1129results about "Mass spectrometers" patented technology

The invention discloses an inductively coupled plasma mass spectrometer with an automatic sample injection structure, and particularly relates to the technical field of mass spectrometers, the inductively coupled plasma mass spectrometer comprises a mass spectrometer body, and a mounting table is mounted at the bottom of one side of the mass spectrometer body; a sample introduction disc is mounted on the mounting table, and a plurality of test tube bodies are limited on the sample introduction disc. According to the switching sampling mechanism, sampling work is completed on solutions in the test tube bodies when the sampling tube moves up and down, and the sampling disc is synchronously driven to complete active rotation switching when the sampling tube moves up and resets, so that continuous active switching sampling operation on the test tube bodies on the sampling disc is completed, the sampling efficiency is improved, and the sampling time is shortened. Manual operation of technicians is not needed, time and labor are saved, the shielding mechanism is additionally arranged on the sample introduction disc and used for shielding the tops of the multiple test tube bodies, external impurities are prevented from falling into the test tube bodies, meanwhile, the shielding mechanism and the sample introduction switching mechanism are linked, and the whole sampling work is safely and stably carried out.

An integrated sample processing system including an analyzer and a mass spectrometer is disclosed. The integrated sample processing system can perform multiple different types of detection, thereby providing improved flexibility and better accuracy in processing samples. The detection systems in the sample processing system may include an optical detection system and a mass spectrometer.

The invention discloses an atomization mechanism for a plasma mass spectrometer, and relates to the technical field of atomizers, the atomization mechanism comprises an atomization cup, an atomization head and a sample introduction hopper which are respectively arranged at two openings of the atomization cup, a transmission mechanism arranged in the atomization cup, and an atomization nozzle communicated with the interior of the atomization cup, the sample feeding hopper is rotationally connected with the inner wall of the atomizing cup, and the transmission mechanism is in transmission connection with the sample feeding hopper; to-be-atomized liquid flows into the sample feeding hopper through the atomizing head; atomized airflow flows into the atomizing cup through the sample injection hopper and can be blown to liquid in the sample injection hopper; the transmission mechanism can drive the sample feeding hopper to rotate under the action of atomized airflow; and the liquid is atomized in the atomizing cup and then is discharged through the atomizing nozzle. In the atomization process, the transmission mechanism can drive the sample feeding hopper to rotate under the action of atomization airflow, powder and particles in liquid raw materials can be well decomposed through rotation of the sample feeding hopper, the stability of the concentration of liquid fed into a plasma light source is guaranteed, and meanwhile the atomizer can be prevented from being blocked.

Methods are described for measuring the amount of one or more of vitamin A, α-tocopherol, and the combination of β-tocopherol and γ-tocopherol in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying one or more of vitamin A, α-tocopherol, and the combination of β-tocopherol and γ-tocopherol in a sample.

A waveform analytical device 4 which analyzes a target waveform which is a chromatogram or an optical spectrum includes a waveform division unit 54 configured to divide the target waveform into a plurality of partial waveforms, a determination unit 55 configured to determine whether each of the plurality of partial waveforms of the target waveform is a peak portion using a learned model created by machine learning using a plurality of sets of a plurality of partial waveforms created by dividing a reference waveform having a peak portion whose position is known, and a classification unit 56 configured to classify the target waveform into a peak region where the peak portion continues and a non-peak region other than the peak region based on a determination result from the determination unit.

The utility model discloses an ionization sample injection platform device for a mass spectrometer. The ionization sample injection platform device comprises a base, and a rotary sample frame, a swing arm grabbing mechanism, a turnover sample injection port mechanism and a high-voltage applying mechanism which are arranged on the base, the rotary sample frame is used for loading a plurality of to-be-tested samples; a sample to be detected is arranged in the suction head; the swing arm grabbing mechanism is used for taking and placing a to-be-tested sample through lifting and rotating actions of an electric gripper; the overturning sample inlet mechanism is arranged at the detection port of the mass spectrometer and is used for controlling the to-be-detected sample to execute an overturning action, so that the to-be-detected sample is aligned with the tip part of the detection port of the mass spectrometer; the high-voltage electricity applying mechanism is used for releasing high-voltage electricity to the tip end of the suction head. The ionization sample introduction platform device structure for the mass spectrometer enters a field, and the detection efficiency can be remarkably improved.

