1108results about "Samples introduction/extraction" patented technology

The invention discloses a high-temperature ion source ion sampling interface with a built-in phase change working medium heat convection system, and relates to the technical field of high-temperature plasma source and ion or atom detection interface application. The orifice is formed in the center of the interface main body and is used for accessing high-temperature plasma; the interface center edge part is arranged on the periphery of the orifice and is used for being in direct contact with high-temperature plasma; the invention relates to a phase-change heat exchanger which comprises a connector center edge part, a heat convection system is arranged on the periphery edge part of the periphery of the connector center edge part, the heat convection system comprises one or more closed-loop cavities, the closed-loop cavities are filled with filler, and phase-change working media are injected into the closed-loop cavities. The invention aims to solve the problems of difficulty in heat dissipation, limited material selection and the like of the ion sampling interface of the high-temperature ion source.

Systems and methods are described for collecting and combining multiple scan samples from a surface of a semiconducting wafer. A system embodiment includes, but is not limited to, a scan nozzle configured to introduce a first scan solution to a surface of a semiconducting wafer to remove impurities from the surface to provide a first scan sample and retrieve the first scan sample, the scan nozzle further configured to introduce a second scan solution to the surface of the semiconducting wafer to remove residual impurities from the surface to provide a second scan sample and retrieve the second scan sample; and a collection vessel in fluid communication with the scan nozzle, the collection vessel configured to receive each of the first scan sample and the second scan sample from the nozzle and to mix the first scan sample with the second scan sample to provide a combined scan sample.

The present disclosure is related to an analytical system comprising a liquid chromatographic (LC) system comprising a plurality of fluidic streams alternately connectable to a common detector via a stream-selection valve connected to the detector via a valve-to-detector conduit. The analytical system further comprises a wash pump fluidically connected to the stream-selection valve and configured to connect to the valve-to-detector conduit between two consecutive fluidic streams in order to wash liquid from a previous fluidic stream out of the valve-to-detector conduit before liquid from a subsequent fluidic stream enters the valve-to-detector conduit. An analytical method comprising switching between the fluidic streams and washing in between is also disclosed.

The invention relates to the technical field of instruments and meters, in particular to an inductively coupled plasma mass spectrometer system for intelligent data processing and report generation. Comprising a sample introduction unit, a plasma excitation and ionization unit, a mass analyzer and detection unit, a vacuum system unit and an intelligent data processing and report generation unit. Efficient ionization is achieved through a bipolar radio frequency switching and AI optimized reaction gas plasma source, the AI optimization module monitors in real time and dynamically adjusts parameters so that the ionization efficiency can be stabilized at 92% + / -2%, and meanwhile a reaction gas control system can optimize plasma conditions to suppress interference ions. And the mass analyzer and the detection unit realize high-precision ion separation by utilizing AI interference correction and a QMS-TOF double analyzer mode, and an interference elimination module can automatically eliminate polyatomic ion interference, so that the ionization efficiency, the analysis precision and the accuracy are improved, the interference is effectively inhibited, and the analysis capability of the system on a complex sample is enhanced.

The invention discloses an atomization mechanism for a plasma mass spectrometer, and relates to the technical field of atomizers, the atomization mechanism comprises an atomization cup, an atomization head and a sample introduction hopper which are respectively arranged at two openings of the atomization cup, a transmission mechanism arranged in the atomization cup, and an atomization nozzle communicated with the interior of the atomization cup, the sample feeding hopper is rotationally connected with the inner wall of the atomizing cup, and the transmission mechanism is in transmission connection with the sample feeding hopper; to-be-atomized liquid flows into the sample feeding hopper through the atomizing head; atomized airflow flows into the atomizing cup through the sample injection hopper and can be blown to liquid in the sample injection hopper; the transmission mechanism can drive the sample feeding hopper to rotate under the action of atomized airflow; and the liquid is atomized in the atomizing cup and then is discharged through the atomizing nozzle. In the atomization process, the transmission mechanism can drive the sample feeding hopper to rotate under the action of atomization airflow, powder and particles in liquid raw materials can be well decomposed through rotation of the sample feeding hopper, the stability of the concentration of liquid fed into a plasma light source is guaranteed, and meanwhile the atomizer can be prevented from being blocked.

