630 results about "Vial" patented technology

The invention provides a medicine dispensing machine which comprises a frame, and a medicine bottle box for storing ampoule bottles and penicillin bottles, a liquid bag box for storing liquid bags and a suction and injection device hanging frame for conveying suction and injection devices are arranged in the frame. An ampoule bottle opening device for opening an ampoule bottle, a penicillin bottle cover opening device for opening a bottle cover of the penicillin bottle, a penicillin bottle liquid medicine mixing device for mixing and uniformly shaking liquid medicine injected into the ampoule bottle, and a marking device for marking a liquid bag injected with the mixed liquid medicine are arranged in the frame; the frame is internally provided with a sucking and injecting manipulator which is used for clamping a sucking and injecting device and sucking and injecting liquid medicine of an ampoule bottle into a penicillin bottle, all the devices are transferred through a transferring manipulator, full-automatic medicine dispensing is carried out, and the medicine dispensing efficiency is improved.

A tamper evident seal structure for a vial septum or other cover having a housing including a sidewall terminating in oppositely disposed open and closed ends. A retainer is fixedly disposed within the housing and structured for retaining engagement with a portion of a vial, substantially adjacent the vial cover. The housing also includes a pressure member disposed within an interior thereof in attached, relation to the closed-end. The pressure member and the retainer are cooperatively disposed and structured to respectively exert pressure on the vial cover concurrent to retaining engagement with the vial. Tamper evident capabilities are at least partially defined by a detachment of a removable sidewall section from a remainder of said sidewall.

An apparatus and method for determining the presence of a disease by analyzing a specimen by providing a vial partially containing the specimen and partially containing a headspace above the specimen, injecting an inert gas into the specimen in the vial to cause bubbling of the gas throughout at least a portion of the specimen such that the gas mixes with volatile organic compounds (VOCs) present in the specimen to create a VOC / gas mixture that is released into the headspace, collecting the VOC / gas mixture from the headspace in the vial, supplying the VOC / gas mixture to a chamber within the apparatus, causing the VOC / gas mixture to pass over a sensor array in proximity to the chamber, the sensor array generating an electrical signal as a function of VOCs detected in the VOC / gas mixture, and processing the electrical signal to determine the presence of a disease in the specimen.

An apparatus for processing pharmaceutical containers, in particular vials, syringes or carpules, and a filling device for filling pharmaceutical containers. The apparatus includes a frame that can be positioned on a set-down surface and has a surface, a first side and a second side, a processing station, and a transport device arranged between the first side and the second side, with circulating holding elements for the containers which move along a transport direction on a transport segment and counter to the transport direction on a return segment. The processing station is arranged at the transport segment, and the transport segment and the return segment are arranged above the surface. The transport plane is inclined by an angle of inclination relative to a plane of the surface and / or a horizontal plane, and the transport segment is arranged above the return segment in the direction of gravity.

The present disclosure provides a method of preparing a lyophilized bispecific molecule composition comprising (a) inducing ice nucleation in a liquid protein composition having a bispecific molecule concentration of at least about 10 mg / ml in a vial exposed to a first temperature of about-18 DEG C to about-10 DEG C for about 60 minutes to about 270 minutes; (b) exposing the vial of (a) to a second temperature of about-25 DEG C to-50 DEG C for about 1 hour to about 5 hours; and (c) drying the composition of (b) at a third temperature of about-5 DEG C to about-25 DEG C for about 25 hours to about 70 hours, and (d) further drying the composition of (c) at a fourth temperature of about 25 DEG C to about 50 DEG C for about 4 hours to about 12 hours to obtain a vial comprising a lyophilized bispecific molecular composition, the composition has a percentage content of high molecular weight material (HMWS) of less than or equal to about 1.5% (mA / ). The disclosure further provides lyophilized bispecific molecule compositions prepared via the methods described herein.

A geological analysis system, device, and method using x-ray fluorescence and spectroscopy are provided. The geological analysis system includes a sample tray which holds the geological sample materials, and sensors including an X-ray fluorescence (XRF) unit and spectrometer. The sample tray includes chambers formed in an upper surface, ports, and passages, each providing communication between an interior of a chamber and an interior of a port. The ports are configured to be attachable to vials. The system positions the sample tray with respect to the sensors for sensing one or more properties of geological sample materials in the sample tray.

