103 results about "Mass analysis" patented technology

Systems and methods are disclosed for automated method parameter configuration for differential mobility separations. As non-limiting examples, various aspects of this disclosure provide receiving a sample in an open port interface; transferring the sample to an ionization source; ionizing the transferred sample; introducing the ionized sample into a mass spectrometer; mass analyzing the ionized sample to produce an initial mass analysis result; determining a peak width of the initial mass analysis result; and determining a dwell time for subsequent measurements based on the determined peak width, a pre-defined number of data points across subsequent mass analysis peak widths, and a number of different analytes to be assessed for the sample. The sample may be diluted and transferred to the ionization source by a sample introduction apparatus selected from a group including an acoustic droplet ejector (ADE), a pneumatic ejector, a piezoelectric ejector, and a hydraulic ejector.

Systems / techniques are provided for facilitating mass analyzer calibration via reinforcement learning. In various embodiments, a system can predict, via execution of one or more reinforcement learning neural networks on present-time state data of a mass analyzer of a scientific instrument, what adjustments to one or more operational parameters of the mass analyzer would cause the mass analyzer to approach a calibrated state, wherein the one or more operational parameters include an electrode voltage of the mass analyzer or a timing control of the mass analyzer. In various aspects, the system can modify the one or more operational parameters based on the adjustments, thereby causing the mass analyzer to approach the calibrated state.

Methods for acquiring mass spectral data of a sample across at least a portion of an m / z range include receiving mass spectral data of the sample across the m / z range. The m / z range is partitioned into one or more sets of m / z sub-ranges, each set comprising one or more m / z sub-ranges, by dividing the m / z range into a plurality of m / z bins, determining an indication of ion abundance for each m / z bin, based on the mass spectral data, and forming an m / z sub-range of the one or more sets of m / z sub-ranges by assigning m / z bins having ion abundances that correspond to at least a threshold degree to the formed m / z sub-range. A mass analysis is performed on the sample for each set of m / z sub-ranges, thereby acquiring one or more partial mass spectral data sets.

The application discloses a coal body compression mechanics test acoustic emission signal processing method and system, relates to coal and rock mass analysis, and comprises the following steps: collecting acoustic emission original data sets of the whole process of coal body uniaxial compression destruction under the condition of supercritical water coupling; respectively performing time domain processing, frequency domain conversion and space positioning calculation on the original data sets, outputting time domain characteristic parameters, a frequency domain characteristic parameter set and a space position parameter set; fusing the time domain characteristic parameter set, the frequency domain characteristic parameter set and the space position parameter set, establishing a multi-dimensional characteristic data matrix through time synchronization, and analyzing acoustic emission signal rules of different destruction stages of the coal body under the condition of supercritical water coupling. The application improves the recognition accuracy by performing time domain processing, frequency domain conversion and space positioning calculation on the acoustic emission original data set, and solves the problem of low recognition accuracy of the coal body destruction stage under the condition of supercritical water coupling.

The invention provides a mass spectrum detector which comprises a shell, a sample injection device, a gas analysis device, a vacuum device and a control device, the sample injection device comprises a valve terminal, the valve terminal is arranged in the shell and used for being communicated with a to-be-detected sample, the gas analysis device is arranged in the shell and comprises an ion source, a mass analyzer and a detector, and the vacuum device is arranged in the shell and used for being communicated with the to-be-detected sample. The ion source is communicated with the valve terminal, the input end of the mass analyzer is communicated with the ion source, the output end of the mass analyzer is communicated with the detector, the vacuum system is arranged in the shell, the vacuum system is communicated with the mass analyzer, the control device is arranged in the shell, the control device is connected with the detector, and the control device is electrically connected with the ion source, the mass analyzer and the detector. Wherein the valve terminal is used for realizing gas circuit connection and on-off control among a to-be-tested sample, the gas analysis device and the vacuum device. By adopting the scheme, the mounting efficiency of the mass spectrum detector can be improved, the control efficiency of the gas circuit is improved, and the sample injection device is convenient to maintain.

