, the flexible member is not partly or completely located in a rigid enclosure

The present invention relates to a pre-assembled reconstitution and injection device, comprising an injection section having a cartridge for holding a diluent or drug product and a reconstitution section having a vial for holding a drug, whereby the injection section may only be disassembled from the reconstitution section after activation of the device has occurred. In an embodiment for use with a pen needle, the reconstitution section comprises a vial needle hub having a reconstitution needle for piercing both the vial and cartridge. In an embodiment of the invention for use with a hypodermic needle, the injection section comprises a cartridge needle hub with a cartridge needle and male luer connection having threads for securing a hypodermic needle, and the reconstitution section comprises a needle hub with a vial needle and a female luer connection for engagement with the male luer connection.

The invention discloses a method for detecting perfluoroalkyl (polyfluoroalkyl) compounds in sludge, which comprises the following steps: screening concentrated sludge of a sewage plant, removing foreign matters, pretreating, putting into a centrifugal tube, and adding an extraction internal standard; the method comprises the following steps: extracting PFAS in sludge by using an alkaline organic solvent to obtain a PFAS extracting solution; filtering and acidifying the PFAS extracting solution to obtain an acidified extracting solution; purifying and eluting the acidified extracting solution through a solid-phase extraction column to obtain an eluent; drying the eluent, re-dissolving to 1mL by using methanol, filtering, and collecting the supernate into a sample injection bottle; and adding a sample introduction internal standard into the sample introduction bottle, mixing, and determining the PFAS in the sludge by using a liquid chromatography tandem mass spectrometer. By optimizing a pretreatment method for determining the PFAS in the sludge and a mode for reducing the matrix effect, a method capable of accurately quantifying the PFAS (51 different types) in complex environmental samples such as the sludge and biological solids is developed, and the analysis range and accuracy of the PFAS in the sludge are improved.

The disclosure relates to a method for marking a container comprising a vial containing a medicinal substance and closed by a cap secured to the vial by a ring. With the container being at least partially covered with frost, the method further comprises a step of laser marking the ring through the frost. The disclosure also relates to a device for marking a container.

Disclosed herein are improved methods for quantifying monoclonal antibody (mAb) titer using Protein A affinity High-Performance Liquid Chromatography (HPLC). The methods address inaccuracies caused by mAb adsorption to sample vial surfaces by incorporating a surfactant into the mobile phase used for sample dilution. This approach enhances the accuracy, linearity, and robustness of the titer assay, making it suitable for process control and quality assessment in biopharmaceutical development and manufacturing. The methods can be applied as a platform approach for various mAb products.

The present invention relates to an improved kit for preparing injectable carmustine solutions, methods of preparing and administering such solutions, and methods of treatment with such solutions. The kit includes a product vial containing lyophilised carmustine and a diluent vial containing an ethanol-free non-aqueous diluent. Reconstitution of the lyophilised carmustine in the ethanol-free non-aqueous diluent results in a carmustine solution with improved solubility and stability.

The invention relates to a packaging in the form of an infusion bag, having a connector for a vial, said connector having a spike for piercing the septum of the vial to establish a fluid connection to the inner volume of the infusion bag. The spike is designed to be rotatable. When the vial is rotated, the spike is rotated and the fluid connection between the vial and the inner volume of the infusion bag is opened.

To provide an albumin preparation that suppresses generation of insoluble matter even with an increased volume.SOLUTION: An albumin preparation comprises a vial and an aqueous solution containing serum albumin enclosed in the vial, wherein the vial has a main body having an opening and a stopper that seals the opening, an inner surface of the main body is subjected to elution suppression treatment, and a surface of the stopper that comes into contact with the aqueous solution containing serum albumin is subjected to laminate treatment.SELECTED DRAWING: None

This invention relates to a system flow path for solid-phase extraction and its application method. The system flow path is characterized by a pump inlet port located below a rotary valve, several solvent inlet ports on the circumference of the rotary valve, a solvent outlet port and a waste liquid port on the circumference of the rotary valve, a gas path system connecting the solvent outlet port of the rotary valve to the solvent interface of the sample loader, and a sample loader comprising a valve core and a valve body. The top of the valve body is connected to a sample vial, and a spray needle is also located at the top of the valve body. The valve core is located within the valve body. The sample flow channel is connected to a guide tube, and a membrane adapter is located below the guide tube. The membrane adapter is connected to a collection docking point, which is connected to a dehydration device and a collection vial. The collection docking point is also connected to a flow path switching system. This invention features a compact structure, anti-clogging and anti-cross-contamination advantages, and spray cleaning of the sample vial ensures complete sample loading, improving experimental recovery rates. The online filtration and dehydration functions enable full-process automation.

