553 results about "Mass analysis" patented technology

The invention discloses a coal and rock mass fracture instability multivariate signal fusion analysis method, and belongs to coal and rock mass analysis. The method comprises the following steps: carrying out time-frequency domain processing on an acoustic emission signal to obtain an accumulated ringing characteristic value # imgabs0 # and an accumulated b characteristic value # imgabs1 #; a main control frequency characteristic value # imgabs2 # and an amplitude characteristic value # imgabs3 # are accumulated; a spatial characteristic value # imgabs4 # of acoustic emission; fitting a fitting function # imgabs7 # from the characteristic value # imgabs5 # to the characteristic value # imgabs6 # respectively; according to the fitting function # imgabs8 #, calculating a correlation coefficient matrix R between the characteristic values # imgabs9 # to # imgabs10 #; according to the matrix R, determining a weight coefficient # imgabs11 # of each characteristic value; a first-order derivative function # imgabs13 # and a second-order derivative function # imgabs14 # of the fitting function # imgabs12 # are obtained, and according to the first-order derivative function # imgabs15 # and the second-order derivative function # imgabs16 #, a demarcation time point # imgabs17 # in the coal and rock mass damage process is determined; and the boundary time point # imgabs19 # is corrected by using the weight coefficient # imgabs18 #, and a corrected boundary time point # imgabs20 # is obtained. In order to solve the problems that an existing coal and rock mass fracture instability judgment index is single, and coal and rock mass fracture instability early warning is low in single index precision, the early warning precision is improved through multi-element signal fusion.

The invention discloses an intelligent data acquisition and optimization control system applied to a mine filling system, and relates to the technical field of computer automatic control, the system comprises an ore body stress analysis unit, a filling slurry solid phase mass analysis unit, a filling body physical property analysis unit and a filling control and analysis unit; the ore body stress analysis unit is used for establishing a three-dimensional ore body geometric model according to an ore body geological exploration result, dividing the three-dimensional ore body geometric model into finite element grids and calculating the solid phase mass concentration of filling slurry; the filling body physical property analysis unit is used for establishing a rheological model of the filling slurry according to the solid phase mass concentration of the filling slurry; and the filling control and analysis unit is used for calculating the filling stability according to the three-dimensional stress tensor field of the ore body and the pore water pressure of the filling slurry to obtain a stability coefficient. The filling speed can be intelligently controlled, the construction stability is evaluated in real time, and the safety and high efficiency of the filling construction process are ensured.

The invention belongs to the technical field of aircraft oil leakage monitoring, and relates to an aircraft oil leakage detection method based on a high-sensitivity mass spectrometry technology, and the method comprises the steps: obtaining a time-resolved mass spectrogram of aviation kerosene molecules in a sample testing stage, and storing the time-resolved mass spectrogram in a database; then oil gas molecules are captured at leakage-prone points of an aircraft pipeline system through a gas collection probe, the captured oil gas molecules are transmitted to an ion source end of a proton transfer reaction mass spectrometer through a negative pressure transmission system to be ionized to generate ions, and the ions are analyzed by a mass analysis system to obtain a mass spectrum; comparing the mass spectrogram obtained by analysis with a time-resolved mass spectrogram in a database, and judging whether leakage occurs or not; based on the method, the problems of insufficient anti-interference capability, difficulty in sample collection and the like of a high-sensitivity mass spectrum oil gas leak detection method can be solved in a targeted manner, and the functions of environmental interference suppression, efficient collection of oil gas molecules, improvement of spatial scanning resolution and the like can be realized at the same time.

The invention relates to the technical field of high-level liquid waste evaporation in nucleation post-treatment and nucleation glass curing, in particular to a liquid waste evaporation end point automatic judgment method and a liquid waste evaporation control method and device. The method comprises the following steps: acquiring waste liquid parameters of an evaporation system before evaporation and target parameters of waste liquid in a kettle type evaporator after evaporation; determining the target liquid level in the stock solution tank after evaporation according to the mass of the standard substance before evaporation calculated according to the waste liquid parameters, the target parameters of the waste liquid and the mass conservation of the standard substance before and after evaporation; according to the method, the mass of the standard substance of the waste liquid in the evaporation process is analyzed, and the evaporation end point is determined through mass conservation of the standard substance before and after evaporation, so that the evaporation end point can be automatically determined by analyzing the parameters of the waste liquid in the evaporation system, and the efficiency of the evaporation system is improved. Meanwhile, the evaporation end point is determined based on mass analysis and calculation of the target substance, so that the determination of the evaporation end point is more accurate.