To provide a system for performing multiplexed ion pre-separation for mass spectrometry.SOLUTION: The system includes a pre-separation device for separating the precursor ions into a set of discrete fractions of precursor ions based on a physical property of the precursor ions and for sequentially transmitting a first subset of the discrete fractions of precursor ions included in the set of discrete fractions of precursor ions. The system further includes a mass spectrometer positioned downstream of the pre-separation device for receiving the first subset of the discrete fraction of precursor ions. The mass spectrometer includes an ion storage for accumulating a first population of product ions generated from each discrete fraction of precursor ions included in the first subset of discrete fractions of precursor ions and a mass analyzer for performing mass analysis of the first population of product ions.SELECTED DRAWING: Figure 1

A data processing device (20) for a liquid chromatograph, capable of performing peak tracking regardless of a mass spectrum pattern, is provided with: a storage unit (21) in which first chromatographic data and first mass analysis data for a main detector based on first analysis conditions and second chromatographic data and second mass analysis data for the main detector based on second analysis conditions are stored; a chromatographic peak extraction unit (34) that extracts a first peak and a second peak from the first chromatographic data and the second chromatographic data; a mass-to-charge ratio acquisition unit (35) that acquires the mass-to-charge ratio of ions in the first peak and the mass-to-charge ratio of ions in the second peak; a molecular weight calculation unit (36) that calculates molecular weights on the basis of the mass-to-charge ratio of the first peak and the mass-to-charge ratio of the second peak; and a peak correlation unit (37) that correlates the first peak and the second peak on the basis of the molecular weight of the first peak and the molecular weight of the second peak.

A high-energy ion implantation system has an ion source and mass analyzer to form and analyze an ion beam along a beam path. A first RF LINAC accelerates the ion beam to a first accelerator exit, and a second RF LINAC accelerates the ion beam to a second accelerator exit along the beam path. A first magnet between the first and second RF LINACs alters the beam path along a first plane. A third RF LINAC accelerates the ion beam, and a second magnet between the second and third RF LINACs alters the beam path along a second plane. A beam shaping apparatus defines a shape of the ion beam, and a third magnet between the third RF LINAC beam shaping apparatus alters the beam path along a third plane, where the first, second, and third planes are not coplanar.

The application discloses a high-inert electrostatic dissipation type collision cell device and a mass spectrometer system thereof, comprising a collision cell device, one end of the collision cell device is connected with a first quadrupole mass analyzer, the other end of the collision cell device is connected with a third quadrupole mass analyzer, and a metal flange is assembled at the positions where the collision cell device is connected with the first quadrupole mass analyzer and the third quadrupole mass analyzer.The high-inert electrostatic dissipation type collision cell device and the mass spectrometer system thereof increase a gas path precise regulation and control module, the module can accurately adjust the gas inlet flow, pressure and gas inlet rate of the collision gas according to the type and ion property of the detected sample, cooperates with a gas flow guide structure in the gas chamber shell, realizes uniform distribution of the collision gas in the gas chamber, supports dynamic switching and precise proportioning of the collision gas at the same time, adapts to different collision dissociation requirements, and improves the universality and detection flexibility of the device.

The invention discloses an ion control device and a mass spectrometer, and belongs to the technical field of mass spectrometers, the ion control device has a guide mode, a deflection mode and a pulse release mode, in the guide mode, the ion control device continuously transmits ions generated by an ion source to a first mass analyzer through first electric field configuration, and in the deflection mode, the ion control device continuously transmits the ions generated by the ion source to a second mass analyzer through second electric field configuration. In a pulse release mode, the ion control device firstly enriches ions generated by the ion source through second electric field configuration, then transmits the enriched ions to the second mass analyzer through third electric field configuration, and in a pulse release mode, the ion control device firstly enriches ions generated by the ion source through fourth electric field configuration, and transmits the enriched ions to the second mass analyzer through third electric field configuration. The enriched ions are then synchronously transmitted to a first mass analyzer through a fifth electric field configuration. The ion control device can be used as a universal ion router, the transmission direction and transmission mode of ions are changed through electrical control, high integration of multiple functions is achieved, the instrument structure is remarkably simplified, and the cost is reduced.

In various aspects, the methods and systems disclosed herein are capable of operating a Fourier transform mass spectrometer (FTMS) quadrupole mass analyzer in two modes of operation: transmission mode and trapped mode. In trapped mode, ions are first trapped and cooled within the FTMS mass analyzer, then subjected to an excitation pulse and ejected from the FTMS mass analyzer for detection. However, in transmission mode, the FTMS mass analyzer can provide faster analysis because the excitation pulse is applied to ions of a beam of ions that are continuously transmitted through the FTMS mass analyzer.

The mass spectrometer includes a storage device and an analyzer. The analyzer includes a mirror, an accelerator that receives ions from the storage device and pulses them onto one of the mirrors, causing the ions to reflect back and forth in a first dimension between the mirrors as the ions drift in the drift dimension, a reflector that reflects the ions in the drift dimension, a detector, and control circuitry that activates the reflector to make multiple passes along the drift dimension and deactivates one of the reflectors so that the ions pass to the detector and can be detected, the timing of the reflector activation and deactivation being such that only ions within a first range of mass-to-charge ratios undergo the same number of passes in the drift dimension at any one time that they are detected by the detector. The control circuitry synchronizes the time of pulses from the storage device with the time of pulses from the ion accelerator so that only ions having a mass-to-charge ratio within the first range are pulsed onto one of the mirrors by the accelerator.