The vacuum interface of the mass spectrometer comprises a main body part and a sample introduction piece, the main body part is provided with an interface body and a first connecting piece which are formed into a split piece, one end of the first connecting piece is connected with the interface body, the interface body is formed into an integrally formed piece, and the interior of the interface body is hollow to form a vacuum cavity; the vacuum cavity is provided with a first opening and a second opening which are oppositely arranged, a mass analyzer is suitable for being arranged in the vacuum cavity, the sample injection piece is arranged at the first opening and detachably connected with the other end of the first connecting piece, the sample injection piece is provided with a sample injection port communicated with the first opening, the sample injection port is used for conveying ions to be detected towards the vacuum cavity, and the sample injection port is communicated with the second opening in the direction towards the vacuum cavity. And the opening sizes of at least part of the sample inlets are gradually increased. According to the vacuum interface of the mass spectrometer provided by the embodiment of the invention, not only can the installation precision of the sample introduction piece be ensured, but also the interface body has good sealing performance, so that the working performance of the mass spectrometer can be improved.

A hybrid inductively coupled plasma mass spectrometer (ICP-MS) system is disclosed for simultaneous elemental and molecular analysis in positive and negative polarities. It includes an ICP torch that generates plasma with a buffer gas, producing both positively and negatively charged ions from a sample. Positioned between the sampler and skimmer, an insert with a defined geometry forms a reaction chamber. Various embodiments feature multiple apertures for pressure control, a rotatable disk for aperture regulation, a slider gate for pressure adjustment, a circular gate with adjustable radial apertures, and an inlet for introducing gases, reagents, dopants, or analytes. These components enable precise pressure modulation, optimizing performance for dual-polarity mass spectrometry. The system enhances analytical flexibility by facilitating controlled ion reactions, improving sensitivity and specificity for both elemental and molecular applications. This innovation expands ICP-MS functionality, supporting diverse scientific and industrial applications requiring high-precision mass analysis.

The invention belongs to the technical field of online analysis of organic pollutants, and particularly relates to a device and a method for real-time online analysis of non-volatile organic pollutants. The device comprises a sample injection module, a vacuum ultraviolet lamp, an ionization source cavity, a repulsion electrode, an ion funnel, a mass analyzer and a vacuumizing module, the ionization source cavity is provided with a sample injection port, a vacuum extraction port and an ion output port, and the vacuum ultraviolet lamp, the repulsion electrode and the ion funnel are sequentially arranged in the ionization source cavity at intervals in the axis direction of the ion output port; the ion funnel is close to the ion output port; the sample injection module is arranged at the sample injection port; the vacuumizing module is arranged on the vacuum extraction opening; the ion output port is externally connected with a mass analyzer; a direct-current voltage is applied to the repulsion electrode, and a direct-current voltage and a radio-frequency voltage are applied to the ion funnel. According to the invention, the ions with relatively large initial distribution area can be focused, so that the detection sensitivity is further improved, and the detection requirements on trace non-volatile organic pollutants are met.

The invention relates to the field of mass spectrometry, in particular to a double-helix ion funnel with an auxiliary electrode in ion transmission. The double-spiral ion funnel with the auxiliary electrodes comprises two spiral electrodes, each spiral electrode is provided with a constant inner diameter section and a conical inner diameter section which are connected in the ion transmission direction, the four auxiliary electrodes are arranged at an outlet of the conical inner diameter section, the four auxiliary electrodes are matched with the double-spiral electrodes, positive electrodes and negative electrodes are alternately arranged, and the two spiral electrodes are arranged in a staggered mode. And a hexapole rod structure is formed at the outlet of the double-helix ion funnel to improve a fringing field. Under the cooperation of the auxiliary electrode and the double-helix electrode, the influence of a fringing field on the double-helix electrode structure is greatly improved. And the transmission efficiency of ions with low and medium mass-to-charge ratios in a coarse vacuum region is enhanced, and the transmission efficiency is hardly influenced by potential traps. Meanwhile, the ionic strength is enhanced, and lower detection limit and higher sensitivity can be realized.

