311results about "Tube vacuum systems" patented technology

The invention relates to the technical field of instruments and meters, in particular to an inductively coupled plasma mass spectrometer system for intelligent data processing and report generation. Comprising a sample introduction unit, a plasma excitation and ionization unit, a mass analyzer and detection unit, a vacuum system unit and an intelligent data processing and report generation unit. Efficient ionization is achieved through a bipolar radio frequency switching and AI optimized reaction gas plasma source, the AI optimization module monitors in real time and dynamically adjusts parameters so that the ionization efficiency can be stabilized at 92% + / -2%, and meanwhile a reaction gas control system can optimize plasma conditions to suppress interference ions. And the mass analyzer and the detection unit realize high-precision ion separation by utilizing AI interference correction and a QMS-TOF double analyzer mode, and an interference elimination module can automatically eliminate polyatomic ion interference, so that the ionization efficiency, the analysis precision and the accuracy are improved, the interference is effectively inhibited, and the analysis capability of the system on a complex sample is enhanced.

A hybrid inductively coupled plasma mass spectrometer (ICP-MS) system is disclosed for simultaneous elemental and molecular analysis in positive and negative polarities. It includes an ICP torch that generates plasma with a buffer gas, producing both positively and negatively charged ions from a sample. Positioned between the sampler and skimmer, an insert with a defined geometry forms a reaction chamber. Various embodiments feature multiple apertures for pressure control, a rotatable disk for aperture regulation, a slider gate for pressure adjustment, a circular gate with adjustable radial apertures, and an inlet for introducing gases, reagents, dopants, or analytes. These components enable precise pressure modulation, optimizing performance for dual-polarity mass spectrometry. The system enhances analytical flexibility by facilitating controlled ion reactions, improving sensitivity and specificity for both elemental and molecular applications. This innovation expands ICP-MS functionality, supporting diverse scientific and industrial applications requiring high-precision mass analysis.

Systems and methods described herein provide for charge state control of multiply-charged anions in a front end, high pressure ion guide. In some example aspects, a mass spectrometer system is provided comprising a first vacuum chamber (121) maintained at a pressure above about 500 mTorr. At least one ion guide (106) is disposed within the first vacuum chamber, the at least one ion guide comprising a plurality of rods extending along a central longitudinal axis. A controller (193) is configured to adjust an amplitude of an RF voltage signal provided to the plurality of rods so as to alternatively operate the ion guide in a first mode of operation with a lower amplitude of the RF voltage signal so as to reduce the likelihood of charge reduction by electron detachment so as to substantially maintain the isotopic distribution of the ions during transmission of ions through the ion guide, and a second mode of operation with a higher amplitude of the RF voltage signal so as to increase the likelihood of electron detachment from ions being transmitted therethrough.

An orthogonal acceleration time-of-flight mass spectrometer includes: a first vacuum chamber and a second vacuum chamber; an insulating spacer member; a former-stage-side ring electrode; subsequent-stage-side ring electrodes; a first fixation member including a first displacement member to displace a central axis of the former-stage-side ring electrode and the subsequent-stage-side ring electrodes in a predetermined direction orthogonal to the central axis by thermal expansion; and a second fixation member including a second displacement member to displace the central axis in the predetermined direction orthogonal to the central axis by thermal expansion, a difference between a thermal expansion amount of the first displacement member per unit temperature and a thermal expansion amount of the second displacement member per unit temperature being 30% or less of the thermal expansion amount of the first displacement member.

A mass or mobility spectrometer comprising: a first vacuum chamber; and a collision cell arranged in the first vacuum chamber, wherein the collision cell comprises: an ion entrance at an upstream end thereof; an ion exit at a downstream end thereof; a main body portion between the ion entrance and ion exit; and an elongated tube between the main body portion and the ion exit. The collision cell comprises one or more ion guide extending through the main body portion, and / or through the elongated tube, for radially confining ions within the one or more ion guide. The spectrometer is configured to maintain the main body portion of the collision cell at a higher pressure than the first vacuum chamber; and the elongated tube is configured to limit the gas conductance out of the downstream end of the collision cell.

A pulse generator is disclosed. The pulse generator includes a DC source; a plurality of switches, a transformer; and a pulsing output. The pulse generator can be coupled with a plasma chamber. The pulsing output outputs high voltage pulses having a peak-to-peak voltage greater than 1 kV and a voltage portion between consecutive high voltage bipolar pulses that has a negative slope that substantially offsets the voltage reduction on a wafer within a plasma chamber due to an ion current. The resulting voltage at the wafer may be substantially flat between consecutive pulses.

