550results about "Samples introduction/extraction" patented technology

The invention discloses a sampling device for ICP-MS (Inductively Coupled Plasma Mass Spectrometry) in the technical field of instrumental analysis. The sampling device comprises a liquid inlet mechanism and an atomization mechanism, the liquid inlet mechanism is used for inputting a liquid sample into the atomization mechanism, the atomization mechanism comprises a concentric atomizer and an atomization chamber, the concentric atomizer is communicated with the atomization chamber, and the atomization chamber is communicated with a waste liquid barrel and an ICP torch pipe; a self-cleaning mechanism is arranged on a communication path of the concentric atomizer and the atomizing chamber, the self-cleaning mechanism comprises a movable cylinder, the movable cylinder is rotationally connected into a nozzle of the concentric atomizer, contact electrodes are symmetrically arranged in the movable cylinder, and when the movable cylinder is blocked, the contact electrodes form a path; the contact electrode is electrically connected with a torsion mechanism and a reverse blowing mechanism, the torsion mechanism is used for twisting the movable cylinder when the contact electrode forms a path, and the reverse blowing mechanism is used for intercepting carrier gas input into the concentric atomizer and reversely blowing the carrier gas out of a nozzle of the concentric atomizer. According to the invention, self-cleaning can be carried out when blockage occurs in the sample introduction process, and sample analysis interruption caused by blockage is reduced.

The invention relates to the technical field of mass spectrometer sampling, in particular to a sampling device of an inductively coupled plasma mass spectrometer, which comprises a bottom plate, and an inductively coupled plasma mass spectrometer body is fixedly mounted at the top of the bottom plate. During application, the sample introduction mechanism adopts a first motor to drive a turntable to carry a sample during use, power is amplified through transmission of a large belt wheel and a small belt wheel, and a non-contact magnetic coupling drives a pumping spiral driving blade to rotate to generate negative pressure, so that automatic sample extraction, negative pressure control of opening and closing of a plugging plate and accurate control of a sample conveying channel are realized; by means of the design, carrying power is converted into pumping power, the equipment structure is simplified, the number of parts and energy consumption are reduced, the equipment operation and maintenance cost is reduced, an automatic continuous sample injection process replaces traditional single-pipe extraction, the sample injection time is greatly shortened, and the sample treatment efficiency is improved.

The invention provides a reactor and a dual-light-source mass spectrum device for in-situ detection of gas-phase species in a catalytic reaction. The reactor comprises a control part, a first tube body and a second tube body, the control part comprises a first shell and a switching piece; the first shell is provided with a first channel and a second channel which are arranged in the first direction. The switching piece is arranged between the first channel and the second channel; the first pipe body extends in the first direction and is located on the side, away from the second channel, of the switching piece. The first pipe body is communicated with the first channel; the second pipe body extends in the first direction and is partially located in the second channel. The second pipe body is connected with the first shell and can move in the first direction relative to the first shell. The switching piece moves relative to the first shell to control connection and disconnection of the first channel and the second channel. When the first channel communicates with the second channel, the second pipe body is allowed to partially extend into the second pipe body, and when the first channel is isolated from the second channel, the second pipe body is located on the side, away from the first channel, of the switching piece. The application of the reactor realizes material replacement on the premise of not breaking vacuum.

A mass or mobility spectrometer comprising: a first vacuum chamber; and a collision cell arranged in the first vacuum chamber, wherein the collision cell comprises: an ion entrance at an upstream end thereof; an ion exit at a downstream end thereof; a main body portion between the ion entrance and ion exit; and an elongated tube between the main body portion and the ion exit. The collision cell comprises one or more ion guide extending through the main body portion, and / or through the elongated tube, for radially confining ions within the one or more ion guide. The spectrometer is configured to maintain the main body portion of the collision cell at a higher pressure than the first vacuum chamber; and the elongated tube is configured to limit the gas conductance out of the downstream end of the collision cell.