In order to improve the ionization efficiency and ion collection efficiency in an ESI ion source to achieve a higher level of analysis sensitivity while improving the throughput of the analysis, one mode of the present invention provides an ion analyzer equipped with an ion source employing an electrospray ionization method, where the ion source (2) includes: a plurality of capillaries (211-218) configured to spray a supplied liquid sample in the same direction; one or more auxiliary electrodes (23, 231-328) arranged so as to be surrounded by the plurality of capillaries; and a voltage supplier (24) configured to apply, to the plurality of capillaries, a DC high voltage for which the potential of the one or more auxiliary electrodes is used as a reference.

The invention relates to the field of mass spectrum equipment, in particular to a low-noise and high-sensitivity mass spectrometer Faraday cup. The Faraday cup comprises a rectangular housing, one side of which is open; the suppression grid is arranged in the shell and is close to the opening; the collector is arranged in the shell and is adjacent to the suppression grid; a slit baffle is arranged at the opening of the shell; the collector is fixed through the insulating lining, insulated from the shell, and used for receiving the ion beam and generating current; the suppression grid electrode is fixed through an insulating lining and a metal positioning block, and negative bias voltage is applied to suppress escape of secondary electrons; the top cover is assembled on the shell to form a sealed whole; the collector connecting piece is arranged on the lower portion of the collector, one end of the Faraday cup outgoing line is welded to the collector connecting piece, and the other end of the Faraday cup outgoing line is led out of the shell. Noise is remarkably reduced, and the detection sensitivity of a mass spectrometer is improved.

The invention discloses a gas mass spectrometer ion source performance testing device, and belongs to the technical field of mass spectrometer testing, the ion source performance testing device comprises an ion source testing assembly, the ion source testing assembly is used for fixing and testing a to-be-tested ion source and converting ions into ion beams, and the ion source testing assembly is connected with an adjustable flight tube assembly. The adjustable flight tube assembly provides a flight channel for the ion beam, the adjustable flight tube assembly can stretch and retract relative to the ion source test assembly to adjust the flight distance of the ion beam, one end, far away from the ion source test assembly, of the adjustable flight tube assembly is connected with an adjustable observation assembly, and the adjustable observation assembly can slide relative to the ion source test assembly. Therefore, the observation position and the ion beam flight distance are adjusted. According to the invention, the installed to-be-detected ion source can be rapidly detected in a high-vacuum environment, the detection time is shortened from two days to half an hour aiming at complex operation of an existing ion source on an instrument, and the installation and detection efficiency of the ion source is greatly improved.

The invention relates to data independent acquisition with parallel isolation multiplexing. The system may control a mass spectrometer to acquire a set of mass spectra of product ions derived from precursor ions isolated based on parallel isolation windows continuously positioned throughout the precursor mass-to-charge ratio (m / z) range during a plurality of acquisitions constituting an acquisition cycle. The precursor m / z range is divided into a plurality of isolation window cells. For each acquisition of the acquisition cycle, the parallel isolation window includes a set of isolation sub-windows corresponding to a different set of isolation window cells of the precursor m / z range. At least two adjacent isolation sub-windows of the parallel isolation window are discontinuous. Each isolation window cell of the precursor m / z range is analyzed at least twice during the acquisition cycle. A mass spectrum for the precursor m / z range may be generated based on the set of mass spectra acquired during the acquisition cycle.

