309 results about "Mass analysis" patented technology

The invention discloses a coal and rock mass fracture instability multivariate signal fusion analysis method, and belongs to coal and rock mass analysis. The method comprises the following steps: carrying out time-frequency domain processing on an acoustic emission signal to obtain an accumulated ringing characteristic value # imgabs0 # and an accumulated b characteristic value # imgabs1 #; a main control frequency characteristic value # imgabs2 # and an amplitude characteristic value # imgabs3 # are accumulated; a spatial characteristic value # imgabs4 # of acoustic emission; fitting a fitting function # imgabs7 # from the characteristic value # imgabs5 # to the characteristic value # imgabs6 # respectively; according to the fitting function # imgabs8 #, calculating a correlation coefficient matrix R between the characteristic values # imgabs9 # to # imgabs10 #; according to the matrix R, determining a weight coefficient # imgabs11 # of each characteristic value; a first-order derivative function # imgabs13 # and a second-order derivative function # imgabs14 # of the fitting function # imgabs12 # are obtained, and according to the first-order derivative function # imgabs15 # and the second-order derivative function # imgabs16 #, a demarcation time point # imgabs17 # in the coal and rock mass damage process is determined; and the boundary time point # imgabs19 # is corrected by using the weight coefficient # imgabs18 #, and a corrected boundary time point # imgabs20 # is obtained. In order to solve the problems that an existing coal and rock mass fracture instability judgment index is single, and coal and rock mass fracture instability early warning is low in single index precision, the early warning precision is improved through multi-element signal fusion.

The invention belongs to the technical field of aircraft oil leakage monitoring, and relates to an aircraft oil leakage detection method based on a high-sensitivity mass spectrometry technology, and the method comprises the steps: obtaining a time-resolved mass spectrogram of aviation kerosene molecules in a sample testing stage, and storing the time-resolved mass spectrogram in a database; then oil gas molecules are captured at leakage-prone points of an aircraft pipeline system through a gas collection probe, the captured oil gas molecules are transmitted to an ion source end of a proton transfer reaction mass spectrometer through a negative pressure transmission system to be ionized to generate ions, and the ions are analyzed by a mass analysis system to obtain a mass spectrum; comparing the mass spectrogram obtained by analysis with a time-resolved mass spectrogram in a database, and judging whether leakage occurs or not; based on the method, the problems of insufficient anti-interference capability, difficulty in sample collection and the like of a high-sensitivity mass spectrum oil gas leak detection method can be solved in a targeted manner, and the functions of environmental interference suppression, efficient collection of oil gas molecules, improvement of spatial scanning resolution and the like can be realized at the same time.

The invention relates to the technical field of instruments and meters, in particular to an inductively coupled plasma mass spectrometer system for intelligent data processing and report generation. Comprising a sample introduction unit, a plasma excitation and ionization unit, a mass analyzer and detection unit, a vacuum system unit and an intelligent data processing and report generation unit. Efficient ionization is achieved through a bipolar radio frequency switching and AI optimized reaction gas plasma source, the AI optimization module monitors in real time and dynamically adjusts parameters so that the ionization efficiency can be stabilized at 92% + / -2%, and meanwhile a reaction gas control system can optimize plasma conditions to suppress interference ions. And the mass analyzer and the detection unit realize high-precision ion separation by utilizing AI interference correction and a QMS-TOF double analyzer mode, and an interference elimination module can automatically eliminate polyatomic ion interference, so that the ionization efficiency, the analysis precision and the accuracy are improved, the interference is effectively inhibited, and the analysis capability of the system on a complex sample is enhanced.

