1740results about "Samples introduction/extraction" patented technology

The invention discloses a high-temperature ion source ion sampling interface with a built-in phase change working medium heat convection system, and relates to the technical field of high-temperature plasma source and ion or atom detection interface application. The orifice is formed in the center of the interface main body and is used for accessing high-temperature plasma; the interface center edge part is arranged on the periphery of the orifice and is used for being in direct contact with high-temperature plasma; the invention relates to a phase-change heat exchanger which comprises a connector center edge part, a heat convection system is arranged on the periphery edge part of the periphery of the connector center edge part, the heat convection system comprises one or more closed-loop cavities, the closed-loop cavities are filled with filler, and phase-change working media are injected into the closed-loop cavities. The invention aims to solve the problems of difficulty in heat dissipation, limited material selection and the like of the ion sampling interface of the high-temperature ion source.

The invention discloses an inductively coupled plasma mass spectrometer with an automatic sample injection structure, and particularly relates to the technical field of mass spectrometers, the inductively coupled plasma mass spectrometer comprises a mass spectrometer body, and a mounting table is mounted at the bottom of one side of the mass spectrometer body; a sample introduction disc is mounted on the mounting table, and a plurality of test tube bodies are limited on the sample introduction disc. According to the switching sampling mechanism, sampling work is completed on solutions in the test tube bodies when the sampling tube moves up and down, and the sampling disc is synchronously driven to complete active rotation switching when the sampling tube moves up and resets, so that continuous active switching sampling operation on the test tube bodies on the sampling disc is completed, the sampling efficiency is improved, and the sampling time is shortened. Manual operation of technicians is not needed, time and labor are saved, the shielding mechanism is additionally arranged on the sample introduction disc and used for shielding the tops of the multiple test tube bodies, external impurities are prevented from falling into the test tube bodies, meanwhile, the shielding mechanism and the sample introduction switching mechanism are linked, and the whole sampling work is safely and stably carried out.

Systems and methods are described for collecting and combining multiple scan samples from a surface of a semiconducting wafer. A system embodiment includes, but is not limited to, a scan nozzle configured to introduce a first scan solution to a surface of a semiconducting wafer to remove impurities from the surface to provide a first scan sample and retrieve the first scan sample, the scan nozzle further configured to introduce a second scan solution to the surface of the semiconducting wafer to remove residual impurities from the surface to provide a second scan sample and retrieve the second scan sample; and a collection vessel in fluid communication with the scan nozzle, the collection vessel configured to receive each of the first scan sample and the second scan sample from the nozzle and to mix the first scan sample with the second scan sample to provide a combined scan sample.

MS-based methods and systems are provided herein in which a desorption solvent desorbs one or more analyte species from an SPME device within a sampling interface that is fluidly coupled to an ion source for subsequent mass spectrometric analysis. In accordance with various aspects of the applicants teachings, the sampling interface includes an internal sampling conduit that provides increased interaction between the desorption solvent and the sampling substrate, thereby improving mass transfer (e.g., increased extraction or desorption speed).

The present disclosure is related to an analytical system comprising a liquid chromatographic (LC) system comprising a plurality of fluidic streams alternately connectable to a common detector via a stream-selection valve connected to the detector via a valve-to-detector conduit. The analytical system further comprises a wash pump fluidically connected to the stream-selection valve and configured to connect to the valve-to-detector conduit between two consecutive fluidic streams in order to wash liquid from a previous fluidic stream out of the valve-to-detector conduit before liquid from a subsequent fluidic stream enters the valve-to-detector conduit. An analytical method comprising switching between the fluidic streams and washing in between is also disclosed.