In one aspect, an apparatus for use in a mass spectrometer is disclosed, which comprises an ion reaction device, which includes an ion dissociation unit (e.g., an ion-electron interaction unit) that can receive a plurality of precursor ions and cause their dissociation to generate a plurality of product ions, and a linear ion trap that can receive the product ions and isolate a target product ion of interest for mass analysis. The linear ion trap is positioned in a magnetic field and includes a set of quadrupole rods formed of a paramagnetic material to substantially shield the space between the quadrupole rods from the magnetic field, thereby reducing and preferably eliminating the interference of the magnetic field with the process of isolating the target product ion of interest.

This invention relates to the field of metal detection technology and discloses a precious metal detection and analysis device, including a main unit with a mass analyzer installed inside. The device further includes: an atomizing component for atomizing a sample solution into an aerosol; a mixing component for dividing argon gas into multiple fine gas streams to contact the aerosol; and a grinding component for grinding undissolved solutes in the sample solution. The mixing component also includes a stirring section for promoting the mixing of argon gas and the aerosol. Through the cooperation of the mixing component and the atomizing component, the multiple pores of the mixing tube, in conjunction with the inlet hood, allow argon gas to be dispersed into multiple fine gas streams. As these pores rotate continuously, the argon gas enters the mixing tube through the pores and contacts the aerosol, thereby increasing the contact area between argon gas and the aerosol and preventing localized argon gas accumulation.

The utility model discloses a mass analyzer and ion implantation equipment, and the mass analyzer comprises a cavity which is internally provided with an ion channel for the circulation of an ion beam current; the beam current detection device is movably installed in the ion channel, the beam current detection device comprises a beam current receiving assembly used for receiving the ion beam current, and when the beam current detection device is in a detection state, the beam current receiving assembly blocks the ion channel, so that the first surface of the beam current receiving assembly receives the ion beam current; the purpose of detecting the beam current in the middle section of the beam current is achieved, when the ion beam current detection result does not meet the preset requirement and the beam current needs to be adjusted, due to the fact that the number of parts needing to be adjusted in front of the mass analyzer is small, the difficulty of adjusting the ion beam current is reduced, and the efficiency of adjusting the ion beam current is also improved.

A method for determining the presence of a perfluoro- or polyfluorochemical (PFC), such as a PFAS compound, in a sample is described. The method involves generating sample ions from the sample using electron impact ionization (El), direct laser ionization, or field desorption ionization, and mass-analyzing the sample ions using a mass analyzer to generate mass spectral data. The mass analyzer has a mass accuracy of approximately ≤ 100 ppm and a resolution of approximately ≥ 10,000. The method further includes determining whether an ion peak is present in the mass spectral data exhibiting an accurate mass-to-charge ratio within ± 100 ppm of a first accurate mass-to-charge ratio (m / z). The first accurate mass-to-charge ratio (m / z) is the exact mass-to-charge ratio of an ion that indicates the presence of a PFC in the sample.The procedure further includes determining whether a PFC is present in the sample if it is determined that an ion peak is present which has an accurate mass-to-charge ratio within ± 100 ppm of the first accurate mass-to-charge ratio m / z.

This invention discloses an isotope separation and enrichment device with a multipole mass analyzer, comprising a pre-chamber and a vacuum chamber, and a vacuum interface between the two. An ICP ion source assembly is installed inside the pre-chamber, and the ICP ion source assembly is connected to an ion extraction system inside the vacuum chamber via the vacuum interface. The multipole mass analyzer is connected to the rear side of the ion extraction system, followed by a pluggable receiver and a signal amplifier. The isotope separation and enrichment device also includes an electronic control system. This invention can improve the ionization efficiency of existing technologies, reduce device construction costs, and reduce maintenance difficulty.

A multi-reflection mass analyser comprises a pair of opposed ion-optical mirrors elongated linearly along a longitudinal axis that extends centrally through the mass analyser, and either one or both ion-optical mirrors comprises a series of spaced apart electrodes. Each electrode is elongated along the longitudinal axis. The series of electrodes extend in a direction transverse to the longitudinal axis and the electrodes are spaced apart by a series of gaps. The series of electrodes comprises a first pair of adjacent electrodes and a second pair of adjacent electrodes. The first pair of adjacent electrodes are separated by a straight gap defined by respective straight edges of the adjacent electrodes. The second pair of adjacent electrodes are separated by a curved gap defined by respective curved edges of the adjacent electrodes.