The invention relates to a continuous ion beam screening and enriching system and method and a mass spectrograph, and the continuous ion beam screening and enriching system comprises a vacuum differential unit, a first ion focusing unit, a mass screening unit, a second ion focusing unit, an enriching and releasing unit and a third ion focusing unit which are sequentially arranged from upstream to downstream. The enrichment and release unit is provided with a shell and a plurality of annular electrode plates which are arranged in parallel and located in a cavity of the shell, a resistor and a capacitor are connected between every two adjacent annular electrode plates to form a gradient electric field, and center holes of the annular electrode plates are concentrically arranged to jointly form an ion channel penetrating between an inlet and an outlet of the enrichment and release unit. According to the invention, continuous ion beam low-energy-consumption enrichment and pulse release can be realized, and strict requirements of scientific and industrial fields on mass spectrum detection and ion control precision are met.

The invention provides an ion source detection system and method, and the system comprises a vacuum device which is used for providing a preset vacuum environment for an ion source; the n ion sources are connected with the vacuum device; each ion source is further provided with a first communication valve used for controlling and communicating with the vacuum environment. The ion source detection devices and the ion sources are arranged in a one-to-one correspondence manner, and the ion source detection devices are electrically connected with the corresponding ion sources; and each ion source detection device is used for providing working voltage for the ion source and collecting an ion intensity electric signal output when the ion source works. According to the invention, the vacuum device and the ion source detection device are arranged to provide an independent detection system for the ion source to be detected.

The invention discloses a composite ion source device for coupling atmospheric pressure interface orbitrap mass spectrometry, which belongs to the field of mass spectrometry detection and comprises a photo ionization / photo-induced association ionization ionization and ion transmission mechanism, a gas sample introduction mechanism, a high-flux radio frequency vacuum ultraviolet light source mechanism and an ion source and mass spectrometry interface mechanism. By adopting the composite ion source device for coupling the atmospheric pressure interface orbitrap mass spectrum, organic components with different polarities, ionization energy and ion affinity in a complex mixture can be efficiently ionized, and through reasonable structural design, the organic components are coupled with the high-resolution orbitrap mass spectrum with the atmospheric pressure interface, so that the high-resolution orbitrap mass spectrum is obtained. The detection range of complex organic components is widened, and the resolution capability and the detection sensitivity of low-abundance or high-molecular-weight organic components are improved.

Sample introduction system (50) for a spectrometer, comprising: a desolvation chamber (60) configured to obtain or generate sample ions from a solvent matrix and to detach at least a portion of the solvent matrix from the sample ions; a separation chamber (70) downstream of the desolvation chamber (60) and having a separation chamber inlet (72) in fluidic communication with the desolvation chamber (60) to receive the desolvated sample ions along with solvent vapors comprising non-ionized solvent and solvent ions, wherein the separation chamber (70) has electrodes (210, 220) for generating an electric field within the separation chamber (70) that defines a first flow path for sample ions between the separation chamber inlet (72) and a separation chamber outlet (75), but which causes unwanted solvent ions and unwanted non-ionized solvent vapors to be diverted away from the separation chamber outlet (75); and a reaction chamber (80) having an inlet in fluidic communication with the separation chamber outlet (75) to receive the sample ions from the separation chamber (70) and to decompose the received ions into smaller products.

The invention discloses a sampling device for ICP-MS (Inductively Coupled Plasma Mass Spectrometry) in the technical field of instrumental analysis. The sampling device comprises a liquid inlet mechanism and an atomization mechanism, the liquid inlet mechanism is used for inputting a liquid sample into the atomization mechanism, the atomization mechanism comprises a concentric atomizer and an atomization chamber, the concentric atomizer is communicated with the atomization chamber, and the atomization chamber is communicated with a waste liquid barrel and an ICP torch pipe; a self-cleaning mechanism is arranged on a communication path of the concentric atomizer and the atomizing chamber, the self-cleaning mechanism comprises a movable cylinder, the movable cylinder is rotationally connected into a nozzle of the concentric atomizer, contact electrodes are symmetrically arranged in the movable cylinder, and when the movable cylinder is blocked, the contact electrodes form a path; the contact electrode is electrically connected with a torsion mechanism and a reverse blowing mechanism, the torsion mechanism is used for twisting the movable cylinder when the contact electrode forms a path, and the reverse blowing mechanism is used for intercepting carrier gas input into the concentric atomizer and reversely blowing the carrier gas out of a nozzle of the concentric atomizer. According to the invention, self-cleaning can be carried out when blockage occurs in the sample introduction process, and sample analysis interruption caused by blockage is reduced.