A method of pretreatment of a sample containing a cell for mass spectrometry, including contacting the cell with a first acidic solution containing an organic acid; and extracting a cytoplasmic component of the cell by heating the cell in contact with the first acidic solution.

In a sampling system for mass spectrometry, a method and apparatus are set forth for high flow-rate flushing and sample delivery via a sampling probe (10). The sampling system includes a sampling probe (10) having a first fluid conduit (40) with an inlet, a second fluid conduit (42) with an outlet, and a sampling port fluidly connecting the first fluid conduit (40) and second fluid conduit (42). A fluid source (50) is attached to the inlet and a vacuum source (60) is attached to the outlet for causing fluid to flow through the first fluid conduit (40) past the sampling port and exit through the second fluid conduit (42). A cap (90) is provided for selectively closing and opening the sampling port. When the cap is removed, thus when the sampling port is open, sample may be introduced into, and captured by fluid flowing through the sampling port. When the cap is in place, thus when the sampling port is closed, a flushing fluid is supplied for flushing the sampling probe (10).

A trace of intensity versus time values is received for a series of samples produced by a mass spectrometer. Also, a series of ejections times corresponding to the series of samples produced by a sample introduction system is received. A series of expected peak times corresponding to the series of ejection times are calculated using a known delay time from ejection to mass analysis. At least one isolated peak of the trace is identified using the series of expected peak times. A peak profile is calculated by fitting a mixture of at least two different distribution functions to the at least one isolated peak. For at least one time of the series of expected peak times, an area of a peak at the one time is calculated by fitting the peak profile to the trace at the one time and calculating an area of the fitted peak profile.

The invention discloses a mass spectrometer and an ion processing device.The mass spectrometer comprises an ion source, the ion processing device, a transmission device and a detection device.The ion source is used for generating charged ions, the ion processing device is arranged at the output end of the ion source, and the ion processing device comprises a first base body, a second base body, a connecting piece and a heating assembly; the first base body is close to the ion source and is provided with an ion inlet, the second base body is provided with an ion outlet, the first base body and the second base body are arranged in a spaced mode to form a containing space, and the first base body and the second base body are connected with a power source so that an electromagnetic field can be formed between the first base body and the second base body; the electromagnetic field can be used for providing kinetic energy for the charged ions in the accommodating space, so that the charged ions can be transmitted through the ion transmission channel; the heating assembly is used for heating the medium in the accommodating space, the transmission channel is used for transmitting the charged ions processed by the ion processing device, and the detection device is used for analyzing the charged ions transmitted by the transmission device.

Provided are methods for determining the amount of estradiol in a sample using mass spectrometry. The methods generally involve ionizing estradiol in a sample and detecting and quantifying the amount of the ion to determine the amount of estradiol in the sample.

Systems and methods are disclosed for automated method parameter configuration for differential mobility separations. As non-limiting examples, various aspects of this disclosure provide receiving a sample in an open port interface; transferring the sample to an ionization source; ionizing the transferred sample; introducing the ionized sample into a mass spectrometer; mass analyzing the ionized sample to produce an initial mass analysis result; determining a peak width of the initial mass analysis result; and determining a dwell time for subsequent measurements based on the determined peak width, a pre-defined number of data points across subsequent mass analysis peak widths, and a number of different analytes to be assessed for the sample. The sample may be diluted and transferred to the ionization source by a sample introduction apparatus selected from a group including an acoustic droplet ejector (ADE), a pneumatic ejector, a piezoelectric ejector, and a hydraulic ejector.

An inlet for an analytical instrument comprises a transfer tube having an upstream end and a downstream end and a deposition region arranged at or adjacent to the upstream end of the transfer tube. The transfer tube is configured to transfer ions together with a gas flow from the upstream end to the downstream end. The transfer tube and the deposition region are configured such that the gas flow experiences at least one turn in the deposition region, whereupon relatively large particles entrained in the gas flow are deposited in the deposition region. The at least one turn in the gas flow is created by: a change in cross-sectional area of the gas flow in the deposition region, a change in diameter of the gas flow in the deposition region, and / or a change in cross-sectional shape of the gas flow in the deposition region.