The application discloses an ion manipulation device and a mass spectrometer, and belongs to the technical field of mass spectrometers. The ion manipulation device has a guiding mode, a deflection mode and a pulsed release mode. In the guiding mode, the ion manipulation device continuously transmits ions generated by an ion source to a first mass analyzer through a first electric field configuration. In the deflection mode, the ion manipulation device first enriches the ions generated by the ion source through a second electric field configuration, and then transmits the enriched ions to a second mass analyzer through a third electric field configuration. In the pulsed release mode, the ion manipulation device first enriches the ions generated by the ion source through a fourth electric field configuration, and then synchronously transmits the enriched ions to the first mass analyzer through a fifth electric field configuration. The ion manipulation device can be used as a general ion router, and can change the transmission direction and mode of the ions through electrical control, realize the high integration of multiple functions, and significantly simplify the instrument structure and reduce the cost.

Systems / techniques are provided to facilitate the calibration of mass analyzers using reinforcement learning. In various embodiments, a system can predict, by executing one or more neural reinforcement learning networks on current state data of a mass analyzer in a scientific instrument, which adjustments to one or more operating parameters of the mass analyzer would cause it to approach a calibrated state. These operating parameters include an electrode voltage or timing of the mass analyzer. Based on these adjustments, the system can modify the operating parameter(s) in various ways, thereby causing the mass analyzer to approach the calibrated state.

This invention discloses an isotope separation and enrichment method using a multipole mass analyzer, comprising: injecting a high-concentration solution into a first chamber; ionizing the high-concentration solution in the first chamber using an ICP ion source assembly to form plasma; the plasma vacuum chamber formed in the first chamber then enters an ion extraction system; the extracted ions are introduced into a subsequent multipole mass analyzer; adjusting the voltage applied to the multipole mass analyzer according to the different elements in the sample to be enriched, so that a specific isotope to be separated passes through the multipole mass analyzer and enters a subsequent receiver; this invention can improve the ionization efficiency of existing technologies, reduce the construction cost of the device, and reduce the difficulty of maintenance.

A method of performing mass spectrometry includes accumulating ions resulting from components eluted from a chromatographic column over an accumulation time and transferring the accumulated ions to a mass analyzer. During an acquisition, a mass spectrum is acquired of detected ions originating from the transferred ions. An elution profile is obtained from a series of acquired mass spectra including the acquired mass spectrum and a plurality of previously acquired mass spectra. The elution profile includes a plurality of detection points representing a change in intensity of the detected ions over time. A current signal state of the elution profile is classified based on a subset of detection points included in the plurality of detection points. The accumulation time is set for a next acquisition of a mass spectrum based on the classified current signal state of the elution profile.

A method for quantifying Hex4, lyso-GM1, Fuc-GlcNAc-Asn, or lyso-sulfatide included in cerebrospinal fluid, the method including adding an internal standard substance to a solution including the cerebrospinal fluid, submitting the solution including the cerebrospinal fluid, to which the internal standard substance has been added, to liquid chromatography to obtain an eluate, and subjecting the eluate to mass analysis.

The invention discloses a single-focus high-resolution mass analyzer system and an aberration adjustment method. The system comprises an ion source, a fan-shaped electromagnet, a detector and a static octopole rod, an ion beam formed by the ion source enters the detector through the fan-shaped electromagnet; the electrostatic octupole rod is arranged between the ion source and the fan-shaped electromagnet and / or between the fan-shaped electromagnet and the detector, and aberration of the ion beam current is reduced or eliminated by adjusting voltage combination of the electrostatic octupole rod; and the electrostatic octupole rod is of a regular octupole rod structure with a vertical antipode rod. According to the invention, the octupole rod is added in the single-focus mass analyzer system as a universal tuner, so that various aberrations of the single-focus mass analyzer are eliminated and reduced, and the purposes of simple structure, single focus and high resolution are achieved; the double-focus high-resolution mass analyzer system applied at present is replaced, the instrument structure and the operation process can be simplified, and the cost of a high-resolution mass spectrometer is reduced.