The present invention relates to a mass spectrometric method for determining isomeric amino acid residues of a peptide and comprises the steps of: generating a list of peptide candidates using the amino acid lead sequence of the peptide, said lead sequence comprising positions of determined amino acid residues and at least one position with undetermined isomeric amino acid residues; predicting the collision cross section for each peptide candidate; comparing the predicted collision cross section of each peptide candidate with an experimentally determined collision cross section of the peptide and assigning the isomeric amino acid residues of the best matching peptide candidate to the isomeric amino acid residues of the peptide.

The presently disclosed subject matter provides compositions and methods for the synthesizing and the application of heterobifunctional photo-crosslinkers for the analysis of protein-protein interactions in mass spectrometry, tandem mass spectrometry, and cross-linking mass spectrometry.

The disclosure relates to methods for determining an amount of seawater, an amount of aquifer water, and an amount of original reservoir water in a produced water sample using oxygen and hydrogen isotope ratios. An 18O / 16O ratio (δ18O) and a D / H ratio (δD) are measured for a seawater sample, an aquifer water sample, and an original reservoir water sample and are used to make a mixing model. δ18O and δD are measured in a produced water sample and the mixing model can be used to determine the amounts of each constituent in the produced water sample.

The invention relates to the technical field of mass spectrometer sampling, in particular to a sampling device of an inductively coupled plasma mass spectrometer, which comprises a bottom plate, and an inductively coupled plasma mass spectrometer body is fixedly mounted at the top of the bottom plate. During application, the sample introduction mechanism adopts a first motor to drive a turntable to carry a sample during use, power is amplified through transmission of a large belt wheel and a small belt wheel, and a non-contact magnetic coupling drives a pumping spiral driving blade to rotate to generate negative pressure, so that automatic sample extraction, negative pressure control of opening and closing of a plugging plate and accurate control of a sample conveying channel are realized; by means of the design, carrying power is converted into pumping power, the equipment structure is simplified, the number of parts and energy consumption are reduced, the equipment operation and maintenance cost is reduced, an automatic continuous sample injection process replaces traditional single-pipe extraction, the sample injection time is greatly shortened, and the sample treatment efficiency is improved.

The invention relates to a femtosecond laser-assisted chemical ionization method for mass spectrometry of organic molecules. According to the method, high-concentration primary reagent ions are provided for subsequent chemical ionization by femtosecond laser ionization; high-concentration charges carried by primary reagent ions are transferred to a low-concentration to-be-analyzed sample by chemical ionization, the ionization volume of femtosecond laser ionization is equivalently enlarged, and meanwhile, the soft ionization characteristic of two ionization methods is maintained, so that the high-concentration to-be-analyzed sample can be analyzed under the condition of an open or closed air chamber. And carrying out ultrahigh-sensitivity mass spectrometry on the to-be-analyzed sample. The method is combined with a desorption technology or a liquid sample gas distribution device, and can be expanded to analysis of gas, solid and liquid samples; the device is compatible with wide air pressure conditions and can be applied to closed air chamber or open detection environment; the universality and soft ionization characteristics of femtosecond laser ionization and chemical ionization are reserved, and an ionization method with universality and ultrahigh sensitivity is provided for mass spectrometric detection of organic molecules.

The present invention relates to the field of analytical chemistry, and discloses a mass spectrum ionization element for macrolide antibiotic detection and a preparation method thereof, the mass spectrum ionization element comprises: a conductive substrate made of stainless steel; the adsorption layer is attached to at least part of the surface of the substrate, the adsorption layer is formed by a boric acid functionalized covalent organic framework, and the boric acid functionalized covalent organic framework is of a polycyclic structure composed of repeated units shown in the formula I in the specification. The mass spectrum ionization element is uniform in coating, high in selectivity on macrolide enriched antibiotics in a complex matrix and high in enrichment capacity, an eluent of the mass spectrum ionization element can be used for detection based on a liquid chromatography method and can also serve as a mass spectrum ion source solid substrate, mass spectrum detection is conducted through electrospray ionization, the detection steps are simple, and the mass spectrum ionization element is suitable for mass spectrum detection. And the detected background noise is low.

