709results about "Samples introduction/extraction" patented technology

The invention discloses an atomization mechanism for a plasma mass spectrometer, and relates to the technical field of atomizers, the atomization mechanism comprises an atomization cup, an atomization head and a sample introduction hopper which are respectively arranged at two openings of the atomization cup, a transmission mechanism arranged in the atomization cup, and an atomization nozzle communicated with the interior of the atomization cup, the sample feeding hopper is rotationally connected with the inner wall of the atomizing cup, and the transmission mechanism is in transmission connection with the sample feeding hopper; to-be-atomized liquid flows into the sample feeding hopper through the atomizing head; atomized airflow flows into the atomizing cup through the sample injection hopper and can be blown to liquid in the sample injection hopper; the transmission mechanism can drive the sample feeding hopper to rotate under the action of atomized airflow; and the liquid is atomized in the atomizing cup and then is discharged through the atomizing nozzle. In the atomization process, the transmission mechanism can drive the sample feeding hopper to rotate under the action of atomization airflow, powder and particles in liquid raw materials can be well decomposed through rotation of the sample feeding hopper, the stability of the concentration of liquid fed into a plasma light source is guaranteed, and meanwhile the atomizer can be prevented from being blocked.

A hybrid inductively coupled plasma mass spectrometer (ICP-MS) system is disclosed for simultaneous elemental and molecular analysis in positive and negative polarities. It includes an ICP torch that generates plasma with a buffer gas, producing both positively and negatively charged ions from a sample. Positioned between the sampler and skimmer, an insert with a defined geometry forms a reaction chamber. Various embodiments feature multiple apertures for pressure control, a rotatable disk for aperture regulation, a slider gate for pressure adjustment, a circular gate with adjustable radial apertures, and an inlet for introducing gases, reagents, dopants, or analytes. These components enable precise pressure modulation, optimizing performance for dual-polarity mass spectrometry. The system enhances analytical flexibility by facilitating controlled ion reactions, improving sensitivity and specificity for both elemental and molecular applications. This innovation expands ICP-MS functionality, supporting diverse scientific and industrial applications requiring high-precision mass analysis.

The invention discloses a sampling device for ICP-MS (Inductively Coupled Plasma Mass Spectrometry) in the technical field of instrumental analysis. The sampling device comprises a liquid inlet mechanism and an atomization mechanism, the liquid inlet mechanism is used for inputting a liquid sample into the atomization mechanism, the atomization mechanism comprises a concentric atomizer and an atomization chamber, the concentric atomizer is communicated with the atomization chamber, and the atomization chamber is communicated with a waste liquid barrel and an ICP torch pipe; a self-cleaning mechanism is arranged on a communication path of the concentric atomizer and the atomizing chamber, the self-cleaning mechanism comprises a movable cylinder, the movable cylinder is rotationally connected into a nozzle of the concentric atomizer, contact electrodes are symmetrically arranged in the movable cylinder, and when the movable cylinder is blocked, the contact electrodes form a path; the contact electrode is electrically connected with a torsion mechanism and a reverse blowing mechanism, the torsion mechanism is used for twisting the movable cylinder when the contact electrode forms a path, and the reverse blowing mechanism is used for intercepting carrier gas input into the concentric atomizer and reversely blowing the carrier gas out of a nozzle of the concentric atomizer. According to the invention, self-cleaning can be carried out when blockage occurs in the sample introduction process, and sample analysis interruption caused by blockage is reduced.

The invention relates to the technical field of mass spectrometer sampling, in particular to a sampling device of an inductively coupled plasma mass spectrometer, which comprises a bottom plate, and an inductively coupled plasma mass spectrometer body is fixedly mounted at the top of the bottom plate. During application, the sample introduction mechanism adopts a first motor to drive a turntable to carry a sample during use, power is amplified through transmission of a large belt wheel and a small belt wheel, and a non-contact magnetic coupling drives a pumping spiral driving blade to rotate to generate negative pressure, so that automatic sample extraction, negative pressure control of opening and closing of a plugging plate and accurate control of a sample conveying channel are realized; by means of the design, carrying power is converted into pumping power, the equipment structure is simplified, the number of parts and energy consumption are reduced, the equipment operation and maintenance cost is reduced, an automatic continuous sample injection process replaces traditional single-pipe extraction, the sample injection time is greatly shortened, and the sample treatment efficiency is improved.