A vial accumulator for use in a high volume pharmacy facility includes: a feed plate having an aperture; a vial staging unit mounted to the feed plate, the vial staging unit comprising at least one receiving compartment; a gate movably mounted to the feed plate, the gate movable relative to the feed plate between a blocking position, wherein the gate prevents a vial from exiting one of the receiving compartments, and a dispensing position, in which the gate allows passage of a vial in one of the receiving compartments through the aperture in the feed plate; and a controller operatively associated with the vial staging unit and the gate.

1. Name of the designed product: packing box (Maxigreen red bottle). 2. Use of the designed product: packing box for packing products. 3. Design points of the designed product: combination of shape and pattern. 4. Picture or photo showing the design points: perspective view.

1. The name of the design product: blister box (injection bottle). 2. The use of the design product: blister box for product packaging protection. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view 1.

1. The name of the design product: smell bottle (Y02). 2. The use of the design product: for perfume, liquor, coffee beans, essential oil, tea and other products smell sample flavor. 3. The design points of the design product: in shape. 4. The picture or photo that best shows the design points: design 1 perspective view. 5. Design 1 is designated as the basic design.

Multi-route drug delivery device designed with two modular bodies. The first body houses batteries, heaters, vials containing extracts, formulations, diluents or cleaners, and the control unit. This unit features two or more peristaltic pumps that enable precise dosage control and ensure homogeneous mixing of substances. The pumps also incorporate purging and cleaning process cross-contamination. The second body is the administration unit, which can be fitted with interchangeable nozzles to different delivery methods. These options include an atomizer, nasal spray, or sublingual spray. By changing the dispenser nozzles, it can accommodate a wide range of delivery routes, including pulmonary, sublingual, nasal, and mucosal. Designed to meet the needs of patients, clinical trial participants, general users, and livestock.

The invention relates to the field of tea evaluation, in particular to a black tea aroma substance detection method. The method comprises the following steps: extracting tea aroma components by adopting headspace solid-phase extraction: adding tea into a solid-phase micro-extraction headspace bottle, then adding sodium chloride, distilled water and ethyl decanoate, then putting the solid-phase micro-extraction headspace bottle on a constant-temperature magnetic hot plate stirrer, heating, stabilizing, inserting SPME fibers into the solid-phase micro-extraction headspace bottle, and carrying out headspace solid-phase extraction; performing aroma adsorption; and analyzing the aroma by adopting a gas chromatograph and a mass spectrometer, wherein the reaction condition of the gas chromatograph is as follows: an Rtx-5MS chromatographic column is adopted.

The utility model relates to the technical field of medical equipment, in particular to a portable tray for medical examination, an anti-toppling mechanism comprises a mounting rack, the mounting rack is fixedly connected into a tray body, the upper end of the mounting rack is connected with a plurality of placing grooves at equal intervals in the length direction, grooves are formed in the two sides of the interior of each placing groove, and an anti-toppling mechanism is arranged in each placing groove. The upper end of the interior of each groove is rotationally connected with an extrusion plate, the bottom end of each extrusion plate is located outside the corresponding groove, each extrusion plate is fixedly connected with a spring, and one end of each spring is fixedly connected to the corresponding groove. A small bottle of reagent is inserted into the placement groove, the small bottle of reagent moves downwards to push and press the extrusion plate, the extrusion plate rotates towards the groove, the extrusion plate extrudes the spring in the rotating process, the spring generates elastic force after being pressed, and the elastic force generated by the spring pushes the extrusion plate, so that the extrusion plate is in extrusion contact with the small bottle of reagent; and the small-bottle reagent cannot topple over in the transferring process, and cannot collide with the tray body.