The utility model discloses an ionization sample injection platform device for a mass spectrometer. The ionization sample injection platform device comprises a base, and a rotary sample frame, a swing arm grabbing mechanism, a turnover sample injection port mechanism and a high-voltage applying mechanism which are arranged on the base, the rotary sample frame is used for loading a plurality of to-be-tested samples; a sample to be detected is arranged in the suction head; the swing arm grabbing mechanism is used for taking and placing a to-be-tested sample through lifting and rotating actions of an electric gripper; the overturning sample inlet mechanism is arranged at the detection port of the mass spectrometer and is used for controlling the to-be-detected sample to execute an overturning action, so that the to-be-detected sample is aligned with the tip part of the detection port of the mass spectrometer; the high-voltage electricity applying mechanism is used for releasing high-voltage electricity to the tip end of the suction head. The ionization sample introduction platform device structure for the mass spectrometer enters a field, and the detection efficiency can be remarkably improved.

The vacuum interface of the mass spectrometer comprises a main body part and a sample introduction piece, the main body part is provided with an interface body and a first connecting piece which are formed into a split piece, one end of the first connecting piece is connected with the interface body, the interface body is formed into an integrally formed piece, and the interior of the interface body is hollow to form a vacuum cavity; the vacuum cavity is provided with a first opening and a second opening which are oppositely arranged, a mass analyzer is suitable for being arranged in the vacuum cavity, the sample injection piece is arranged at the first opening and detachably connected with the other end of the first connecting piece, the sample injection piece is provided with a sample injection port communicated with the first opening, the sample injection port is used for conveying ions to be detected towards the vacuum cavity, and the sample injection port is communicated with the second opening in the direction towards the vacuum cavity. And the opening sizes of at least part of the sample inlets are gradually increased. According to the vacuum interface of the mass spectrometer provided by the embodiment of the invention, not only can the installation precision of the sample introduction piece be ensured, but also the interface body has good sealing performance, so that the working performance of the mass spectrometer can be improved.

A hybrid inductively coupled plasma mass spectrometer (ICP-MS) system is disclosed for simultaneous elemental and molecular analysis in positive and negative polarities. It includes an ICP torch that generates plasma with a buffer gas, producing both positively and negatively charged ions from a sample. Positioned between the sampler and skimmer, an insert with a defined geometry forms a reaction chamber. Various embodiments feature multiple apertures for pressure control, a rotatable disk for aperture regulation, a slider gate for pressure adjustment, a circular gate with adjustable radial apertures, and an inlet for introducing gases, reagents, dopants, or analytes. These components enable precise pressure modulation, optimizing performance for dual-polarity mass spectrometry. The system enhances analytical flexibility by facilitating controlled ion reactions, improving sensitivity and specificity for both elemental and molecular applications. This innovation expands ICP-MS functionality, supporting diverse scientific and industrial applications requiring high-precision mass analysis.

The invention discloses a composite ion source device for coupling atmospheric pressure interface orbitrap mass spectrometry, which belongs to the field of mass spectrometry detection and comprises a photo ionization / photo-induced association ionization ionization and ion transmission mechanism, a gas sample introduction mechanism, a high-flux radio frequency vacuum ultraviolet light source mechanism and an ion source and mass spectrometry interface mechanism. By adopting the composite ion source device for coupling the atmospheric pressure interface orbitrap mass spectrum, organic components with different polarities, ionization energy and ion affinity in a complex mixture can be efficiently ionized, and through reasonable structural design, the organic components are coupled with the high-resolution orbitrap mass spectrum with the atmospheric pressure interface, so that the high-resolution orbitrap mass spectrum is obtained. The detection range of complex organic components is widened, and the resolution capability and the detection sensitivity of low-abundance or high-molecular-weight organic components are improved.