The invention relates to the technical field of instruments and meters, in particular to an inductively coupled plasma mass spectrometer system for intelligent data processing and report generation. Comprising a sample introduction unit, a plasma excitation and ionization unit, a mass analyzer and detection unit, a vacuum system unit and an intelligent data processing and report generation unit. Efficient ionization is achieved through a bipolar radio frequency switching and AI optimized reaction gas plasma source, the AI optimization module monitors in real time and dynamically adjusts parameters so that the ionization efficiency can be stabilized at 92% + / -2%, and meanwhile a reaction gas control system can optimize plasma conditions to suppress interference ions. And the mass analyzer and the detection unit realize high-precision ion separation by utilizing AI interference correction and a QMS-TOF double analyzer mode, and an interference elimination module can automatically eliminate polyatomic ion interference, so that the ionization efficiency, the analysis precision and the accuracy are improved, the interference is effectively inhibited, and the analysis capability of the system on a complex sample is enhanced.

The invention provides a trapped ion mobility separator (TIMS) and methods to operate it wherein an ion region of the TIMS, through which ions travel along an axis from an entrance to an exit, has an elongate cross-sectional profile perpendicular to the axis with a long dimension and a short dimension. First and second counteracting forces on the ions along the axis are provided, wherein at least one of the first and second forces has an effect on the ions that is ion mobility dependent, and wherein at least one of the first and second forces varies spatially along the axis such that ions are trapped and separated by ion mobility. Different embodiments provide the first and second forces using different combinations of gas flow and electric field potential, and employ various electrode structures that provide the system with different advantageous characteristics.

An integrated sample processing system including an analyzer and a mass spectrometer is disclosed. The integrated sample processing system can perform multiple different types of detection, thereby providing improved flexibility and better accuracy in processing samples. The detection systems in the sample processing system may include an optical detection system and a mass spectrometer.

The invention discloses an atomization mechanism for a plasma mass spectrometer, and relates to the technical field of atomizers, the atomization mechanism comprises an atomization cup, an atomization head and a sample introduction hopper which are respectively arranged at two openings of the atomization cup, a transmission mechanism arranged in the atomization cup, and an atomization nozzle communicated with the interior of the atomization cup, the sample feeding hopper is rotationally connected with the inner wall of the atomizing cup, and the transmission mechanism is in transmission connection with the sample feeding hopper; to-be-atomized liquid flows into the sample feeding hopper through the atomizing head; atomized airflow flows into the atomizing cup through the sample injection hopper and can be blown to liquid in the sample injection hopper; the transmission mechanism can drive the sample feeding hopper to rotate under the action of atomized airflow; and the liquid is atomized in the atomizing cup and then is discharged through the atomizing nozzle. In the atomization process, the transmission mechanism can drive the sample feeding hopper to rotate under the action of atomization airflow, powder and particles in liquid raw materials can be well decomposed through rotation of the sample feeding hopper, the stability of the concentration of liquid fed into a plasma light source is guaranteed, and meanwhile the atomizer can be prevented from being blocked.

The disclosure provides a test device and a test method for isotope measurement of noble gases in lunar soil. The testing device includes a carbon dioxide laser ultra-high vacuum sample melting system, zirconium-aluminum getters, a vacuum dry pump, a first molecular pump, a second molecular pump, a neon gas capture unit, an argon gas capture unit, an argon krypton-xenon capture unit, a dilution tank, a sputtering ion pump and a noble gas mass spectrometer which are connected through pipelines, and each pipeline and each component are connected through a specific way; in addition, control valves for controlling the opening and closing of the pipelines are installed on the connection path between each pipeline and each component, and the disclosure also provides a matching test method.

The utility model discloses an ionization sample injection platform device for a mass spectrometer. The ionization sample injection platform device comprises a base, and a rotary sample frame, a swing arm grabbing mechanism, a turnover sample injection port mechanism and a high-voltage applying mechanism which are arranged on the base, the rotary sample frame is used for loading a plurality of to-be-tested samples; a sample to be detected is arranged in the suction head; the swing arm grabbing mechanism is used for taking and placing a to-be-tested sample through lifting and rotating actions of an electric gripper; the overturning sample inlet mechanism is arranged at the detection port of the mass spectrometer and is used for controlling the to-be-detected sample to execute an overturning action, so that the to-be-detected sample is aligned with the tip part of the detection port of the mass spectrometer; the high-voltage electricity applying mechanism is used for releasing high-voltage electricity to the tip end of the suction head. The ionization sample introduction platform device structure for the mass spectrometer enters a field, and the detection efficiency can be remarkably improved.