In a sampling system for mass spectrometry, a method and apparatus are set forth for high flow-rate flushing and sample delivery via a sampling probe (10). The sampling system includes a sampling probe (10) having a first fluid conduit (40) with an inlet, a second fluid conduit (42) with an outlet, and a sampling port fluidly connecting the first fluid conduit (40) and second fluid conduit (42). A fluid source (50) is attached to the inlet and a vacuum source (60) is attached to the outlet for causing fluid to flow through the first fluid conduit (40) past the sampling port and exit through the second fluid conduit (42). A cap (90) is provided for selectively closing and opening the sampling port. When the cap is removed, thus when the sampling port is open, sample may be introduced into, and captured by fluid flowing through the sampling port. When the cap is in place, thus when the sampling port is closed, a flushing fluid is supplied for flushing the sampling probe (10).

The utility model provides a mass spectrometer which comprises a rack, and the rack is provided with a plurality of containing spaces arranged in the height direction of the rack and a vacuum cavity arranged side by side with the containing space on the bottommost layer. The flight time mass analyzer is fixed outside the rack; the vacuumizing module is at least positioned in the accommodating space at the bottommost layer and is used for vacuumizing the vacuum cavity; the shell wraps the rack and the flight time mass analyzer, and a display screen is integrated on the shell; a module assembly is further included, the module assembly at least comprises an industrial mainboard, and the industrial mainboard is located in one containing space; the industrial mainboard is used for converting signals collected by the time-of-flight mass analyzer into atlases and displaying the atlases on the display screen. The industrial mainboard for processing the signals acquired by the time-of-flight mass analyzer and the display screen are integrated on the mass spectrometer, so that a work station does not need to be additionally established to process and detect data, the integration level of the mass spectrometer is improved, and the occupied space of the mass spectrometer is reduced.

A sampling interface 100 for use in mass spectroscopy apparatus, comprising: an inlet 110 for receiving a quantity of particles from an ion source; a skimmer 115 having an aperture arranged downstream

An apparatus for ion manipulations includes an ion manipulation path extending between an inlet and an outlet, at least one continuous electrode configured to receive a first RF voltage signal, and a plurality of segmented electrodes configured to receive a second voltage signal and generate a traveling wave field based thereon. The ion manipulation path includes a first region extending in a first direction, a second region extending in a second direction, and a curved region extending between the first and second regions. The at least one continuous electrode extends through the first region, the curved region, and second region. The segmented electrodes are arranged along the ion manipulation path in the first region, the curved region, and the second region. The traveling wave field is configured to cause ions to travel through, the first region, the curved region, and the second region.

The invention discloses a mass spectrometer vacuum cavity high-pressure introduction device which comprises a fixed plate installed on a mass spectrometer, and the left edge and the right edge of the fixed plate are vertically bent upwards to form a pair of supporting vertical plates. A sliding seat capable of horizontally sliding left and right is arranged between the two supporting vertical plates, a strip-shaped hole consistent with the sliding direction of the sliding seat is formed in the middle of the sliding seat, two groups of high-voltage connectors capable of vertically moving are arranged in the strip-shaped hole at intervals in the length direction, and the upper ends of the two high-voltage connectors penetrate into a vacuum cavity of the mass spectrometer in a sealed mode; the lower end is vertically inserted into a radio frequency unit of the mass spectrometer; two pairs of limiting chutes in one-to-one correspondence with the high-voltage connectors are formed in the hole walls of the two long sides of the strip-shaped hole in pairs, and each high-voltage connector is provided with an accompanying sliding block correspondingly clamped in the corresponding limiting chute. The high-voltage connector has the advantages that the horizontal movement of the sliding seat can be converted into the vertical movement of the high-voltage connector, the disassembly time is effectively saved, the convenience and the working efficiency of maintenance in the vacuum cavity are greatly improved, and the radio frequency unit is prevented from being damaged.

The present disclosure relates to a mass spectrometer (10) comprising a vacuum system (14) and a method of operating a vacuum system (14). A method of operating the vacuum system (14) of the mass spectrometer (10) is used to prevent vapor diffusion from a vacuum pump (41) of the mass spectrometer (10) into an analyzer (12) of the mass spectrometer (10). The mass spectrometer (10) includes an analyzer (12), a vacuum pump (41), and a vacuum conduit (45) extending between the vacuum pump (41) and the analyzer (12). The method comprises: operating the mass spectrometer (10) in a standby mode, wherein a sample is not present in the analyzer (12) for analysis; and inducing a standby fluid flow in the vacuum conduit (45) away from the analyzer (12) towards the vacuum pump (41) when the mass spectrometer (10) is in the standby mode.