The invention provides a reactor and a dual-light-source mass spectrum device for in-situ detection of gas-phase species in a catalytic reaction. The reactor comprises a control part, a first tube body and a second tube body, the control part comprises a first shell and a switching piece; the first shell is provided with a first channel and a second channel which are arranged in the first direction. The switching piece is arranged between the first channel and the second channel; the first pipe body extends in the first direction and is located on the side, away from the second channel, of the switching piece. The first pipe body is communicated with the first channel; the second pipe body extends in the first direction and is partially located in the second channel. The second pipe body is connected with the first shell and can move in the first direction relative to the first shell. The switching piece moves relative to the first shell to control connection and disconnection of the first channel and the second channel. When the first channel communicates with the second channel, the second pipe body is allowed to partially extend into the second pipe body, and when the first channel is isolated from the second channel, the second pipe body is located on the side, away from the first channel, of the switching piece. The application of the reactor realizes material replacement on the premise of not breaking vacuum.

A mass or mobility spectrometer comprising: a first vacuum chamber; and a collision cell arranged in the first vacuum chamber, wherein the collision cell comprises: an ion entrance at an upstream end thereof; an ion exit at a downstream end thereof; a main body portion between the ion entrance and ion exit; and an elongated tube between the main body portion and the ion exit. The collision cell comprises one or more ion guide extending through the main body portion, and / or through the elongated tube, for radially confining ions within the one or more ion guide. The spectrometer is configured to maintain the main body portion of the collision cell at a higher pressure than the first vacuum chamber; and the elongated tube is configured to limit the gas conductance out of the downstream end of the collision cell.

A method of pretreatment of a sample containing a cell for mass spectrometry, including contacting the cell with a first acidic solution containing an organic acid; and extracting a cytoplasmic component of the cell by heating the cell in contact with the first acidic solution.

In a sampling system for mass spectrometry, a method and apparatus are set forth for high flow-rate flushing and sample delivery via a sampling probe (10). The sampling system includes a sampling probe (10) having a first fluid conduit (40) with an inlet, a second fluid conduit (42) with an outlet, and a sampling port fluidly connecting the first fluid conduit (40) and second fluid conduit (42). A fluid source (50) is attached to the inlet and a vacuum source (60) is attached to the outlet for causing fluid to flow through the first fluid conduit (40) past the sampling port and exit through the second fluid conduit (42). A cap (90) is provided for selectively closing and opening the sampling port. When the cap is removed, thus when the sampling port is open, sample may be introduced into, and captured by fluid flowing through the sampling port. When the cap is in place, thus when the sampling port is closed, a flushing fluid is supplied for flushing the sampling probe (10).

A trace of intensity versus time values is received for a series of samples produced by a mass spectrometer. Also, a series of ejections times corresponding to the series of samples produced by a sample introduction system is received. A series of expected peak times corresponding to the series of ejection times are calculated using a known delay time from ejection to mass analysis. At least one isolated peak of the trace is identified using the series of expected peak times. A peak profile is calculated by fitting a mixture of at least two different distribution functions to the at least one isolated peak. For at least one time of the series of expected peak times, an area of a peak at the one time is calculated by fitting the peak profile to the trace at the one time and calculating an area of the fitted peak profile.

The invention discloses a mass spectrometer and an ion processing device.The mass spectrometer comprises an ion source, the ion processing device, a transmission device and a detection device.The ion source is used for generating charged ions, the ion processing device is arranged at the output end of the ion source, and the ion processing device comprises a first base body, a second base body, a connecting piece and a heating assembly; the first base body is close to the ion source and is provided with an ion inlet, the second base body is provided with an ion outlet, the first base body and the second base body are arranged in a spaced mode to form a containing space, and the first base body and the second base body are connected with a power source so that an electromagnetic field can be formed between the first base body and the second base body; the electromagnetic field can be used for providing kinetic energy for the charged ions in the accommodating space, so that the charged ions can be transmitted through the ion transmission channel; the heating assembly is used for heating the medium in the accommodating space, the transmission channel is used for transmitting the charged ions processed by the ion processing device, and the detection device is used for analyzing the charged ions transmitted by the transmission device.