A rock mass informatization model establishment method based on laser point cloud relates to the field of model identification and analysis, and is characterized by comprising the following steps: unmanned aerial vehicle laser data acquisition; establishing an inclination model; re-matching the laser point cloud flight strip; carrying out refined point cloud classification; establishing a triangulation network model; establishing a rock form model; establishing a rock mass information model; establishing a rock mass analysis system; and collapse simulation. The method provided by the embodiment of the invention has the advantages that the unmanned aerial vehicle can be used for carrying the laser radar to carry out close-to-land imitation flight, structures such as collapse, cracks and rockfall of the mountain under the dense forest can be directly measured by using the good vegetation penetrating ability of the laser point cloud, and compared with the original modes such as field investigation and photogrammetry, the method has the advantages that the measurement accuracy is greatly improved. The information obtained by the laser point cloud is more accurate and comprehensive, and the geometric dimension, the steep cliff section shape, the structural surface feature, the lithology, the boundary condition and other features of the dangerous rock mass can be directly confirmed.

Disclosed are methods for detecting and quantifying target analytes in a sample by mass analysis that include detecting the presence of ions of the target analyte in the sample and quantifying the amount of the target analyte. The methods can include one or more standards (e.g., internal and / or external standards) that may be labelled (e.g., isotopically labelled).

The invention relates to the technical field of instruments and meters, in particular to an inductively coupled plasma mass spectrometer system for intelligent data processing and report generation. Comprising a sample introduction unit, a plasma excitation and ionization unit, a mass analyzer and detection unit, a vacuum system unit and an intelligent data processing and report generation unit. Efficient ionization is achieved through a bipolar radio frequency switching and AI optimized reaction gas plasma source, the AI optimization module monitors in real time and dynamically adjusts parameters so that the ionization efficiency can be stabilized at 92% + / -2%, and meanwhile a reaction gas control system can optimize plasma conditions to suppress interference ions. And the mass analyzer and the detection unit realize high-precision ion separation by utilizing AI interference correction and a QMS-TOF double analyzer mode, and an interference elimination module can automatically eliminate polyatomic ion interference, so that the ionization efficiency, the analysis precision and the accuracy are improved, the interference is effectively inhibited, and the analysis capability of the system on a complex sample is enhanced.

To improve the performance of a mass spectrometer.SOLUTION: An ion trap type mass spectrometer that ionizes a sample adhering to a test object and separates ions on the basis of the mass and charge, comprises: a heating unit 1 which heats and vaporizes a sample; a sample introduction tube 10 which introduces the sample vaporized by the heating unit 1 to an ion source 15; the ion source 15 which applies a charge to the sample; a container 210 whose inside is in the vacuum state; a first pore 51 which introduces the sample ionized by the ion source 15 to the container 210; an ion trap unit 300 which is provided in the container 210; and a second pore 71, an intermediate lens 90 and an adjustment lens 110 which are sequentially provided between the first pore 51 and the ion trap unit 300 and transports the ions being the sample introduced to the container 210 to the ion trap unit 300. In the adjustment lens 110, the amount of ions passing through the adjustment lens 110 is controlled by a control unit connected to the mass spectrometer.SELECTED DRAWING: Figure 1

A method of mass spectrometry comprising: a) providing a mass spectrometer having a time of flight (TOP) mass analyser: b) performing a survey scan comprising separating a packet of precursor ion species and mass analysing ions so as to obtain first mass spectral data: c) determining a time window over which one of the precursor ion species. or fragment or product ions derived therefrom, were mass analysed: d) separating another packet of precursor ion species and mass analysing ions so as to obtain second mass spectral data. wherein the pusher of the TOP mass analyser is pulsed according to a plurality of consecutive pulse sequences during a plurality of respective pulse sequence time periods. wherein each pulse sequence consists of consecutive pushes that are arranged such that the duration between any pair of pushes in the pulse sequence is different to the duration between any other pair of pushes within the pulse sequence: f) selecting mass spectral data, from the second mass spectral data, that was obtained during a time period corresponding to said time window of the survey scan, so as to obtain selected data; g) repeating steps d) to f) at least one further time such that multiple sets of said selected data are obtained; combining said multiple sets of selected data and decoding the combined data to obtain mass spectral data representative of the mass to charge ratios of the ions detected by the TOP mass analyser.