A device (100) configured as an inline pump, in particular as an inline vacuum pump, further in particular as an inline ion pump, is described, the device (100) comprising: i) a housing (110) defining a central opening (115), in particular a central channel, for in-line operation of the device (100); and ii) a tempering device (120) coupled to the housing (110) and configured to provide tempering with respect to inline operation.

The invention discloses a vacuum system for a mass spectrometer. The vacuum system includes a first vacuum region, a second vacuum region, a vacuum interlock connected to the first vacuum region by a first valve and to the second vacuum region by a second valve, a first pump connected to the first vacuum region and the second vacuum region, a second pump connected to the second vacuum region, a pressure sensor configured to determine a pressure within the second vacuum region, and a controller configured to adjust a position of the second valve in response to the pressure within the second vacuum region. The vacuum interlock device is configured to receive a sample. The first pump is configured to reduce pressure within the first vacuum region and discharge air to the second vacuum region. The second pump is configured to reduce pressure within the vacuum interlock. The controller is configured to prevent pressure fluctuations in the second vacuum region.

A sampling interface enables the sampling of ions in a mass spectrometer for subsequent spectroscopic analysis. The sampling interface comprises: an inlet receiving a quantity of particles from an ion source, the quantity of particles including ions for spectroscopic analysis; a skimmer downstream of the inlet and comprising an aperture through which particles from the inlet pass; an extraction lens downstream of the skimmer and configured for extracting ions from the particles passed through the aperture at the skimmer; an adjustable voltage source applying a bias voltage to the extraction lens so as to generate an electric field in at least a region between the extraction lens and the skimmer; and a controller controlling the adjustable voltage source to apply a bias voltage to the extraction lens, in order to control the reduced electric field in the region immediately downstream of the skimmer.

Aspects of the present disclosure describe systems, methods, and structures that implement compact UHV ion trap systems that can operate at temperatures higher than cryogenic temperatures. Ion trap systems according to the present disclosure are surface treated and sealed while held in a UHV environment, with different components joined via UHV seals, such as welded joints, compressible metal flanges, and UHV compatible welded joints. As a result, no cryogenic pumps are needed, thereby enabling a very small volume system.

A pump management system may determine an operating mode for a mass spectrometer; set, based on the operating mode, a pump speed of a turbo pump used to create one or more vacuum stages for the mass spectrometer; and cause the turbo pump to operate at the pump speed while the mass spectrometer operates in accordance with the operating mode. Additionally or alternatively, the pump management system may monitor, using one or more instruments external to the turbo pump, a condition associated with the mass spectrometer while the mass spectrometer operates in accordance with the operating mode; determine, based on the monitoring, that the condition changes by more than a threshold value; and adjust, based on the condition changing by more than the threshold value and while the mass spectrometer is in operation, the pump speed.

An aspect of the present invention is an ion analysis apparatus comprising an interface unit (3) for introducing ions generated from a liquid sample in an ionization chamber (11) at substantially atmospheric pressure into a vacuum chamber (12), wherein the interface unit includes: a transport tube (30) through which ions flow; a first heating block (34) in which a heater (35) is embedded or provided in contact, the first heating block being attached to the ionization chamber side of a partition wall (9) that is part of an apparatus main body separating the ionization chamber and the vacuum chamber; a second heating block (33), separate from the first heating block, having a hole (33b) through which the transport tube is inserted; and a cover member (32) that is detachably attached to the ionization chamber side of the partition wall and covers the first and second heating blocks such that one end of the transport tube inserted through the hole of the second heating block protrudes, wherein when attached to the partition wall, the cover member presses the second heating block against the first heating block in a state where both heating blocks are in surface contact.

Provided herein is an ion source containing a plurality of components, at least one of which is partially coated with a layer of silicon. The ion source reduces reactivity between the sample and the c

One aspect of a method for manufacturing a quadrupole mass filter according to the present invention is a method for manufacturing a quadrupole mass filter including four rod electrodes, comprising a first step (S1, S2) of forming a hyperbolic surface by cutting at least a part of a side surface or a peripheral surface of each of four rod-shaped members over a longitudinal direction, each of the four rod-shaped members having a length in a range of 80 mm or more and 120 mm or less, and a second step (S3) of positioning and fixing the four rod-shaped members, on which the hyperbolic surfaces are respectively formed, as rod electrodes using a holding member, such that the four rod electrodes surround a central axis and the hyperbolic surface of each rod electrode faces the central axis.