The vacuum interface of the mass spectrometer comprises a main body part and a sample introduction piece, the main body part is provided with an interface body and a first connecting piece which are formed into a split piece, one end of the first connecting piece is connected with the interface body, the interface body is formed into an integrally formed piece, and the interior of the interface body is hollow to form a vacuum cavity; the vacuum cavity is provided with a first opening and a second opening which are oppositely arranged, a mass analyzer is suitable for being arranged in the vacuum cavity, the sample injection piece is arranged at the first opening and detachably connected with the other end of the first connecting piece, the sample injection piece is provided with a sample injection port communicated with the first opening, the sample injection port is used for conveying ions to be detected towards the vacuum cavity, and the sample injection port is communicated with the second opening in the direction towards the vacuum cavity. And the opening sizes of at least part of the sample inlets are gradually increased. According to the vacuum interface of the mass spectrometer provided by the embodiment of the invention, not only can the installation precision of the sample introduction piece be ensured, but also the interface body has good sealing performance, so that the working performance of the mass spectrometer can be improved.

A hybrid inductively coupled plasma mass spectrometer (ICP-MS) system is disclosed for simultaneous elemental and molecular analysis in positive and negative polarities. It includes an ICP torch that generates plasma with a buffer gas, producing both positively and negatively charged ions from a sample. Positioned between the sampler and skimmer, an insert with a defined geometry forms a reaction chamber. Various embodiments feature multiple apertures for pressure control, a rotatable disk for aperture regulation, a slider gate for pressure adjustment, a circular gate with adjustable radial apertures, and an inlet for introducing gases, reagents, dopants, or analytes. These components enable precise pressure modulation, optimizing performance for dual-polarity mass spectrometry. The system enhances analytical flexibility by facilitating controlled ion reactions, improving sensitivity and specificity for both elemental and molecular applications. This innovation expands ICP-MS functionality, supporting diverse scientific and industrial applications requiring high-precision mass analysis.

A method of establishing a cancer screening model is provided, including: providing a plurality of samples and a plurality of corresponding cancer states; analyzing these samples by a low-resolution mass spectrometer to obtain a plurality of mass spectral data, wherein the low-resolution mass spectrometer is undertaken a mass accuracy level above 5 ppm and a mass resolution (m / Δm) below 10,000; inputting these mass spectral data into a machine learning algorithm to obtain a plurality of markers by a feature selection method; and using these markers and these cancer states by the machine learning algorithms to establish cancer screening model.

The present invention relates to a mass spectrometer for analyzing an analyte sample, comprising: a plasma ion source configured to generate a plasma; an interface device configured to form a plasma flux from the plasma and flow it to the mass analyzer, where the interface device comprises at least one cone comprising an orifice through which the plasma flux flows and at least one capillary comprising an inlet and an outlet, an outlet and arranged and configured to introduce an analyte sample into the plasma flux at the orifice or in the plasma expansion zone downstream of the orifice such that the analyte sample is ionized by means of the plasma flux and ions are generated, with the outlet in contact with the plasma flux; a mass analyzer configured to filter and / or separate the generated ions; and a detector configured to detect ions generated from the analyte sample.