The invention discloses a thermal desorption sample injection ion source with a separation function, which comprises an ionization cavity, and the top end of the ionization cavity is detachably connected with a heat insulation pad; the heating cavity is fixed to the top end of the heat insulation pad, and a mounting base is mounted at the bottom in the heating cavity; according to the sample injection system, a heating cavity comprises a sample injection unit installed at the top end of the heating cavity, a sample injection pipe is fixedly connected to an installation base, and the sample injection unit is communicated with the sample injection pipe through a sample separation column; the heating system is mounted on the mounting seat; the ionization unit is vertically fixed on one side wall of the ionization cavity, and the ionization unit and the sample feeding pipe are vertically arranged; the detection unit is vertically and fixedly connected to the other side wall of the ionization cavity; a waste liquid opening is formed in the bottom of the ionization cavity. According to the invention, the ionization competition of the target compound of the atmospheric pressure ionization source can be greatly reduced, the sensitivity and the quantitative stability are improved, and more accurate rapid detection is realized.

The invention discloses a sampling device for ICP-MS (Inductively Coupled Plasma Mass Spectrometry) in the technical field of instrumental analysis. The sampling device comprises a liquid inlet mechanism and an atomization mechanism, the liquid inlet mechanism is used for inputting a liquid sample into the atomization mechanism, the atomization mechanism comprises a concentric atomizer and an atomization chamber, the concentric atomizer is communicated with the atomization chamber, and the atomization chamber is communicated with a waste liquid barrel and an ICP torch pipe; a self-cleaning mechanism is arranged on a communication path of the concentric atomizer and the atomizing chamber, the self-cleaning mechanism comprises a movable cylinder, the movable cylinder is rotationally connected into a nozzle of the concentric atomizer, contact electrodes are symmetrically arranged in the movable cylinder, and when the movable cylinder is blocked, the contact electrodes form a path; the contact electrode is electrically connected with a torsion mechanism and a reverse blowing mechanism, the torsion mechanism is used for twisting the movable cylinder when the contact electrode forms a path, and the reverse blowing mechanism is used for intercepting carrier gas input into the concentric atomizer and reversely blowing the carrier gas out of a nozzle of the concentric atomizer. According to the invention, self-cleaning can be carried out when blockage occurs in the sample introduction process, and sample analysis interruption caused by blockage is reduced.

The presently disclosed subject matter provides compositions and methods for the synthesizing and the application of heterobifunctional photo-crosslinkers for the analysis of protein-protein interactions in mass spectrometry, tandem mass spectrometry, and cross-linking mass spectrometry.

The invention relates to the technical field of mass spectrometer sampling, in particular to a sampling device of an inductively coupled plasma mass spectrometer, which comprises a bottom plate, and an inductively coupled plasma mass spectrometer body is fixedly mounted at the top of the bottom plate. During application, the sample introduction mechanism adopts a first motor to drive a turntable to carry a sample during use, power is amplified through transmission of a large belt wheel and a small belt wheel, and a non-contact magnetic coupling drives a pumping spiral driving blade to rotate to generate negative pressure, so that automatic sample extraction, negative pressure control of opening and closing of a plugging plate and accurate control of a sample conveying channel are realized; by means of the design, carrying power is converted into pumping power, the equipment structure is simplified, the number of parts and energy consumption are reduced, the equipment operation and maintenance cost is reduced, an automatic continuous sample injection process replaces traditional single-pipe extraction, the sample injection time is greatly shortened, and the sample treatment efficiency is improved.