The vacuum interface of the mass spectrometer comprises a main body part and a sample introduction piece, the main body part is provided with an interface body and a first connecting piece which are formed into a split piece, one end of the first connecting piece is connected with the interface body, the interface body is formed into an integrally formed piece, and the interior of the interface body is hollow to form a vacuum cavity; the vacuum cavity is provided with a first opening and a second opening which are oppositely arranged, a mass analyzer is suitable for being arranged in the vacuum cavity, the sample injection piece is arranged at the first opening and detachably connected with the other end of the first connecting piece, the sample injection piece is provided with a sample injection port communicated with the first opening, the sample injection port is used for conveying ions to be detected towards the vacuum cavity, and the sample injection port is communicated with the second opening in the direction towards the vacuum cavity. And the opening sizes of at least part of the sample inlets are gradually increased. According to the vacuum interface of the mass spectrometer provided by the embodiment of the invention, not only can the installation precision of the sample introduction piece be ensured, but also the interface body has good sealing performance, so that the working performance of the mass spectrometer can be improved.

The present disclosure relates to the field of mass spectrometry, and particularly provides a method for determining a chemical structure of a lipid and an ion mobility-tandem mass spectrometer. The method for determining a chemical structure of a lipid includes: an ionization step of ionizing a sample to obtain sample ions; an ion mobility-based separation step of separating target lipid ions from the sample ions based on ion mobility; a first dissociation step of dissociating the target lipid ions with dissociation energy adjusted to break a first chemical bond of the target lipid ions; a mass-based selection step of selecting the target lipid ions, whose first chemical bond is broken, based on a mass number to obtain fragment ions; a second dissociation step of dissociating the fragment ions to at least break a second chemical bond of the fragment ions which has bond energy higher than the first chemical bond, to obtain diagnostic ions; and a mass analysis step of performing a mass analysis on the diagnostic ions.

A method of calibrating a mass spectrometer 10 is provided. The method comprises generating calibration ions from an ion source 20. The calibration ions are transported from the ion source 20 to a mas

A hybrid inductively coupled plasma mass spectrometer (ICP-MS) system is disclosed for simultaneous elemental and molecular analysis in positive and negative polarities. It includes an ICP torch that generates plasma with a buffer gas, producing both positively and negatively charged ions from a sample. Positioned between the sampler and skimmer, an insert with a defined geometry forms a reaction chamber. Various embodiments feature multiple apertures for pressure control, a rotatable disk for aperture regulation, a slider gate for pressure adjustment, a circular gate with adjustable radial apertures, and an inlet for introducing gases, reagents, dopants, or analytes. These components enable precise pressure modulation, optimizing performance for dual-polarity mass spectrometry. The system enhances analytical flexibility by facilitating controlled ion reactions, improving sensitivity and specificity for both elemental and molecular applications. This innovation expands ICP-MS functionality, supporting diverse scientific and industrial applications requiring high-precision mass analysis.

The invention belongs to the technical field of online analysis of organic pollutants, and particularly relates to a device and a method for real-time online analysis of non-volatile organic pollutants. The device comprises a sample injection module, a vacuum ultraviolet lamp, an ionization source cavity, a repulsion electrode, an ion funnel, a mass analyzer and a vacuumizing module, the ionization source cavity is provided with a sample injection port, a vacuum extraction port and an ion output port, and the vacuum ultraviolet lamp, the repulsion electrode and the ion funnel are sequentially arranged in the ionization source cavity at intervals in the axis direction of the ion output port; the ion funnel is close to the ion output port; the sample injection module is arranged at the sample injection port; the vacuumizing module is arranged on the vacuum extraction opening; the ion output port is externally connected with a mass analyzer; a direct-current voltage is applied to the repulsion electrode, and a direct-current voltage and a radio-frequency voltage are applied to the ion funnel. According to the invention, the ions with relatively large initial distribution area can be focused, so that the detection sensitivity is further improved, and the detection requirements on trace non-volatile organic pollutants are met.