Described are an apparatus for generating and collecting nanospray reactive droplets and a method for analyzing a protein digestion. The apparatus includes a capillary, counter electrode, collection vessel, electrostatic lenses, and voltage control module. The capillary receives a mixture that includes a protein and an enzyme and has an outlet disposed in the aperture to dispense the mixture. The collection vessel has a concave surface to receive a nanospray plume emitted from the capillary outlet. The counter electrode and electrostatic lenses are disposed along a nanospray path defined between the capillary outlet and the collection vessel. Each electrostatic lens is formed of an electrically conductive plate having an aperture therein to pass a nanospray reactive plume. The voltage control module is in electrical communication with and is configured to independently control the voltage of the capillary, the counter electrode, the collection vessel and each of the electrostatic lenses.

The invention relates to a device and a method for applying matrix material for matrix-assisted ionization, in particular for applying matrix material for matrix-assisted laser desorption / ionization. The invention also relates to the use of a device according to the invention for applying matrix material for matrix-assisted ionization. The invention also relates to the use of a sample carrier comprising matrix material for matrix-assisted ionization, which has been applied by means of a method according to the invention, for ion spectrometric analyses.

The utility model discloses a droplet microextraction-flow type electrospray ionization device, which belongs to the technical field of chemical analysis and comprises a digital peristaltic pump, a direct-current high-voltage power supply, a stainless steel two-way connector and a conductive metal transmitting tube. A transmission hose is arranged on the digital peristaltic pump, one end of the conductive metal transmitting tube is connected with the transmission hose of the digital peristaltic pump through a stainless steel two-way connector, the other end of the conductive metal transmitting tube corresponds to a mass spectrometer inlet and is used for generating electrospray, and the direct-current high-voltage power supply is electrically connected with the conductive metal transmitting tube. The direct-current high-voltage power supply applies voltage to the conductive metal transmitting tube; according to the droplet microextraction-flow type electrospray ionization device adopting the structure, micro-droplet flow type sample injection and non-contact flow type sample injection are combined, and electrospray can be stably generated under the condition of not depending on gas assistance.

A coupling tube made of a stretchable elastomeric material. The "stretchy" coupling tubing allows for improved reliability / repeatability of coupling performance. For example, the stretch provided can take up tolerances between positions of imager and reader instruments. In one example, the stretch can take up tolerances between positions of the junction between the rigid portion of tubing inside the IMC unit and the injector to an ionization source. The coupling tube may also be provided with a reduced inner diameter (ID) as compared to standard coupling components. A taper in the inner diameter (ID) can occur before the flow enters the stretchable coupling tube. Barbed ends may also be provided for securing the coupling tube into place.

An apparatus for ion manipulations includes an ion manipulation path extending between an inlet and an outlet, at least one continuous electrode configured to receive a first RF voltage signal, and a plurality of segmented electrodes configured to receive a second voltage signal and generate a traveling wave field based thereon. The ion manipulation path includes a first region extending in a first direction, a second region extending in a second direction, and a curved region extending between the first and second regions. The at least one continuous electrode extends through the first region, the curved region, and second region. The segmented electrodes are arranged along the ion manipulation path in the first region, the curved region, and the second region. The traveling wave field is configured to cause ions to travel through, the first region, the curved region, and the second region.

A method of newborn screening (“NBS”) is disclosed comprising directing ultrasonic energy or ultrasonic waves into a metabolite or analyte sample derived from a newborn, neonate or infant so as to cause a mist of charged sample droplets or sample ions to be ejected. The charged sample droplets or sample ions are then mass analysed and a determination is made as to whether or not one or more first metabolites or analytes indicative of a disorder or inborn error are present in the sample.