The invention discloses a composite ion source device for coupling atmospheric pressure interface orbitrap mass spectrometry, which belongs to the field of mass spectrometry detection and comprises a photo ionization / photo-induced association ionization ionization and ion transmission mechanism, a gas sample introduction mechanism, a high-flux radio frequency vacuum ultraviolet light source mechanism and an ion source and mass spectrometry interface mechanism. By adopting the composite ion source device for coupling the atmospheric pressure interface orbitrap mass spectrum, organic components with different polarities, ionization energy and ion affinity in a complex mixture can be efficiently ionized, and through reasonable structural design, the organic components are coupled with the high-resolution orbitrap mass spectrum with the atmospheric pressure interface, so that the high-resolution orbitrap mass spectrum is obtained. The detection range of complex organic components is widened, and the resolution capability and the detection sensitivity of low-abundance or high-molecular-weight organic components are improved.

The invention discloses a thermal desorption sample injection ion source with a separation function, which comprises an ionization cavity, and the top end of the ionization cavity is detachably connected with a heat insulation pad; the heating cavity is fixed to the top end of the heat insulation pad, and a mounting base is mounted at the bottom in the heating cavity; according to the sample injection system, a heating cavity comprises a sample injection unit installed at the top end of the heating cavity, a sample injection pipe is fixedly connected to an installation base, and the sample injection unit is communicated with the sample injection pipe through a sample separation column; the heating system is mounted on the mounting seat; the ionization unit is vertically fixed on one side wall of the ionization cavity, and the ionization unit and the sample feeding pipe are vertically arranged; the detection unit is vertically and fixedly connected to the other side wall of the ionization cavity; a waste liquid opening is formed in the bottom of the ionization cavity. According to the invention, the ionization competition of the target compound of the atmospheric pressure ionization source can be greatly reduced, the sensitivity and the quantitative stability are improved, and more accurate rapid detection is realized.

The invention discloses a sampling device for ICP-MS (Inductively Coupled Plasma Mass Spectrometry) in the technical field of instrumental analysis. The sampling device comprises a liquid inlet mechanism and an atomization mechanism, the liquid inlet mechanism is used for inputting a liquid sample into the atomization mechanism, the atomization mechanism comprises a concentric atomizer and an atomization chamber, the concentric atomizer is communicated with the atomization chamber, and the atomization chamber is communicated with a waste liquid barrel and an ICP torch pipe; a self-cleaning mechanism is arranged on a communication path of the concentric atomizer and the atomizing chamber, the self-cleaning mechanism comprises a movable cylinder, the movable cylinder is rotationally connected into a nozzle of the concentric atomizer, contact electrodes are symmetrically arranged in the movable cylinder, and when the movable cylinder is blocked, the contact electrodes form a path; the contact electrode is electrically connected with a torsion mechanism and a reverse blowing mechanism, the torsion mechanism is used for twisting the movable cylinder when the contact electrode forms a path, and the reverse blowing mechanism is used for intercepting carrier gas input into the concentric atomizer and reversely blowing the carrier gas out of a nozzle of the concentric atomizer. According to the invention, self-cleaning can be carried out when blockage occurs in the sample introduction process, and sample analysis interruption caused by blockage is reduced.

The presently disclosed subject matter provides compositions and methods for the synthesizing and the application of heterobifunctional photo-crosslinkers for the analysis of protein-protein interactions in mass spectrometry, tandem mass spectrometry, and cross-linking mass spectrometry.

The invention relates to the technical field of mass spectrometer sampling, in particular to a sampling device of an inductively coupled plasma mass spectrometer, which comprises a bottom plate, and an inductively coupled plasma mass spectrometer body is fixedly mounted at the top of the bottom plate. During application, the sample introduction mechanism adopts a first motor to drive a turntable to carry a sample during use, power is amplified through transmission of a large belt wheel and a small belt wheel, and a non-contact magnetic coupling drives a pumping spiral driving blade to rotate to generate negative pressure, so that automatic sample extraction, negative pressure control of opening and closing of a plugging plate and accurate control of a sample conveying channel are realized; by means of the design, carrying power is converted into pumping power, the equipment structure is simplified, the number of parts and energy consumption are reduced, the equipment operation and maintenance cost is reduced, an automatic continuous sample injection process replaces traditional single-pipe extraction, the sample injection time is greatly shortened, and the sample treatment efficiency is improved.