A method of mass spectrometry comprising: a) providing a mass spectrometer having a time of flight (TOP) mass analyser: b) performing a survey scan comprising separating a packet of precursor ion species and mass analysing ions so as to obtain first mass spectral data: c) determining a time window over which one of the precursor ion species. or fragment or product ions derived therefrom, were mass analysed: d) separating another packet of precursor ion species and mass analysing ions so as to obtain second mass spectral data. wherein the pusher of the TOP mass analyser is pulsed according to a plurality of consecutive pulse sequences during a plurality of respective pulse sequence time periods. wherein each pulse sequence consists of consecutive pushes that are arranged such that the duration between any pair of pushes in the pulse sequence is different to the duration between any other pair of pushes within the pulse sequence: f) selecting mass spectral data, from the second mass spectral data, that was obtained during a time period corresponding to said time window of the survey scan, so as to obtain selected data; g) repeating steps d) to f) at least one further time such that multiple sets of said selected data are obtained; combining said multiple sets of selected data and decoding the combined data to obtain mass spectral data representative of the mass to charge ratios of the ions detected by the TOP mass analyser.

A hybrid inductively coupled plasma mass spectrometer (ICP-MS) system is disclosed for simultaneous elemental and molecular analysis in positive and negative polarities. It includes an ICP torch that generates plasma with a buffer gas, producing both positively and negatively charged ions from a sample. Positioned between the sampler and skimmer, an insert with a defined geometry forms a reaction chamber. Various embodiments feature multiple apertures for pressure control, a rotatable disk for aperture regulation, a slider gate for pressure adjustment, a circular gate with adjustable radial apertures, and an inlet for introducing gases, reagents, dopants, or analytes. These components enable precise pressure modulation, optimizing performance for dual-polarity mass spectrometry. The system enhances analytical flexibility by facilitating controlled ion reactions, improving sensitivity and specificity for both elemental and molecular applications. This innovation expands ICP-MS functionality, supporting diverse scientific and industrial applications requiring high-precision mass analysis.

The invention discloses a coal body compression mechanical test acoustic emission signal processing method and system, and relates to coal rock mass analysis. The method comprises the steps that under the supercritical water coupling effect condition, an acoustic emission original data set of the whole coal body uniaxial compression damage process is collected; respectively carrying out time domain processing, frequency domain conversion and spatial positioning calculation on the original data set, and outputting a time domain characteristic parameter, a frequency domain characteristic parameter set and a spatial position parameter set; and performing data fusion on the time domain characteristic parameter set, the frequency domain characteristic parameter set and the spatial position parameter set, establishing a multi-dimensional characteristic data matrix through time synchronization, and analyzing acoustic emission signal laws of different damage stages of the coal body under the supercritical water coupling effect. Aiming at the low recognition precision of the coal body damage stage under the supercritical water coupling effect, the recognition precision is improved by performing time domain processing, frequency domain conversion, spatial positioning calculation and the like on an acoustic emission original data set.

Method and system of mass spectrometry is provided. The method comprises performing a first and a second MS1 scans on precursor ions produced by ionising a sample. The first MS1 scan comprises mass analysing a first set of the precursor ions transported to a mass analyser using an ion transport device operated at a first setting. The second MS1 scan comprises mass analysing a second set of the precursor ions transported to a mass analyser using the ion transport device operated at a second setting. Energies imparted on the precursor ions by the ion transport device are different in the first and second settings. Based on intensities of mass spectral peaks of the first and second MS1 scans, a mass spectral peak in at least one of the first MS1 scan or the second MS1 scan indicative of a precursor ion mass spectral peak is determined.

A method and corresponding devices to reduce the presence of unwanted ions within the pseudo-potential well of the RF fields for inductively coupled plasma mass spectrometry is disclosed. This method reduces space-charge effects and leaves more room available for the ions of interest and, hence, leads to increased transmission of the desired ions into the mass analyzer. In the present invention, the space charge is reduced by adding a low-band resolving DC potential, or a fast sweeping resolving DC potential with a notch, or a fast constant resolving DC potential with a notch, or by adding auxiliary quadrupolar or dipolar RF potential to the quadrupole ion guide, such that all the unwanted ions will be outside the stable region and therefore ejected. This reduces the charge density in the ion beam and ameliorate space charge effects.

A method of operating an analytical instrument comprises ionising a sample to produce sample ions; (i) performing a first ion separation scan by separating sample ions according to a first physico-chemical property, and analysing the separated sample ions by performing one or more MS1 mass analysis scans; and (ii) performing a second ion separation scan by separating sample ions according to the first physico-chemical property, and analysing the separated sample ions by performing a plurality of MS2 mass analysis scans. Each MS2 scan of the plurality of MS2 mass analysis scans uses one MS2 isolation window of a plurality of MS2 isolation windows. The method further comprises analysing MS1 data acquired from the one or more MS1 mass analysis scan(s), and configuring the plurality of MS2 isolation windows based on the analysis of the MS1 data.