The invention discloses a 3D printing manufacturing method of a linear ion trap mass analyzer for a QTRAP composite mass spectrum system. The method comprises the following steps: firstly, constructing an integrated 3D printing model, then integrally forming a ceramic green body comprising an electrode stem, an insulating fixing ring, an Exit Barrier lens holder and a Collars annular flange by adopting a photocuring ceramic 3D printing technology, carrying out post-treatment to obtain a sintered structure, and then carrying out surface pretreatment. And then, a selective PVD / CVD gold plating process is adopted to be matched with a precise shielding template, an electrical function partition is formed on the same ceramic substrate, the main body electrode area and the Collars electrode area are made to be plated with gold and conductive, and the preset ceramic isolation belt is kept insulated. And finally, post-processing and precision detection are performed on the gold-plated assembly, and manufacturing is completed. Multi-part assembly errors are eliminated through integrated forming, a traditional sapphire bead insulation structure is replaced with the insulation property of the ceramic substrate, precise electrical partitioning is achieved in combination with selective gold plating, the ion trap is compatible with a multi-frequency RF system, and the performance, reliability and manufacturing efficiency of the ion trap are remarkably improved.

The invention relates to a method and an apparatus for analyzing a sample material on a sample carrier, comprising the following modes of operation: providing a time-of-flight mass analyzer having an ion generating unit, an ion generation unit having a mount for the sample carrier, an ion receiver, a flight path defining a longest flight time therebetween, an ion selector disposed along the path, and a clock generator for repeatedly triggering an ion generation pulse at the sample carrier and a subsequent pulse for accelerating ion species into the flight path; defining one or more mass-to-charge ratio (m / z) ranges, each range upper limit corresponding to a flight time shorter than the longest flight time; selecting the cycle period of the ion generation pulse so that the continuous pulse interval is shorter than the longest flight time but longer than the acceleration time; and using the mass analyzer, selecting a pulse cycle mode and an ion selector to analyze the sample material.

A method of analysing a field of a mass spectrometer comprising a mass analyser and a static field mass filter having a first Wien filter and a second Wien filter is provided. The method includes, for each of a plurality of predetermined strengths of one of an electric field or a magnetic field of the first and second Wien filters: setting the one of the electric field or the magnetic field of the first and second Wien filters to the predetermined strength; causing a beam of ions comprising one or more ion species to be injected through the static field mass filter; and measuring, using the mass analyser, a respective intensity of ions of each of the one or more ion species in the beam.

Embodiments of the present application relate to a mass spectrometry analysis system and a method for operating a mass spectrometry analysis module. The mass spectrometry analysis system comprises: a sample information acquisition module configured to acquire test item information of a sample; a mass spectrometry analysis module, comprising a first mass analyzer, a collision cell, a second mass analyzer, and a power supply unit, wherein the power supply unit is configured to generate a first direct current voltage and a radio frequency voltage having a first operating frequency that are to be applied to the first mass analyzer, and a second direct current voltage and a radio frequency voltage having a second operating frequency that are to be applied to the second mass analyzer; and a controller configured to: determine, on the basis of the test item information of the sample, a first operating frequency matching the test item information and / or a second operating frequency matching the test item information; and when controlling the mass spectrum analysis module to detect the sample, enable the first mass analyzer to operate at the first operating frequency and / or enable the second mass analyzer to operate at the second operating frequency.

In one aspect, a method of performing mass spectrometry is disclosed, which includes acquiring mass detection signals generated by an ion detector during an ion extraction event in a time-of-flight (ToF) mass analyzer in response to incidence of ions thereon, and applying an adjustable gain to the mass detection signals, wherein the step of applying the adjustable gain to the mass detection signals is performed dynamically based on m / z regions associated with said mass detection signals.

The invention relates to the technical field of semiconductor preparation, in particular to a semiconductor gaseous molecular pollutant high-coverage detection mass spectrum device and method. The device comprises a quasi-normal-pressure chemical ionization cavity, a differential transmission cavity, a low-pressure chemical ionization cavity and a mass analyzer which are sequentially connected in series, wherein vacuum difference is realized among the cavities through three ion extraction electrodes; the quasi-normal-pressure chemical ionization cavity performs chemical reaction ionization on polar components of sample gas through first reagent ions and transmits the first reagent ions and the polar components of the sample gas; the differential transmission cavity is used for efficiently transmitting the ionized sample; and the low-pressure chemical ionization cavity carries out low-pressure chemical ionization on the non-polar or weak-polar neutral sample which is not ionized through second reagent ions, and the second reagent ions are efficiently transmitted into the mass analyzer for mass spectrometric detection. According to the invention, the coupling of the quasi-normal-pressure chemical ionization source and the low-pressure chemical ionization source is realized through the multi-stage vacuum differential design, so that the non-polar or polar trace AMC compounds in the semiconductor can be detected with high sensitivity and high coverage.