The present subject matter is related to identification / extraction and quantification of mass separated chromatographic peaks obtained from chromatography coupled mass spectrometry instruments This includes both liquid and gas chromatography as well as high resolution and triple quadrupole type mass analyzers. This also includes the case when these are operated in conjunction with ion mobility separation devices. The raw data generated by the instrument is first converted into an open source format such as the mzML format, obvious noise is removed by applying ad hoc filters, mass scans are centroided, regions of interest (ROI) are built in Retention Time dimension, ROIs are binned into 3 or more buckets, longer ROIs are broken into special smaller ROIs using overlapping and sliding window approach, ROIs are classified as peak or noise, peak boundaries identified if classified as peak, longer ROIs formed from special smaller ROIs, and chromatography coupled mass spectrometry data Features are quantified and reported in Retention Time dimension. The ROI classification and peak boundary detection steps make use of specially trained deep learning methods.

The present invention relates to a mass spectrometer for analyzing an analyte sample, comprising: a plasma ion source configured to generate a plasma; an interface device configured to form a plasma flux from the plasma and flow it to the mass analyzer, where the interface device comprises at least one cone comprising an orifice through which the plasma flux flows and at least one capillary comprising an inlet and an outlet, an outlet and arranged and configured to introduce an analyte sample into the plasma flux at the orifice or in the plasma expansion zone downstream of the orifice such that the analyte sample is ionized by means of the plasma flux and ions are generated, with the outlet in contact with the plasma flux; a mass analyzer configured to filter and / or separate the generated ions; and a detector configured to detect ions generated from the analyte sample.

The invention discloses a coal body compression mechanical test acoustic emission signal processing method and system, and relates to coal rock mass analysis. The method comprises the steps that under the supercritical water coupling effect condition, an acoustic emission original data set of the whole coal body uniaxial compression damage process is collected; respectively carrying out time domain processing, frequency domain conversion and spatial positioning calculation on the original data set, and outputting a time domain characteristic parameter, a frequency domain characteristic parameter set and a spatial position parameter set; and performing data fusion on the time domain characteristic parameter set, the frequency domain characteristic parameter set and the spatial position parameter set, establishing a multi-dimensional characteristic data matrix through time synchronization, and analyzing acoustic emission signal laws of different damage stages of the coal body under the supercritical water coupling effect. Aiming at the low recognition precision of the coal body damage stage under the supercritical water coupling effect, the recognition precision is improved by performing time domain processing, frequency domain conversion, spatial positioning calculation and the like on an acoustic emission original data set.

Systems and methods are disclosed for performing a DDA mass spectrometry experiment. A precursor ion survey scan of a mass range is performed to generate a precursor ion peak list. A series of steps are performed for each precursor ion peak of the peak list. A peak mass range including the precursor ion peak is selected. A precursor ion mass selection window with a width smaller than the peak mass range is canned across the peak mass range in overlapping steps, producing a series of overlapping windows across the peak mass range. Each overlapping precursor ion mass selection window of the series is fragmented. Product ions produced from each overlapping precursor ion mass selection window of the series are mass analyzed, producing a product ion spectrum for each overlapping precursor ion mass selection window of the series and a plurality of product ion spectra for the peak.

A method for determining a convolved peak intensity in a sample trace includes ejecting a plurality of sample ejections from a sample well plate. An ejection time log is generated which includes an ejection time of each of the plurality of sample ejections from the sample well plate. The plurality of sample ejections is analyzed with a mass analyzer. The sample trace of intensity versus time values is produced for the plurality of sample ejections based on the analysis. A known peak shape is obtained. A convolved peak intensity is determined for a convolved peak of the sample trace based at least in part on the known peak shape and the ejection time log.