A trace of intensity versus time values is received for a series of samples produced by a mass spectrometer. Also, a series of ejections times corresponding to the series of samples produced by a sample introduction system is received. A series of expected peak times corresponding to the series of ejection times are calculated using a known delay time from ejection to mass analysis. At least one isolated peak of the trace is identified using the series of expected peak times. A peak profile is calculated by fitting a mixture of at least two different distribution functions to the at least one isolated peak. For at least one time of the series of expected peak times, an area of a peak at the one time is calculated by fitting the peak profile to the trace at the one time and calculating an area of the fitted peak profile.

Systems and methods are disclosed for automated method parameter configuration for differential mobility separations. As non-limiting examples, various aspects of this disclosure provide receiving a sample in an open port interface; transferring the sample to an ionization source; ionizing the transferred sample; introducing the ionized sample into a mass spectrometer; mass analyzing the ionized sample to produce an initial mass analysis result; determining a peak width of the initial mass analysis result; and determining a dwell time for subsequent measurements based on the determined peak width, a pre-defined number of data points across subsequent mass analysis peak widths, and a number of different analytes to be assessed for the sample. The sample may be diluted and transferred to the ionization source by a sample introduction apparatus selected from a group including an acoustic droplet ejector (ADE), a pneumatic ejector, a piezoelectric ejector, and a hydraulic ejector.

A high-energy ion implantation system has an ion source and mass analyzer to form and analyze an ion beam along a beam path. A first RF LINAC accelerates the ion beam to a first accelerator exit, and a second RF LINAC accelerates the ion beam to a second accelerator exit along the beam path. A first magnet between the first and second RF LINACs alters the beam path along a first plane. A third RF LINAC accelerates the ion beam, and a second magnet between the second and third RF LINACs alters the beam path along a second plane. A beam shaping apparatus defines a shape of the ion beam, and a third magnet between the third RF LINAC beam shaping apparatus alters the beam path along a third plane, where the first, second, and third planes are not coplanar.

Systems / techniques are provided for facilitating mass analyzer calibration via reinforcement learning. In various embodiments, a system can predict, via execution of one or more reinforcement learning neural networks on present-time state data of a mass analyzer of a scientific instrument, what adjustments to one or more operational parameters of the mass analyzer would cause the mass analyzer to approach a calibrated state, wherein the one or more operational parameters include an electrode voltage of the mass analyzer or a timing control of the mass analyzer. In various aspects, the system can modify the one or more operational parameters based on the adjustments, thereby causing the mass analyzer to approach the calibrated state.

The application discloses a quality analysis method for extracting effective components of Gastrodia elata by using HDES, and comprises the following steps: (1) synthesizing HDES by using L-menthol and DL-lactic acid; (2) adding the HDES in step (1) into Gastrodia elata medicinal material powder, stirring to extract effective components, centrifuging and diluting the obtained mixture after the extraction is completed, obtaining a test sample solution, and performing chromatographic analysis to determine the content of the effective components; (3) detecting the quality indexes of the test sample solution in step (2); and (4) analyzing the quality of Gastrodia elata by using a chemometrics analysis method. The extraction method is green, simple, fast and high in extraction efficiency, and is favorable for the extraction of effective components in medicine and food homologous medicinal materials.

The invention relates to the technical field of mass spectrometers, and discloses an analytical instrument based on glow discharge and quadrupole mass spectrometry combination, which comprises an ion source, an ion transmission system and an ion separator, wherein the ion source is a glow discharge ion source; the ion separator is a quadrupole rod mass analyzer, and the quadrupole rod mass analyzer comprises four electrodes which are arranged in parallel. Compared with an existing analytical instrument, the glow discharge ion source can directly analyze a solid sample without being pretreated into a solution, and compared with an inductively coupled plasma source, the glow discharge ion source is small in matrix effect and especially suitable for high-salt and high-carbon samples; the quadrupole rod mass analyzer is simple in structure, small in size, low in cost, especially suitable for commercialized popularization and high in scanning speed.

