Mass analysis system with low pressure differential mobility spectrometer

a mobility spectrometer and mass analysis technology, applied in mass spectrometers, instruments, separation processes, etc., can solve the problems of reducing the sensitivity of the instrument observed upon installation of the dms, eliminating the ability to decluster, and reducing the sensitivity of the dms, so as to improve the applicability of dms-ms analysis, improve the sensitivity and selectivity, and improve the mobility based resolution and specificity
US20110183431A1Inactive Publication Date: 2011-07-28MDS ANALYTICAL TECH A BUSINESS UNIT OF MDS +1
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
MDS ANALYTICAL TECH A BUSINESS UNIT OF MDS
Publication Date
2011-07-28
Estimated Expiration
Not applicable · inactive patent

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Abstract

A mass analysis system including a low pressure dissociation region and a differential mobility spectrometer. The differential mobility spectrometer including at least one pair of filter electrodes defining an ion flow path where the filter electrodes generate an electric field for passing through a selected portion of the sample ions based on the mobility characteristics of the sample ions. The differential mobility spectrometer also includes a voltage source that provides DC and RF voltages to at least one of the filter electrodes to generate the electric field, an ion inlet that receives sample ions that have passed through the low pressure dissociation region, and an ion outlet that outputs the selected portion of the sample ions. A mass spectrometer receives some or all of the selected portion of the sample ions.
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Description

REFERENCE TO RELATED APPLICATIONS

[0001] This application claims benefit of U.S. Provisional Application No. 61 / 299,086 filed Jan. 28, 2010 and entitled “Mass Analysis System With Low Pressure Differential Mobility Spectrometer” the entirety of which is incorporated herein by reference.INTRODUCTION

[0002] A Differential Mobility Spectrometer (DMS), also referred to as a Field Asymmetric Waveform Ion Mobility Spectrometer (FAIMS) or Field Ion Spectrometer (FIS), typically performs gas phase ion sample separation and analysis. In some circumstances, a DMS has been interfaced with a mass spectrometer (MS) to take advantage of the atmospheric pressure, gas phase, and continuous ion separation capabilities of the DMS and the detection accuracy of the MS.

[0003] By interfacing a DMS with an MS, numerous areas of sample analysis, including proteomics, peptide / protein conformation, pharmacokinetic, and metabolism analysis have been enhanced. In addition to pharmaceutical and biotech applications,...

Claims

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