The invention relates to a femtosecond laser-assisted chemical ionization method for mass spectrometry of organic molecules. According to the method, high-concentration primary reagent ions are provided for subsequent chemical ionization by femtosecond laser ionization; high-concentration charges carried by primary reagent ions are transferred to a low-concentration to-be-analyzed sample by chemical ionization, the ionization volume of femtosecond laser ionization is equivalently enlarged, and meanwhile, the soft ionization characteristic of two ionization methods is maintained, so that the high-concentration to-be-analyzed sample can be analyzed under the condition of an open or closed air chamber. And carrying out ultrahigh-sensitivity mass spectrometry on the to-be-analyzed sample. The method is combined with a desorption technology or a liquid sample gas distribution device, and can be expanded to analysis of gas, solid and liquid samples; the device is compatible with wide air pressure conditions and can be applied to closed air chamber or open detection environment; the universality and soft ionization characteristics of femtosecond laser ionization and chemical ionization are reserved, and an ionization method with universality and ultrahigh sensitivity is provided for mass spectrometric detection of organic molecules.

The invention provides an in-situ pyrolysis device adopting a glow ionization source. The in-situ pyrolysis device comprises a high-temperature pyrolysis device, a glow ionization device, a two-stage sampling cone, a quadrupole rod device and a flight time mass analyzer, the high-temperature pyrolysis device comprises a first copper block, a second copper block, a graphite sleeve and a long graphite pipe; the glow ionization device comprises a first electrode fixing cylinder, a second electrode fixing cylinder and an annular electrode; the two-stage sampling cone is divided into a first-stage sampling cone and a second-stage sampling cone; and the quadrupole rod device comprises four quadrupole rod electrodes which are parallel to one another and are symmetrically arranged. Pyrolysis reactants generate fullerene and intermediate products thereof through a high-temperature pyrolysis device, then product molecules are ionized through a glow ionization device, ionized ions pass through a two-stage sampling cone and are guided by a radio-frequency electric field and a direct-current electric field of a quadrupole rod device to reach a time-of-flight mass analyzer for in-situ mass spectrometric analysis, and the mass spectrometric analysis result is obtained. In-situ mass spectrometry analysis of'first ionization and second sampling 'can be realized, and fullerene and intermediates thereof formed by high-temperature pyrolysis can be captured.

A method for determining a convolved peak intensity in a sample trace includes ejecting a plurality of sample ejections from a sample well plate. An ejection time log is generated which includes an ejection time of each of the plurality of sample ejections from the sample well plate. The plurality of sample ejections is analyzed with a mass analyzer. The sample trace of intensity versus time values is produced for the plurality of sample ejections based on the analysis. A known peak shape is obtained. A convolved peak intensity is determined for a convolved peak of the sample trace based at least in part on the known peak shape and the ejection time log.

The utility model provides a sample introduction device of a plasma mass spectrometer, which belongs to the technical field of sample introduction devices and comprises a mass spectrometer, a fixed table and an adjusting table, the fixed table and the adjusting table are arranged on the mass spectrometer, and a pump body is mounted at a sample introduction port of the mass spectrometer. According to the sample tube replacement device, the second sector gear is matched with the gear ring, so that the fixed shaft drives the mounting table above the fixed shaft to rotate so as to replace the sample tube, and the fixed shaft rotates 60 degrees every time the driving shaft rotates by a circle, so that the sample tube is convenient to replace; an ejector rod is matched with a spring to slide out of an insertion groove to eject a sample pipe above, so that a fixed pipe extends into the sample pipe, a sample is conveniently and automatically sampled, a first sector gear rotated by a driving shaft by 90 degrees is matched with a rack to enable the ejector rod to slide downwards into a sliding groove, and the sample pipe is put down to expose the fixed pipe in a pipe body; the fixed pipe and the sample pipe are automatically separated, so that the sample pipe is conveniently replaced by subsequent rotation, different samples are directly sampled, and the sample injection efficiency is improved.