A method of mass spectrometry comprising: a) separating a sample in a separator device and then mass analysing the sample so as to obtain a list of sample peaks in which a mass to charge ratio for each peak is associated with a retention time in the separator device; b) providing a list of library peaks in which a mass to charge ratio for each peak is associated with a retention time in a separator device; c) dividing the list of sample peaks, according to retention time, into multiple sample peak sub-lists, and dividing the list of library peaks, according to retention time, into multiple library peak sub-lists; d) peak- matching at least a first peak in a first of the sample peak sub-lists with at least a first respective peak in a first of the library peak sub-lists so as to obtain at least a first pair of matched peaks; e) determining an error in the mass to charge ratio of the first peak in the first sample peak sub-list based on the mass to charge ratios of the peaks in the first pair of matched peaks; and f) adjusting the mass to charge ratio of at least the first peak in the first sample peak sub-list using said error in mass to charge ratio so as to provide an adjusted first sample peak sub-list.

An apparatus fortime-of-flight, TOF, tandem mass spectrometry comprises an ion source for providing precursor ions, a linear ion trap comprising a set of electrodes configured for receiving the precursor ions into the ion trap. A voltage source is configured for applying to the set of electrodes a trapping voltage(s) configured to generate an axial trapping potential field forming a potential barrier to axially trap the received precursor ions within the linear ion trap, and for applying to the set of electrodes an RF voltage(s) configured to generate a radial trapping potential field to radially trap received precursor ions. The voltage source selectively changes the radial trapping potential field to increase the kinetic energy of precursor ions in the ion trapping region so that precursor ions can overcome the potential barrier thereby axially ejecting the selected precursor ions from the linear ion trap. A collision cell is configured to receive the ejected precursor ions and to apply to them a process of collision-induced dissociation to generate product ions therefrom. A mass analyser, such as a time-of-flight, TOF, mass analyser, receives the product ions (and / or any remaining unfragmented precursor ions) and to apply to them a process of mass analysis.

A data-dependent analysis (DDA) mass spectrometry technique involves ionizing a sample to generate sample ions, analyzing the sample ions by performing one or more MS1 mass analysis scans to obtain MS1 ​​data, identifying one or more precursor ions from the MS1 data, and subsequently analyzing the sample ions by performing one or more MS2 mass analysis scans. Each MS2 scan targets one of the one or more precursor ions identified from the MS1 data.The procedure further includes, for each of the one or more precursor ions identified from the MS1 data: determining a value from the MS1 data that is indicative of a collision cross section (CCS) of that precursor ion; and selecting, based on the CCS-indicative value(s), which precursor ion(s) the one or more MS2 bulk analysis scans should target, and / or determining, based on the CCS-indicative value(s), an order in which the one or more MS2 bulk analysis scans should target the precursor ions.

To relate to a mass spectrometry field and particularly to provide a method for determining a chemical structure of a lipid and an ion mobility-tandem mass spectrometer.SOLUTION: A method for determining a chemical structure of a lipid includes: an ionization step of ionizing a sample to obtain sample ions; an ion mobility-based separation step of separating target lipid ions from the sample ions, based on ion mobility; a first dissociation step of dissociating a target lipid ions with dissociation energy adjusted to break a first chemical bond of the target lipid ions; a mass-based selection step of selecting the target lipid ions, whose first chemical bond is broken, based on a mass number to obtain fragment ions; a second dissociation step of dissociating the fragment ions to at least break a second chemical bond of the fragment ions which has bond energy higher than the first chemical bond, to obtain diagnostic ions; and a mass analysis step of performing a mass analysis on the diagnostic ions.SELECTED DRAWING: Figure 1

Method and system for calibrating a mass spectrometer having one or more ion lenses and a mass analyser, the method comprising the steps of acquiring from the mass analyser a plurality of mass spectra from a sample, the sample comprising a plurality of ion masses, wherein a voltage value applied to the one or more ion lenses is static while each mass spectrum is obtained and the voltage value is varied between different mass spectra. Determining from the plurality of mass spectra and corresponding voltage applied to the one or more ion lenses during acquisition of each mass spectrum, a voltage value providing an optimum ion signal for each of the plurality of ion masses in the sample. Storing data indicating the ion mass value and corresponding voltage value providing the optimum ion signal for each of the plurality of ion masses in the sample.