A method for a structural analysis of a sample molecule using a mass spectrometer includes: a process for obtaining a standard analysis condition for each of setting items for performing a molecular-related ion measurement, where the setting items include an ion amount setting item, a mass-to-charge-ratio range setting item, and a signal intensity setting item; a process for performing a product ion measurement under an altered analysis condition, to acquire mass spectrum data of the product ion measurement, where the altered analysis condition is prepared by changing at least one of analysis conditions of the ion amount setting item, the mass-to-charge-ratio range setting item and the signal intensity setting item in the standard analysis condition; a process for extracting peaks corresponding to the fragment ions; and a process for determining at least a portion of the structure of the sample molecule based on mass information of the extracted peaks.

Provided are methods for determining the amount of estradiol in a sample using mass spectrometry. The methods generally involve ionizing estradiol in a sample and detecting and quantifying the amount of the ion to determine the amount of estradiol in the sample.

Systems and methods are disclosed for automated method parameter configuration for differential mobility separations. As non-limiting examples, various aspects of this disclosure provide receiving a sample in an open port interface; transferring the sample to an ionization source; ionizing the transferred sample; introducing the ionized sample into a mass spectrometer; mass analyzing the ionized sample to produce an initial mass analysis result; determining a peak width of the initial mass analysis result; and determining a dwell time for subsequent measurements based on the determined peak width, a pre-defined number of data points across subsequent mass analysis peak widths, and a number of different analytes to be assessed for the sample. The sample may be diluted and transferred to the ionization source by a sample introduction apparatus selected from a group including an acoustic droplet ejector (ADE), a pneumatic ejector, a piezoelectric ejector, and a hydraulic ejector.

An isotope ratio spectrometer is operated for measurement of a sample. First isotope ratios and first signal intensities are measured for a reference in the spectrometer, over a first measurement time period. A first relationship comprising a relationship between the first isotope ratios and the first signal intensities is determined. Sample isotope ratios and sample signal intensities are measured in the spectrometer, over a second measurement time period subsequent to the first measurement time period. Second isotope ratios and second signal intensities for a reference are measured in the spectrometer, over a third measurement time period subsequent to the second measurement time period. A second relationship comprising a relationship between the second isotope ratios and the second signal intensities is determined. A reference isotope ratio is estimated for a time X within the second measurement time period, based on the first relationship and the second relationship.

An inlet for an analytical instrument comprises a transfer tube having an upstream end and a downstream end and a deposition region arranged at or adjacent to the upstream end of the transfer tube. The transfer tube is configured to transfer ions together with a gas flow from the upstream end to the downstream end. The transfer tube and the deposition region are configured such that the gas flow experiences at least one turn in the deposition region, whereupon relatively large particles entrained in the gas flow are deposited in the deposition region. The at least one turn in the gas flow is created by: a change in cross-sectional area of the gas flow in the deposition region, a change in diameter of the gas flow in the deposition region, and / or a change in cross-sectional shape of the gas flow in the deposition region.

Improved multi-pass time-of-flight mass spectrometers MPTOF, either multi-reflecting (MR) or multi-turn (MT) TOF are proposed with elongated pulsed converters—either orthogonal accelerator or radially ejecting ion trap. The converter 35 is displaced from the MPTOF s-surface of isochronous ion motion in the orthogonal Y-direction. Long ion packets 38 are pulsed deflected in the transverse Y-direction and brought onto said isochronous trajectory s-surface, this way bypassing said converter. Ion packets are isochronously focused in the drift Z-direction within or immediately after the accelerator, either by isochronous trans-axial lens / wedge 68 or Fresnel lens. The accelerator is improved by the ion beam confinement within an RF quadrupolar field or within spatially alternated DC quadrupolar field. The accelerator improves the duty cycle and / or space charge capacity of MPTOF by an order of magnitude.