A method of operating an analytical instrument comprises ionising a sample to produce sample ions; (i) performing a first ion separation scan by separating sample ions according to a first physico-chemical property, and analysing the separated sample ions by performing one or more MS1 mass analysis scans; and (ii) performing a second ion separation scan by separating sample ions according to the first physico-chemical property, and analysing the separated sample ions by performing a plurality of MS2 mass analysis scans. Each MS2 scan of the plurality of MS2 mass analysis scans uses one MS2 isolation window of a plurality of MS2 isolation windows. The method further comprises analysing MS1 data acquired from the one or more MS1 mass analysis scan(s), and configuring the plurality of MS2 isolation windows based on the analysis of the MS1 data.

One embodiment of the invention is directed to a sample processing system for analyzing a biological sample from a patient. The sample processing system comprises: a plurality of analyzers comprising at least one mass spectrometer, wherein each analyzer in the plurality of analyzers is configured to acquire at least one measurement value corresponding to at least one characteristic of the biological sample; at least one data storage component which stores (i) a list of parameters for the plurality of analyzers, and (ii) at least two condition sets, which contain data associated with completing one or more test orders. The condition sets contain data which differ by at least one variable; and a control system operatively coupled to the plurality of analyzers, and the at least one data storage component. The control system is configured to (i) determine which condition set of the at least two condition sets to use based on the determined condition set, (ii) determine which analyzer or analyzers of the plurality of analyzers to use to process each test order based on the determined condition set and one or more parameters from the list of parameters, and (iii) cause the determined analyzer or analyzers to acquire one or more measurement values for the biological sample.

The invention discloses an online continuous detection system and method for feed components, and belongs to the technical field of production detection. Feed particles are made into powder, the humidity is measured, the ionization temperature is determined according to the humidity, the electric field intensity is adjusted, ionized ions are conveyed to the repulsion device through the transmission device, and the ions are conveyed to the analysis device by applying pulse voltage to the repulsion electrode. According to the data received by the analysis device, the type and content of the to-be-detected components in the feed are obtained, meanwhile, the activation time of the analysis device is calibrated according to the collection time of matrix ions in the feed, and the sampling drift of the system is reduced. Detection parameters are adjusted according to the physical form and chemical components of feed particles, non-stop continuous detection is achieved, and the device is suitable for large-scale production and meets the requirements of the workshop working environment.

The utility model discloses a combined rectangular tube structure which comprises a bottom support, a first inserting hole is formed in one end of the bottom support, a second inserting hole communicated with the first inserting hole is formed in the other end of the bottom support, an atomizer connector is inserted into the first inserting hole in a matched mode, and a central tube connector is inserted into the second inserting hole in a matched mode. The end, away from the atomizer connector, of the bottom support is detachably connected with a rectangular tube base, the end, close to the atomizer connector, of the rectangular tube base is provided with a third insertion hole matched with the central tube connector in an inserted mode, and a fourth insertion hole communicated with the third insertion hole is formed in the rectangular tube base. A fifth inserting hole communicated with the fourth inserting hole is formed in the end, away from the atomizer connector, of the rectangular tube base, a rectangular tube inner tube is inserted and matched with the end, away from the atomizer connector, of the central tube connector, and a rectangular tube middle tube arranged on the outer side of the rectangular tube inner tube in a sleeving mode is inserted and matched with the interior of the fourth inserting hole; a rectangular pipe outer pipe arranged on the outer side of the rectangular pipe middle pipe in a sleeving mode is inserted into the fifth inserting hole in a matched mode. The use cost of the instrument is saved.