The present invention relates to automated operations for the preparation of medicaments, in particular image-based progression and / or result verification, and / or detection of fault conditions related to dissolution of a medicament material contained in a vial. In some examples, imaging and image processing are used to track the progression of a process that converts solids and / or concentrated materials (e.g., crystallized and / or lyophilized) to fluid solutions and / or suspensions. The dilution time may change along with the change of conditions; detection of fault conditions may reduce risk and / or reduce waste. In some examples, the amount of fluid used in dissolution / dilution itself is monitored at one or more stages. The invention also relates to methods of evaluating the fluid content of vials, including vials dispensed for manual manipulation, which may include viewing obstructions, such as labels.

The utility model discloses a bottle breakage prevention device for bottle filling, and particularly relates to the technical field of filling, which comprises a lower turntable and an upper turntable fixed on the surface of the lower turntable, a motor for driving the lower turntable and the upper turntable to rotate is arranged at the bottom of the lower turntable, and the upper turntable rotates to drive penicillin bottles to move and fill. The lower rotating disc extends outwards for a certain distance from the bottom end of the upper rotating disc, a protection disc surrounding the periphery of the upper rotating disc is arranged on the lower rotating disc, a plurality of bottle grooves which are arranged at equal intervals are formed in the edge of the upper rotating disc, and penicillin bottles are embedded in the bottle grooves. The bottle opening guiding pieces and the bottle grooves are consistent in number and angle. The feeding hopper is arranged between the needle head and the penicillin bottle body in an isolation mode, the needle head can be prevented from colliding with a bottle opening or the inner wall, and even if the needle head inclines, high-speed liquid medicine ejected out cannot impact the bottle body or the bottle bottom, and the bottle body cannot be broken.

Conveyor system device (82a-e) for the orderly conveying of elongated and / or cylindrically extended objects (10a-e) such as ampoules, cartridges, syringes, pipettes, vials or the like, with at least one object recording unit (14a-e) which is movably mounted along a direction of movement (12a-e) and is designed for the piece-by-piece recording of the individual objects (10a-e), which comprises at least one object gripper (20a-e) forming at least one object holding contact surface (16a-e) and providing for holding a single object (10a-e) in a receiving area (18a-e) of the object receiving unit (14a-e), with at least one first gripper element (22a-e) and with at least one second gripper element (24a-e), characterized by the fact that the first gripper element (22a-e) forms an object-carrying contact surface (26a-e) which is intended to contact the object (10a-e) to be conveyed in at least one operating state and to carry it along with the object-receiving unit (14a-e) and that the second gripper element (24a-e) has an object-guiding contact surface (36a-e) which is intended to guide the movement of the object (10a-e) relative to the first gripper element (22a-e) from a first position (28a-e), in which the object (10a-e) predominantly contacts the object-carrying contact surface (26a-e), to a second position (30a-e), in which the object (10a-e) predominantly contacts the object-holding contact surface (16a-e).

1. The name of the design product: cosmetic container bottle (double cavity vacuum vial). 2. The use of the design product: the product is used for containing cosmetics. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view.

The invention provides a method for determining perfluorotripropylamine in consumer goods. The method comprises the following steps: sampling; adding a first reagent with a first volume into the sample, and carrying out ultrasonic treatment at a first specified temperature for a first specified time to obtain an extract liquid; adding a second volume of a second reagent into the extract liquor, carrying out ultrasonic treatment at a second specified temperature for a second specified time, and filtering to obtain a loading test solution; taking a third volume of the loading test solution, placing the loading test solution in a headspace bottle, sealing the headspace bottle, and placing the headspace bottle in a headspace-gas chromatograph-mass spectrometer for qualitative and quantitative detection analysis; wherein the analysis parameters of the headspace-gas chromatograph-mass spectrometer comprise: headspace temperature: 90 DEG C; the balance time is 30 minutes; the chromatographic column is DB-624; the flow velocity of the carrier gas is 0.6 ml / min; the column box temperature is kept at 40 DEG C for 3 minutes; raising the temperature to 240 DEG C at 25 DEG C / min, and keeping the temperature for The quantitative ion: 168.9; and qualitative ions: 68.9 and 213.9. The conditions and parameters of the method are optimized, and the perfluorotripropylamine in the consumer goods can be accurately determined.