The invention belongs to the technical field of mass spectrum ionization sources, provides an online detection mass spectrum ionization source for gas components at an outlet of a combustion chamber of an aero-engine, and solves the problem that an existing ionization source is difficult to be applied to a field test for measuring the concentration of components at the outlet of a combustion chamber of a real aero-engine. According to the technical scheme, the device comprises an ionization source cavity and a radio frequency windowless discharge lamp, a plate electrode, a taper hole electrode, a lamp holder electrode, a direct current transmission electrode, a radio frequency transmission electrode and a differential electrode are sequentially arranged in the ionization source cavity in the axis direction, and a discharge gas inlet is formed in the ionization source cavity. One end of the radio frequency windowless discharge lamp is connected to the discharge gas inlet, and the other end of the radio frequency windowless discharge lamp extends into the lamp holder electrode; the taper hole electrode enables fuel gas to be fed in a molecular beam mode, efficient transmission of stable components and active components in the fuel gas is guaranteed, efficient transmission of ions is achieved in the mode that the direct-current transmission electrode and the radio-frequency transmission electrode are combined, and full-spectrum online analysis of the components of the fuel gas at the outlet of a combustion chamber of an aero-engine can be achieved.

The invention provides a reactor and a dual-light-source mass spectrum device for in-situ detection of gas-phase species in a catalytic reaction. The reactor comprises a control part, a first tube body and a second tube body, the control part comprises a first shell and a switching piece; the first shell is provided with a first channel and a second channel which are arranged in the first direction. The switching piece is arranged between the first channel and the second channel; the first pipe body extends in the first direction and is located on the side, away from the second channel, of the switching piece. The first pipe body is communicated with the first channel; the second pipe body extends in the first direction and is partially located in the second channel. The second pipe body is connected with the first shell and can move in the first direction relative to the first shell. The switching piece moves relative to the first shell to control connection and disconnection of the first channel and the second channel. When the first channel communicates with the second channel, the second pipe body is allowed to partially extend into the second pipe body, and when the first channel is isolated from the second channel, the second pipe body is located on the side, away from the first channel, of the switching piece. The application of the reactor realizes material replacement on the premise of not breaking vacuum.

A mass or mobility spectrometer comprising: a first vacuum chamber; and a collision cell arranged in the first vacuum chamber, wherein the collision cell comprises: an ion entrance at an upstream end thereof; an ion exit at a downstream end thereof; a main body portion between the ion entrance and ion exit; and an elongated tube between the main body portion and the ion exit. The collision cell comprises one or more ion guide extending through the main body portion, and / or through the elongated tube, for radially confining ions within the one or more ion guide. The spectrometer is configured to maintain the main body portion of the collision cell at a higher pressure than the first vacuum chamber; and the elongated tube is configured to limit the gas conductance out of the downstream end of the collision cell.

A system and method for controlling the flow of aerosols. In some embodiments, a system includes a fluid channel, an actuator, and an actuator drive circuit. The actuator and the actuator drive circuit may be configured to impart vibrations, to a wall of the fluid channel, which produce waves in a gas in the fluid channel and cause aerosols in the gas to be nonuniformly distributed across the interior of the fluid channel, the waves producing a pressure pattern including a plurality of nodes or a plurality of antinodes within the fluid channel.

A method of detecting vitamin D in blood using laser desorption / ionization mass spectrometry (LDI-MS) and an apparatus therefor according to the present invention are not complicated in a measurement, do not require a number of measurement steps, and allow for easy measurement and collection of results in real time with a quick analysis. In addition, precise analysis may be performed even at a lower concentration of a sample, such that sensitivity and precision are excellent, various subtypes of vitamin D may be simultaneously detected, a throughput is high, and structural analysis and quantitative analysis of vitamin D that has undergone a metabolic process in blood may be accurately performed without a matrix interference.