A lyophilization method for lyophilizing products inside one or more vials within a lyophilization chamber is disclosed which includes humidifying a charge gas to a predetermined relative humidity, cooling shelves in the lyophilization chamber to a predetermined temperature, pressurizing the chamber with the humidified charge gas to a pressurization threshold to thereby achieving a target relative humidity level within the lyophilization chamber, and suddenly releasing pressure within the lyophilization chamber until a depressurization threshold is reached in a short time interval up to about 4 seconds, during the depressurization, product inside one or more vials nucleate.

The utility model discloses a bottle cap assembly which is used for sealing a double-cavity clamping type bottle and comprises a top plug and a top cap. The top plug is pressed by the plug pressing assembly so as to be embedded with the double-cavity clamping type bottle, so that the double-cavity clamping type bottle is sealed; the top cover is used for fixing the top plug and sealing a bottle opening of the double-cavity clamping bottle; the plug pressing assembly comprises a press-in jig and a holding jig. According to the bottle cap assembly and the double-cavity clamping type bottle, high-precision self-plug-pressing sealing with good sealing performance can be conducted through the plug pressing assembly in a freeze dryer, meanwhile, the time cost and operation complexity needed by plug pressing and cover sealing of the double-cavity clamping type bottle in the whole freeze-drying technological process are reduced, and the freeze-drying efficiency and the freeze-drying product quality are improved.

In certain embodiments, a vial adaptor comprises a housing configured to couple the adaptor with a vial, an access channel, a regulator channel, and a regulator assembly. The access channel is configured to facilitate withdrawal of fluid from the vial when the adaptor is coupled to the vial. The regulator channel is configured to facilitate a flow of a regulating fluid from the regulator assembly to compensate for changes in volume of a medical fluid in the vial. The regulator assembly can include a valve configured to transition between a closed configuration and an opened configuration.

The invention provides a radiation shielding assembly, a drug vial assembly system, a method of dispensing a drug vial assembly system, and a radiopharmaceutical infusion device. The radiation shielding assembly is used for shielding a medicine bottle assembly containing radiopharmaceuticals, and the medicine bottle assembly is provided with a puncture communication piece capable of transversely moving. The shielding body is provided with a top opening, a small bottle containing cavity and a combination port, and the medicine bottle assembly is contained in the containing cavity through the top opening. The containing cavity is provided with a circumferential matching wall, the distance between the matching wall and the vertical center line is gradually decreased from the starting end to the tail end, and a moving path is provided for assembly. The medicine bottle is guided to move along the wall, and the bottom puncture communicating piece is guided to transversely move inwards and is in butt joint with the combination port when reaching the assembly completion position. After assembly is completed, the puncture communicating piece is in butt joint with the combination port. According to the invention, only one needle puncturing the top of the medicine bottle is used as an inflow channel. Needle adjustment is not needed when medicine is nearly empty, operation is simplified, and the error rate is reduced.

To provide a method for transporting thermoplastic resin vials under sterile conditions and in an exogenous pyrogen-free state, introducing the vials into a filling assembly line, and thereafter allowing the vials to stand without tipping or dropping them, the method is a method for packing vials for filling with contents such as medicaments or cells by vacuum-packing the vials, and includes the following steps:(I) inserting a plurality of vials in a tray with opening portion sides of the vials facing a bottom of the tray,(II) installing a soft film on bottom portions of the vials,(III) introducing the tray having the vials installed therein and the soft film into a gas-impermeable flexible film bag,(IV) depressurizing the inside of the flexible film bag to a prescribed vacuum pressure, and(V) sealing an opening of the flexible film bag.

A pre-filled dual-chamber medical agent delivery system assembled and configured to allow delivery of a single dose of a combined therapeutic agent (e.g., vaccine, drug, medicament, etc.) from a Blow-Fill-Seal (BFS) vial to a patient. The delivery assembly generally includes a modular design consisting of separately constructed components cooperatively arranged and coupled to one another, such as to facilitate delivery of a reconstituted lyophilized agent to a patient.