The present invention relates to an ion source device and a mass spectrometer, wherein the ion source device comprises: a cover plate, the cover plate being used to cover one end of a vacuum chamber; an ion source assembly, one end of the ion source assembly being provided with a first mating portion, the first mating portion being used to position and cooperate with the second mating portion; a support column, one end of the support column being connected to the cover plate, and the ion source assembly being slidably connected to the support column; a reset member, the reset member being provided between the cover plate and the ion source assembly, and the ion source assembly being reset and cooperated with the cover plate through the reset member. The above-mentioned ion source device is easy to install due to the positioning function of the first mating portion and the second mating portion, and can improve the positioning convenience of the ion source assembly and the mass analyzer, thereby ensuring the centering and positioning accuracy of the assembly after maintenance, making the ion transmission channel concentric, thereby ensuring the ion transmission efficiency of the mass spectrometer and improving the working reliability after assembly.

A door 4 includes a closing portion 41 that closes an opening 302 in a closed state, and a holding portion 42 that holds the closing portion 41 and is connected to a hinge portion 5. The closing portion 41 is connected to the holding portion 42 on the side opposite to the hinge portion 5 side, and is configured to be separable from the holding portion 42 on the hinge portion 5 side. In a case where the door 4 is rotated from an open state to a closed state, the closing portion 41 is configured to be in contact with a peripheral edge portion of the opening 302 on the side opposite to the hinge portion 5 side before the closing portion 41 comes into contact with a peripheral edge portion of the opening 302 on the hinge portion 5 side.

An atmospheric pressure electron impact ionization mass spectrometer system includes an atmospheric pressure ionization component operated at an atmospheric pressure. An electron impact ionization mass spectrometer includes an electron ionization source. An atmospheric pressure interface operates below about 10 Torr. The atmospheric pressure interface includes a source block to focus a plurality of molecules and ions from the atmospheric pressure ionization component at the atmospheric pressure into the electron ionization source which operates at a pressure below about 10-3 Torr.

An atmospheric pressure electron impact ionization mass spectrometer system comprises an atmospheric pressure ionization component operating at atmospheric pressure. An electron impact ionization mass spectrometer comprises an electron ionization source. An atmospheric pressure interface operates below approximately 10 Torr. The atmospheric pressure interface comprises a source block for focusing multiple molecules and ions from the atmospheric pressure ionization component at atmospheric pressure into the electron ionization source, which operates at a pressure below approximately 10 -3 Torr is working.

In some examples, a three-dimensional printed nanospray interface for mass spectrometry may include a body including a sheath fluid inlet connected to a sheath fluid outlet for circulating sheath fluid to an emitter. The emitter may include a sidewall including a stepped texture on an inner surface of the sidewall.

Systems and methods for analyzing a sample are provided. In some embodiments, the systems include: The mass spectrometer may include a source configured to output one or more ions, a plurality of chambers having different pressures, a detector configured to detect the one or more ions, and a particle guide. The plurality of chambers may include at least a first chamber having a first pressure lower than atmospheric pressure and a second chamber having a second pressure lower than the first pressure. In some embodiments, the particle guide may include a conduit through which the one or more ions may travel along the entire length of the particle guide. The conduit may be disposed within at least the first chamber and the second chamber, and a vent may be disposed to define a passage between the chambers and the conduit.

An ion mobility analyser is disclosed having a gas flow directed along the ion travel axis and a set of electrodes to which DC voltages are applied to establish a DC field. The opposing forces of the gas flow and DC field cause ions to be trapped within a separation region in axial regions determined by their ion mobilities. A gas recirculator, having inlet and outlet ends respectively located downstream and upstream of the separation region, supplies at least fifty percent of the gas flow within the separation region, thereby reducing vacuum pumping requirements.

Described herein are mass spectrometers, ion manifolds, and analytical methods for high-duty cycle, tandem mass spectrometery.

A low power mass spectrometer assembly includes at least an ionization component, an electrostatic analyzer, a lens assembly, a magnet assembly and at least one detector located in a same plane as the entrance to the magnet assembly for detecting the deflected sample ions and / or fragments of sample ions, including ions or ion fragments indicative of the Vitamin D metabolite within the sample.