The invention provides an in-situ pyrolysis device adopting a glow ionization source. The in-situ pyrolysis device comprises a high-temperature pyrolysis device, a glow ionization device, a two-stage sampling cone, a quadrupole rod device and a flight time mass analyzer, the high-temperature pyrolysis device comprises a first copper block, a second copper block, a graphite sleeve and a long graphite pipe; the glow ionization device comprises a first electrode fixing cylinder, a second electrode fixing cylinder and an annular electrode; the two-stage sampling cone is divided into a first-stage sampling cone and a second-stage sampling cone; and the quadrupole rod device comprises four quadrupole rod electrodes which are parallel to one another and are symmetrically arranged. Pyrolysis reactants generate fullerene and intermediate products thereof through a high-temperature pyrolysis device, then product molecules are ionized through a glow ionization device, ionized ions pass through a two-stage sampling cone and are guided by a radio-frequency electric field and a direct-current electric field of a quadrupole rod device to reach a time-of-flight mass analyzer for in-situ mass spectrometric analysis, and the mass spectrometric analysis result is obtained. In-situ mass spectrometry analysis of'first ionization and second sampling 'can be realized, and fullerene and intermediates thereof formed by high-temperature pyrolysis can be captured.

The utility model provides a sample introduction device of a plasma mass spectrometer, which belongs to the technical field of sample introduction devices and comprises a mass spectrometer, a fixed table and an adjusting table, the fixed table and the adjusting table are arranged on the mass spectrometer, and a pump body is mounted at a sample introduction port of the mass spectrometer. According to the sample tube replacement device, the second sector gear is matched with the gear ring, so that the fixed shaft drives the mounting table above the fixed shaft to rotate so as to replace the sample tube, and the fixed shaft rotates 60 degrees every time the driving shaft rotates by a circle, so that the sample tube is convenient to replace; an ejector rod is matched with a spring to slide out of an insertion groove to eject a sample pipe above, so that a fixed pipe extends into the sample pipe, a sample is conveniently and automatically sampled, a first sector gear rotated by a driving shaft by 90 degrees is matched with a rack to enable the ejector rod to slide downwards into a sliding groove, and the sample pipe is put down to expose the fixed pipe in a pipe body; the fixed pipe and the sample pipe are automatically separated, so that the sample pipe is conveniently replaced by subsequent rotation, different samples are directly sampled, and the sample injection efficiency is improved.

The invention belongs to the technical field of mass spectrum ionization sources, provides an online detection mass spectrum ionization source for gas components at an outlet of a combustion chamber of an aero-engine, and solves the problem that an existing ionization source is difficult to be applied to a field test for measuring the concentration of components at the outlet of a combustion chamber of a real aero-engine. According to the technical scheme, the device comprises an ionization source cavity and a radio frequency windowless discharge lamp, a plate electrode, a taper hole electrode, a lamp holder electrode, a direct current transmission electrode, a radio frequency transmission electrode and a differential electrode are sequentially arranged in the ionization source cavity in the axis direction, and a discharge gas inlet is formed in the ionization source cavity. One end of the radio frequency windowless discharge lamp is connected to the discharge gas inlet, and the other end of the radio frequency windowless discharge lamp extends into the lamp holder electrode; the taper hole electrode enables fuel gas to be fed in a molecular beam mode, efficient transmission of stable components and active components in the fuel gas is guaranteed, efficient transmission of ions is achieved in the mode that the direct-current transmission electrode and the radio-frequency transmission electrode are combined, and full-spectrum online analysis of the components of the fuel gas at the outlet of a combustion chamber of an aero-engine can be achieved.

The invention provides a reactor and a dual-light-source mass spectrum device for in-situ detection of gas-phase species in a catalytic reaction. The reactor comprises a control part, a first tube body and a second tube body, the control part comprises a first shell and a switching piece; the first shell is provided with a first channel and a second channel which are arranged in the first direction. The switching piece is arranged between the first channel and the second channel; the first pipe body extends in the first direction and is located on the side, away from the second channel, of the switching piece. The first pipe body is communicated with the first channel; the second pipe body extends in the first direction and is partially located in the second channel. The second pipe body is connected with the first shell and can move in the first direction relative to the first shell. The switching piece moves relative to the first shell to control connection and disconnection of the first channel and the second channel. When the first channel communicates with the second channel, the second pipe body is allowed to partially extend into the second pipe body, and when the first channel is isolated from the second channel, the second pipe body is located on the side, away from the first channel, of the switching piece. The application of the reactor realizes material replacement on the premise of not breaking vacuum.