Methods for acquiring mass spectral data of a sample across at least a portion of an m / z range include receiving mass spectral data of the sample across the m / z range. The m / z range is partitioned into one or more sets of m / z sub-ranges, each set comprising one or more m / z sub-ranges, by dividing the m / z range into a plurality of m / z bins, determining an indication of ion abundance for each m / z bin, based on the mass spectral data, and forming an m / z sub-range of the one or more sets of m / z sub-ranges by assigning m / z bins having ion abundances that correspond to at least a threshold degree to the formed m / z sub-range. A mass analysis is performed on the sample for each set of m / z sub-ranges, thereby acquiring one or more partial mass spectral data sets.

The present application relates to the field of mass spectrometers, and discloses an ion extraction method, device and mass spectrometer. The method includes: controlling target ions to be input from an introduction electrode into a collision cell in a vacuum chamber; applying a first voltage to a gate electrode to enable the target ions to enter an ion storage unit from the collision cell, and applying a second voltage to an extraction electrode to enable the target ions to accumulate in the ion storage unit; after a preset time period, adjusting the magnitude of the first voltage and / or the second voltage so that the target ions are sequentially output from the extraction electrode in the order of decreasing mass-to-charge ratio. By adjusting the magnitude of the applied voltage, the output time of the target ions is correspondingly adjusted in the embodiments of the present application, facilitating the subsequent time-of-flight mass analysis device to collect the time-of-flight mass spectrometry of target ions with different mass-to-charge ratios at the same moment, and broadening the effective mass-to-charge ratio range of the mass spectrometry.

There is provided a data dependent acquisition (DDA) method of mass spectrometry using a dual analyser mass spectrometer. The method comprises: performing, by a first mass analyser, an MS1 scan of the

The application relates to the technical field of mass spectrometers, in particular to an electrode rod for a mass spectrometer and a mass spectrometer. The mass spectrometer comprises a mass analyzer which is axially connected with an ionization cylinder and is connected with a detector through the mass analyzer. An installation base is connected to the inner wall of the lower end of the mass analyzer. A positioning ring coaxial with the mass analyzer is clamped in the inner upper end of the installation base. Four electrode rods are connected in the inner positioning ring and are arranged in rotational symmetry with the central axis of the mass analyzer. A position adjusting assembly for limiting the four electrode rods is arranged between the positioning ring and the four electrode rods. The distance between the four electrode rods is synchronously increased or reduced through the position adjusting assembly. When the applied composite voltage remains unchanged, increasing the distance can make the ion passing space larger, thereby improving the detection sensitivity. Reducing the distance can enhance the electric field constraint, improve the ion screening precision and the resolution capacity, so as to adapt to different detection requirements.

The invention relates to an imaging elemental analyzer for imaging one or more analyte elements in an organic sample, wherein the analyzer comprises: a chamber for receiving an organic sample containing one or more analyte elements to be imaged, wherein the internal chamber pressure surrounding the sample is in the range of 10 -5 up to 10 -2mbar; at least one irradiant selected from: (i) an ion gun for irradiating the sample with a high-intensity primary ion beam, wherein the primary ions are generated in the ion gun at a pressure below 1 mbar, the ion gun serving to focus the primary ion beam onto a localized spot on the sample surface and to move the spot over time to a plurality of locations on the sample surface; (ii) a laser for irradiating a localized spot on the sample surface and to move the spot over time to a plurality of locations on the sample surface; a gas-filled RF ion guide for receiving the generated ions, comprising the elements released from the sample in response to irradiation by the primary ions or the laser, wherein the RF ion guide prevents the propagation of any ions whose m / z values ​​are less than the mass or mass range of the analyte elements;and a time-of-flight (TOF) mass analyzer for recording the ions or reaction products of the secondary ions formed from the RF ion guidance, wherein the TOF mass analyzer is configured for a repetition rate of at least 5 kHz. The invention also relates to a corresponding method and a corresponding device for imaging one or more inorganic, non-volatile elements.