In certain embodiments, a vial adaptor comprises a housing configured to couple the adaptor with a vial, an access channel, a regulator channel, and a regulator assembly. The access channel is configured to facilitate withdrawal of fluid from the vial when the adaptor is coupled to the vial. The regulator channel is configured to facilitate a flow of a regulating fluid from the regulator assembly to compensate for changes in volume of a medical fluid in the vial. In some embodiments, the regulator assembly includes a flexible member configured to expand and contract in accordance with changes in the volume of the medical fluid in the vial. In some embodiments, the flexible member is substantially free to expand and contract. In some embodiments, the flexible member is not partly or completely located in a rigid enclosure

In certain embodiments, a vial adaptor comprises a housing configured to couple the adaptor with a vial, an access channel, a regulator channel, and a regulator assembly. The access channel is configured to facilitate withdrawal of fluid from the vial when the adaptor is coupled to the vial. The regulator channel is configured to facilitate a flow of a regulating fluid from the regulator assembly to compensate for changes in volume of a medical fluid in the vial. In some embodiments, the regulator assembly includes a flexible member configured to expand and contract in accordance with changes in the volume of the medical fluid in the vial. In some embodiments, the flexible member is substantially free to expand and contract. In some embodiments, the flexible member is not partly or completely located in a rigid enclosure.

The present invention relates to a pre-assembled reconstitution and injection device, comprising an injection section having a cartridge for holding a diluent or drug product and a reconstitution section having a vial for holding a drug, whereby the injection section may only be disassembled from the reconstitution section after activation of the device has occurred. In an embodiment for use with a pen needle, the reconstitution section comprises a vial needle hub having a reconstitution needle for piercing both the vial and cartridge. In an embodiment of the invention for use with a hypodermic needle, the injection section comprises a cartridge needle hub with a cartridge needle and male luer connection having threads for securing a hypodermic needle, and the reconstitution section comprises a needle hub with a vial needle and a female luer connection for engagement with the male luer connection.

The invention discloses a method for detecting perfluoroalkyl (polyfluoroalkyl) compounds in sludge, which comprises the following steps: screening concentrated sludge of a sewage plant, removing foreign matters, pretreating, putting into a centrifugal tube, and adding an extraction internal standard; the method comprises the following steps: extracting PFAS in sludge by using an alkaline organic solvent to obtain a PFAS extracting solution; filtering and acidifying the PFAS extracting solution to obtain an acidified extracting solution; purifying and eluting the acidified extracting solution through a solid-phase extraction column to obtain an eluent; drying the eluent, re-dissolving to 1mL by using methanol, filtering, and collecting the supernate into a sample injection bottle; and adding a sample introduction internal standard into the sample introduction bottle, mixing, and determining the PFAS in the sludge by using a liquid chromatography tandem mass spectrometer. By optimizing a pretreatment method for determining the PFAS in the sludge and a mode for reducing the matrix effect, a method capable of accurately quantifying the PFAS (51 different types) in complex environmental samples such as the sludge and biological solids is developed, and the analysis range and accuracy of the PFAS in the sludge are improved.

The invention relates to the technical field of detection, and discloses a detection method and application of p-phenylenediamine antioxidants and quinone derivatives thereof, and the method comprises the following steps: taking a blood sample or a tissue sample, placing in a centrifuge tube, adding a recovery rate indicator solution and a glutathione solution, adding an extraction solvent, extracting twice, and combining the two solutions; centrifuging for 4-6 minutes at the speed of 3000-4500 rpm after each extraction, and combining the two extracts to obtain an extract to be detected; concentrating the to-be-detected extracting solution to be dry under soft nitrogen to obtain a to-be-detected concentrated dry substance; purifying with / without an HLB column; further concentrating the eluent, adding acetonitrile for redissolving, passing through an organic filter membrane, putting into a small sample injection bottle, and concentrating again; adding an internal standard solution to a constant volume to obtain a to-be-detected sample solution; and finally, detecting the sample solution to be detected by using an ultra-high performance liquid chromatography system and a mass spectrometer. According to the invention, the blank of no corresponding detection method for various PPDs and PPD-Qs in human blood and tissues is filled up.

The disclosure relates to a method for marking a container comprising a vial containing a medicinal substance and closed by a cap secured to the vial by a ring. With the container being at least partially covered with frost, the method further comprises a step of laser marking the ring through the frost. The disclosure also relates to a device for marking a container.

Disclosed herein are improved methods for quantifying monoclonal antibody (mAb) titer using Protein A affinity High-Performance Liquid Chromatography (HPLC). The methods address inaccuracies caused by mAb adsorption to sample vial surfaces by incorporating a surfactant into the mobile phase used for sample dilution. This approach enhances the accuracy, linearity, and robustness of the titer assay, making it suitable for process control and quality assessment in biopharmaceutical development and manufacturing. The methods can be applied as a platform approach for various mAb products.

The present invention relates to an improved kit for preparing injectable carmustine solutions, methods of preparing and administering such solutions, and methods of treatment with such solutions. The kit includes a product vial containing lyophilised carmustine and a diluent vial containing an ethanol-free non-aqueous diluent. Reconstitution of the lyophilised carmustine in the ethanol-free non-aqueous diluent results in a carmustine solution with improved solubility and stability.