A mass or mobility spectrometer comprising: a first vacuum chamber; and a collision cell arranged in the first vacuum chamber, wherein the collision cell comprises: an ion entrance at an upstream end thereof; an ion exit at a downstream end thereof; a main body portion between the ion entrance and ion exit; and an elongated tube between the main body portion and the ion exit. The collision cell comprises one or more ion guide extending through the main body portion, and / or through the elongated tube, for radially confining ions within the one or more ion guide. The spectrometer is configured to maintain the main body portion of the collision cell at a higher pressure than the first vacuum chamber; and the elongated tube is configured to limit the gas conductance out of the downstream end of the collision cell.

A system and method for controlling the flow of aerosols. In some embodiments, a system includes a fluid channel, an actuator, and an actuator drive circuit. The actuator and the actuator drive circuit may be configured to impart vibrations, to a wall of the fluid channel, which produce waves in a gas in the fluid channel and cause aerosols in the gas to be nonuniformly distributed across the interior of the fluid channel, the waves producing a pressure pattern including a plurality of nodes or a plurality of antinodes within the fluid channel.

A method of pretreatment of a sample containing a cell for mass spectrometry, including contacting the cell with a first acidic solution containing an organic acid; and extracting a cytoplasmic component of the cell by heating the cell in contact with the first acidic solution.

In a sampling system for mass spectrometry, a method and apparatus are set forth for high flow-rate flushing and sample delivery via a sampling probe (10). The sampling system includes a sampling probe (10) having a first fluid conduit (40) with an inlet, a second fluid conduit (42) with an outlet, and a sampling port fluidly connecting the first fluid conduit (40) and second fluid conduit (42). A fluid source (50) is attached to the inlet and a vacuum source (60) is attached to the outlet for causing fluid to flow through the first fluid conduit (40) past the sampling port and exit through the second fluid conduit (42). A cap (90) is provided for selectively closing and opening the sampling port. When the cap is removed, thus when the sampling port is open, sample may be introduced into, and captured by fluid flowing through the sampling port. When the cap is in place, thus when the sampling port is closed, a flushing fluid is supplied for flushing the sampling probe (10).

A trace of intensity versus time values is received for a series of samples produced by a mass spectrometer. Also, a series of ejections times corresponding to the series of samples produced by a sample introduction system is received. A series of expected peak times corresponding to the series of ejection times are calculated using a known delay time from ejection to mass analysis. At least one isolated peak of the trace is identified using the series of expected peak times. A peak profile is calculated by fitting a mixture of at least two different distribution functions to the at least one isolated peak. For at least one time of the series of expected peak times, an area of a peak at the one time is calculated by fitting the peak profile to the trace at the one time and calculating an area of the fitted peak profile.

The invention discloses a mass spectrometer and an ion processing device.The mass spectrometer comprises an ion source, the ion processing device, a transmission device and a detection device.The ion source is used for generating charged ions, the ion processing device is arranged at the output end of the ion source, and the ion processing device comprises a first base body, a second base body, a connecting piece and a heating assembly; the first base body is close to the ion source and is provided with an ion inlet, the second base body is provided with an ion outlet, the first base body and the second base body are arranged in a spaced mode to form a containing space, and the first base body and the second base body are connected with a power source so that an electromagnetic field can be formed between the first base body and the second base body; the electromagnetic field can be used for providing kinetic energy for the charged ions in the accommodating space, so that the charged ions can be transmitted through the ion transmission channel; the heating assembly is used for heating the medium in the accommodating space, the transmission channel is used for transmitting the charged ions processed by the ion processing device, and the detection device is used for analyzing the charged ions transmitted by the transmission device.