Method and system of mass spectrometry is provided. The method comprises performing a first and a second MS1 scans on precursor ions produced by ionising a sample. The first MS1 scan comprises mass analysing a first set of the precursor ions transported to a mass analyser using an ion transport device operated at a first setting. The second MS1 scan comprises mass analysing a second set of the precursor ions transported to a mass analyser using the ion transport device operated at a second setting. Energies imparted on the precursor ions by the ion transport device are different in the first and second settings. Based on intensities of mass spectral peaks of the first and second MS1 scans, a mass spectral peak in at least one of the first MS1 scan or the second MS1 scan indicative of a precursor ion mass spectral peak is determined.

A method and corresponding devices to reduce the presence of unwanted ions within the pseudo-potential well of the RF fields for inductively coupled plasma mass spectrometry is disclosed. This method reduces space-charge effects and leaves more room available for the ions of interest and, hence, leads to increased transmission of the desired ions into the mass analyzer. In the present invention, the space charge is reduced by adding a low-band resolving DC potential, or a fast sweeping resolving DC potential with a notch, or a fast constant resolving DC potential with a notch, or by adding auxiliary quadrupolar or dipolar RF potential to the quadrupole ion guide, such that all the unwanted ions will be outside the stable region and therefore ejected. This reduces the charge density in the ion beam and ameliorate space charge effects.

An analytical instrument comprises an ion mobility separator, a mass filter downstream of the ion mobility separator, and a mass analyser downstream of the mass filter. The ion mobility separator performs ion mobility separation scans to separate ions according to ion mobility. The mass filter filters the separated ions using an isolation window, and during each scan: (i) scanning a centre mass to charge ratio (m / z) of the isolation window, and (ii) controlling a width Δmz of the isolation window such that ions emerging from the ion mobility separator within an ion mobility arrival time range ΔT are transmitted by the mass filter. The mass analyser performs mass analysis scan(s) during each ion mobility separation scan in which the mass analyser analyses ions transmitted by or derived from ions transmitted by the mass filter, each mass analysis scan having a duration T, and wherein ΔT<T.

A method of operating an analytical instrument comprises ionising a sample to produce sample ions; (i) performing a first ion separation scan by separating sample ions according to a first physico-chemical property, and analysing the separated sample ions by performing one or more MS1 mass analysis scans; and (ii) performing a second ion separation scan by separating sample ions according to the first physico-chemical property, and analysing the separated sample ions by performing a plurality of MS2 mass analysis scans. Each MS2 scan of the plurality of MS2 mass analysis scans uses one MS2 isolation window of a plurality of MS2 isolation windows. The method further comprises analysing MS1 data acquired from the one or more MS1 mass analysis scan(s), and configuring the plurality of MS2 isolation windows based on the analysis of the MS1 data.

A method of operating an analytical instrument is provided. The analytical instrument comprises: an ion mobility separator; a mass filter disposed downstream of the ion mobility separator; and a mass analyzer disposed downstream of the mass filter. The method includes an ion mobility separator performing a plurality of ion mobility separation scans, where in each ion mobility separation scan, the ion mobility separator receives ions and separates the ions according to their ion mobility. The method includes the mass filter filtering the separated ions using an isolation window, and during each ion mobility separation scan: (i) scanning the center mass-to-charge ratio (m / z) of the isolation window, and (ii) controlling the width [Delta] mz of the isolation window such that during the ion mobility separation scan, the center mass-to-charge ratio (m / z) of the isolation window is greater than the center mass-to-charge ratio (m / z) of the isolation window. Ions emerging from the ion mobility separator over an ion mobility arrival time range [Delta] T are transported by the mass filter. The method includes the mass analyzer performing one or more mass analysis scans during each ion mobility separation scan, where in each mass analysis scan, the mass analyzer receives and analyzes ions transmitted by the mass filter or ions sourced from the ions transmitted by the mass filter, wherein each mass analysis scan has a duration T, and wherein [Delta] Tlt; t.