The invention relates to a packaging in the form of an infusion bag, having a connector for a vial, said connector having a spike for piercing the septum of the vial to establish a fluid connection to the inner volume of the infusion bag. The spike is designed to be rotatable. When the vial is rotated, the spike is rotated and the fluid connection between the vial and the inner volume of the infusion bag is opened.

To provide an albumin preparation that suppresses generation of insoluble matter even with an increased volume.SOLUTION: An albumin preparation comprises a vial and an aqueous solution containing serum albumin enclosed in the vial, wherein the vial has a main body having an opening and a stopper that seals the opening, an inner surface of the main body is subjected to elution suppression treatment, and a surface of the stopper that comes into contact with the aqueous solution containing serum albumin is subjected to laminate treatment.SELECTED DRAWING: None

This invention relates to a system flow path for solid-phase extraction and its application method. The system flow path is characterized by a pump inlet port located below a rotary valve, several solvent inlet ports on the circumference of the rotary valve, a solvent outlet port and a waste liquid port on the circumference of the rotary valve, a gas path system connecting the solvent outlet port of the rotary valve to the solvent interface of the sample loader, and a sample loader comprising a valve core and a valve body. The top of the valve body is connected to a sample vial, and a spray needle is also located at the top of the valve body. The valve core is located within the valve body. The sample flow channel is connected to a guide tube, and a membrane adapter is located below the guide tube. The membrane adapter is connected to a collection docking point, which is connected to a dehydration device and a collection vial. The collection docking point is also connected to a flow path switching system. This invention features a compact structure, anti-clogging and anti-cross-contamination advantages, and spray cleaning of the sample vial ensures complete sample loading, improving experimental recovery rates. The online filtration and dehydration functions enable full-process automation.

A vial accumulator for use in a high volume pharmacy facility includes: a feed plate having an aperture; a vial staging unit mounted to the feed plate, the vial staging unit comprising at least one receiving compartment; a gate movably mounted to the feed plate, the gate movable relative to the feed plate between a blocking position, wherein the gate prevents a vial from exiting one of the receiving compartments, and a dispensing position, in which the gate allows passage of a vial in one of the receiving compartments through the aperture in the feed plate; and a controller operatively associated with the vial staging unit and the gate.

1. Name of the designed product: packing box (Maxigreen red bottle). 2. Use of the designed product: packing box for packing products. 3. Design points of the designed product: combination of shape and pattern. 4. Picture or photo showing the design points: perspective view.

1. The name of the design product: blister box (injection bottle). 2. The use of the design product: blister box for product packaging protection. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view 1.

1. The name of the design product: smell bottle (Y02). 2. The use of the design product: for perfume, liquor, coffee beans, essential oil, tea and other products smell sample flavor. 3. The design points of the design product: in shape. 4. The picture or photo that best shows the design points: design 1 perspective view. 5. Design 1 is designated as the basic design.

Multi-route drug delivery device designed with two modular bodies. The first body houses batteries, heaters, vials containing extracts, formulations, diluents or cleaners, and the control unit. This unit features two or more peristaltic pumps that enable precise dosage control and ensure homogeneous mixing of substances. The pumps also incorporate purging and cleaning process cross-contamination. The second body is the administration unit, which can be fitted with interchangeable nozzles to different delivery methods. These options include an atomizer, nasal spray, or sublingual spray. By changing the dispenser nozzles, it can accommodate a wide range of delivery routes, including pulmonary, sublingual, nasal, and mucosal. Designed to meet the needs of patients, clinical trial participants, general users, and livestock.

The invention relates to the field of tea evaluation, in particular to a black tea aroma substance detection method. The method comprises the following steps: extracting tea aroma components by adopting headspace solid-phase extraction: adding tea into a solid-phase micro-extraction headspace bottle, then adding sodium chloride, distilled water and ethyl decanoate, then putting the solid-phase micro-extraction headspace bottle on a constant-temperature magnetic hot plate stirrer, heating, stabilizing, inserting SPME fibers into the solid-phase micro-extraction headspace bottle, and carrying out headspace solid-phase extraction; performing aroma adsorption; and analyzing the aroma by adopting a gas chromatograph and a mass spectrometer, wherein the reaction condition of the gas chromatograph is as follows: an Rtx-5MS chromatographic column is adopted.