Devices and methods for characterizing an analyte mixture are provided. Some methods described herein include performing an enrichment step on a device prior to discharging an enriched analyte fraction from the device for subsequent analysis. The invention also comprises a device for carrying out the enrichment steps.

Systems and methods to provide rapid and autonomous detection of biological and chemical analyte particles in gas and liquid samples. Systems and methods for capturing and identifying biological and chemical aerosol analyte particles using matrix assisted laser desorption mass spectrometry (MALDI-MS) and using time-of-flight mass spectrometry (TOFMS) are disclosed. High specificity for capture and detection of aerosolized fentanyl was demonstrated using a portable sample capture and analysis system.

A sample support is a sample support for ionizing a sample. The sample support includes a substrate having a first surface, a second surface opposite to the first surface, and an irregular porous structure opening to at least the first surface. The porous structure is formed of a plurality of large particles connected to each other and a plurality of small particles having a diameter smaller than that of the large particles. At least a part of the plurality of small particles is held between two or more of the large particles constituting the first surface.

An ion focusing device comprising an ion collection element comprising a plurality of N curved electrodes extending around an axis of the ion collection element and an aperture on an axis of the ion collection element. A multipole ion guide adjacent the ion collection element and having a plurality of N elongate electrodes extending parallel to and around an axis of the multipole ion guide, wherein the axis of the multipole ion guide coincides with the axis of the ion collection element, wherein each of the N curved electrodes of the ion collection element are configured to receive a radio frequency, RF, signal having the same phase as an RF signal configured to be applied to at least one elongate electrode of the plurality of elongate electrodes of the multipole ion guide, and further wherein at least two of the N electrodes of the ion collection element are configured to receive RF signals of a different phase.

A method and system for calculating the arrival time window of a plume at an analyzer is presented. The plume is generated from a tissue or geological sample by laser ablation. In some embodiments, external sensors measure ambient parameters such as temperature and pressure to more accurately calculate the arrival time window. In other embodiments, direct measurements of the plume's arrival time or non-contact measurements of the plume's flow velocity in a pipe are used to determine the arrival time window of the plume at the analyzer.

A flow control device for aerosolised sample delivery in an inductively coupled plasma (ICP) analytical system is provided. The device includes a body that at least in part defines a sample flow separating region, the sample flow separating region having a longitudinal flow direction and having an upstream end through which the aerosolised sample enters and a downstream end through which a modified aerosolised sample exits. The body further includes an injection duct having an opening adjacent to the sample flow separating region, the injection duct configured to direct a stream of gas in an injection direction to the sample flow separating region. The injection direction is angled relative to the longitudinal flow direction such that, upon introduction of the stream of gas through the opening, a vortex flow is generated in the sample flow separating region, the vortex flow having a direction counter to the direction of flow of the aerosolised sample to provide control of droplet size in the modified aerosolised sample.

To provide a sample support that enables highly sensitive mass spectrometry, and a method for manufacturing the sample support.SOLUTION: A sample support is a sample support used to ionize the component of a sample. The sample support 1 includes a substrate 2, a conductive layer 5, and a plurality of particles 71. The substrate 2 has a first main surface 2a and a plurality of holes 2c opening to the first main surface 2a. The conductive layer 5 is provided on the first main surface 2a such that the holes 2c are not blocked. The plurality of particles 71 are provided on the surface 5a of the conductive layer 5. The absorptance of the plurality of particles 71 with respect to the energy rays used for ionization is greater than or equal to the absorptance of the conductive layer 5 with respect to the energy rays.SELECTED DRAWING: Figure 5