In this composition estimation method, first data that includes a change in mass of a sample and second data that includes the mass spectrum of the gas constituents of a sample are acquired. The second data is broken down into the product of a base spectrum matrix and an intensity distribution matrix by non-negative matrix factorization; a second intensity distribution matrix is obtained by correcting the effects of differences in ionization efficiency for each gas constituent reflected in the intensity distribution matrix on the basis of the first data to produce a mass reference; the second intensity distribution matrix is subjected to non-negative matrix factorization and broken down into the product of a matrix that includes mass proportions in each sample of a virtual sample and a matrix that includes characteristic vectors of the virtual sample; a (k − 1)-dimensional simplex is established that encompasses all of the characteristic vectors and has characteristic vectors as end members; and the content ratio of each constituent element in the sample is estimated on the basis of the distance ratios between K end members and the characteristic vectors of the sample. According to this method, the problem of the accuracy and / or the reproducibility inherent in conventional methods can be improved.

A trace of intensity versus time values is received for a series of samples produced by a mass spectrometer. Also, a series of ejections times corresponding to the series of samples produced by a sample introduction system is received. A series of expected peak times corresponding to the series of ejection times are calculated using a known delay time from ejection to mass analysis. At least one isolated peak of the trace is identified using the series of expected peak times. A peak profile is calculated by fitting a mixture of at least two different distribution functions to the at least one isolated peak. For at least one time of the series of expected peak times, an area of a peak at the one time is calculated by fitting the peak profile to the trace at the one time and calculating an area of the fitted peak profile.

Systems and methods are disclosed for automated method parameter configuration for differential mobility separations. As non-limiting examples, various aspects of this disclosure provide receiving a sample in an open port interface; transferring the sample to an ionization source; ionizing the transferred sample; introducing the ionized sample into a mass spectrometer; mass analyzing the ionized sample to produce an initial mass analysis result; determining a peak width of the initial mass analysis result; and determining a dwell time for subsequent measurements based on the determined peak width, a pre-defined number of data points across subsequent mass analysis peak widths, and a number of different analytes to be assessed for the sample. The sample may be diluted and transferred to the ionization source by a sample introduction apparatus selected from a group including an acoustic droplet ejector (ADE), a pneumatic ejector, a piezoelectric ejector, and a hydraulic ejector.

The invention relates to the technical field of rock mass analysis, in particular to a karst area limestone mechanical property degradation mechanism analysis method and system, and the method comprises the following steps: obtaining limestone of a karst area to construct a limestone test sample; testing the limestone test sample to obtain a test result; observing the limestone test sample to obtain a microscopic feature observation result of the limestone test sample; analyzing the microscopic characteristic observation result to obtain a microscopic characteristic analysis result of the limestone test sample; and analyzing the limestone mechanical property degradation mechanism by combining the test result and the microscopic characteristic analysis result. The dynamic corrosion test is constructed to more accurately fit the rock mass degradation condition in the natural environment, and the change rule of the limestone mechanical property parameters is researched based on the dynamic corrosion test, so that the mechanical property degradation mechanism of the limestone in the karst area is analyzed, and a reliable theoretical technical support is provided for engineering application.

A dual analyser mass spectrometer obtains MS1 / MS2 scans of positive and negative ions by: operating an ion source and processing region at a first polarity; performing, by a first mass analyser (FMA) at the first polarity, MS1 or MS2 scan(s); switching polarity of the FMA to a second polarity; performing, by a second mass analyser (SMA) at the first polarity, MS1 or MS2 scan(s), wherein at least part of the MS1 or MS2 scan(s) performed by the SMA is performed while the FMA is switching polarity. Alternatively, the FMA may be operated at a first polarity and the SMA at a second polarity opposite to the first, and after initiating at least one MS1 scan and / or MS2 scan by the FMA, switching the polarity of the source and ion processing region to a second polarity and performing at least one MS1 scan and / or MS2 scan with the SMA.

Systems and methods are disclosed for dynamically switching an ion guide and a TOF mass analyzer between concentrating or not concentrating ions in a targeted acquisition. Product ions are ejected from the ion guide into the TOF mass analyzer and the intensity of a known product ion is measured at two or more time steps. The ion guide initially ejects product ions using a sequential or Zeno pulsing mode that concentrates product ions with different m / z values within the TOF mass analyzer at the same time. If the intensity of the product ion is increasing and greater than a threshold intensity, the ion guide switches to a continuous or normal pulsing mode that does not concentrate ions with different m / z values in the TOF mass analyzer at the same time. Similarly, if the intensity decreases below a threshold in continuous mode, the ion guide switches back to sequential mode.