Before a sample is introduced into a liquid sample transport device, an ion source device receives an aqueous mobile phase solution from the liquid sample transport device and ionizes compounds in the aqueous mobile phase solution, thereby generating an ion beam. A tandem mass spectrometer performs a first neutral loss scan of the ion beam to generate a first intensity, wherein the first neutral loss value is set to the molecular weight of a first known solvent, and the tandem mass spectrometer performs a second neutral loss scan of the ion beam to generate a second intensity, wherein the second neutral loss value is set to the molecular weight of a second known solvent. A ratio of the first intensity to the second intensity is calculated. Based on the ratio, it is determined whether the aqueous mobile phase solution is being properly transported by the liquid sample transport device.

Described are an apparatus for generating and collecting nanospray reactive droplets and a method for analyzing a protein digestion. The apparatus includes a capillary, counter electrode, collection vessel, electrostatic lenses, and voltage control module. The capillary receives a mixture that includes a protein and an enzyme and has an outlet disposed in the aperture to dispense the mixture. The collection vessel has a concave surface to receive a nanospray plume emitted from the capillary outlet. The counter electrode and electrostatic lenses are disposed along a nanospray path defined between the capillary outlet and the collection vessel. Each electrostatic lens is formed of an electrically conductive plate having an aperture therein to pass a nanospray reactive plume. The voltage control module is in electrical communication with and is configured to independently control the voltage of the capillary, the counter electrode, the collection vessel and each of the electrostatic lenses.

The invention relates to a device and a method for applying matrix material for matrix-assisted ionization, in particular for applying matrix material for matrix-assisted laser desorption / ionization. The invention also relates to the use of a device according to the invention for applying matrix material for matrix-assisted ionization. The invention also relates to the use of a sample carrier comprising matrix material for matrix-assisted ionization, which has been applied by means of a method according to the invention, for ion spectrometric analyses.

The utility model discloses a droplet microextraction-flow type electrospray ionization device, which belongs to the technical field of chemical analysis and comprises a digital peristaltic pump, a direct-current high-voltage power supply, a stainless steel two-way connector and a conductive metal transmitting tube. A transmission hose is arranged on the digital peristaltic pump, one end of the conductive metal transmitting tube is connected with the transmission hose of the digital peristaltic pump through a stainless steel two-way connector, the other end of the conductive metal transmitting tube corresponds to a mass spectrometer inlet and is used for generating electrospray, and the direct-current high-voltage power supply is electrically connected with the conductive metal transmitting tube. The direct-current high-voltage power supply applies voltage to the conductive metal transmitting tube; according to the droplet microextraction-flow type electrospray ionization device adopting the structure, micro-droplet flow type sample injection and non-contact flow type sample injection are combined, and electrospray can be stably generated under the condition of not depending on gas assistance.

The invention discloses integrated equipment for inductively coupled plasma mass spectrometry and sample introduction, and belongs to the technical field of instrument equipment. The apparatus comprises: an instrument body for detecting an entered sample solution; the sample injection pump is arranged on the upper surface of the instrument body; a liquid inlet pipe is arranged on one side of the circular nozzle, spraying holes are distributed in the other side of the circular nozzle at equal intervals, the liquid inlet pipe is connected with the sample injection pump, and the circular nozzle is used for atomizing a sample solution; wherein an inner cavity of the circular nozzle is provided with a flow control assembly, the flow control assembly comprises two arc plates, and the arc plates are attached to the inner wall of the circular nozzle. According to the invention, when a sample solution is atomized, the spraying area and the spraying pressure can be controlled by controlling the rotation of the arc plate, so that the atomization speed of the sample solution is reasonably controlled, the sample injection amount of the sample solution is accurately controlled, and the purpose of saving the sample solution is achieved.

A coupling tube made of a stretchable elastomeric material. The "stretchy" coupling tubing allows for improved reliability / repeatability of coupling performance. For example, the stretch provided can take up tolerances between positions of imager and reader instruments. In one example, the stretch can take up tolerances between positions of the junction between the rigid portion of tubing inside the IMC unit and the injector to an ionization source. The coupling tube may also be provided with a reduced inner diameter (ID) as compared to standard coupling components. A taper in the inner diameter (ID) can occur before the flow enters the stretchable coupling tube. Barbed ends may also be provided for securing the coupling tube into place.