This invention provides a cryo-laser ablation chamber for reflected light fluid inclusions, belonging to the field of geosciences for the analysis of the composition of single fluid inclusions. The device mainly consists of an outer shell, a cryo chamber, an ablation chamber, and a top cover. The cryo chamber, located at the bottom of the outer shell, is made of pure silver, and its top is mirror-polished and connected to a liquid nitrogen tank and pump via a Teflon hose. The ablation chamber, located above the liquid nitrogen chamber, has a standard sample mounting hole. The chamber is spindle-shaped and has inlet and outlet ports at both ends, connected to a carrier gas pipeline. The top cover is equipped with a calcium fluoride glass viewing window, allowing 193nm laser light to pass through. This invention uses a silver cryo chamber to ensure the required cooling effect; simultaneously, the mirror design at the top of the cryo chamber converts the light emitted by the reflected light microscope into transmitted light, thus enabling precise observation and positioning of the fluid inclusions under test without relying on conventional transmitted light systems.

The present invention describes a gate for loading and unloading a sample receiving element into and out of a mass spectrometer. In addition, a holder for a sample receiving element is described. Furthermore, a kit is described, comprising a holder for a sample-receiving element and a sample-receiving element that can be held by the holder. In addition, a mass spectrometer, in particular a MALDI-TOF mass spectrometer, is also described.

The present application relates to a kind of photoionization ion mobility spectrometry of fast switching combination reagent ion, including photoionization ion mobility spectrometry, reagent ion generation device, reagent molecule carrier gas is introduced to reagent molecule into the reaction zone of ion mobility spectrometry, different types of reagent ions can be obtained by switching different gas paths and reagent molecules in positive ion mode, and the reagent ions in conventional gas flow mode are mainly (C3H6O)2H + , after switching combination gas path device, new hydrate cluster reagent ion H3O (H2O) n + Is generated by the regulation of acetone and water reagent molecule, and the reactivity is higher, the sensitivity of target detection is higher, so that by switching different gas paths, the high sensitivity and high selectivity detection of target compound can be realized, such as the detection of exhaled air ammonia and atmospheric ammonia in complex matrix background, and any sample pretreatment process is not needed.

A lock for introducing and discharging a sample receiving element into a mass spectrometer is described. Also described is a set comprising a holder for sample receiving elements and a sample receiving element that can be held by the holder. Also described is a mass spectrometer, in particular a MALDI-TOF mass spectrometer.

The invention discloses a plasma electrospray fusion ionization source and mass spectrum combined system and a detection method. The plasma electrospray fusion ionization source and mass spectrum combined system comprises a coaxially nested electrospray needle, a sample injector, an ultrahigh voltage generator, a grounded metal grid mesh, a mass spectrometer and a detector thereof. A grounded metal grid is installed between a spray needle and a mass spectrum inlet, voltage is applied to the spray needle, carrier gas is excited to generate plasmas, the macroscopic plasmas at the front end of the spray needle are fused with electrospray, and the plasmas and micro-droplets at the tip of the spray needle are fused. According to the unique ionization source constructed by the plasma-micro-droplet fusion system, on one hand, the ionization efficiency is improved, mass spectrum signals are enhanced, the application range of analytes is widened, excellent sensitivity to high-polarity compounds is kept, and effective ionization and detection of low-polarity compounds are achieved; on the other hand, higher energy and active species are provided for the micro-droplet reaction, the energy barrier required by traditional synthesis is broken, and efficient spontaneous product generation of the micro-droplet chemical reaction is achieved.

An interface and a sample analysis method using the same are disclosed herein. In some embodiments, an interface is between a liquid chromatography (LC), an ionization device, and a mass spectrometer (MS), wherein a sample containing a target eluted from the liquid chromatography is ionized by the ionization device and the sample is introduced into the mass spectrometer, wherein the interface includes a droplet sprayer, an evaporator having a heatable block, and an introduction tube, wherein the heatable block has one or more openings, the droplet sprayer for converting the sample into sample droplets and for spraying the sample droplets, the evaporator for evaporating a solvent in the sample droplets to generate a gaseous target by passing the droplets through the one or more openings, the introduction tube for receiving the gaseous target and for introducing an ionized gaseous target into the mass spectrometer.