In order to enable high-precision mass analysis, the present invention is provided with: a plotting processing unit (212) that plots, as correction points, a quadrupole RF voltage obtained as a result of measuring a plurality of correction ions having known m / z by a mass analysis device (100), and the m / z of each correction ion, on coordinates having the quadrupole RF voltage and m / z as coordinate axes; a correction processing unit (213) that corrects the correction points by correcting the outliers if there is an outlier for each of the correction points; and a measurement processing unit (213) that performs measurement of the correction ions by the mass spectrometer (100) within a scanning range centered on the quadrupole RF voltage calculated by the corrected correction point.

The application discloses a coal body compression mechanics test acoustic emission signal processing method and system, relates to coal and rock mass analysis, and comprises the following steps: collecting acoustic emission original data sets of the whole process of coal body uniaxial compression destruction under the condition of supercritical water coupling; respectively performing time domain processing, frequency domain conversion and space positioning calculation on the original data sets, outputting time domain characteristic parameters, a frequency domain characteristic parameter set and a space position parameter set; fusing the time domain characteristic parameter set, the frequency domain characteristic parameter set and the space position parameter set, establishing a multi-dimensional characteristic data matrix through time synchronization, and analyzing acoustic emission signal rules of different destruction stages of the coal body under the condition of supercritical water coupling. The application improves the recognition accuracy by performing time domain processing, frequency domain conversion and space positioning calculation on the acoustic emission original data set, and solves the problem of low recognition accuracy of the coal body destruction stage under the condition of supercritical water coupling.

The present invention relates to an ion source device and a mass spectrometer, wherein the ion source device comprises: a cover plate, the cover plate being used to cover one end of a vacuum chamber; an ion source assembly, one end of the ion source assembly being provided with a first mating portion, the first mating portion being used to position and cooperate with the second mating portion; a support column, one end of the support column being connected to the cover plate, and the ion source assembly being slidably connected to the support column; a reset member, the reset member being provided between the cover plate and the ion source assembly, and the ion source assembly being reset and cooperated with the cover plate through the reset member. The above-mentioned ion source device is easy to install due to the positioning function of the first mating portion and the second mating portion, and can improve the positioning convenience of the ion source assembly and the mass analyzer, thereby ensuring the centering and positioning accuracy of the assembly after maintenance, making the ion transmission channel concentric, thereby ensuring the ion transmission efficiency of the mass spectrometer and improving the working reliability after assembly.

An illustrative method comprises determining, based on a mass analysis performed by an electron multiplier-based mass analyzer on a first ion population produced from a sample, a mass spectrum comprising one or more peaks representing intensity as a function of mass-to-charge ratio (m / z) of the first ion population across a range of m / z values; determining, based on the mass spectrum, a total ion count of the first ion population and a peak ion count associated with a peak located at a particular m / z value; determining, based on the total ion count of the first ion population and the peak ion count, a total ion count of a second ion population produced from the sample and injected into an image current-based mass analyzer for mass analysis; and setting, based on the total ion count of the second ion population, a calibration parameter for the image current-based mass analyzer.

The present invention improves the performance of a power module. In particular, the generation of discharge is prevented within the power module, and the power module is miniaturized. As a means for this, a plurality of substrates are arranged within the power module so as to overlap when viewed from above. In this case, a low-voltage circuit (3) and a high-voltage circuit are formed on a first substrate (2) while maintaining a distance (L) between each other for preventing creeping discharge, and a low-voltage circuit (5) is formed on a second substrate (4). In addition, the distance between the components constituting the high-voltage AC circuit (8) formed in the high-voltage circuit and the components constituting the low-voltage circuit (5) is at least three times the shortest distance (D) between the components constituting the high-voltage DC circuit (7) formed in the high-voltage circuit and the components constituting the low-voltage circuit (5) at which no space discharge occurs.