The invention discloses a gas exchange device in front of a sample introduction cone of an inductively coupled plasma mass spectrometer, the gas exchange device in front of the sample introduction cone is arranged outside an ICP torch tube in a sleeving manner, and the gas exchange device in front of the sample introduction cone is mounted on a partition plate around the sample introduction cone; the sample injection cone front gas exchange device comprises a porous breathable layer and a shell; an argon inlet is formed in one end, close to the sample introduction cone, of the shell; one end, far away from the sample introduction cone, of a space between the porous breathable layer and the ICP torch tube is opened and is communicated with the atmosphere. According to the invention, the environmental gas components in the space between the ICP torch tube and the mass spectrum interface device are exchanged into the preset clean gas, so that the sample ionization process is not interfered by the environmental air components, a lower noise baseline is obtained, and meanwhile, the generation of environmental component ions such as nitrogen oxide ions which possibly interfere mass spectrum analysis is reduced; the sensitivity of mass spectrometry detection and the environment anti-interference capability are improved.

An apparatus for ion manipulations includes an ion manipulation path extending between an inlet and an outlet, at least one continuous electrode configured to receive a first RF voltage signal, and a plurality of segmented electrodes configured to receive a second voltage signal and generate a traveling wave field based thereon. The ion manipulation path includes a first region extending in a first direction, a second region extending in a second direction, and a curved region extending between the first and second regions. The at least one continuous electrode extends through the first region, the curved region, and second region. The segmented electrodes are arranged along the ion manipulation path in the first region, the curved region, and the second region. The traveling wave field is configured to cause ions to travel through, the first region, the curved region, and the second region.

A method of newborn screening (“NBS”) is disclosed comprising directing ultrasonic energy or ultrasonic waves into a metabolite or analyte sample derived from a newborn, neonate or infant so as to cause a mist of charged sample droplets or sample ions to be ejected. The charged sample droplets or sample ions are then mass analysed and a determination is made as to whether or not one or more first metabolites or analytes indicative of a disorder or inborn error are present in the sample.

Devices and methods for characterizing an analyte mixture are provided. Some methods described herein include performing an enrichment step on a device prior to discharging an enriched analyte fraction from the device for subsequent analysis. The invention also comprises a device for carrying out the enrichment steps.

Systems and methods to provide rapid and autonomous detection of biological and chemical analyte particles in gas and liquid samples. Systems and methods for capturing and identifying biological and chemical aerosol analyte particles using matrix assisted laser desorption mass spectrometry (MALDI-MS) and using time-of-flight mass spectrometry (TOFMS) are disclosed. High specificity for capture and detection of aerosolized fentanyl was demonstrated using a portable sample capture and analysis system.

A sample support is a sample support for ionizing a sample. The sample support includes a substrate having a first surface, a second surface opposite to the first surface, and an irregular porous structure opening to at least the first surface. The porous structure is formed of a plurality of large particles connected to each other and a plurality of small particles having a diameter smaller than that of the large particles. At least a part of the plurality of small particles is held between two or more of the large particles constituting the first surface.

An ion focusing device comprising an ion collection element comprising a plurality of N curved electrodes extending around an axis of the ion collection element and an aperture on an axis of the ion collection element. A multipole ion guide adjacent the ion collection element and having a plurality of N elongate electrodes extending parallel to and around an axis of the multipole ion guide, wherein the axis of the multipole ion guide coincides with the axis of the ion collection element, wherein each of the N curved electrodes of the ion collection element are configured to receive a radio frequency, RF, signal having the same phase as an RF signal configured to be applied to at least one elongate electrode of the plurality of elongate electrodes of the multipole ion guide, and further wherein at least two of the N electrodes of the ion collection element are configured to receive RF signals of a different phase.

A method and system for calculating the arrival time window of a plume at an analyzer is presented. The plume is generated from a tissue or geological sample by laser ablation. In some embodiments, external sensors measure ambient parameters such as temperature and pressure to more accurately calculate the arrival time window. In other embodiments, direct measurements of the plume's arrival time or non-contact measurements of the plume's flow velocity in a pipe are used to determine the arrival time window of the plume at the analyzer.