A method for a structural analysis of a sample molecule using a mass spectrometer includes: a process for obtaining a standard analysis condition for each of setting items for performing a molecular-related ion measurement, where the setting items include an ion amount setting item, a mass-to-charge-ratio range setting item, and a signal intensity setting item; a process for performing a product ion measurement under an altered analysis condition, to acquire mass spectrum data of the product ion measurement, where the altered analysis condition is prepared by changing at least one of analysis conditions of the ion amount setting item, the mass-to-charge-ratio range setting item and the signal intensity setting item in the standard analysis condition; a process for extracting peaks corresponding to the fragment ions; and a process for determining at least a portion of the structure of the sample molecule based on mass information of the extracted peaks.

Provided are methods for determining the amount of estradiol in a sample using mass spectrometry. The methods generally involve ionizing estradiol in a sample and detecting and quantifying the amount of the ion to determine the amount of estradiol in the sample.

Systems and methods are disclosed for automated method parameter configuration for differential mobility separations. As non-limiting examples, various aspects of this disclosure provide receiving a sample in an open port interface; transferring the sample to an ionization source; ionizing the transferred sample; introducing the ionized sample into a mass spectrometer; mass analyzing the ionized sample to produce an initial mass analysis result; determining a peak width of the initial mass analysis result; and determining a dwell time for subsequent measurements based on the determined peak width, a pre-defined number of data points across subsequent mass analysis peak widths, and a number of different analytes to be assessed for the sample. The sample may be diluted and transferred to the ionization source by a sample introduction apparatus selected from a group including an acoustic droplet ejector (ADE), a pneumatic ejector, a piezoelectric ejector, and a hydraulic ejector.

An isotope ratio spectrometer is operated for measurement of a sample. First isotope ratios and first signal intensities are measured for a reference in the spectrometer, over a first measurement time period. A first relationship comprising a relationship between the first isotope ratios and the first signal intensities is determined. Sample isotope ratios and sample signal intensities are measured in the spectrometer, over a second measurement time period subsequent to the first measurement time period. Second isotope ratios and second signal intensities for a reference are measured in the spectrometer, over a third measurement time period subsequent to the second measurement time period. A second relationship comprising a relationship between the second isotope ratios and the second signal intensities is determined. A reference isotope ratio is estimated for a time X within the second measurement time period, based on the first relationship and the second relationship.

An inlet for an analytical instrument comprises a transfer tube having an upstream end and a downstream end and a deposition region arranged at or adjacent to the upstream end of the transfer tube. The transfer tube is configured to transfer ions together with a gas flow from the upstream end to the downstream end. The transfer tube and the deposition region are configured such that the gas flow experiences at least one turn in the deposition region, whereupon relatively large particles entrained in the gas flow are deposited in the deposition region. The at least one turn in the gas flow is created by: a change in cross-sectional area of the gas flow in the deposition region, a change in diameter of the gas flow in the deposition region, and / or a change in cross-sectional shape of the gas flow in the deposition region.

Improved multi-pass time-of-flight mass spectrometers MPTOF, either multi-reflecting (MR) or multi-turn (MT) TOF are proposed with elongated pulsed converters—either orthogonal accelerator or radially ejecting ion trap. The converter 35 is displaced from the MPTOF s-surface of isochronous ion motion in the orthogonal Y-direction. Long ion packets 38 are pulsed deflected in the transverse Y-direction and brought onto said isochronous trajectory s-surface, this way bypassing said converter. Ion packets are isochronously focused in the drift Z-direction within or immediately after the accelerator, either by isochronous trans-axial lens / wedge 68 or Fresnel lens. The accelerator is improved by the ion beam confinement within an RF quadrupolar field or within spatially alternated DC quadrupolar field. The accelerator improves the duty cycle and / or space charge capacity of MPTOF by an order of magnitude.